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Effects of a synthetic peptide of a parathyroid hormone-related protein on calcium homeostasis, renal tubular calcium reabsorption, and bone metabolism in vivo and in vitro in rodents.
A J Yates, … , J W Poser, G R Mundy
A J Yates, … , J W Poser, G R Mundy
Published March 1, 1988
Citation Information: J Clin Invest. 1988;81(3):932-938. https://doi.org/10.1172/JCI113406.
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Effects of a synthetic peptide of a parathyroid hormone-related protein on calcium homeostasis, renal tubular calcium reabsorption, and bone metabolism in vivo and in vitro in rodents.

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Abstract

A synthetic peptide corresponding to the first 34 amino acids of the parathyroid hormone-related protein (PTH-rP) produced by a human tumor associated with hypercalcemia was examined for skeletal and renal effects on calcium metabolism in vivo and in vitro. These effects were compared with those of human parathyroid hormone (1-34), hPTH (1-34). Equal doses of PTH-rP(1-34) and hPTH(1-34) produced equivalent stimulation of adenylate cyclase in vitro in bone cells and kidney cells and tubules. Subcutaneous injection of PTH-rP(1-34) in mice caused a significant dose-related increase in blood ionized calcium similar to that seen with hPTH(1-34) at equivalent doses. Repeated injections of equal doses of both peptides caused sustained hypercalcemia which was significantly greater in PTH-rP(1-34)-treated mice, although each induced comparable increases in histomorphometric indices of osteoclastic bone resorption. PTH-rP(1-34) and hPTH(1-34) also caused similar increases in bone resorption when incubated with fetal rat long bones in organ culture. Infusion of either peptide into thyroparathyroidectomized rats suppressed urinary calcium excretion and increased urinary excretion of cyclic AMP. PTH-rP appears to have similar effects to those of PTH on the skeleton, the kidney, and overall calcium homeostasis.

Authors

A J Yates, G E Gutierrez, P Smolens, P S Travis, M S Katz, T B Aufdemorte, B F Boyce, T K Hymer, J W Poser, G R Mundy

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CJ Pirola, HM Wang, A Kamyar, S Wu, H Enomoto, B Sharifi, JS Forrester, TL Clemens, JA Fagin
The Journal of biological chemistry 1993
Parathyroid hormone-related protein and calcium phosphate metabolism.
Law F, Ferrari S, Rizzoli R, Bonjour JP
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Iguchi H, Katakami H, Ichinose Y, Nishi Y, Tanaka S, Hara N, Ohta M, Haji M, Nawata H
Japanese journal of cancer research : Gann 1993
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H Imamura, K Sato, K Shizume, T Satoh, K Kasono, M Ozawa, E Ohmura, T Tsushima, H Demura
Journal of Bone and Mineral Research 1991
Evaluation of bone resorption and renal tubular reabsorption of calcium and phosphate in malignant and nonmalignant hypercalcemia
B Buchs, R Rizzoli, JP Bonjour
Bone 1991
Mechanisms of osteolytic bone destruction
GR Mundy
Bone 1991
Structural requirements for the action of parathyroid hormone-related protein (PTHrP) on bone resorption by isolated osteoclasts
RS Evely, A Bonomo, HG Schneider, JM Moseley, J Gallagher, TJ Martin
Journal of Bone and Mineral Research 1991
Parathyroid hormone-related protein inhibits stimulated uterine contraction in vitro
RL Shew, JA Yee, DB Kliewer, YJ Keflemariam, DL McNeill
Journal of Bone and Mineral Research 1991
Stimulation by parathyroid hormone-related protein and transforming growth factor-α of phosphate transport in osteoblast-like cells
