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Citations to this article

Radioimmunoassay of growth hormone-dependent insulinlike growth factor binding protein in human plasma.
R C Baxter, J L Martin
R C Baxter, J L Martin
Published December 1, 1986
Citation Information: J Clin Invest. 1986;78(6):1504-1512. https://doi.org/10.1172/JCI112742.
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Radioimmunoassay of growth hormone-dependent insulinlike growth factor binding protein in human plasma.

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Abstract

A specific radioimmunoassay has been established for a growth hormone-dependent insulinlike growth factor (IGF) binding protein (BP) from human plasma. Although the assay was directed against a 53-kD, acid-stable BP subunit, the main immunoreactive BP in the circulation had an apparent molecular mass of approximately 125 kD. Only higher primate species showed cross-reactivity, and IGF-I, IGF-II, and other peptides were without effect. Circulating BP levels in healthy subjects rose threefold from early childhood to puberty. In 65 adults aged 18 to 65, the mean level (+/- SD) was 6.12 +/- 1.43 micrograms/ml, and declined with age. Strong growth hormone-dependence of BP was also seen; there was a 2.2-fold increase in active acromegaly and a 50-80% reduction in growth hormone deficiency. Poorly controlled diabetic subjects had BP levels 40% below normal, whereas in renal failure and third-term pregnancy a mild elevation was seen. Measurement of BP may provide a useful adjunct to IGF assays in growth disorders.

