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A synthetic peptide corresponding to the first 34 amino acids of the parathyroid hormone-related protein (PTH-rP) produced by a human tumor associated with hypercalcemia was examined for skeletal and renal effects on calcium metabolism in vivo and in vitro. These effects were compared with those of human parathyroid hormone (1-34), hPTH (1-34). Equal doses of PTH-rP(1-34) and hPTH(1-34) produced equivalent stimulation of adenylate cyclase in vitro in bone cells and kidney cells and tubules. Subcutaneous injection of PTH-rP(1-34) in mice caused a significant dose-related increase in blood ionized calcium similar to that seen with hPTH(1-34) at equivalent doses. Repeated injections of equal doses of both peptides caused sustained hypercalcemia which was significantly greater in PTH-rP(1-34)-treated mice, although each induced comparable increases in histomorphometric indices of osteoclastic bone resorption. PTH-rP(1-34) and hPTH(1-34) also caused similar increases in bone resorption when incubated with fetal rat long bones in organ culture. Infusion of either peptide into thyroparathyroidectomized rats suppressed urinary calcium excretion and increased urinary excretion of cyclic AMP. PTH-rP appears to have similar effects to those of PTH on the skeleton, the kidney, and overall calcium homeostasis.
A J Yates, G E Gutierrez, P Smolens, P S Travis, M S Katz, T B Aufdemorte, B F Boyce, T K Hymer, J W Poser, G R Mundy
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Principles of Bone Biology
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Endocrinology & Metabolism Clinics of North America | 2000 |
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Technical and Clinical Validation of an Immunoradiometric Assay for Circulating Parathyroid Hormone-related Protein
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Bone resorption induced by parathyroid hormone is strikingly diminished in collagenase-resistant mutant mice
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A Chimeric Form of Osteoprotegerin Inhibits Hypercalcemia and Bone Resorption Induced by IL-1β, TNF-α, PTH, PTHrP, and 1,25(OH)2D3
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Interactions of PTH and PTHrP with the PTH/PTHrP Receptor and with Downstream Signaling Pathways: Exceptions That Provide the Rules
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Regulatory Peptides | 1999 |
Hypercalcemia Complicating Leukemic Transformation of Agnogenic Myeloid Metaplasia-Myelofibrosis
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Mayo Clinic Proceedings | 1999 |
Stimulation of Bone Formation in Vitro and in Rodents by Statins
G Mundy |
Science | 1999 |
Hormonal Control of Calcium Homeostasis
GR Mundy, TA Guise |
Clinical chemistry | 1999 |
Osteoclast Differentiation Requires Ascorbic Acid
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Journal of Bone and Mineral Research | 1998 |
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Conformational studies of a potent Leu11, D-Trp12-containing lactam-bridged parathyroid hormone-related protein-derived antagonist
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Metabolic Bone Disease and Clinically Related Disorders
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Cancer and Bone*
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Parathyroid hormone-related protein and hypercalcemia
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Cancer | 1997 |
A murine model of human myeloma bone disease
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Bone | 1997 |
Hypercalcemia in Patients With Metastatic Renal Cell Carcinoma: Effect of Nephrectomy and Metabolic Evaluation
MC Walther, B Patel, PL Choyke, IA Lubensky, CD Vocke, C Harris, D Venzon, WJ Burtis, WM Linehan |
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Parathyroid hormone-related protein and bone metastases
TA Guise |
Cancer | 1997 |
Dose-response study of ibandronate in the treatment of cancer-associated hypercalcaemia
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Hypercalcemia in Patients With Metastatic Renal Cell Carcinoma
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The American Journal of Medicine | 1997 |
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Immunocytochemical expression of parathyroid hormone related protein (PTHrP) in odontogenic jaw cysts
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British Journal of Oral and Maxillofacial Surgery | 1997 |
Relaxation of porcine tracheal smooth muscle by parathyroid hormone-related protein
JS Shenberger, RL Shew, DE Johnson, MS Kannan |
Respiration Physiology | 1997 |
Suki and Massry’s THERAPY OF RENAL DISEASES AND RELATED DISORDERS
WN Suki, SG Massry |
1997 | |