L Pizurki, R Rizzoli, J Caverzasio, JP Bonjour
Journal of Bone and Mineral Research 1991
Effects of guanine nucleotides and parathyroid hormone on inositol 1,4,5-trisphosphate metabolism in canine renal cortical tubular cell membranes
DT Coleman, BS Morrow, JP Bilezikian
Journal of Bone and Mineral Research 1991
Parathyroid hormone—like peptide
DJ Drucker
Endocrine Pathology 1991
Chicken parathyroid hormone-related protein and its expression during embryologic development
DT Schermer, SD Chan, R Bruce, RA Nissenson, WI Wood, GJ Strewler
Journal of Bone and Mineral Research 1991
Effects of transforming growth factor-α on parathyroid hormone- and parathyroid hormone-related protein- mediated bone resorption and adenylate cyclase stimulation in vitro
TJ Rosol, JI Merryman, RM Nohutcu, LK McCauley, CC Capen
Domestic Animal Endocrinology 1991
Multiple recurrent giant cell lesions associated with high circulating levels of parathyroid hormone-related peptide in a young adult
JP Davis, DJ Archer, C Fisher, SJ Wimalawansa, D Baldwin, SJ Wimalawansa
British Journal of Oral and Maxillofacial Surgery 1991
A 7–34 analog of the parathyroid hormone-related protein has potent antagonist and partial agonist activity in vivo
N Horiuchi, T Hongo, TL Clemens
Bone and Mineral 1991
Parathyroid hormone-related protein(50–69) and response to pamidronate therapy for tumour-induced hypercalcaemia
DJ Dodwell, SK Abbas, AR Morton, A Howell
European Journal of Cancer and Clinical Oncology 1991
Osteoclast Differentiation
GD Roodman
Critical Reviews in Oral Biology & Medicine 1991
Prostaglandins enhance parathyroid hormone-evoked increase in free cytosolic calcium concentration in osteoblast-like cells
DT Yamaguchi, J Green, CR Kleeman, S Muallem
Cell Calcium 1991
Ectopic Production of Calciotropic Peptides
GR Mundy
Endocrinology and metabolism clinics of North America 1991
Analogues of parathyroid hormone modified at positions 3 and 6. Effects on receptor binding and activation of adenylyl cyclase in kidney and bone
FE Cohen, GJ Strewler, MS Bradley, M Carlquist, M Nilsson, M Ericsson, TL Ciardelli, RA Nissenson
The Journal of biological chemistry 1991
Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo
IR Garrett, BF Boyce, RO Oreffo, L Bonewald, J Poser, GR Mundy
Journal of Clinical Investigation 1990
Incidence and pathophysiology of hypercalcemia
GR Mundy
Calcified Tissue International 1990
Comparison of the effects of amino-terminal synthetic parathyroid hormone-related peptide (PTHrP) of malignancy and parathyroid hormone on resorption of cultured fetal rat long bones
LG Raisz, HA Simmons, SJ Vargas, BE Kemp, TJ Martin
Calcified Tissue International 1990
Circulating concentrations of parathyroid hormone-like peptide in malignancy and in hyperparathyroidism
JE Henderson, C Shustik, R Kremer, SA Rabbani, GN Hendy, D Goltzman, GN Hendy, D Goltzman
Journal of Bone and Mineral Research 1990
Quantitative evaluation of anticalciuretic effects of synthetic parathyroid hormonelike peptides
SJ Scheinman, ME Mitnick, AF Stewart
Journal of Bone and Mineral Research 1990
Parathyroid hormone-related protein and hypercalcemia in pancreatic neuro-endocrine tumors
R Rizzoli, AP Sappino, JP Bonjour
International Journal of Cancer 1990
Human PTH-(3-34) inhibited the effects of human parathyroid hormone-related protein on phosphate uptake in a cultured renal cell line (OK cells)
M Nakai, M Fukase, T Yamaguchi, T Tsukamoto, N Fujii, T Fujita
Journal of Bone and Mineral Research 1990
Hypercalcemia in malignancy
GJ Strewler, RA Nissenson
The Western journal of medicine 1990
