In autoimmune gastritis antibodies against a membrane-bound parietal cell antigen of previously unknown function are present in the sera of patients. In this study, a vesicular membrane preparation of porcine gastric mucosa cells was found to be a potent antigenic source. This preparation blocked greater than 90% of antibody binding to a lysate of gastric mucosa cells. The membrane fraction contained H+,K+-ATPase (EC 3.6.1.36) as the major protein, which in sodium dodecyl sulfate-polyacrylamide gel electrophoresis migrated with a weight of 92 kD. After reduction and alkylation, this component was resolved into two bands of similar staining intensity (92 and 88 kD). Immunoblotting analysis showed that sera of patients recognized antigen with pattern identical to the major protein of the vesicular membranes. Protein A-Sepharose beads preincubated with immunoglobulins of five individual patient (but not control) sera were all found to reduce both the H+,K+-ATPase activity and the amount of parietal cell antigen of a preparation of vesicular membranes solubilized in n-octylglucoside. Taken together, the results of this study indicate that the major parietal cell antigen is identical to the acid-producing enzyme, H+,K+-ATPase, of the parietal cell.
F A Karlsson, P Burman, L Lööf, S Mårdh
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BH Toh, IR van Driel, PA Gleeson |
Autoimmunity | 1992 |
Diagnostic Elisa for Parietal Cell Autoantibody Using Tomato Lectin-Purified Gastric H+/K+-Atpase (Proton Pump)
JS Chuang, JM Callaghan, PA Gleeson, BH Toh |
Autoimmunity | 1992 |
The Autoimmune Diseases II
CC Bernard, TE Mandel, IR Mackay |
The Autoimmune Diseases II | 1992 |
A study of autoimmune gastritis in the postpartum period and at a 5-year follow-up
P Burman, O Kämpe, W Kraaz, L Lööfv, A Smolka, A Karlsson, A Karlsson-Parra |
Gastroenterology | 1992 |
Identification of alpha- and beta-cardiac myosin heavy chain isoforms as major autoantigens in dilated cardiomyopathy
AL Caforio, M Grazzini, JM Mann, PJ Keeling, GF Bottazzo, WJ McKenna, S Schiaffino |
Circulation | 1992 |
The mouse gastric H,K-ATPase beta subunit. Gene structure and co-ordinate expression with the alpha subunit during ontogeny
GP Morley, JM Callaghan, JB Rose, BH Toh, PA Gleeson, IR van Driel |
The Journal of biological chemistry | 1992 |
Autoimmune Gastric Disease Chemical and Clinical Studies with Special Reference to H+, K+-ATPase
P Burman |
Upsala Journal of Medical Sciences | 1991 |
Autoantibodies as mechanisms, markers, and mediators of B-cell disease
TJ Wilkin |
Diabetes / Metabolism Reviews | 1991 |
For Debate: Enzymes as Targets for Autoantibodies in Human Autoimmune disease: Relevance to Pathogenesis?
JP Banga, AM McGregor |
Autoimmunity | 1991 |
Novel Considerations on the Antibody/Autoantigen System in Type I (insulin-dependent) Diabetes Mellitus
GF Bottazzo, S Genovese, E Bosi, BM Dean, MR Christie, E Bonifacio |
Annals of Medicine | 1991 |
cDNA cloning of the β-subunit of the human gastric H,K-ATPase
M Jing-yie, Y Song, SE Sjöstrand, L Rask, S Mårdh |
Biochemical and Biophysical Research Communications | 1991 |
The Sydney System: Auto-immune gastritis
RG Strickland |
Journal of Gastroenterology and Hepatology | 1991 |
Reverse immunoaffinity chromatography: Application to the purification of the 60- to 90-kDa gastric parietal cell autoantigen associated with autoimmune gastritis
I Goldkorn, PA Gleeson, BH Toh |
Analytical Biochemistry | 1991 |
Molecular targets in pernicious anaemia
PA Gleeson, BH Toh |
Immunology Today | 1991 |
Occurrence of Autoantibodies against Intrinsic Factor, H,K-ATPase, and Pepsinogen in Atrophic Gastritis and Rheumatoid Arthritis
S Mårdh, JY Ma, YH Song, A Aly, K Henriksson |
