Since human acute renal failure (ARF) is frequently the result of multiple rather than single insults, we used a combination of treatments to induce ARF in rats. Uninephrectomized, salt-depleted rats injected with indomethacin developed ARF after administration of radiocontrast. After 24 h, the plasma creatine rose from 103 +/- 3 to 211 +/- 22 mumol/liter (mean +/- SE) and the creatinine clearance dropped from 0.7 +/- 0.1 to 0.2 +/- 0.04 ml/min (P less than 0.001). Severe injury was confined to the outer medulla and comprised necrosis of medullary thick ascending limbs (mTALs), tubular collapse, and casts. Other nephron segments were free of damage except for the proximal convoluted tubules which showed vacuole formation originating from lateral limiting membranes that resembled changes reported in human contrast nephropathy. Cell damage to mTALs included mitochondrial swelling, nuclear pyknosis, and cytoplasmic disruption with superimposed calcification; these changes were most severe in the deepest areas of the outer medulla, away from vasa recta in zones remote from oxygen supply. The fraction of mTALs with severe damage was 30 +/- 7% (range 2-68) and the extent of injury was correlated with a rise in plasma creatinine (r = 0.8, P less than 0.001). Thus, the nature of mTAL injury was similar to the selective lesions observed in isolated kidneys perfused with cell-free medium and was shown to derive from an imbalance between high oxygen demand by actively transporting mTALs and the meager oxygen supply to the renal medulla. Combined multiple renal insults in the rat produce ARF that resembles the clinical syndrome of contrast nephropathy and is characterized by selective mTAL injury conditioned by medullary hypoxia.
S N Heyman, M Brezis, C A Reubinoff, Z Greenfeld, C Lechene, F H Epstein, S Rosen
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Prevention of post-contrast kidney injury in patients with cancer
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Drugs in Context | 2024 |
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International journal of molecular sciences | 2024 |
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Meariman JK, Zulli H, Perez A, Bajracharya SD, Mohandas R |
2023 | |
Nitric Oxide Signalling in Descending Vasa Recta after Hypoxia/Re-Oxygenation
Xu M, Lichtenberger FB, Erdoǧan C, Lai E, Persson PB, Patzak A, Khedkar PH |
International journal of molecular sciences | 2022 |
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S Krishnan, AD SuarezMartinez, P Bagher, A Gonzalez, R Liu, WL Murfee, R Mohandas |
Microcirculation (New York, N.Y. : 1994) | 2020 |
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L Bankir, L Figueres, C Prot-Bertoye, N Bouby, G Crambert, JH Pratt, P Houillier |
American journal of physiology. Renal physiology | 2020 |
New Insight into Cerebrovascular Diseases - An Updated Comprehensive Review
PB Ambrosi, R Ahmad, A Abdullahi, A Agrawal |
2020 | |
Why Have Detection, Understanding and Management of Kidney Hypoxic Injury Lagged Behind those for the Heart?
Z Abassi, S Rosen, S Lamothe, SN Heyman |
Journal of Clinical Medicine | 2019 |
Contrast Induced Acute Kidney Injury and Direct Cytotoxicity of Iodinated Radiocontrast Media on Renal Proximal Tubule Cells
DB Ward, MA Valentovic |
The Journal of pharmacology and experimental therapeutics | 2019 |
Role of Hypoxia in Renal Failure Caused by Nephrotoxins and Hypertonic Solutions
SN Heyman, M Khamaisi, D Zorbavel, S Rosen, Z Abassi |
Seminars in Nephrology | 2019 |
Chronic exposure to hypoxia attenuates renal injury and innate immunity activation in the remnant kidney model
LC Rempel, VD Faustino, O Foresto-Neto, C Fanelli, SC Arias, GC da Silva Moreira, TF Nascimento, VF Ávila, DM Malheiros, NO Câmara, CK Fujihara, R Zatz |
American journal of physiology. Renal physiology | 2019 |
Effect of Repeated Injection of Iodixanol on Renal Function in Healthy Wistar Rats Using Functional MRI
Y Wang, K Ren, L Xie, W Sun, Y Liu, S Li |
BioMed Research International | 2018 |
Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice
A Andres-Hernando, N Li, C Cicerchi, S Inaba, W Chen, C Roncal-Jimenez, MT Le, MF Wempe, T Milagres, T Ishimoto, M Fini, T Nakagawa, RJ Johnson, MA Lanaspa |
Nature Communications | 2017 |
Understanding and preventing contrast-induced acute kidney injury
M Fähling, E Seeliger, A Patzak, PB Persson |
Nature Reviews Nephrology | 2017 |
