In a cross-sectional study of 70 early postmenopausal women, regional bone measurements were compared with total body calcium (TBCa). Spinal and forearm trabecular bone were mainly related to age and time since menopause. In contrast, TBCa and forearm integral (cortical and trabecular) and cortical bone were unrelated to age, although the time since menopause also had some influence. Forearm integral and cortical bone measurements were quite well correlated with TBCa (r = 0.84 and 0.73, respectively, P less than 0.001). The correlation between spinal bone measurements and any of the forearm measurements, even purely trabecular bone, was weak (r less than 0.52, P less than 0.001). Our results show quite clearly that forearm bone measurements cannot be used to predict bone density in the vertebrae. Loss of ovarian function affects bone in general, and trabecular bone in particular. Bone measurements at specific anatomical sites are clearly necessary for studies of metabolic bone diseases and their response to treatment.
J C Stevenson, L M Banks, T J Spinks, C Freemantle, I MacIntyre, R Hesp, G Lane, J A Endacott, M Padwick, M I Whitehead
Title and authors | Publication | Year |
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Automated, calibration-free quantification of cortical bone porosity and geometry in postmenopausal osteoporosis from ultrashort echo time MRI and deep learning.
Jones BC, Wehrli FW, Kamona N, Deshpande RS, Vu BD, Song HK, Lee H, Grewal RK, Chan TJ, Witschey WR, MacLean MT, Josselyn NJ, Iyer SK, Al Mukaddam M, Snyder PJ, Rajapakse CS |
Bone | 2023 |
Climacteric Commentaries
A Pines |
Climacteric | 2012 |
Menopause
DG Weismiller |
Primary Care Clinics in Office Practice | 2009 |
Treatment of the Postmenopausal Woman
FS Keating, JC Stevenson |
Treatment of the Postmenopausal Woman | 2007 |
Preventing Osteoporosis
K Chapman-Novakofski, E Evans, TC Gallagher |
Journal of Nutrition For the Elderly | 2003 |
Radius Bone Strength in Bending, Compression, and Falling and Its Correlation With Clinical Densitometry at Multiple Sites
EM Lochmüller, CA Lill, V Kuhn, E Schneider, F Eckstein |
Journal of Bone and Mineral Research | 2002 |
Osteoporosis
DL Glaser, FS Kaplan |
Spine | 1997 |
Skeletal effects of menstrual disturbances in athletes
KL Bennell, SA Malcolm, JD Wark, PD Brukner |
Scandinavian Journal of Medicine & Science in Sports | 1997 |
Late prevention of hip fractures with hormone replacement therapy
JC Stevenson |
Osteoporosis International | 1996 |
Vertebral deformity in the thoracic spine in post-menopausal women: value of lumbar spine bone density
C Grey, R Young, PW Bearcroft, JE Compston |
British Journal of Radiology | 1996 |
The impact of bone loss in women with endometriosis
JC Stevenson |
International Journal of Gynecology & Obstetrics | 1995 |
Prevention of early postmenopausal bone loss using low doses of conjugated estrogens and the non-hormonal, bone-active drug ipriflavone
D Agnusdei, C Gennari, L Bufalino |
Osteoporosis International | 1995 |
Major Issues Regarding Estrogen Replacement Therapy in Postmenopausal Women
JP Bilezikian |
Journal of Women's Health | 1994 |
Trabecular and cortical bone changes in vertebral and peripheral skeletons induced by surgical menopause
S Dokou, Y Satou, Y Soeda |
Journal of Bone and Mineral Metabolism | 1994 |
Influence of the menopausal age on the severity of osteoporosis in women with vertebral fractures
EM Vega, MA Egea, CA Mautalen |
Maturitas | 1994 |
Bone mineral density in young women with long-standing amenorrhea: Limited effect of hormone replacement therapy with ethinylestradiol and desogestrel
W Haenggi, JP Casez, MH Birkhaeuser, K Lippuner, P Jaeger |
Osteoporosis International | 1994 |
Preliminary evaluation of a new ultrasound bone densitometer
B Lees, JC Stevenson |
Calcified Tissue International | 1993 |
Bone changes in postmenopausal Spanish women
H Rico, ER Hernndez, M Revilla, LF Villa, MA de Buergo, E Cuende |
Calcified Tissue International | 1993 |
Body composition and bone mass in post-menopausal women
JE Compston, M Bhambhanl, MA Laskey, S Murphy, KT Khaw |
Clinical Endocrinology | 1992 |
Current therapy Hormone replacement therapy: risks and benefits
SI Whitcroft, JC Stevenson |
Clinical Endocrinology | 1992 |
The effect of sex steroids on the skeleton in premenopausal women
R Lindsay |
American Journal of Obstetrics and Gynecology | 1992 |
Ipriflavone and low doses of estrogens in the prevention of bone mineral loss in climacterium
GB Melis, AM Paoletti, R Bartolini, MT Balducci, GB Massi, V Bruni, A Becorpi, S Ottanelli, P Fioretti, M Gambacciani, A Spinetti, N D'Antona, VD Leo, D Agnusdei, A Camporeale, C Gennari |
Bone and Mineral | 1992 |
THE LONG-TERM RISKS AND BENEFITS OF HORMONE REPLACEMENT THERAPY
TC Hillard, S Whitcroft, MC Ellerington, MI Whitehead |
Journal of Clinical Pharmacy and Therapeutics | 1991 |
REVIEW OSTEOPOROSIS
JE Compston |
Clinical Endocrinology | 1990 |
Estrogens, bone loss and preservation
C Christiansen, R Lindsay |
Osteoporosis International | 1990 |
Effects of transdermal versus oral hormone replacement therapy on bone density in spine and proximal femur in postmenopausal women
JC Stevenson, MP Cust, KF Gangar, TC Hillard, BL Lees, MP Cust, KF Gangar, TC Hillard, MI Whitehead |
The Lancet | 1990 |
New Techniques in Metabolic Bone Disease
R Lindsay |
New Techniques in Metabolic Bone Disease | 1990 |
HRT and Osteoporosis
JO Drife, JW Studd |
1990 | |
Transdermal estradiol in the treatment of postmenopausal bone loss
S Adami, R Suppi, F Bertoldo, M Rossini, M Residori, V Maresca, VL Cascio |
Bone and Mineral | 1989 |
Determinants of bone density in normal women: risk factors for future osteoporosis?
JC Stevenson, B Lees, M Devenport, MP Cust, KF Ganger |
BMJ : British Medical Journal | 1989 |
Broadband ultrasonic attenuation and bone mineral density
WD Evans, EO Crawley, JE Compston, C Evans, GM Owen |
Clinical Physics and Physiological Measurement | 1988 |
4 Osteoporosis: pathogenesis and risk factors
JC Stevenson |
Baillière's Clinical Endocrinology and Metabolism | 1988 |
The relation between forearm and vertebral mineral density and fractures in postmenopausal women
BE Nordin, JM Wishart, M Horowitz, AG Need, A Bridges, M Bellon |
Bone and Mineral | 1988 |
Bone mineral content in normal UK subjects
JE Compston, WD Evans, EO Crawley, C Evans |
British Journal of Radiology | 1988 |
Dietary intake of calcium and postmenopausal bone loss
JC Stevenson, MI Whitehead, M Padwick, JA Endacott, C Sutton, LM Banks, C Freemantle, TJ Spinks, R Hesp |
BMJ : British Medical Journal | 1988 |