Authors

R C Baxter, J L Martin

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AB Clavano-Harding, GR Ambler, CT Cowell, SP Garnett, B Al-Toumah, JC Coakley, KK Ho, RC Baxter
Clinical Endocrinology 1999
GH Response to Exercise: Assessment of the Pituitary Refractory Period, and Relationship with Circulating Components of the GH-IGF-I Axis in Adolescent Females
A Eliakim, JA Brasel, DM Cooper
Journal of Pediatric Endocrinology and Metabolism 1999
Moderate Doses of Porcine Somatotropin do not Increase Plasma Insulin-Like Growth factor-I (IGF-I) or IGF Binding Protein-3
FR Dunshea, RH King, PC Owens, PE Walton
Domestic Animal Endocrinology 1999
Reactivation of pituitary hormone release and metabolic improvement by infusion of growth hormone-releasing peptide and thyrotropin-releasing hormone in patients with protracted critical illness
GV Berghe, P Wouters, F Weekers, S Mohan, RC Baxter, JD Veldhuis, CY Bowers, R Bouillon
The Journal of clinical endocrinology and metabolism 1999
The search for trans-acting factors controlling messenger RNA decay
GM Wilson, G Brewer
Progress in nucleic acid research and molecular biology 1999
Evaluation of disease activity by IGF-I and IGF binding protein-3 (IGFBP3) in acromegaly patients distributed according to a clinical score
H Jasper, P Pennisi, M Vitale, A Mella, G Ropelato, A Chervin
Journal of Endocrinological Investigation 1999
Serum IGF-I and IGFBP-3 levels for the assessment of disease activity of acromegaly
HS Chen, HD Lin
Journal of Endocrinological Investigation 1999
Liver-specific and proliferation-induced deoxyribonuclease I hypersensitive sites in the mouse insulin-like growth factor binding protein-1 gene
MA Crissey, JI Leu, RA de Angelis, LE Greenbaum, LM Scearce, K Kovalovich, R Taub
Hepatology 1999
Monoclonal antibodies to growth hormone (GH) prolong liver GH binding and GH-induced IGF-I/IGFBP-3 synthesis
V Beauloye, SM Muaku, P Lause, D Portetelle, R Renaville, AR Robert, JM Ketelslegers, D Maiter
American journal of physiology. Endocrinology and metabolism 1999
Oncogenic ras Causes Resistance to the Growth Inhibitor Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) in Breast Cancer Cells
JL Martin, RC Baxter
The Journal of biological chemistry 1999
Maternal serum insulin-like growth factor binding protein-2 and -3 and fetal growth
RP Holmes, JM Holly, PW Soothill
Human Reproduction 1999
The IGF System
RG Rosenfeld, CT Roberts
1999
Effect of Severe Growth Hormone (GH) Deficiency due to a Mutation in the GH-Releasing Hormone Receptor on Insulin-Like Growth Factors (IGFs), IGF-Binding Proteins, and Ternary Complex Formation Throughout Life1
MH Aguiar-Oliveira, MS Gill, ES de, A Barretto, MR Alcântara, F Miraki-Moud, CA Menezes, AH Souza, CE Martinelli, FA Pereira, R Salvatori, MA Levine, SM Shalet, C Camacho-Hubner, PE Clayton
The Journal of clinical endocrinology and metabolism 1999
Interactions between Growth Hormone, Insulin-Like Growth Factor I, and Basic Fibroblast Growth Factor in Melanocyte Growth1
SR Edmondson, VC Russo, AC McFarlane, CJ Wraight, GA Werther
The Journal of clinical endocrinology and metabolism 1999
The relationship between the growth hormone and insulin-like growth factor axis in long-term survivors of childhood brain tumours
JC Achermann, PC Hindmarsh, CG Brook
Clinical Endocrinology 1998
Growth Hormone Resistance and Somatomedins in Children with End-Stage Liver Disease Awaiting Transplantation
RM Greer, P Quirk, GJ Cleghorn, RW Shepherd
Journal of Pediatric Gastroenterology & Nutrition 1998
Tamoxifen alters levels of serum insulin-like growth factors and binding proteins in postmenopausal breast cancer patients: A prospective paired cohort study
GH Ho, CY Ji, BH Phang, KO Lee, KC Soo, EH Ng
Annals of Surgical Oncology 1998
Ongoing Assessment of Nutritional Status in Children with Malignant Disease
SP Attard-Montalto, J Hadley, JE Kingston, OB Eden, V Saha
Pediatric Hematology-Oncology 1998
Thrity-day monitoring of insulin-like growth factors and their binding proteins in intensive care unit patients
RC Baxter, FH Hawker, C To, PM Stewart, SR Holman
Growth Hormone & IGF Research 1998
Effect of aging on growth hormone-induced insulin-like growth factor-I secretion from cultured rat chondrocytes
N Rousseau, P Brazeau, H Lapierre, T Abribat
Growth Hormone & IGF Research 1998
Expression of Insulin-like Growth Factor Binding Proteins in Bronchoalveolar Lavage Fluid of Patients with Pulmonary Sarcoidosis
JT Allen, CA Bloor, RA Knight, MA Spiteri
American journal of respiratory cell and molecular biology 1998
Development of Resistance to Insulin-like Growth Factor Binding Protein-3 in Transfected T47D Breast Cancer Cells
SM Firth, S Fanayan, D Benn, RC Baxter
Biochemical and Biophysical Research Communications 1998
Follicular fluid insulin-like growth factor-I and insulin-like growth factor-binding protein-1 and -3 vary as a function of ovarian reserve and ovarian stimulation
L Stadtmauer, A Vidali, SR Lindheim, MV Sauer
Journal of Assisted Reproduction and Genetics 1998
Role of insulin-like growth factor binding proteins in human post-nephrectomy proximal tubule cells
DW Johnson, HJ Saunders, MJ Field, CA Pollock
The Journal of Physiology 1998
Follicular Fluid Insulin-like Growth Factor-I and Insulin-like Growth Factor–Binding Protein-1 and -3 Vary as a Function of Ovarian Reserve and Ovarian Stimulation
L Stadtmauer, A Vidali, SR Lindheim, MV Sauer
Journal of Assisted Reproduction and Genetics 1998
Long-Term Effect of Recombinant Human Insulin-Like Growth Factor I on Metabolic and Growth Control in a Patient with Leprechaunism
J Nakae, M Kato, M Murashita, N Shinohara, T Tajima, K Fujieda