Efficacy of oral supplemental hydration for the prevention of contrast-induced nephropathy in rats
T Matsunami, K Hino, R Dosho, S Miyatake, G Ebisu, R Kuwatsuru |
Japanese Journal of Radiology | 2017 |
Contrast-associated acute kidney injury is a myth: We are not sure
K Kashani, A Levin, M Schetz |
Intensive Care Medicine | 2017 |
Experimental model for acute kidney injury caused by uropathogenic Escherichia coli
B Skowron, A Baranowska, J Kaszuba-Zwoińska, G Więcek, A Malska-Woźniak, P Heczko, M Strus |
Postępy Higieny i Medycyny Doświadczalnej | 2017 |
Cellular and Molecular Mechanisms of AKI
A Agarwal, Z Dong, R Harris, P Murray, SM Parikh, MH Rosner, JA Kellum, C Ronco |
Journal of the American Society of Nephrology : JASN | 2016 |
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M Cordaro, D Impellizzeri, G Bruschetta, R Siracusa, R Crupi, RD Paola, E Esposito, S Cuzzocrea |
Toxicology Letters | 2016 |
Histopathological Evaluation of Contrast-Induced Acute Kidney Injury Rodent Models
N Kiss, P Hamar |
BioMed Research International | 2016 |
Induction of diuresis and natriuresis for renal protection: Update on the RenalGuard system™
R Solomon, A Segal |
Médecine Intensive Réanimation | 2016 |
Effect of Iodinated Contrast Medium in Diabetic Rat Kidneys as Evaluated by Blood-Oxygenation-Level–Dependent Magnetic Resonance Imaging and Urinary Neutrophil Gelatinase-Associated Lipocalin:
LP Li, J Lu, T Franklin, Y Zhou, R Solomon, PV Prasad |
Investigative Radiology | 2015 |
Architecture of the human renal inner medulla and functional implications
G Wei, S Rosen, WH Dantzler, TL Pannabecker |
American journal of physiology. Renal physiology | 2015 |
Evaluation of Intrarenal Oxygenation in Iodinated Contrast-Induced Acute Kidney Injury–Susceptible Rats by Blood Oxygen Level–Dependent Magnetic Resonance Imaging:
LP Li, J Lu, Y Zhou, MV Papadopoulou, T Franklin, U Bokhary, R Solomon, A Sen, PV Prasad |
Investigative Radiology | 2014 |
Mechanisms of Contrast-Induced Nephropathy Reduction for Saline (NaCl) and Sodium Bicarbonate (NaHCO3)
WP Burgess, PJ Walker |
BioMed Research International | 2014 |
A novel rat model of contrast-induced acute kidney injury
S Sun, T Zhang, P Nie, L Hu, Y Yu, M Cui, Z Cai, L Shen, B He |
International Journal of Cardiology | 2014 |
Efficacy of Preventive Interventions for Iodinated Contrast-Induced Acute Kidney Injury Evaluated by Intrarenal Oxygenation as an Early Marker:
LP Li, J Thacker, J Lu, T Franklin, Y Zhou, MV Papadopoulou, R Solomon, PV Prasad |
Investigative Radiology | 2014 |
Reference Module in Biomedical Sciences
DL Sackett, RB Haynes |
2014 | |
Core Knowledge in Critical Care Medicine
W Krüger, AJ Ludman |
2014 | |
Early renal dysfunction after contrast media administration despite prophylactic hydration
P Burchardt, P Guzik, P Tabaczewski, T Synowiec, M Bogdan, P Faner, A Chmielarz-Sobocińska, A Palasz |
The International Journal of Cardiovascular Imaging | 2013 |
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PH Vivier, P Storey, H Chandarana, A Yamamoto, K Tantillo, U Khan, JL Zhang, EE Sigmund, H Rusinek, JS Babb, M Bubenheim, VS Lee |
Investigative Radiology | 2013 |
Chronic activation of vasopressin V2 receptor signalling lowers renal medullary oxygen levels in rats
A Dietrich, S Mathia, H Kaminski, K Mutig, C Rosenberger, R Mrowka, S Bachmann, A Paliege |
Acta Physiologica | 2013 |
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K Arakelyan, K Cantow, J Hentschel, B Flemming, A Pohlmann, M Ladwig, T Niendorf, E Seeliger |
Acta Physiologica | 2013 |
Evaluation of Renal Oxygenation in Normal Korean Volunteers Using 3.0 T Blood Oxygen Level-Dependent MRI
SI Hwang, HJ Lee, HJ Chin, DW Chae, KY Na |
Journal of the Korean Society of Magnetic Resonance in Medicine | 2013 |
Renoprotective effect of Alpiniae oxyphyllae Fructus on ischemia/reperfusion-induced acute renal failure
EJ Kim, YJ Lee, YM Ahn, H Lee, DG Kang, HS Lee |
Archives of Pharmacal Research | 2013 |
Ascorbic Acid for the Prevention of Contrast-Induced Nephropathy After Coronary Angiography in Patients With Chronic Renal Impairment: A Randomized Controlled Trial: Ascorbic Acid and Contrast Nephropathy
B Dvoršak, V Kanič, R Ekart, S Bevc, R Hojs |
Therapeutic Apheresis and Dialysis | 2013 |
Descending vasa recta endothelial cells and pericytes form mural syncytia
Z Zhang, H Lin, C Cao, K Payne, TL Pallone |
American journal of physiology. Renal physiology | 2013 |
Why Is Diabetes Mellitus a Risk Factor for Contrast-Induced Nephropathy?