Immunohistochemicaf evidence of parathyroid hormone—related protein in human parathyroid tissue
P Hellman, G Bjerneroth, C Juhlin, P Ridefelt, J Rastad, G Åkerström, H Jüppner
Endocrine Pathology 1990
The synthetic human parathyroid hormone-related protein is inhibited by a parathyroid hormone antagonist in rats in vivo
N Horiuchi, T Hongo, TL Clemens
Journal of Bone and Mineral Research 1990
In vivo effects of human recombinant transforming growth factor β on bone turnover in normal mice
C Marcelli, AJ Yates, GR Mundy
Journal of Bone and Mineral Research 1990
Parathyroid hormone-receptor interactions
MP Caulfield, M Rosenblatt
Trends in Endocrinology & Metabolism 1990
Parathyroid hormone-like peptide in normal and neoplastic mesothelial cells
P McAuley, SL Asa, B Chiu, J Henderson, D Goltzman, DJ Drucker
Cancer 1990
Humoral hypercalcemia of malignancy
KW Ng, TJ Martin
Clinical Biochemistry 1990
Parathyroid hormone-related protein (PTHrP): Studies with synthetic peptides indicate that parathyroid hormone and PTHrP interact with the same receptor
MP Caulfield, RL Mckee, ME Goldman, MA Thiede, DD Thompson, JE Fisher, JJ Levy, JG Seedor, N Horiuchi, TL Clemens, GA Rodan, M Rosenblatt
International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology 1990
Parathyroid Hormone-Related Peptide in Plasma of Patients With Hypercalcemia and Malignant Lesions
PC Kao, GG Klee, RL Taylor, H Heath
Mayo Clinic Proceedings 1990
Bone and Mineral Research
A Perault-Staub, J Staub, G Milhaud
Bone and Mineral Research 1990
7 Mechanisms of hypercalcaemia of malignancy
GE Gutierrez, JW Poser, MS Katz, AJ Yates, HL Henry, GR Mundy
Baillière's Clinical Endocrinology and Metabolism 1990
Inhibition of renal membrane adenylate cyclase by extract of pancreatic cancer associated with humoral hypercalcemia of malignancy
Y Yasutomo, N Kugai, N Nagata, T Akatsu, S Wada, T Kinoshita, H Kosano, O Takatani
Bone and Mineral 1990
Effect of parathyroid hormone-like peptides on 25-hydroxyvitamin D-1 alpha-hydroxylase activity in rodents
AT Walker, AF Stewart, EA Korn, T Shiratori, MA Mitnick, TO Carpenter
American journal of physiology. Endocrinology and metabolism 1990
PARATHYROID HORMONE-RELATED PROTEIN IN HYPERCALCAEMIA OF MALIGNANCY
TJ Martin, LJ Suva
Clinical Endocrinology 1989
Role of bone and kidney in parathyroid hormone-related peptide-induced hypercalcemia in rats
R Rizzoli, J Caverzasio, MC Chapuy, TJ Martin, JP Bonjour
Journal of Bone and Mineral Research 1989
High extracellular calcium increases the production of a parathyroid hormone-like activity by cultured leydig tumor cells associated with humoral hypercalcemia
R Rizzoli, JP Bonjour
Journal of Bone and Mineral Research 1989
Contrasting mechanisms of hypercalcemia in patients with early and advanced humoral hypercalcemia of malignancy
SH Ralston, BF Boyce, RA Cowan, MD Gardner, WD Fraser, IT Boyle
Journal of Bone and Mineral Research 1989
Structure-activity relationships of parathyroid hormone analogs in the opossum kidney cell line
DL Carnes, JA Cole, LR Forte, RE Poelling, PK Thorne, S Eber
Journal of Bone and Mineral Research 1989
COMPARISON OF THREE INTRAVENOUS BISPHOSPHONATES IN CANCER-ASSOCIATED HYPERCALCAEMIA
SH Ralston, U Patel, WD Fraser, SJ Gallacher, FJ Dryburgh, RA Cowan, IT Boyle
The Lancet 1989
High levels of a parathyroid hormone-like protein in milk
AA Budayr, BP Halloran, JC King, D Diep, RA Nissenson, GJ Strewler
Proceedings of the National Academy of Sciences 1989
and antagonists against parathyroid hormone-related protein
K Nagasaki, K Yamaguchi, Y Miyake, C Hayashi, S Honda, K Urakami, K Miki, S Kimura, T Watanabe, K Abe
Biochemical and Biophysical Research Communications 1989