Parathyroid Hormone-Related Peptide-(1–34) [PTHrP- (1–34)] Induces Vasopressin Release from the Rat Supraoptic Nucleus in Vitro through a Novel Receptor Distinct from a Type I or Type II PTH/PTHrP Receptor
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Methods in Bone Biology
TR Arnett, B Henderson |
1997 | |
The Teaching Cases from Annals of Oncology
RL Souhami |
1997 | |
RS-66271, a C-terminally substituted analog of human parathyroid hormone-related protein (1-34), increases trabecular and cortical bone in ovariectomized, osteopenic rats
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Journal of Bone and Mineral Research | 1996 |
PTH-related protein is released into the mother's bloodstream during lactation: Evidence for beneficial effects on maternal calcium-phosphate metabolism
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Journal of Bone and Mineral Research | 1996 |
In vivo demonstration that parathyroid hormone and parathyroid hormone-related protein stimulate expression by osteoblasts of interleukin-6 and leukemia inhibitory factor
JH Pollock, MJ Blaha, SA Lavish, S Stevenson, EM Greenfield |
Journal of Bone and Mineral Research | 1996 |
Effect of parathyroid hormone on renal calbindin-D28k
C Hemmingsen, M Staun, E Lewin, PK Nielsen, K Olgaard |
Journal of Bone and Mineral Research | 1996 |
Humoral hypercalcemia of malignancy: Some enigmas on the clinical features
K Ikeda, E Ogata |
Journal of Cellular Biochemistry | 1995 |
Epidermal growth factor-stimulated parathyroid hormone-related protein expression involves increased gene transcription and mRNA stability
JK Heath, J Southby, S Fukumoto, LM O'Keeffe, TJ Martin, MT Gillespie |
Biochemical Journal | 1995 |
Parathyroid Hormone-Related Protein
JM Moseley, MT Gillespie, MA Thiede |
Critical Reviews in Clinical Laboratory Sciences | 1995 |
Parathyroid hormone and parathyroid hormone-related protein in the investigation of hypercalcaemia in two hospital populations
J Walls, WA Ratcliffe, A Howell, NJ Bundred |
Clinical Endocrinology | 1994 |
Significance of plasma PTH-rp in patients with hypercalcemia of malignancy treated with bisphosphonate
SJ Wimalawansa |
Cancer | 1994 |
Involvement of alkaline phosphatase in the modulation of receptor signaling in osteoblasts: Evidence for a difference between human parathyroid hormone-related protein and human parathyroid hormone
S Fukayama, AH Tashjian |
Journal of Cellular Physiology | 1994 |
Dexamethasone regulation of parathyroid hormone-related protein (PTHrP) expression in a squamous cancer cell line
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Molecular and Cellular Endocrinology | 1994 |
Tartrate resistant acid phosphatase activity in rat cultured osteoclasts is inhibited by a carboxyl terminal peptide (osteostatin) from parathyroid hormone-related protein
MH Zheng, HB McCaughan, JM Papadimitriou, GC Nicholson, DJ Wood |
Journal of Cellular Biochemistry | 1994 |
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I Kostoglou-Athanassiou, K Ntalles, J Gogas, C Markopoulos, E Georgiou, C Proukakis |
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American Journal of Kidney Diseases | 1994 |
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TJ Martin |
Journal of Internal Medicine | 1993 |
Diagnostic tools and biologic markers: Animal models in the study of osteoporosis and oral bone loss
TB Aufdemorte, BD Boyan, WC Fox, D Miller |
Journal of Bone and Mineral Research | 1993 |
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NP O'Rourke, EV McCloskey, S Vasikaran, K Eyres, D Fern, JA Kanis |
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Interleukin-1 receptor antagonist inhibits the hypercalcemia mediated by interleukin-1
TA Guise, IR Garrett, LF Bonewald, GR Mundy |
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TJ Iveson, IE Smith, M Dowsett |
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Effect of transforming growth factor alpha, parathyroid hormone-related protein, or their combination on bone histomorphometry
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AM Patel, DG da Vila, SG Peters |
Mayo Clinic Proceedings | 1993 |
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SA Rabbani, M Haq, D Goltzman |
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Physiology and Pharmacology of Bone
GR Mundy, TJ Martin |
1993 | |
Tamoxifen and hypercalcaemia
G Daugaard |
Annals of Oncology | 1993 |
Angiotensin II regulates parathyroid hormone-related protein expression in cultured rat aortic smooth muscle cells through transcriptional and post-transcriptional mechanisms
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A case of squamous cell lung carcinoma with high concentration of parathyroid hormone-related peptide in serum and pleural effusion presenting hypercalcemia.