SN Heyman, C Rosenberger, S Rosen, M Khamaisi |
BioMed Research International | 2013 |
Contrast-induced acute kidney injury
A Kaul |
Clinical Queries Nephrology | 2012 |
N-acetylcysteine for the prevention of contrast-induced nephropathy in rats
MF İnci, İ Şalk, O Solak, ÜE Vurdem, R İnci |
Actas Urológicas Españolas (English Edition) | 2012 |
Contrast-induced nephropathy: Protective role of fenoldopam
A Caixeta, O Dogan, G Weisz |
Clinical and Experimental Pharmacology and Physiology | 2012 |
N-acethyl-cysteine reduces the occurrence of contrast-induced acute kidney injury in patients with renal dysfunction: a single-center randomized controlled trial
RM Heguilén, AA Liste, M Payaslian, MG Ortemberg, LM Albarracín, AR Bernasconi |
Clinical and Experimental Nephrology | 2012 |
Cardiological Society of India Practice Guidelines for Angiography in Patients with Renal Dysfunction
S Bhandari, A Seth, KK Sethi, S Tyagi, R Gupta, SC Tiwari, S Mehrotra, A Seth, S Guha, PK Deb, A Dasbiswas, PP Mohanan, K Venugopal, N Sinha, B Pinto, A Banerjee, G Sengottuvelu, R Mehran, PM Collough |
Indian Heart Journal | 2012 |
Uso de n-acetilcisteína para la prevención de la nefropatía inducida por contraste en ratas
MF İnci, İ Şalk, O Solak, ÜE Vurdem, R İnci |
Actas Urológicas Españolas | 2012 |
The Nephroprotective Properties of Recombinant Human Erythropoietin in Kidney Transplantation: Experimental Facts and Clinical Proofs: Recombinant Human EPO in Kidney Transplantation
N Pallet, M Rabant, C Legendre, F Martinez, G Choukroun |
American Journal of Transplantation | 2012 |
Sphingosine kinase 1 protects against renal ischemia–reperfusion injury in mice by sphingosine-1-phosphate1 receptor activation
SW Park, M Kim, M Kim, VD D'Agati, HT Lee |
Kidney International | 2011 |
Clinical cause of presumed acute tubular necrosis requiring renal replacement therapy and outcome of critically ill patients: post hoc analysis of a prospective 7-year cohort study
H Schiffl, R Fischer |
International Urology and Nephrology | 2011 |
Is Angiotensin-Converting Enzyme Inhibitor a Contraindication for Contrast-Induced Nephropathy Prophylaxis? A Review About its Paradox
X Li, T Li, H Cong |
Cardiovascular Therapeutics | 2011 |
C-Reactive Protein and the Risk of Contrast-Induced Acute Kidney Injury in Patients Undergoing Percutaneous Coronary Intervention
F Gao, YJ Zhou, X Zhu, ZJ Wang, SW Yang, H Shen |
American Journal of Nephrology | 2011 |
Renal ischemia–reperfusion injury causes intercalated cell-specific disruption of occludin in the collecting duct
SY Lee, JA Shin, HM Kwon, ID Weiner, KH Han |
Histochemistry and Cell Biology | 2011 |
Selective intrarenal human A1 adenosine receptor overexpression reduces acute liver and kidney injury after hepatic ischemia reperfusion in mice
SW Park, SW Chen, M Kim, VD D'Agati, HT Lee |
Laboratory Investigation | 2010 |
Constriction of the Vasa Recta, the Vessels Supplying the Area at Risk for Acute Kidney Injury, By Four Different Iodinated Contrast Media, Evaluating Ionic, Nonionic, Monomeric and Dimeric Agents
M Sendeski, A Patzak, PB Persson |
Investigative Radiology | 2010 |
Medullary ray injury in renal allografts
A Kobayashi, I Yamamoto, S Ito, Y Akioka, H Yamamoto, S Teraoka, M Hattori, K Tanabe, T Hosoya, Y Yamaguchi |
Pathology International | 2010 |
Novel approach for the prevention of contrast nephropathy
M Colbay, S Yuksel, I Uslan, G Acarturk, O Karaman, O Bas, H Mollaoglu, M Yagmurca, OA Ozen |
Experimental and Toxicologic Pathology | 2010 |
Comprehensive Toxicology
JM Sands, JW Verlander |
Comprehensive Toxicology | 2010 |
The prevention of contrast induced nephropathy by sarpogrelate in patients with chronic kidney disease: a study protocol for a prospective randomized controlled clinical trial
K Park, WY Chung, JB Seo, SH Kim, JH Zo, MA Kim, YB Park |
Trials | 2010 |
Selective renal overexpression of human heat shock protein 27 reduces renal ischemia-reperfusion injury in mice
M Kim, SW Park, M Kim, SW Chen, WT Gerthoffer, VD D'Agati, HT Lee |
American journal of physiology. Renal physiology | 2010 |
Studies on Renal Disorders
T Miyata, KU Eckardt, M Nangaku |
2010 | |
Iodixanol, constriction of medullary descending vasa recta, and risk for contrast medium-induced nephropathy
M Sendeski, A Patzak, TL Pallone, C Cao, AE Persson, PB Persson |
Radiology | 2009 |
Kidney-specific reconstitution of the A1 adenosine receptor in A1 adenosine receptor knockout mice reduces renal ischemia-reperfusion injury
