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Citations to this article

Control of hair growth and follicle size by VEGF-mediated angiogenesis
Kiichiro Yano, … , Lawrence F. Brown, Michael Detmar
Kiichiro Yano, … , Lawrence F. Brown, Michael Detmar
Published February 15, 2001
Citation Information: J Clin Invest. 2001;107(4):409-417. https://doi.org/10.1172/JCI11317.
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Article Article has an altmetric score of 277

Control of hair growth and follicle size by VEGF-mediated angiogenesis

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Abstract

The murine hair follicle undergoes pronounced cyclic expansion and regression, leading to rapidly changing demands for its vascular support. Our study aimed to quantify the cyclic changes of perifollicular vascularization and to characterize the biological role of VEGF for hair growth, angiogenesis, and follicle cycling. We found a significant increase in perifollicular vascularization during the growth phase (anagen) of the hair cycle, followed by regression of angiogenic blood vessels during the involution (catagen) and the resting (telogen) phase. Perifollicular angiogenesis was temporally and spatially correlated with upregulation of VEGF mRNA expression by follicular keratinocytes of the outer root sheath, but not by dermal papilla cells. Transgenic overexpression of VEGF in outer root sheath keratinocytes of hair follicles strongly induced perifollicular vascularization, resulting in accelerated hair regrowth after depilation and in increased size of hair follicles and hair shafts. Conversely, systemic treatment with a neutralizing anti-VEGF antibody led to hair growth retardation and reduced hair follicle size. No effects of VEGF treatment or VEGF blockade were observed in mouse vibrissa organ cultures, which lack a functional vascular system. These results identify VEGF as a major mediator of hair follicle growth and cycling and provide the first direct evidence that improved follicle vascularization promotes hair growth and increases hair follicle and hair size.

Authors

Kiichiro Yano, Lawrence F. Brown, Michael Detmar

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2005 2004 2002 Total
Citations: 12 19 21 25 33 18 12 5 9 8 16 3 8 6 2 3 4 1 2 3 1 2 213
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2017 (9)

Title and authors Publication Year
Accelerated senescence in skin in a murine model of radiation-induced multi-organ injury
EA McCart, RL Thangapazham, ED Lombardini, SR Mog, RA Panganiban, KM Dickson, RA Mansur, V Nagy, SY Kim, R Selwyn, MR Landauer, TN Darling, RM Day
Journal of Radiation Research 2017
The Use of Adipose-Derived Stem Cells in Selected Skin Diseases (Vitiligo, Alopecia, and Nonhealing Wounds)
A Owczarczyk-Saczonek, A Wociór, W Placek, W Maksymowicz, J Wojtkiewicz
Stem Cells International 2017
Platelet-rich plasma stimulates angiogenesis in mice which may promote hair growth
H Cheng, J Zhang, J Li, M Jia, Y Wang, H Shen
European Journal of Medical Research 2017
Conventional and novel stem cell based therapies for androgenic alopecia
D Talavera-Adame, D Newman, N Newman
Stem cells and cloning : advances and applications 2017
Platelet-rich plasma—an ‘Elixir’ for treatment of alopecia: personal experience on 117 patients with review of literature
S Garg, S Manchanda
Stem Cell Investigation 2017
Morphological analysis of patchy thickening and reddish discoloration of active hair growth areas in the skin of New Zealand White rabbits
T Ishihara, H Yamashita, T Sakurai, J Morita, K Sakamoto, A Ishii, M Sasaki
Journal of Toxicologic Pathology 2017
Extracellular vesicles derived from MSCs activates dermal papilla cell in vitro and promotes hair follicle conversion from telogen to anagen in mice
RL Rajendran, P Gangadaran, SS Bak, JM Oh, S Kalimuthu, HW Lee, SH Baek, L Zhu, YK Sung, SY Jeong, SW Lee, J Lee, BC Ahn
Scientific Reports 2017
Minoxidil Induction of VEGF Is Mediated by Inhibition of HIF-Prolyl Hydroxylase
S Yum, S Jeong, D Kim, S Lee, W Kim, JW Yoo, JA Kim, O Kwon, DD Kim, D Min, Y Jung
International journal of molecular sciences 2017
Effect of Miscanthus sinensis var. purpurascens Flower Extract on Proliferation and Molecular Regulation in Human Dermal Papilla Cells and Stressed C57BL/6 Mice
GH Jeong, WA Boisvert, , Y Zhang, YB Choi, S Cho, S Lee, C Choi, BH Lee
Chinese Journal of Integrative Medicine 2017

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