Citations to this article

Suppressor T cell clones from patients with acute Epstein-Barr virus-induced infectious mononucleosis.
F Wang, … , K C Zoon, G Tosato
F Wang, … , K C Zoon, G Tosato
Published January 1, 1987
Citation Information: J Clin Invest. 1987;79(1):7-14. https://doi.org/10.1172/JCI112810.
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Research Article

Suppressor T cell clones from patients with acute Epstein-Barr virus-induced infectious mononucleosis.

Abstract

Suppression and/or cytotoxicity are believed to play an important role in the defense against Epstein-Barr virus (EBV) infection. To analyze the role of suppressor T cells in relation to EBV, we sought to clone and study these T cells. Analysis of 152 T cell clones derived from the peripheral blood of two patients with acute EBV-induced infectious mononucleosis (IM) yielded 11 highly suppressive clones that had no cytotoxic activity for the natural killer sensitive K562 cell line, an autologous EBV-infected cell line, or an allogeneic EBV-infected B cell line. Four of six suppressor T cell clones also profoundly inhibited EBV-induced immunoglobulin production, and five of five clones delayed the outgrowth of immortalized cells. These results indicate that during acute IM, suppressor T cells capable of inhibiting B cell activation in the absence of cytotoxicity can be identified, and may play a key role in the control of EBV infection.

Authors

F Wang, R M Blaese, K C Zoon, G Tosato

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Citations to this article (13)

Title and authors Publication Year
Heat Shock Protein 90 Expression in Epstein-Barr Virus-Infected B Cells Promotes γδ T-Cell Proliferation In Vitro
M Kotsiopriftis, JE Tanner, C Alfieri 		Journal of virology 2005
Vaccine strategies against Epstein-Barr virus-associated diseases: lessons from studies on cytotoxic T-cell-mediated immune regulation
R Khanna, DJ Moss, SR Burrows 		Immunological Reviews 1999
Adoptive immunotherapy for Epstein-Barr virus-associated lymphoproliferative disorders complicating marrow allografts
RJ O'Reilly, TN Small, E Papadopoulos, K Lucas, J Lacerda, L Koulova 		Springer Seminars in Immunopathology 1998
Epstein-Barr Virus Infection Associated with Interstitial Nephritis and Chronic Fatigue
AL Navidad, P Domingo, JC Talavera, N Rabella, G Verger 		Scandinavian Journal of Infectious Diseases 1996
8 Epstein-Barr virus as an agent of haematological disease
G Tosato, K Taga, AL Angiolillo, C Sgadari 		Baillière's Clinical Haematology 1995
Viral Diseases in Pregnancy
B Gonik 		1994
Emergence of non-major-histocompatibility-complex-restricted lytic CD8+ cells in the blood of nasopharyngeal carcinoma patients
M Lakhdar, H Thameur, M Maalej, FB Ayed, A Ladgham 		Cancer Immunology, Immunotherapy 1993
Selective homing of phenotypically lytic cells within nasopharyngeal carcinoma biopsies: Numerous CD8- and CD16-positive cells in the tumor
M Lakhdar, MH Aribia, M Maalej, A Ladgham 		International Journal of Cancer 1991
T cell responses in allergic rhinitis, asthma and atopic dermatitis
A Sustiel, R Rocklin 		Clinical & Experimental Allergy 1989
Epstein-barr virus: The hematologic and oncologic consequences of virus-host interaction
RH Giller, C Grose, JF Jones 		Critical Reviews in Oncology/Hematology 1989
Urushiol (poison ivy)-triggered suppressor T cell clone generated from peripheral blood
RS Kalish, C Morimoto 		Journal of Clinical Investigation 1988
An Epstein-Barr virus transforming protein associates with vimentin in lymphocytes
D Liebowitz, R Kopan, E Fuchs, J Sample, E Kieff 		Molecular and cellular biology 1987
Infectious Mononucleosis
JR Paul 		Bulletin of the New York Academy of Medicine 1939

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