M Kim, SW Chen, SW Park, M Kim, VD D'Agati, J Yang, HT Lee |
Kidney International | 2009 |
Contrast-Induced Acute Kidney Injury (CIAKI)
R Solomon |
Radiologic Clinics of North America | 2009 |
Animal models of renal dysfunction: acute kidney injury
SN Heyman, S Rosen, C Rosenberger |
Expert Opinion on Drug Discovery | 2009 |
Franklin H. Epstein—Researcher, Teacher, Clinician, and Humanist
RS Brown, SA Karumanchi, VP Sukhatme, ML Zeidel |
Clinical journal of the American Society of Nephrology : CJASN | 2009 |
Contrast-enhanced ultrasonography with Sonazoid for evaluation of renal microcirculation
S Okayama, T Hirai, N Yamashita, S Somekawa, M Iwano, S Uemura, M Kanauchi, Y Saito |
Journal of Medical Ultrasonics | 2008 |
Hemodynamic and serum biochemical alterations associated with intravenous administration of three types of contrast media in anesthetized dogs
RE Pollard, SM Puchalski, PJ Pascoe |
American Journal of Veterinary Research | 2008 |
Osmotic Nephrosis: Acute Kidney Injury With Accumulation of Proximal Tubular Lysosomes Due to Administration of Exogenous Solutes
M Dickenmann, T Oettl, MJ Mihatsch |
American Journal of Kidney Diseases | 2008 |
The effect of hemodilution during normothermic cardiac surgery on renal physiology and function: a review
H Vermeer, S Teerenstra, RG Sévaux, HA Swieten, PW Weerwind |
Perfusion | 2008 |
Clinical Nephrotoxins
ME Broe, GA Porter, WM Bennett, G Deray |
2008 | |
Apoptosis of the Thick Ascending Limb Results in Acute Kidney Injury
MB Srichai, C Hao, L Davis, A Golovin, M Zhao, G Moeckel, S Dunn, N Bulus, RC Harris, R Zent, MD Breyer |
Journal of the American Society of Nephrology : JASN | 2008 |
Effects of ischemia-reperfusion injury on renal ammonia metabolism and the collecting duct
KH Han, HY Kim, BP Croker, S Reungjui, SY Lee, J Kim, ME Handlogten, CA Adin, ID Weiner |
American journal of physiology. Renal physiology | 2007 |
Evaluation of intrarenal oxygenation in mice by BOLD MRI on a 3.0T human whole-body scanner
LP Li, L Ji, S Lindsay, PV Prasad |
Journal of Magnetic Resonance Imaging | 2007 |
Heme oxygenase-1 protects against radiocontrast-induced acute kidney injury by regulating anti-apoptotic proteins
AI Goodman, R Olszanecki, LM Yang, S Quan, M Li, S Omura, DE Stec, NG Abraham |
Kidney International | 2007 |
The L1 cell adhesion molecule is a potential biomarker of human distal nephron injury in acute tubular necrosis
Y Allory, V Audard, P Fontanges, P Ronco, H Debiec |
Kidney International | 2007 |
Hypoxia-inducible factors and tubular cell survival in isolated perfused kidneys
C Rosenberger, S Rosen, A Shina, W Bernhardt, MS Wiesener, U Frei, KU Eckardt, SN Heyman |
Kidney International | 2006 |
Contrast medium-induced nephropathy: The pathophysiology
PB Persson, M Tepel |
Kidney International | 2006 |
RENAL PARENCHYMAL OXYGENATION AND HYPOXIA ADAPTATION IN ACUTE KIDNEY INJURY
C Rosenberger, S Rosen, SN Heyman |
Clinical and Experimental Pharmacology and Physiology | 2006 |
RENAL OXYGEN DELIVERY: MATCHING DELIVERY TO METABOLIC DEMAND
PM O'Connor |
Clinical and Experimental Pharmacology and Physiology | 2006 |
Detection of evolving acute tubular necrosis with renal 23Na MRI: Studies in rats
N Maril, R Margalit, S Rosen, SN Heyman, H Degani |
Kidney International | 2006 |
Acute-on-Chronic Renal Failure in the Rat: Functional Compensation and Hypoxia Tolerance
M Goldfarb, C Rosenberger, Z Abassi, A Shina, F Zilbersat, KU Eckardt, S Rosen, SN Heyman |
American Journal of Nephrology | 2006 |
Evaluation of intra-renal oxygenation during water diuresis: a time-resolved study using BOLD MRI
SM Tumkur, AT Vu, LP Li, L Pierchala, PV Prasad |
Kidney International | 2006 |
Evaluation of intrarenal oxygenation at 3.0 T using 3-dimensional multiple gradient-recalled echo sequence
S Tumkur, A Vu, L Li, PV Prasad |
Investigative Radiology | 2006 |
Concomitant drugs with exposure to contrast media
C Erley |
Kidney International | 2006 |
Evaluation of Intrarenal Oxygenation at 3.0 T Using 3-Dimensional Multiple Gradient-Recalled Echo Sequence
S Tumkur, A Vu, L Li, PV Prasad |
Investigative Radiology | 2006 |
Pathophysiology of Contrast-Induced Nephropathy
J Tumlin, F Stacul, A Adam, CR Becker, C Davidson, N Lameire, PA McCullough |
The American Journal of Cardiology | 2006 |
Renal medullary tissue oxygenation is dependent on both cortical and medullary blood flow
PM O'Connor, MM Kett, WP Anderson, RG Evans |