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Japanese journal of cancer research : Gann | 1993 |
Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice
BF Boyce, T Yoneda, C Lowe, P Soriano, GR Mundy |
Journal of Clinical Investigation | 1992 |
Dynamics of parathyroid hormone release and serum calcium regulation after surgery for primary hyperparathyroidism
W Graf, J Rastad, G Åkerström, L Wide, S Ljunghall |
World Journal of Surgery | 1992 |
Expression of human transforming growth factor α by chinese hamster ovarian tumors in nude mice causes hypercalcemia and increased osteoclastic bone resorption
AJ Yates, BF Boyce, G Favarato, TB Aufdemorte, C Marcelli, MB Kester, R Walker, BC Langton, LF Bonewald, GR Mundy |
Journal of Bone and Mineral Research | 1992 |
Dissociation between parathyroid hormone-stimulated cAMP and calcium increase in UMR-106-01 cells
BS Merritt, DT Yamaguchi, J Green, CR Kleeman, S Muallem |
Journal of Cellular Physiology | 1992 |
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GR Mundy |
The International Journal of Cell Cloning | 1992 |
Parathyroid hormone-related peptide: Expression in fetal and neonatal development
PB Burton, C Moniz, P Quirke, A Malik, TD Bui, H Juppner, GV Segre, DE Knight |
The Journal of Pathology | 1992 |
A parathyroid-related peptide induces transcaltachia (the rapid, hormonal stimulation of intestinal Ca2+ transport)
LX Zhou, I Nemere, AW Norman |
Biochemical and Biophysical Research Communications | 1992 |
Regulation of Parathyroid Hormonelike Protein Production in Cultured Normal and Malignant Keratinocytes
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Journal of Investigative Dermatology | 1992 |
Tumor necrosis factor and interleukin 1 inhibit parathyroid hormone-responsive adenylate cyclase in clonal osteoblast-like cell by down-regulating parathyroid hormone receptors
MS Katz, GE Gutierrez, GR Mundy, MP Caulfield, TK Hymer, RL McKee |
Journal of Cellular Physiology | 1992 |
Role of assays for parathyroid-hormone-related protein in investigation of hypercalcaemia
WA Ratcliffe, JG Ratcliffe, AC Hutchesson, NJ Bundred |
The Lancet | 1992 |
Parathyroid hormone related protein and skeletal morbidity in breast cancer
NJ Bundred, JM Morrison, WA Ratcliffe, JG Ratcliffe, J Warwick, RA Walker |
European Journal of Cancer | 1992 |
The Control of Fat and Lean Deposition
P Reeds, T Davis |
The Control of Fat and Lean Deposition | 1992 |
Primary hyperparathyroidism or hypercalcaemia of malignancy?
