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Citations to this article

Seasonal modulation of the circadian time structure of circulating T and natural killer lymphocyte subsets from healthy subjects.
F A Lévi, … , A Reinberg, G Mathé
F A Lévi, … , A Reinberg, G Mathé
Published February 1, 1988
Citation Information: J Clin Invest. 1988;81(2):407-413. https://doi.org/10.1172/JCI113333.
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Research Article

Seasonal modulation of the circadian time structure of circulating T and natural killer lymphocyte subsets from healthy subjects.

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Abstract

A seasonal modulation of the circadian time structure of circulating T and natural killer (NK) lymphocyte subtypes was documented in five healthy men aged 24-36 yr. Venous blood was obtained every 4 h for 24 h from each subject in January, March, June, August, and November 1984. Three subjects were also studied in April and/or August and/or November 1983 for the T subsets only. Mononuclear cells were isolated on Ficoll-Paque gradient and aliquots were incubated with OKT3, OKT4, OKT8, or HNK-1 monoclonal antibodies for characterizing all, T, T helper, T suppressor-cytotoxic, and NK lymphocytes, respectively, under an epifluorescence microscope. An effect of both sampling time and study month was statistically validated (P less than 0.01) with both two-way analysis of variance and cosinor for the peripheral counts in total, pan-T, T helper, and NK lymphocytes (cells per cubic millimeter). Seasonal changes affected both the circadian patterns and the 24-h mean values. Thus the double amplitude (total extent of variation) of the circadian rhythm in circulating total, T and T helper lymphocytes varied between 0 in March (P greater than 0.30; no rhythm) and up to 46-68% of the 24-h-mean (M) in November, with acrophases (times of maximum, 0) localized in the first half of the night (P less than 0.001). Maximal values were found at 8:30 h for both T suppressor-cytotoxic and NK lymphocytes; a smaller second peak was also found at 20:30 h, and a 12-h rhythm was validated by cosinor (P less than 0.0001), with no patient change in waveform along the year scale. A circannual rhythm was statistically validated by cosinor for total (0 in November), pan-T (0 in March), T suppressor-cytotoxic (0 in December), and NK lymphocytes (0 in October). A rhythm with a period equal to 6 mo was found for circulating T helper cells with 0 occurring both in April and October. Seasonal variations in the incidence of several immunologically related diseases may correspond to an endogenous circannual time structure.

Authors

F A Lévi, C Canon, Y Touitou, A Reinberg, G Mathé

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Total citations by year

Year: 2023 2022 2021 2020 2019 2018 2015 2014 2013 2011 2010 2008 2007 2005 2004 2003 2002 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 Total
Citations: 1 2 1 1 2 1 1 3 3 3 3 2 5 3 1 2 4 4 3 1 4 2 3 7 4 4 3 6 5 84
Citation information
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Citations to this article in year 2007 (5)

Title and authors Publication Year
Seasonal variation and the immune response: A fish perspective
TJ Bowden, KD Thompson, AL Morgan, RM Gratacap, S Nikoskelainen
Fish & Shellfish Immunology 2007
Seasonal modulation of post-resection breast cancer metastasis
EY Oh, PA Wood, J Du-Quiton, WJ Hrushesky
Breast Cancer Research and Treatment 2007
Biological and methodological variation of lymphocyte subsets in blood of human adults
K Backteman, J Ernerudh
Journal of Immunological Methods 2007
Expression of Clock Genes in Human Peripheral Blood Mononuclear Cells throughout the Sleep/Wake and Circadian Cycles
FO James, DB Boivin, S Charbonneau, V Bélanger, N Cermakian
Chronobiology International 2007
Possible Linkage between the Ability to Change the Period (τ) of the Prolactin and Cortisol Rhythms in Women and Breast Cancer Risk
H Lewy, E Haus, IE Ashkenazi
Chronobiology International 2007

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