American journal of physiology. Renal physiology | 2006 |
A 1 adenosine receptor knockout mice are protected against acute radiocontrast nephropathy in vivo
HT Lee, M Jan, SC Bae, JD Joo, FR Goubaeva, J Yang, M Kim |
American journal of physiology. Renal physiology | 2006 |
Inhibition of Fas/Fas ligand interaction reduces apoptosis of glomerular endothelial cells induced by ischemia and reperfusion in mouse kidney
Z Ozaki-Chen, H Yoshikawa, MS Kurokawa, C Masuda, E Takada, Y Natsuki, K Kimura, N Suzuki |
Inflammation and Regeneration | 2006 |
Effect of Specific and Non-Specific Inhibition of COX-2 on Renal Oxygenation before and after Water Diuresis
S Gilbert, C Zuo, FH Epstein |
Nephron Physiology | 2005 |
Residual Urinary Concentrating Ability and AQP2 Expression in a Rat Model for Chronic Renal Failure
K Suzuki, R Hatano, M Michimata, I Kazama, M Suzuki, N Miyama, A Sato, S Satomi, Y Ejima, T Yanagisawa, M Matsubara |
Nephron Physiology | 2005 |
Contrast Material-Induced Renal Failure: An Overview
R Schrader |
Journal of Interventional Cardiology | 2005 |
Pathophysiology of contrast medium–induced nephropathy
PB Persson, P Hansell, P Liss |
Kidney International | 2005 |
Up-regulation of HIF in experimental acute renal failure: Evidence for a protective transcriptional response to hypoxia
C Rosenberger, SN Heyman, S Rosen, A Shina, M Goldfarb, W Griethe, U Frei, P Reinke, S Bachmann, KU Eckardt |
Kidney International | 2005 |
Nephropathy induced by contrast media: pathogenesis, risk factors and preventive strategies
I Goldenberg, S Matetzky |
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne | 2005 |
Lights and shadows on the pathogenesis of contrast-induced nephropathy: state of the art
S Detrenis, M Meschi, S Musini, G Savazzi |
Nephrology Dialysis Transplantation | 2005 |
Contrast-Induced Nephropathy in Interventional Cardiovascular Medicine
V Mathur |
Contrast-Induced Nephropathy in Interventional Cardiovascular Medicine | 2005 |
Contrast Medium–induced Nephrotoxicity: Which Pathway?1
RW Katzberg |
Radiology | 2005 |
Identification of persistently altered gene expression in the kidney after functional recovery from ischemic acute renal failure
DP Basile, K Fredrich, M Alausa, CP Vio, M Liang, MR Rieder, AS Greene, AW Cowley |
American journal of physiology. Renal physiology | 2005 |
Radiocontrast-Induced Acute Renal Failure
SD Weisbord, PM Palevsky |
Journal of Intensive Care Medicine | 2005 |
Expression of human heme oxygenase-1 in the thick ascending limb attenuates angiotensin II-mediated increase in oxidative injury1
S Quan, L Yang, S Shnouda, ML Schwartzman, A Nasjletti, AI Goodman, NG Abraham |
Kidney International | 2004 |
Evaluation of intrarenal oxygenation by BOLD MRI at 3.0 T
LP Li, AT Vu, BS Li, E Dunkle, PV Prasad |
Journal of magnetic resonance imaging : JMRI | 2004 |
Evaluation of the reproducibility of intrarenal R2* and DeltaR2* measurements following administration of furosemide and during waterload
LP Li, P Storey, L Pierchala, W Li, J Polzin, P Prasad |
Journal of magnetic resonance imaging : JMRI | 2004 |
Gadolinium contrast media are more nephrotoxic than a low osmolar iodine medium employing doses with equal x-ray attenuation in renal arteriography: An experimental study in pigs1
B Elmståhl, U Nyman, P Leander, CM Chai, B Frennby, T Almén |
Academic Radiology | 2004 |
Ionic radiocontrast inhibits endothelium-dependent vasodilation of the canine renal artery in vitro: possible mechanism of renal failure following contrast medium infusion
B Discigil, PR Evora, PJ Pearson, F Viaro, AJ Rodrigues, HV Schaff |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] | 2004 |
Prophylaxis of Iodinated Contrast Media-Induced Nephropathy: A Pharmacological Point of View
JM Id, E Lancelot, E Pines, C Corot |
Investigative Radiology | 2004 |
Radiocontrast-induced nephropathy and percutaneous coronary intervention: a review of preventive measures
EP Mintz, L Gruberg |
Expert Opinion on Pharmacotherapy | 2003 |
Nonionic contrast media are less nephrotoxic than ionic contrast media to rat renal cortical slices
K Soejima, J Uozumi, T Kanou, C Fujiyama, Z Masaki |
Toxicology Letters | 2003 |
Endothelial dysfunction in ischemic acute renal failure: rescue by transplanted endothelial cells
SV Brodsky, T Yamamoto, T Tada, B Kim, J Chen, F Kajiya, MS Goligorsky |
American journal of physiology. Renal physiology | 2002 |
Is contrast as bad as we think?