KI Birkeland, F Gallefoss, S Olsson, E Haug |
Scandinavian Journal of Clinical & Laboratory Investigation | 1992 |
Stimulation of bone resorption results in a selective increase in the growth rate of spontaneously metastatic Walker 256 cancer cells in bone
PJ Kostenuik, G Singh, KL Suyama, FW Orr |
Clinical & Experimental Metastasis | 1992 |
Enhanced growth of a human keratinocyte cell line induced by antisense RNA for parathyroid hormone-related peptide
SM Kaiser, P Laneuville, SM Bernier, JS Rhim, R Kremer, D Goltzman |
The Journal of biological chemistry | 1992 |
Evidence that tumor necrosis factor plays a pathogenetic role in the paraneoplastic syndromes of cachexia, hypercalcemia, and leukocytosis in a human tumor in nude mice
T Yoneda, MA Alsina, JB Chavez, L Bonewald, R Nishimura, GR Mundy |
Journal of Clinical Investigation | 1991 |
Abundant expression of parathyroid hormone-related protein in primary rat aortic smooth muscle cells accompanies serum-induced proliferation
T Hongo, J Kupfer, H Enomoto, B Sharifi, D Giannella-Neto, JS Forrester, FR Singer, D Goltzman, GN Hendy, C Pirola |
Journal of Clinical Investigation | 1991 |
Hypercalcemia of malignancy: pathophysiology, diagnosis and treatment
L Mosekilde, EF Eriksen, P Charles |
Critical Reviews in Oncology/Hematology | 1991 |
Parathyroid Hormone-Related Protein: Biochemistry and Molecular Biology
TJ Martin, JM Moseley, MT Gillespie, HM Kmnenbwg |
Critical Reviews in Biochemistry and Molecular Biology | 1991 |
Interspecies comparison of renal cortical receptors for parathyroid hormone and parathyroid hormone-related protein
JJ Orloff, D Goumas, TL Wu, AF Stewart |
Journal of Bone and Mineral Research | 1991 |
Urinary excretion of parathyroid hormone-related protein fragments in patients with humoral hypercalcemia of malignancy and hypercalcemic tumor-bearing nude mice
H Imamura, K Sato, K Shizume, T Satoh, K Kasono, M Ozawa, E Ohmura, T Tsushima, H Demura |
Journal of Bone and Mineral Research | 1991 |
Evaluation of bone resorption and renal tubular reabsorption of calcium and phosphate in malignant and nonmalignant hypercalcemia
B Buchs, R Rizzoli, JP Bonjour |
Bone | 1991 |
Mechanisms of osteolytic bone destruction
GR Mundy |
Bone | 1991 |
Structural requirements for the action of parathyroid hormone-related protein (PTHrP) on bone resorption by isolated osteoclasts
RS Evely, A Bonomo, HG Schneider, JM Moseley, J Gallagher, TJ Martin |
Journal of Bone and Mineral Research | 1991 |
Parathyroid hormone-related protein inhibits stimulated uterine contraction in vitro
RL Shew, JA Yee, DB Kliewer, YJ Keflemariam, DL McNeill |
Journal of Bone and Mineral Research | 1991 |
Stimulation by parathyroid hormone-related protein and transforming growth factor-α of phosphate transport in osteoblast-like cells
L Pizurki, R Rizzoli, J Caverzasio, JP Bonjour |
Journal of Bone and Mineral Research | 1991 |
Effects of guanine nucleotides and parathyroid hormone on inositol 1,4,5-trisphosphate metabolism in canine renal cortical tubular cell membranes
DT Coleman, BS Morrow, JP Bilezikian |
Journal of Bone and Mineral Research | 1991 |
Parathyroid hormone—like peptide
DJ Drucker |
Endocrine Pathology | 1991 |
Chicken parathyroid hormone-related protein and its expression during embryologic development
DT Schermer, SD Chan, R Bruce, RA Nissenson, WI Wood, GJ Strewler |
Journal of Bone and Mineral Research | 1991 |
