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Citations to this article

Major parietal cell antigen in autoimmune gastritis with pernicious anemia is the acid-producing H+,K+-adenosine triphosphatase of the stomach.
F A Karlsson, … , L Lööf, S Mårdh
F A Karlsson, … , L Lööf, S Mårdh
Published February 1, 1988
Citation Information: J Clin Invest. 1988;81(2):475-479. https://doi.org/10.1172/JCI113344.
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Research Article

Major parietal cell antigen in autoimmune gastritis with pernicious anemia is the acid-producing H+,K+-adenosine triphosphatase of the stomach.

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Abstract

In autoimmune gastritis antibodies against a membrane-bound parietal cell antigen of previously unknown function are present in the sera of patients. In this study, a vesicular membrane preparation of porcine gastric mucosa cells was found to be a potent antigenic source. This preparation blocked greater than 90% of antibody binding to a lysate of gastric mucosa cells. The membrane fraction contained H+,K+-ATPase (EC 3.6.1.36) as the major protein, which in sodium dodecyl sulfate-polyacrylamide gel electrophoresis migrated with a weight of 92 kD. After reduction and alkylation, this component was resolved into two bands of similar staining intensity (92 and 88 kD). Immunoblotting analysis showed that sera of patients recognized antigen with pattern identical to the major protein of the vesicular membranes. Protein A-Sepharose beads preincubated with immunoglobulins of five individual patient (but not control) sera were all found to reduce both the H+,K+-ATPase activity and the amount of parietal cell antigen of a preparation of vesicular membranes solubilized in n-octylglucoside. Taken together, the results of this study indicate that the major parietal cell antigen is identical to the acid-producing enzyme, H+,K+-ATPase, of the parietal cell.

