Citations to this article

Properties of the Na+-K+ pump in human red cells with increased number of pump sites.
J A Halperin, … , J Ingwall, D C Tosteson
J A Halperin, … , J Ingwall, D C Tosteson
Published July 1, 1987
Citation Information: J Clin Invest. 1987;80(1):128-137. https://doi.org/10.1172/JCI113037.
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Properties of the Na+-K+ pump in human red cells with increased number of pump sites.

Abstract

We studied the Na+/K+ pump in red cells from an obese human subject (MAJ) in which the number of pumps/cell was 10-20 times higher than normal. Through measurements of the kinetic properties of several modes of operation of the Na+/K+ pump we determined that the pumps in MAJ cells are kinetically normal. In the presence of adequate metabolic substrate the maximum rates of Na+ pumping and lactate production saturated at 60 and 12 nmol/1 cell per h, respectively. Under physiological conditions pump and "leak" Na+ fluxes were similar in MAJ and normal cells. Since internal Na+ was lower in MAJ than in normal cells (Nai+ approximately 2 and 8 mmol/1 cell, respectively), we conclude that the reduction in cell Na+ allows the Na+/K+ pump in MAJ cells to operate at lower fraction of maximum capacity and to compensate for the increased number of pumps.

Authors

J A Halperin, C Brugnara, A S Kopin, J Ingwall, D C Tosteson

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Citations to this article (18)

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Q Li, C Dong, A Deng, M Katsumata, A Nakadai, T Kawada, S Okada, C Clayberger, AM Krensky 		Antimicrobial agents and chemotherapy 2005
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L Soldati, R Spaventa, G Vezzoli, S Zerbi, D Adamo, A Caumo, R Rivera, G Bianchi 		Biochemical and Biophysical Research Communications 1997
Molecular Biology of Membrane Transport Disorders
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Relations of sodium-lithium countertransport kinetics to plasma and red cell membrane phospholipids in hyperlipidemia
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Epidermal growth factor stimulates Ca2+ uptake of human erythrocytes
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A voltage-activated cation transport pathway associated with the sodium pump
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Digitalis-like properties of an inhibitor of the pump in human cerebrospinal fluid
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Salt and Hypertension
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