Citations to this article

Circulating dihydrotestosterone may not reflect peripheral formation.
V Toscano, R Horton
V Toscano, R Horton
Published June 1, 1987
Citation Information: J Clin Invest. 1987;79(6):1653-1658. https://doi.org/10.1172/JCI113003.
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Research Article

Circulating dihydrotestosterone may not reflect peripheral formation.

Abstract

We compared the blood (PBDHT) and urine (PUDHT) production rate of dihydrotestosterone (DHT) in normal men and women to determine whether peripheral formation was totally reflected in blood. PBDHT was similar when measured at both sites in men (674 +/- 79 vs. 788 +/- 207 SE micrograms/d); however, PUDHT was greater than PBDHT in women (174 +/- 55 vs. 55 +/- 8 micrograms/d, P less than 0.02). Excretion rates of DHT and 3 alpha-androstanediol (3 alpha diol) were similar in both sexes despite major differences in blood levels. However, between sexes large differences were present in 3 alpha diol glucuronide (3 alpha diolG) in both plasma and urine. These observations indicate that peripheral (renal) formation of DHT and probably 3 alpha diol were not accurately determined by measurement of these steroids in blood. The large difference between blood and urine production rates in women suggests an important role of non-testosterone precursors of 5 alpha-reduced steroids. Measurements of 3 alpha diolG may provide more insight into these peripheral events.

Authors

V Toscano, R Horton

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Citations to this article (20)

Title and authors Publication Year
Doping in Sports
D Thieme, P Hemmersbach 		2009
Doping in Sports
D Thieme, P Hemmersbach 		2009
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D Thieme, P Hemmersbach 		2009
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Effect of finasteride in idiopathic hirsutism
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Plasma 3α-androstanediol glucuronide in precocious adrenarche
R Balducci, G Finocchi, A Mangiantini, P Bianchi, R Guglielmi, V Toscano 		Journal of Endocrinological Investigation 1993
Possible indices for the detection of the administration of dihydrotestosterone to athletes
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Dihydrotestosterone Is a Peripheral Paracrine Hormone
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Is plasma 5α-androstane 3α, 17β-diol glucuronide a biochemical marker of hirsutism in women?
VA Giagulli, R Giorgino, A Vermeulen 		The Journal of Steroid Biochemistry and Molecular Biology 1991
Hirsutism: pilosebaceous unit dysregulation. Role of peripheral and glandular factors
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BIOACTIVE AND PERIPHERAL ANDROGENS IN PREPUBERTAL SIMPLE HYPERTRICHOSIS
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Serum levels of 5-androstene-3β, 7β-DIOL sulphate, 5α-androstane-3α,17β-DIOL sulphate and glucuronide, in late onset 21-hydroxylase deficiency
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Markers of peripheral androgen action in vivo and in vitro
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