P Vassiliu, J Sava, KG Toutouzas, GC Velmahos |
Journal of the American College of Surgeons | 2002 |
Difficulties in understanding human "acute tubular necrosis": Limited data and flawed animal models
S Rosen, SN Heyman |
Kidney International | 2001 |
Compensated heart failure predisposes to outer medullary tubular injury: Studies in rats
M Goldfarb, Z Abassi, S Rosen, A Shina, M Brezis, SN Heyman |
Kidney International | 2001 |
Review of Studies Establishing the Aging Male Spontaneously Hypertensive Rat as a Detector and Quantifier of the Kidney Toxicity of Radiocontrast Media and Other Chemicals
CG Duarte, J Zhang, SY ELLIS |
Investigative Radiology | 2001 |
Changes in intrarenal oxygenation as evaluated by BOLD MRI in a rat kidney model for radiocontrast nephropathy
PV Prasad, A Priatna, K Spokes, FH Epstein |
Journal of magnetic resonance imaging : JMRI | 2001 |
Effects of enhanced oxygen release from hemoglobin by RSR13 in an acute renal failure model
TJ Burke, D Malhotra, JI Shapiro |
Kidney International | 2001 |
Allosteric Modification of Oxygen Delivery by Hemoglobin
JA Wahr, M Gerber, J Venitz, N Baliga |
Anesthesia and Analgesia | 2001 |
Toward Proteomics in Uroscopy: Urinary Protein Profiles after Radiocontrast Medium Administration
DJ Hampel, C Sansome, MA Sha, S Brodsky, WE Lawson, MS Goligorsky |
Journal of the American Society of Nephrology : JASN | 2001 |
Reversibility of experimental acute renal failure in rats: Assessment with USPIO-enhanced MR imaging
JP Laissy, JM Id�e, A Loshkajian, S Benderbous, S Chillon, H Beaufils, E Schouman-Claeys |
Journal of Magnetic Resonance Imaging | 2000 |
PATHOPHYSIOLOGY AND MANAGEMENT OF RENAL INSUFFICIENCY IN THE PERIOPERATIVE AND CRITICALLY ILL PATIENT
M Hladunewich, MH Rosenthal |
Anesthesiology Clinics of North America | 2000 |
The Kidney and Hypertension in Diabetes Mellitus
CE Mogensen |
2000 | |
Changes in renal medullary pO2 during water diuresis as evaluated by blood oxygenation level–dependent magnetic resonance imaging: Effects of aging and cyclooxygenase inhibition
PV Prasad, FH Epstein |
Kidney International | 1999 |
Effects of Radiocontrast, Mannitol, and Endothelin on Blood Pressure and Renal Damage in the Aging Male Spontaneously Hypertensive Rat
CG Duarte, J Zhang, S Ellis |
Investigative Radiology | 1999 |
Pathophysiology of Radiocontrast Nephropathy
SN Heyman, J Reichman, M Brezis |
Investigative Radiology | 1999 |
Evaluation of changes in intrarenal oxygenation in rats using multiple gradient-recalled echo (mGRE) sequence
A Priatna, FH Epstein, K Spokes, PV Prasad |
Journal of magnetic resonance imaging : JMRI | 1999 |
Effects of Radiocontrast, Mannitol, and Endothelin on Blood Pressure and Renal Damage in the Aging Male Spontaneously Hypertensive Rat:
CG Duarte, J Zhang, S Ellis |
Investigative Radiology | 1999 |
MAPK activation determines renal epithelial cell survival during oxidative injury
M Brezis, S Rosen |
The American journal of physiology | 1999 |
Nephrotoxicity of contrast media
G Deray |
Nephrology Dialysis Transplantation | 1999 |
Hypercholesterolemia aggravates radiocontrast nephrotoxicity: Protective role of L-arginine
L Andrade, SB Campos, AC Seguro |
Kidney International | 1998 |
Prevention of contrast-media-induced renal impairment by adenosine antagonists in humans
CM Erley, H Osswald |
Drug Development Research | 1998 |
Contrast media-induced nephrotoxicity--questions and answers
SK Morcos |
British Journal of Radiology | 1998 |
Acute Renal Failure in Experimental Envenomation with Africanized Bee Venom
MA Reis, RS Costa, TM Coimbra, VP Teixeira |
Renal Failure | 1998 |
Critical Care Nephrology
C Ronco, R Bellomo |
1998 | |
Renal microcirculation and tissue damage during acute ureteral obstruction in the rat: Effect of saline infusion, indomethacin and radiocontrast
SN Heyman, S Fuchs, R Jaffe, A Shina, L Ellezian, M Brezis, S Rosen |
Kidney International | 1997 |
The SHR as a Small Animal Model for Radiocontrast Renal Failure. Relation of Nephrotoxicity to Animal's Age, Gender, Strain, and Dose of Radiocontrast
CG Duarte, J Zhang, S Ellis |
Renal Failure | 1997 |
The role of endothelin in radiocontrast nephropathy
A Anarat, N Duman, A Noyan, M Kibar, R Anarat |
International Urology and Nephrology | 1997 |
MR assessment of iodinated contrast-medium-induced nephropathy in rats using ultrasmall particles of iron oxide
JP Laissy, S Benderbous, JM Idée, S Chillon, H Beaufils, E Schouman-Claeys |
Journal of Magnetic Resonance Imaging | 1997 |
Endothelin and atrial natriuretic peptide levels following radiocontrast exposure in humans
BA Clark, D Kim, FH Epstein |