Scandinavian Journal of Gastroenterology | 1991 |
H + K + -ATPase Antibodies in Autoimmune Gastritis: Observations on the Development of Pernicious Anemia
P Burman, FA Karlsson, L Lööf, PB Szesci, K Borch |
Scandinavian Journal of Gastroenterology | 1991 |
Autoimmune Reactions to Gastric Mucosa in Chronic Gastritis: A Review
R Uibo, V Salupere, K Krohn |
Scandinavian Journal of Gastroenterology | 1991 |
Autoimmune Thyroiditis
WA Scherbaum, U Bogner, B Weinheimer, GF Bottazzo |
1991 | |
The Molecular Genetics of Three Thyroid Autoantigens: Thyroglobulin, Thyroid Peroxidase and the Thyrotropin Receptor
M Ludgate, G Vassart |
Autoimmunity | 1990 |
Characterization of a beta subunit of the gastric H+/K(+)-transporting ATPase
MA Reuben, LS Lasater, G Sachs |
Proceedings of the National Academy of Sciences | 1990 |
The 60- to 90-kDa parietal cell autoantigen associated with autoimmune gastritis is a beta subunit of the gastric H+/K(+)-ATPase (proton pump)
BH Toh, PA Gleeson, RJ Simpson, RL Moritz, JM Callaghan, I Goldkorn, CM Jones, TM Martinelli, FT Mu, DC Humphris |
Proceedings of the National Academy of Sciences | 1990 |
Studies with Recombinant Autoepitopes of Thyroid Peroxidase: Evidence Suggesting an Epitope Shared Between the Thyroid and the Gastric Parietal Cell
R Elisei, S Mariotti, S Swillens, G Vassart, M Ludgate |
Autoimmunity | 1990 |
The β-subunit of the gastric H+/K+-ATPase can occur without the α-subunit
GS Baldwin |
FEBS Letters | 1990 |
The occurrence of auto-antibodies in patients with gastro-duodenal lesions
S Mårdh, YH Song |
Journal of Internal Medicine | 1990 |
Do organ-specific suppressor T cells prevent autoimmune gastritis?
CO Elson |
Gastroenterology | 1990 |
Gastritis
RG Strickland |
Springer Seminars in Immunopathology | 1990 |
Islet cell and other organ-specific autoantibodies in all children developing Type 1 (insulin-dependent) diabetes mellitus in Sweden during one year and in matched control children
M Landin-Olsson, A Karlsson, G Dahlquist, L Blom, Lernmark, G Sundkvist |
Diabetologia | 1989 |
Relation of parietal cell and thyroid antibodies to the state of gastric mucosa and basal serum gastrin levels during a 6-year follow up
R Uibo, K Krohn, K Villako, R Tammur, A Tamm |
Clinical & Experimental Immunology | 1989 |
The ontogeny of rat gastric H+/K+-ATPase
F Hervatin, F Benkouka, JC Robert, G Péranzi, A Soumarmon |
Biochimica et Biophysica Acta (BBA) - Biomembranes | 1989 |
Characterization of antigenic structures in autoimmune atrophic gastritis with pernicious anaemia. The parietal cell H,K-ATPase and the chief cell pepsinogen are the two major antigens
S Mårrdh, YH Song |
Acta Physiologica Scandinavica | 1989 |
Parietal cell antibodies in pernicious anemia inhibit H+, K+-adenosine triphosphatase, the proton pump of the stomach
P Burman, S Mårdh, L Norberg, FA Karlsson |
Gastroenterology | 1989 |
Parietal cell autoantigens involved in neonatal thymectomy-induced murine autoimmune gastritis. Studies using monoclonal autoantibodies
Y Mori, K Fukuma, Y Adachi, K Shigeta, R Kannagi, H Tanaka, M Sakai, K Kuribayashi, H Uchino, T Masuda |
Gastroenterology | 1989 |
Gastric parietal cell antigens of 60–90, 92, and 100–120 kDa associated with autoimmune gastritis and pernicious anemia
I Goldkorn, PA Gleeson, BH Toh |
The Journal of biological chemistry | 1989 |
Islet cell and other organ-specific autoantibodies in all children developing Type 1 (insulin-dependent) diabetes mellitus in Sweden during one year and in matched control children
M Landin-Olsson, A Karlsson, G Dahlquist, L Blom, , G Sundkvist |
Diabetologia | 1989 |
New Comprehensive Biochemistry
S Yamamoto |
New Comprehensive Biochemistry | 1983 |
Pernicious Anemia
WA Younge |
Journal of the National Medical Association | 1943 |