Renal vasodilation and microvessel adenylate cyclase stimulation by synthetic parathyroid hormone-like protein fragments
MJ Musso, M Plante, C Judes, M Barthelmebs, JJ Helwig
European Journal of Pharmacology 1989
Effects of parathyroid hormone on cyclic-AMP concentrations of in vitro Necturus maculosus gastric antrum
MJ Rutten, HT Chern, CD Moore, J Hamilton, LY Cheung
General and Comparative Endocrinology 1989
Parathyroid hormone-like peptide: Molecular characterization and biological properties
D Goltzman, GN Hendy, D Banville
Trends in Endocrinology & Metabolism 1989
The effects of human parathyroid hormone-related peptide on cytosolic free calcium and cAMP production in opossum kidney cell
Y Yamamoto, M Fukase, Y Fujii, T Fujita
Bone and Mineral 1989
Proceedings of the 1988 Laurentian Hormone Conference
T Martin, E Allan, I Caple, A Zare, J Danks, H Diefenbach-Jagger, P Ebeling, M Zillespie, G Hammonds, J Heath, P Hudson, B Kemp, M Kubota, S Kukreja, J Moseley, K Ng, L Raisz, C Rodda, H Simmons, L Suva, R Wettenhal, W Wood
Proceedings of the 1988 Laurentian Hormone Conference 1989
Recent Advances in Pathophysiology and Treatment of Hypercalcemia of Malignancy
GR Mundy, AJ Yates
American Journal of Kidney Diseases 1989
Tumors of the Parathyroid Gland and Circulating Parathyroid Hormone-Related Protein Associated with Persistent Hypercalcemia
TJ Rosol, CC Capen
Toxicologic pathology 1989
Humoral Hypercalcemia of Malignancy: The Role of Parathyroid Hormone-related Protein
KL Insogna
Endocrinology and metabolism clinics of North America 1989
Characterization of Canine Renal Receptors for the Parathyroid Hormone-like Protein Associated with Humoral Hypercalcemia of Malignancy
JJ Orloff, TL Wu, HW Heath, TG Brady, ML Brines, AF Stewart
The Journal of biological chemistry 1989
Characterization of the human parathyroid hormone-like peptide gene
T Yasuda, D Banville, GN Hendy, D Goltzman
The Journal of biological chemistry 1989
Hypercalcaemia of malignancy
PJ Kelly, JA Eisman
Cancer and Metastasis Reviews 1989
Hypercalcemia of malignancy revisited
GR Mundy
Journal of Clinical Investigation 1988
Antibodies to parathyroid hormone-related protein lower serum calcium in athymic mouse models of malignancy-associated hypercalcemia due to human tumors
SC Kukreja, DH Shevrin, SA Wimbiscus, PR Ebeling, JA Danks, CP Rodda, WI Wood, TJ Martin
Journal of Clinical Investigation 1988
Vitamin D
A Portale, Β Halloran, E Lonergan, R Morris
Vitamin D 1988
Effects of infusion of human parathyroid hormone-related protein-(1-40) in nude mice: Histomorphometric and biochemical investigations
TJ Rosol, CC Capen, RL Horst
Journal of Bone and Mineral Research 1988
Increased renal calcium reabsorption in an animal model of hypercalcemia of human malignancy
PJ Shipley, DH Shevrin, SC Kukreja
Journal of Bone and Mineral Research 1988
Human parathyroid hormone related protein fragment-(1–34) had glucose-6-phosphate dehydrogenase activity on distal convoluted tubules in cytochemical bioassay
M Nakai, M Fukase, K Sakaguchi, T Noda, N Fujii, T Fujita
Biochemical and Biophysical Research Communications 1988
9 Parathyroid hormone-related protein: A novel gene product
TJ Martin, LJ Suva
Baillière's Clinical Endocrinology and Metabolism 1988
Synthetic peptides comprising the amino-terminal sequence of a parathyroid hormone-like protein from human malignancies. Binding to parathyroid hormone receptors and activation of adenylate cyclase in bone cells and kidney
RA Nissenson, D Diep, GJ Strewler
The Journal of biological chemistry 1988

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