Effects of transforming growth factor-α on parathyroid hormone- and parathyroid hormone-related protein- mediated bone resorption and adenylate cyclase stimulation in vitro
TJ Rosol, JI Merryman, RM Nohutcu, LK McCauley, CC Capen |
Domestic Animal Endocrinology | 1991 |
Multiple recurrent giant cell lesions associated with high circulating levels of parathyroid hormone-related peptide in a young adult
JP Davis, DJ Archer, C Fisher, SJ Wimalawansa, D Baldwin, SJ Wimalawansa |
British Journal of Oral and Maxillofacial Surgery | 1991 |
A 7–34 analog of the parathyroid hormone-related protein has potent antagonist and partial agonist activity in vivo
N Horiuchi, T Hongo, TL Clemens |
Bone and Mineral | 1991 |
Parathyroid hormone-related protein(50–69) and response to pamidronate therapy for tumour-induced hypercalcaemia
DJ Dodwell, SK Abbas, AR Morton, A Howell |
European Journal of Cancer and Clinical Oncology | 1991 |
Osteoclast Differentiation
GD Roodman |
Critical Reviews in Oral Biology & Medicine | 1991 |
Prostaglandins enhance parathyroid hormone-evoked increase in free cytosolic calcium concentration in osteoblast-like cells
DT Yamaguchi, J Green, CR Kleeman, S Muallem |
Cell Calcium | 1991 |
Ectopic Production of Calciotropic Peptides
GR Mundy |
Endocrinology and metabolism clinics of North America | 1991 |
Analogues of parathyroid hormone modified at positions 3 and 6. Effects on receptor binding and activation of adenylyl cyclase in kidney and bone
FE Cohen, GJ Strewler, MS Bradley, M Carlquist, M Nilsson, M Ericsson, TL Ciardelli, RA Nissenson |
The Journal of biological chemistry | 1991 |
Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo
IR Garrett, BF Boyce, RO Oreffo, L Bonewald, J Poser, GR Mundy |
Journal of Clinical Investigation | 1990 |
Incidence and pathophysiology of hypercalcemia
GR Mundy |
Calcified Tissue International | 1990 |
Comparison of the effects of amino-terminal synthetic parathyroid hormone-related peptide (PTHrP) of malignancy and parathyroid hormone on resorption of cultured fetal rat long bones
LG Raisz, HA Simmons, SJ Vargas, BE Kemp, TJ Martin |
Calcified Tissue International | 1990 |
Circulating concentrations of parathyroid hormone-like peptide in malignancy and in hyperparathyroidism
JE Henderson, C Shustik, R Kremer, SA Rabbani, GN Hendy, D Goltzman, GN Hendy, D Goltzman |
Journal of Bone and Mineral Research | 1990 |
Quantitative evaluation of anticalciuretic effects of synthetic parathyroid hormonelike peptides
SJ Scheinman, ME Mitnick, AF Stewart |
Journal of Bone and Mineral Research | 1990 |
Parathyroid hormone-related protein and hypercalcemia in pancreatic neuro-endocrine tumors
R Rizzoli, AP Sappino, JP Bonjour |
International Journal of Cancer | 1990 |
Human PTH-(3-34) inhibited the effects of human parathyroid hormone-related protein on phosphate uptake in a cultured renal cell line (OK cells)
M Nakai, M Fukase, T Yamaguchi, T Tsukamoto, N Fujii, T Fujita |
Journal of Bone and Mineral Research | 1990 |
Hypercalcemia in malignancy
GJ Strewler, RA Nissenson |
The Western journal of medicine | 1990 |
Immunohistochemicaf evidence of parathyroid hormone—related protein in human parathyroid tissue
P Hellman, G Bjerneroth, C Juhlin, P Ridefelt, J Rastad, G Åkerström, H Jüppner |
Endocrine Pathology | 1990 |
The synthetic human parathyroid hormone-related protein is inhibited by a parathyroid hormone antagonist in rats in vivo
N Horiuchi, T Hongo, TL Clemens |
Journal of Bone and Mineral Research | 1990 |
In vivo effects of human recombinant transforming growth factor β on bone turnover in normal mice