Authors

F A Karlsson, P Burman, L Lööf, S Mårdh

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Journal of Internal Medicine 1993
Parietal Cell Antibodies among Peruvians with Gastric Pathologic Changes
IC Kohlstadt, EA de Mayolo, RH Gilman, R Leon-Barua, A Ramirez-Ramos, C Rodriguez, S Recavarren, W Spira, J Watanabe, R Berenson, C Guevara, J Palomino, M Alvarez, J Cok, C Ramirez-Icaza
Scandinavian Journal of Gastroenterology 1993
Involvement of the H+/K+-ATPase α subunit as a major antigenic protein in autoimmune gastritis induced by neonatal thymectomy in mice
K Kontani, O Taguchi, T Takahashi
Clinical & Experimental Immunology 1992
Glutamic acid decarboxylase in insulin-dependent diabetes mellitus
HJ DeAizpurua, LC Harrison
Diabetes / Metabolism Reviews 1992
B-cell responses in autoimmune diseases
C Boitard
Current Opinion in Immunology 1992
Involvement of the H+/K(+)-ATPase alpha subunit as a major antigenic protein in autoimmune gastritis induced by neonatal thymectomy in mice
K Kontani, O Taguchi, T Takahashi
Clinical & Experimental Immunology 1992
Antitopoisomerase I monoclonal autoantibodies from scleroderma patients and tight skin mouse interact with similar epitopes
T Muryoi, KN Kasturi, MJ Kafina, DS Cram, LC Harrison, T Sasaki, CA Bona
Journal of Experimental Medicine 1992
Reassessment of the relative prevalences of antibodies to gastric parietal cell and to intrinsic factor in patients with pernicious anaemia: influence of patient age and race
R Carmel
Clinical & Experimental Immunology 1992
Rapid purification of the gastric H+/K(+)-ATPase complex by tomato-lectin affinity chromatography
JM Callaghan, BH Toh, RJ Simpson, GS Baldwin, PA Gleeson
Biochemical Journal 1992
Identification by molecular cloning of an autoantigen associated with Addison's disease as steroid 17α-hydroxylase
K Krohn, R Uibo, E Aavik, P Peterson, K Savilahti, R Uibo, P Peterson
The Lancet 1992
21-hydroxylase, a major autoantigen in idiopathic Addison's disease
O Winqvist, FA Karlsson, O Kämpe
The Lancet 1992
Autoimmune Gastritis: Tolerance and Autoimmunity to the Gastric H+/K+Atpase (Proton Pump)
BH Toh, IR van Driel, PA Gleeson
Autoimmunity 1992
Diagnostic Elisa for Parietal Cell Autoantibody Using Tomato Lectin-Purified Gastric H+/K+-Atpase (Proton Pump)
JS Chuang, JM Callaghan, PA Gleeson, BH Toh
Autoimmunity 1992
The Autoimmune Diseases II
CC Bernard, TE Mandel, IR Mackay
The Autoimmune Diseases II 1992
A study of autoimmune gastritis in the postpartum period and at a 5-year follow-up
P Burman, O Kämpe, W Kraaz, L Lööfv, A Smolka, A Karlsson, A Karlsson-Parra
Gastroenterology 1992
Identification of alpha- and beta-cardiac myosin heavy chain isoforms as major autoantigens in dilated cardiomyopathy
AL Caforio, M Grazzini, JM Mann, PJ Keeling, GF Bottazzo, WJ McKenna, S Schiaffino
Circulation 1992
The mouse gastric H,K-ATPase beta subunit. Gene structure and co-ordinate expression with the alpha subunit during ontogeny
GP Morley, JM Callaghan, JB Rose, BH Toh, PA Gleeson, IR van Driel
The Journal of biological chemistry 1992
Autoimmune Gastric Disease Chemical and Clinical Studies with Special Reference to H+, K+-ATPase
P Burman
Upsala Journal of Medical Sciences 1991
Autoantibodies as mechanisms, markers, and mediators of B-cell disease
TJ Wilkin
Diabetes / Metabolism Reviews 1991
For Debate: Enzymes as Targets for Autoantibodies in Human Autoimmune disease: Relevance to Pathogenesis?
JP Banga, AM McGregor
Autoimmunity 1991
Novel Considerations on the Antibody/Autoantigen System in Type I (insulin-dependent) Diabetes Mellitus
GF Bottazzo, S Genovese, E Bosi, BM Dean, MR Christie, E Bonifacio
Annals of Medicine 1991
cDNA cloning of the β-subunit of the human gastric H,K-ATPase
M Jing-yie, Y Song, SE Sjöstrand, L Rask, S Mårdh
Biochemical and Biophysical Research Communications 1991
The Sydney System: Auto-immune gastritis
RG Strickland
Journal of Gastroenterology and Hepatology 1991
Reverse immunoaffinity chromatography: Application to the purification of the 60- to 90-kDa gastric parietal cell autoantigen associated with autoimmune gastritis
I Goldkorn, PA Gleeson, BH Toh
Analytical Biochemistry 1991
Molecular targets in pernicious anaemia
PA Gleeson, BH Toh
Immunology Today 1991
Occurrence of Autoantibodies against Intrinsic Factor, H,K-ATPase, and Pepsinogen in Atrophic Gastritis and Rheumatoid Arthritis
S Mårdh, JY Ma, YH Song, A Aly, K Henriksson
Scandinavian Journal of Gastroenterology 1991
H + K + -ATPase Antibodies in Autoimmune Gastritis: Observations on the Development of Pernicious Anemia
P Burman, FA Karlsson, L Lööf, PB Szesci, K Borch
Scandinavian Journal of Gastroenterology 1991
Autoimmune Reactions to Gastric Mucosa in Chronic Gastritis: A Review
R Uibo, V Salupere, K Krohn
Scandinavian Journal of Gastroenterology 1991
Autoimmune Thyroiditis
WA Scherbaum, U Bogner, B Weinheimer, GF Bottazzo
1991
The Molecular Genetics of Three Thyroid Autoantigens: Thyroglobulin, Thyroid Peroxidase and the Thyrotropin Receptor
M Ludgate, G Vassart
Autoimmunity 1990
Characterization of a beta subunit of the gastric H+/K(+)-transporting ATPase
MA Reuben, LS Lasater, G Sachs
Proceedings of the National Academy of Sciences 1990
The 60- to 90-kDa parietal cell autoantigen associated with autoimmune gastritis is a beta subunit of the gastric H+/K(+)-ATPase (proton pump)
BH Toh, PA Gleeson, RJ Simpson, RL Moritz, JM Callaghan, I Goldkorn, CM Jones, TM Martinelli, FT Mu, DC Humphris
Proceedings of the National Academy of Sciences 1990
Studies with Recombinant Autoepitopes of Thyroid Peroxidase: Evidence Suggesting an Epitope Shared Between the Thyroid and the Gastric Parietal Cell
R Elisei, S Mariotti, S Swillens, G Vassart, M Ludgate
Autoimmunity 1990
The β-subunit of the gastric H+/K+-ATPase can occur without the α-subunit
GS Baldwin
FEBS Letters 1990
The occurrence of auto-antibodies in patients with gastro-duodenal lesions
S Mårdh, YH Song
Journal of Internal Medicine 1990
Do organ-specific suppressor T cells prevent autoimmune gastritis?
CO Elson
Gastroenterology 1990
Gastritis
RG Strickland
Springer Seminars in Immunopathology 1990
Islet cell and other organ-specific autoantibodies in all children developing Type 1 (insulin-dependent) diabetes mellitus in Sweden during one year and in matched control children
M Landin-Olsson, A Karlsson, G Dahlquist, L Blom, Lernmark, G Sundkvist
Diabetologia 1989
Relation of parietal cell and thyroid antibodies to the state of gastric mucosa and basal serum gastrin levels during a 6-year follow up
R Uibo, K Krohn, K Villako, R Tammur, A Tamm
Clinical & Experimental Immunology 1989
The ontogeny of rat gastric H+/K+-ATPase
F Hervatin, F Benkouka, JC Robert, G Péranzi, A Soumarmon
Biochimica et Biophysica Acta (BBA) - Biomembranes 1989
Characterization of antigenic structures in autoimmune atrophic gastritis with pernicious anaemia. The parietal cell H,K-ATPase and the chief cell pepsinogen are the two major antigens
S Mårrdh, YH Song
Acta Physiologica Scandinavica 1989
Parietal cell antibodies in pernicious anemia inhibit H+, K+-adenosine triphosphatase, the proton pump of the stomach
P Burman, S Mårdh, L Norberg, FA Karlsson
Gastroenterology 1989
Parietal cell autoantigens involved in neonatal thymectomy-induced murine autoimmune gastritis. Studies using monoclonal autoantibodies
Y Mori, K Fukuma, Y Adachi, K Shigeta, R Kannagi, H Tanaka, M Sakai, K Kuribayashi, H Uchino, T Masuda
Gastroenterology 1989
Gastric parietal cell antigens of 60–90, 92, and 100–120 kDa associated with autoimmune gastritis and pernicious anemia
I Goldkorn, PA Gleeson, BH Toh
The Journal of biological chemistry 1989
Islet cell and other organ-specific autoantibodies in all children developing Type 1 (insulin-dependent) diabetes mellitus in Sweden during one year and in matched control children
M Landin-Olsson, A Karlsson, G Dahlquist, L Blom, , G Sundkvist
Diabetologia 1989
New Comprehensive Biochemistry
S Yamamoto
New Comprehensive Biochemistry 1983
Pernicious Anemia
WA Younge
Journal of the National Medical Association 1943

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