American Journal of Kidney Diseases | 1997 |
Contrast media induced changes in tubular electrophysiology and glomerular filtration rate in the mouse kidney
NS Morgunov, GS Foster, DJ Hirsch |
Canadian Journal of Physiology and Pharmacology | 1997 |
Suki and Massry’s THERAPY OF RENAL DISEASES AND RELATED DISORDERS
WN Suki, SG Massry |
1997 | |
Nitric Oxide and the Kidney
MS Goligorsky, SS Gross |
1997 | |
Adenosine modulates vasomotor tone in outer medullary descending vasa recta of the rat
EP Silldorff, MS Kreisberg, TL Pallone |
Journal of Clinical Investigation | 1996 |
Reliability of Experimental Models of Iodinated Contrast Media-Induced Acute Renal Failure
JM Idée, B Bonnemain |
Investigative Radiology | 1996 |
Glomerular filtration and saturable absorption of iohexol in the rat isolated perfused kidney
R Masereeuw, MM Moons, P Smits, FG Russel |
British Journal of Pharmacology | 1996 |
Aspects of contrast media nephrotoxicity
SK Morcos, FH Epstein, J Haylor, M Dobrota |
European Journal of Radiology | 1996 |
Continuous urine oxygen tension monitoring in patients undergoing cardiac surgery
M Kainuma, M Yamada, T Miyake |
Journal of Cardiothoracic and Vascular Anesthesia | 1996 |
Effects of Mannitol and Iohexol Infusions on the Renal Cortical Blood Flow in Dehydrated Mice
B Högström, SO Hietala, P Rooth |
Acta Radiologica | 1996 |
Rapid DNA fragmentation from hypoxia along the thick ascending limb of rat kidneys
R Beeri, Z Symon, M Brezis, SA Ben-Sasson, PH Baehr, S Rosen, RA Zager |
Kidney International | 1995 |
The effect of contrast agents on renal function
S Dorph |
European Radiology | 1995 |
Contrast media injection in the rat after multiple renal insults no evidence of additional nephrotoxicity
A Verbacys, N Lameire, S Ringoir, M Praet, GV Maele |
Urological Research | 1995 |
Influence of feeding, blood sampling method and type of anaesthesia on renal function parameters in the normal laboratory rat
A Verbaeys, S Ringoir, GV Maele, N Lameire |
Urological Research | 1995 |
Nitric oxide and prostanoids protect the renal outer medulla from radiocontrast toxicity in the rat
Y Agmon, H Peleg, Z Greenfeld, S Rosen, M Brezis |
Journal of Clinical Investigation | 1994 |
Risk of radiocontrast nephropathy in patients with and without diabetes mellitus
LS Weisberg, PB Kurnik, BR Kurnik |
Kidney International | 1994 |
Iodinated contrast media-induced nephropathy: pathophysiology, clinical aspects and prevention
JM Idée, H Beaufils, B Bonnemain |
Fundamental & Clinical Pharmacology | 1994 |
Physiology of Renal Hypoxiaa
FH Epstein, Y Agmon, M Brezis |
Annals of the New York Academy of Sciences | 1994 |
Contrast nephrotoxicity: Predictive value of urinary enzyme markers in a rat model
SG Naidu, FT Lee |
Academic Radiology | 1994 |
Current Perspectives on Intravascular Contrast Agents for Radiological Imaging
JJ Keizur, S Das |
The Journal of Urology | 1994 |
In Vivo Fluorescence Microscopy of Microcirculation in the Renal Cortex of Mice: Part V. Effects of Mannitol and Iohexol Infusions in Normal, Obese/Hyperglycemic and Diabetic Mice
B Högström, SO Hietala, P Rooth |
Acta Radiologica | 1994 |
Role of endothelin and prostaglandins in radiocontrast-induced renal artery constriction
LG Cantley, K Spokes, B Clark, EG McMahon, J Carter, FH Epstein |
Kidney International | 1993 |
In Vivo Fluorescence Microscopy of Microcirculation in the Renal Cortex of Mice: Part III. Effects of Mannitol and Iohexol Infusions after Pretreatment with Cyclosporin A
B Högström, SO Hietala, P Rooth |
Acta Radiologica | 1993 |
In Vivo Fluorescence Microscopy of Microcirculation in the Renal Cortex of Mice: Part IV. Effects of Mannitol and Iohexol Infusions after Temporary Renal Ischemia
B Högström, SO Hietala, P Rooth |
Acta Radiologica | 1993 |
Nephrology and Urology in the Aged Patient
DG Oreopoulos, MF Michelis, S Herschorn |
1993 | |
Determinants of Intrarenal Oxygenation: Factors in Acute Renal Failure
S Rosen, FH Epstein, M Brezis |
Renal Failure | 1992 |
Forefronts in Nephrology: Summary of the Newer Aspects of Renal Cell Injury
M Brezis |
Kidney International | 1992 |
Effect of Glycine and Hypertrophy on Renal Outer Medullary Hypoxic Injury in Ischemia Reflow and Contrast Nephropathy
SN Heyman, M Brezis, FH Epstein, K Spokes, S Rosen |
American Journal of Kidney Diseases | 1992 |
Cyclosporine Nephropathy: Morphometric Analysis of the Medullary Thick Ascending Limb
IE Stillman, M Brezis, Z Greenfeld, BJ Ransil, SN Heyman, S Rosen |
American Journal of Kidney Diseases | 1992 |
Radiocontrast–induced nephropathy in humans: Role of renal vasoconstriction