C Marcelli, AJ Yates, GR Mundy |
Journal of Bone and Mineral Research | 1990 |
Parathyroid hormone-receptor interactions
MP Caulfield, M Rosenblatt |
Trends in Endocrinology & Metabolism | 1990 |
Parathyroid hormone-like peptide in normal and neoplastic mesothelial cells
P McAuley, SL Asa, B Chiu, J Henderson, D Goltzman, DJ Drucker |
Cancer | 1990 |
Humoral hypercalcemia of malignancy
KW Ng, TJ Martin |
Clinical Biochemistry | 1990 |
Parathyroid hormone-related protein (PTHrP): Studies with synthetic peptides indicate that parathyroid hormone and PTHrP interact with the same receptor
MP Caulfield, RL Mckee, ME Goldman, MA Thiede, DD Thompson, JE Fisher, JJ Levy, JG Seedor, N Horiuchi, TL Clemens, GA Rodan, M Rosenblatt |
International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology | 1990 |
Parathyroid Hormone-Related Peptide in Plasma of Patients With Hypercalcemia and Malignant Lesions
PC Kao, GG Klee, RL Taylor, H Heath |
Mayo Clinic Proceedings | 1990 |
Bone and Mineral Research
A Perault-Staub, J Staub, G Milhaud |
Bone and Mineral Research | 1990 |
7 Mechanisms of hypercalcaemia of malignancy
GE Gutierrez, JW Poser, MS Katz, AJ Yates, HL Henry, GR Mundy |
Baillière's Clinical Endocrinology and Metabolism | 1990 |
Inhibition of renal membrane adenylate cyclase by extract of pancreatic cancer associated with humoral hypercalcemia of malignancy
Y Yasutomo, N Kugai, N Nagata, T Akatsu, S Wada, T Kinoshita, H Kosano, O Takatani |
Bone and Mineral | 1990 |
Effect of parathyroid hormone-like peptides on 25-hydroxyvitamin D-1 alpha-hydroxylase activity in rodents
AT Walker, AF Stewart, EA Korn, T Shiratori, MA Mitnick, TO Carpenter |
American journal of physiology. Endocrinology and metabolism | 1990 |
PARATHYROID HORMONE-RELATED PROTEIN IN HYPERCALCAEMIA OF MALIGNANCY
TJ Martin, LJ Suva |
Clinical Endocrinology | 1989 |
Role of bone and kidney in parathyroid hormone-related peptide-induced hypercalcemia in rats
R Rizzoli, J Caverzasio, MC Chapuy, TJ Martin, JP Bonjour |
Journal of Bone and Mineral Research | 1989 |
High extracellular calcium increases the production of a parathyroid hormone-like activity by cultured leydig tumor cells associated with humoral hypercalcemia
R Rizzoli, JP Bonjour |
Journal of Bone and Mineral Research | 1989 |
Contrasting mechanisms of hypercalcemia in patients with early and advanced humoral hypercalcemia of malignancy
SH Ralston, BF Boyce, RA Cowan, MD Gardner, WD Fraser, IT Boyle |
Journal of Bone and Mineral Research | 1989 |
Structure-activity relationships of parathyroid hormone analogs in the opossum kidney cell line
DL Carnes, JA Cole, LR Forte, RE Poelling, PK Thorne, S Eber |
Journal of Bone and Mineral Research | 1989 |
COMPARISON OF THREE INTRAVENOUS BISPHOSPHONATES IN CANCER-ASSOCIATED HYPERCALCAEMIA
SH Ralston, U Patel, WD Fraser, SJ Gallacher, FJ Dryburgh, RA Cowan, IT Boyle |
The Lancet | 1989 |
High levels of a parathyroid hormone-like protein in milk
AA Budayr, BP Halloran, JC King, D Diep, RA Nissenson, GJ Strewler |
Proceedings of the National Academy of Sciences | 1989 |
and antagonists against parathyroid hormone-related protein
K Nagasaki, K Yamaguchi, Y Miyake, C Hayashi, S Honda, K Urakami, K Miki, S Kimura, T Watanabe, K Abe |
Biochemical and Biophysical Research Communications | 1989 |
Renal vasodilation and microvessel adenylate cyclase stimulation by synthetic parathyroid hormone-like protein fragments
MJ Musso, M Plante, C Judes, M Barthelmebs, JJ Helwig |
