Citations to this article

Identification of a new class of inducible receptors on platelets. Thrombospondin interacts with platelets via a GPIIb-IIIa-independent mechanism.
M L Aiken, … , M H Ginsberg, E F Plow
M L Aiken, … , M H Ginsberg, E F Plow
Published December 1, 1986
Citation Information: J Clin Invest. 1986;78(6):1713-1716. https://doi.org/10.1172/JCI112767.
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Identification of a new class of inducible receptors on platelets. Thrombospondin interacts with platelets via a GPIIb-IIIa-independent mechanism.

Abstract

Thrombospondin with fibrinogen, fibronectin, and von Willebrand factor binds to platelets stimulated with agonists and support platelet adhesive functions. The receptors for the latter three proteins are associated with membrane glycoprotein GPIIb-IIIa. Thrombasthenic platelets deficient in GPIIb-IIIa have been utilized to examine the role of this membrane protein in the interactions of thrombospondin with platelets. Radioiodinated thrombospondin bound to thrombin-stimulated platelets from normal and thrombasthenic donors with a similar affinity and capacity. As monitored with a monoclonal antibody to thrombospondin, the divalent ion-dependent and -independent pathways for the expression of the endogenous pool of thrombospondin on the surface of thrombin-stimulated platelets from normal and thrombasthenic donors were also qualitatively and quantitatively similar. GPIIb-IIIa or ligands associated with GPIIb-IIIa thus are not essential for the binding of thrombospondin to platelets. Therefore, thrombospondin interacts with unique receptors on platelets.

Authors

M L Aiken, M H Ginsberg, E F Plow

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Citations to this article (33)

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Selective inhibition of platelet macroaggregate formation by a recombinant heparin-binding domain of human thrombospondin
C Legrand, V Morandi, S Mendelovitz, H Shaked, JR Hartman, A Panet 		Arteriosclerosis Thrombosis and Vascular Biology 1994
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P Beiso, D Pidard, D Fournier, V Dubernard, C Legrand 		Biochimica et Biophysica Acta (BBA) - General Subjects 1990
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N Kieffer, A Bettaieb, C Legrand, L Coulombel, W Vainchenker, L Edelman, J Breton-Gorius 		Biochemical Journal 1989
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JL McGregor, B Catimel, S Parmentier, P Clezardin, M Dechavanne, LL Leung 		The Journal of biological chemistry 1989
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J Karczewski, KA Knudsen, L Smith, A Murphy, VL Rothman, GP Tuszynski 		The Journal of biological chemistry 1989
Platelet membrane glycoproteins and their function: an overview.
Kunicki TJ 		Blut 1989
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Isolation of the thrombospondin membrane receptor
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