Citations to this article

Elevated plasma atrial natriuretic peptide levels in diabetic rats. Potential mediator of hyperfiltration.
F V Ortola, … , R E Mendez, B M Brenner
F V Ortola, … , R E Mendez, B M Brenner
Published September 1, 1987
Citation Information: J Clin Invest. 1987;80(3):670-674. https://doi.org/10.1172/JCI113120.
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Research Article

Elevated plasma atrial natriuretic peptide levels in diabetic rats. Potential mediator of hyperfiltration.

Abstract

Infusion of atrial natriuretic peptide (ANP) increases the glomerular filtration rate (GFR), and ANP is released from cardiac myocytes in response to extracellular fluid volume expansion. Since diabetes mellitus is associated with glomerular hyperfiltration and volume expansion, we investigated the relationship between ANP and GFR in diabetic rats given insulin to achieve stable moderate hyperglycemia or normoglycemia. At 2 wk after induction of diabetes, moderately hyperglycemic diabetic rats exhibited elevations of plasma ANP levels averaging 281 +/- 28 pg/ml vs. 158 +/- 15 pg/ml in normoglycemic diabetic rats. In hyperglycemic rats, the GFR was also elevated on average to 2.24 +/- 0.28 ml/min as compared with 1.71 +/- 0.13 ml/min in normoglycemic diabetic rats. To test further the relationship between ANP and GFR in diabetes, moderately hyperglycemic diabetic rats were infused either with a specific ANP antiserum or with nonimmune serum. The infusion of specific ANP antiserum uniformly reduced the GFR on average from 2.38 +/- 0.1 ml/min to 1.60 +/- 0.1 ml/min, whereas the infusion of nonimmune serum was without effect. It is concluded that elevated endogenous ANP levels contribute to the hyperfiltration observed in early diabetes in the rat.

Authors

F V Ortola, B J Ballermann, S Anderson, R E Mendez, B M Brenner

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Concentration(s) of atrial natriuretic hormone in the plasma of rats with streptozotocin-induced diabetes mellitus
RA Hebden, JH McNeill 		Life Sciences 1988
Role of altered capillary hemodynamics in the initiation and progression of diabetic microangiopathy
S Anderson, BM Brenner 		Journal of Diabetic Complications 1988
Prolonged Intraperitoneal Dwell Decreases Ultrafiltration Coefficient in Rabbits
JF Maher, P Hirszel, A Shostak, BD Paolo, E Chakrabarti 		American Journal of Kidney Diseases 1988
Hypertension and Diabetes
JR Sowers, J Levy, MB Zemel 		Medical Clinics of North America 1988
Peptide hormones and the regulation of sodium excretion
MH Humphreys, SY Lin 		Hypertension 1988

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