European Journal of Pharmacology | 1989 |
Effects of parathyroid hormone on cyclic-AMP concentrations of in vitro Necturus maculosus gastric antrum
MJ Rutten, HT Chern, CD Moore, J Hamilton, LY Cheung |
General and Comparative Endocrinology | 1989 |
Parathyroid hormone-like peptide: Molecular characterization and biological properties
D Goltzman, GN Hendy, D Banville |
Trends in Endocrinology & Metabolism | 1989 |
The effects of human parathyroid hormone-related peptide on cytosolic free calcium and cAMP production in opossum kidney cell
Y Yamamoto, M Fukase, Y Fujii, T Fujita |
Bone and Mineral | 1989 |
Proceedings of the 1988 Laurentian Hormone Conference
T Martin, E Allan, I Caple, A Zare, J Danks, H Diefenbach-Jagger, P Ebeling, M Zillespie, G Hammonds, J Heath, P Hudson, B Kemp, M Kubota, S Kukreja, J Moseley, K Ng, L Raisz, C Rodda, H Simmons, L Suva, R Wettenhal, W Wood |
Proceedings of the 1988 Laurentian Hormone Conference | 1989 |
Recent Advances in Pathophysiology and Treatment of Hypercalcemia of Malignancy
GR Mundy, AJ Yates |
American Journal of Kidney Diseases | 1989 |
Tumors of the Parathyroid Gland and Circulating Parathyroid Hormone-Related Protein Associated with Persistent Hypercalcemia
TJ Rosol, CC Capen |
Toxicologic pathology | 1989 |
Humoral Hypercalcemia of Malignancy: The Role of Parathyroid Hormone-related Protein
KL Insogna |
Endocrinology and metabolism clinics of North America | 1989 |
Characterization of Canine Renal Receptors for the Parathyroid Hormone-like Protein Associated with Humoral Hypercalcemia of Malignancy
JJ Orloff, TL Wu, HW Heath, TG Brady, ML Brines, AF Stewart |
The Journal of biological chemistry | 1989 |
Characterization of the human parathyroid hormone-like peptide gene
T Yasuda, D Banville, GN Hendy, D Goltzman |
The Journal of biological chemistry | 1989 |
Hypercalcaemia of malignancy
PJ Kelly, JA Eisman |
Cancer and Metastasis Reviews | 1989 |
Hypercalcemia of malignancy revisited
GR Mundy |
Journal of Clinical Investigation | 1988 |
Antibodies to parathyroid hormone-related protein lower serum calcium in athymic mouse models of malignancy-associated hypercalcemia due to human tumors
SC Kukreja, DH Shevrin, SA Wimbiscus, PR Ebeling, JA Danks, CP Rodda, WI Wood, TJ Martin |
Journal of Clinical Investigation | 1988 |
Vitamin D
A Portale, Β Halloran, E Lonergan, R Morris |
Vitamin D | 1988 |
Effects of infusion of human parathyroid hormone-related protein-(1-40) in nude mice: Histomorphometric and biochemical investigations
TJ Rosol, CC Capen, RL Horst |
Journal of Bone and Mineral Research | 1988 |
Increased renal calcium reabsorption in an animal model of hypercalcemia of human malignancy
PJ Shipley, DH Shevrin, SC Kukreja |
Journal of Bone and Mineral Research | 1988 |
Human parathyroid hormone related protein fragment-(1–34) had glucose-6-phosphate dehydrogenase activity on distal convoluted tubules in cytochemical bioassay
M Nakai, M Fukase, K Sakaguchi, T Noda, N Fujii, T Fujita |
Biochemical and Biophysical Research Communications | 1988 |
9 Parathyroid hormone-related protein: A novel gene product
TJ Martin, LJ Suva |
Baillière's Clinical Endocrinology and Metabolism | 1988 |
Synthetic peptides comprising the amino-terminal sequence of a parathyroid hormone-like protein from human malignancies. Binding to parathyroid hormone receptors and activation of adenylate cyclase in bone cells and kidney
RA Nissenson, D Diep, GJ Strewler |
The Journal of biological chemistry | 1988 |