LS Weisberg, PB Kurnik, BR Kurnik |
Kidney International | 1992 |
International Yearbook of Nephrology 1993
VE Andreucci, LG Fine |
1992 | |
Role of nitric oxide in renal medullary oxygenation. Studies in isolated and intact rat kidneys
M Brezis, SN Heyman, D Dinour, FH Epstein, S Rosen |
Journal of Clinical Investigation | 1991 |
Effects of graded oxygen tension on adenosine release by renal medullary and thick ascending limb suspensions
RE Beach, BA Watts, DW Good, CR Benedict, TD DuBose |
Kidney International | 1991 |
Early renal medullary hypoxic injury from radiocontrast and indomethacin
SN Heyman, M Brezis, FH Epstein, K Spokes, P Silva, S Rosen |
Kidney International | 1991 |
Diabetic Nephropathy: Changing Concepts of Pathogenesis and Treatment
DS Bell |
The American Journal of the Medical Sciences | 1991 |
Absence of Functional Renal Effects of Uro-Angiographic Contrast Media on Post-Ischemic Rat Kidneys
A Verbaeys, GV Maele, WD Sy, S Ringoir, N Lameire |
Acta Radiologica | 1991 |
Effect of Indomethacin and Salt Depletion on Renal Proton MR Imaging: An Experimental Study in the Rat
SN Heyman, M Mammen |
Acta Radiologica | 1991 |
Use of Iodinated Contrast Media in Patients with Chronic Renal Insufficiency and in End-Stage Renal Disease
NA Nora, FA Krumlovsky |
The International Journal of Artificial Organs | 1991 |
Update 1991
JL Vincent |
1991 | |
Hypercalcemic nephropathy: Chronic disease with predominant medullary inner stripe injury
S Rosen, Z Greenfeld, J Bernheim, M Rathaus, E Podjarny, M Brezis |
Kidney International | 1990 |
Morphometric correlates of renal excretory function
AJ Howie, BK Gunson, J Sparke |
The Journal of Pathology | 1990 |
Angiotensin II augments medullary hypoxia and predisposes to acute renal failure
M Brezis, Z Greenfeld, A Shina, S Rosen |
European Journal of Clinical Investigation | 1990 |
Ultrastructure of medullary tubules in ischemic acute tubular necrosis and acute interstitial nephritis in man
TS Olsen, HE Hansen |
APMIS | 1990 |
Induction and prevention of radiocontrast-induced nephropathy in dogs with heart failure
KB Margulies, LJ Mckinley, PG Cavero, JC Burnett |
Kidney International | 1990 |
Experimental contrast-associated nephropathy and its clinical implications
GA Porter |
The American Journal of Cardiology | 1990 |
Contrast nephropathy in azotemic diabetic patients undergoing coronary angiography
CL Manske, JM Sprafka, JT Strony, Y Wang |
The American Journal of Medicine | 1990 |
Adriamycin Nephrosis and Contrast Media: A Comparison between Diatrizoate and Iohexol in Rats
HS Thomsen, K Golman, L Hemmingsen, S Larsen, P Skaarup |
Acta Radiologica | 1990 |
Low Sodium Diet, Indomethacin, and Contrast Media: A Comparison between Renal Effects of Diatrizoate and Iohexol in Rats
HS Thomsen, L Hemmingsen, K Golman, P Skaarup, S Larsen |
Acta Radiologica | 1990 |
Acute Renal Failure in the Intensive Therapy Unit
D Bihari, G Neild |
1990 | |
Frontiers in European Radiology
AL Baert, FH Heuck |
1990 | |
Epidermal growth factor enhances renal tubule cell regeneration and repair and accelerates the recovery of renal function in postischemic acute renal failure
HD Humes, DA Cieslinski, TM Coimbra, JM Messana, C Galvao |
Journal of Clinical Investigation | 1989 |
Renal medullary Na-K-ATPase and hypoxic injury in perfused rat kidneys
FH Epstein, P Silva, K Spokes, M Brezis, S Rosen |
Kidney International | 1989 |
Adenine nucleotides, transport activity and hypoxic necrosis in the thick ascending limb of Henle
PF Shanley, GC Johnson |
Kidney International | 1989 |
Nephrotoxicity of contrast media
AS Berns |
Kidney International | 1989 |
A Closer Look at Radiocontrast-Induced Nephropathy
M Brezis, FH Epstein |
New England Journal of Medicine | 1989 |
The Pathophysiological Implications of Medullary Hypoxia
M Brezis, SN Rosen, FH Epstein |
American Journal of Kidney Diseases | 1989 |
The Vulnerability of the Thin Descending Limbs of Henle's Loop in the Isolated Perfused Rat Kidney
J Kopolovic, M Brezis, K Spokes, P Silva, F Epstein, S Rosen |
American Journal of Kidney Diseases | 1989 |
Protective Role of Furosemide and Saline in Radiocontrast-Induced Acute Renal Failure in the Rat
SN Heyman, M Brezis, Z Greenfeld, S Rosen |
American Journal of Kidney Diseases | 1989 |
Southwestern Internal Medicine Conference: Renal Failure Following Radiologic Procedures
RE Cronin |
The American Journal of the Medical Sciences | 1989 |
Nephrotoxicity of Cyclosporin a and Contrast Media: A Comparison between Diatrizoate and Iohexol in Rats
HS Thomsen, S Larsen, P Skaarup, L Hemmingsen, H Dieperink, K Golman |
Acta Radiologica | 1989 |