The Journal of clinical endocrinology and metabolism 1998
Developmental Changes in Serum Levels of Free and Total Insulin-Like Growth Factor I (IGF-I), IGF-Binding Protein-1 and -3, and the Acid-Labile Subunit in Rats 1
J Frystyk, H Grønbæk, C Skjærbæk, A Flyvbjerg, H Ørskov, RC Baxter
Endocrinology 1998
Insulin-like Growth Factor-binding Protein (IGFBP)-3 and IGFBP-5 Share a Common Nuclear Transport Pathway in T47D Human Breast Carcinoma Cells
LJ Schedlich, TF Young, SM Firth, RC Baxter
The Journal of biological chemistry 1998
Structural Determinants of Ligand and Cell Surface Binding of Insulin-like Growth Factor-binding Protein-3
SM Firth, U Ganeshprasad, RC Baxter
The Journal of biological chemistry 1998
Insulin-Like Growth Factor Binding Protein-3: A Novel Biomarker for the Assessment of the Synthetic Capacity of Hepatocytes in Liver Cirrhosis
M Shaarawy, MA Fikry, BA Massoud, S Lotfy
The Journal of clinical endocrinology and metabolism 1998
Insulin-Like Growth Factor-I Resistance*
S Jain, DW Golde, R Bailey, ME Geffner
Endocrine reviews 1998
Age-Related Differences in Serum Insulin-like Growth Factor-I (IGF-I) and IGF-Binding Protein-3 Levels in Congenital Hypothyroidism
N Kandemir, N Yordam, H Oguz
Journal of Pediatric Endocrinology and Metabolism 1997
Insulin-Like Growth Factor-I and Its Binding Protein-3 in Serum: Are They Good Screening Properties for the Diagnosis of Growth Hormone Deficiency?
A Koch, HG Dörr
Clinical Chemistry and Laboratory Medicine 1997
Serum Levels of Insulin-like Growth Factor-I and Insulin-like Growth Factor Binding Protein-3 in Obese Children
A Bideci, P Cinaz, A Hasanoglu, S Elbeg
Journal of Pediatric Endocrinology and Metabolism 1997
Modulation of growth factors by growth hormone in children with chronic renal failure
DR Powell, F Liu, BK Baker, RL Hintz, PD Lee, SK Durham, ED Brewer, JW Frane, SL Watkins, RJ Hogg
Kidney International 1997
Insulin-like growth factor binding proteins and their role in controlling IGF actions
DR Clemmons
Cytokine & Growth Factor Reviews 1997
Effects of single nightly injections of growth hormone—releasing hormone (GHRH 1–29) in healthy elderly men
J Vittone, MR Blackman, J Busby-Whitehead, C Tsiao, KJ Stewart, J Tobin, T Stevens, MF Bellantoni, MA Rogers, G Baumann, J Roth, SM Harman, RG Spencer
Metabolism 1997
Bioactivity of a 29-Kilodalton Insulin-Like Growth Factor Binding Protein-3 Fragment Present in Excess in Chronic Renal Failure Serum
SK Durham, S Mohan, F Liu, BK Baker, PD Lee, RL Hintz, CA Conover, DR Powell
Pediatric Research 1997
Growth hormone secretion in the elderly: Ageing and the somatopause
FC Martin, AL Yeo, PH Sonksen
Baillière's Clinical Endocrinology and Metabolism 1997
The pathogenesis of growth failure in paediatric liver disease
RI Holt, AJ Baker, JP Miell
Journal of Hepatology 1997
Comparative study of insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 (IGFBP-3) level and ratio measurements and their relationship with an index of clinical activity in the management of patients with acromegaly
C Páramo, MA O, E Fluiters, R Luna, J la Fuente, RV García-Mayor
Metabolism 1997
Growth Factors and Cytokines in Health and Disease
P Martin, J McCluskey, P Mallucci, S Nodder
Growth Factors and Cytokines in Health and Disease 1997
Advances in Molecular and Cellular Endocrinology
MR Pollak, EM Brown
Advances in Molecular and Cellular Endocrinology 1997
Growth and hormone characteristics of pubertal development in the hamadryas baboon
BA Crawford, WJ Harewood, DJ Handelsman
Journal of Medical Primatology 1997
Human renal fibroblasts modulate proximal tubule cell growth and transport via the IGF-I axis
DW Johnson, HJ Saunders, BK Brew, A Ganesan, RC Baxter, P Poronnik, DI Cook, AZ Györy, MJ Field, CA Pollock
Kidney International 1997
Simulation of IGF-I pharmacokinetics after infusion of recombinant IGF-I in human subjects
MA Boroujerdi, RH Jones, PH Sonksen, DL Russell-Jones
American journal of physiology. Endocrinology and metabolism 1997
Weight loss and wrestling training: effects on growth-related hormones
JN Roemmich, WE Sinning
Journal of applied physiology 1997
Evidence for Insulin-Like Growth Factor (IGF)-Independent Transcriptional Regulation of IGF Binding Protein-3 by Growth Hormone in SKHEP-1 Human Hepatocarcinoma Cells*
ZS Gucev, Y Oh, KM Kelley, JI Labarta, P Vorwerk, RG Rosenfeld
Endocrinology 1997
Insulin-Like Growth Factor-Binding Proteins in Serum and Other Biological Fluids: Regulation and Functions*
S Rajaram, DJ Baylink, S Mohan
Endocrine reviews 1997
Effect of Aging on the Sensitivity of Growth Hormone Secretion to Insulin-Like Growth Factor-I Negative Feedback*
IM Chapman, ML Hartman, SS Pezzoli, FE Harrell, RL Hintz, KG Alberti, MO Thorner
The Journal of clinical endocrinology and metabolism 1997
Adjunctive Growth Hormone during Ovarian Hyperstimulation Increases Levels of Insulin-Like Growth Factor Binding Proteins in Follicular Fluid: A Randomized, Placebo-Controlled, Cross-Over Study*
J Rabinovici, NA Cataldo, P Dandekar, SM Rosenthal, SE Gargosky, N Gesundheit, MC Martin
The Journal of clinical endocrinology and metabolism 1997
Metabolic effects of recombinant human insulin-like growth factor-I in humans: comparison with recombinant human growth hormone
N Mauras, MW Haymond
Pediatric Nephrology 1996
Collection of blood in heparinized tubes does not alter the molecular distribution or forms of IGFBP-3 and IGF
S Mandel, E Moreland, RG Rosenfeld, SE Gargosky
Endocrine 1996
Insulin-like growth factor binding proteins as growth inhibitors in children with chronic renal failure
DR Powell, F Liu, BK Baker, PD Lee, RL Hintz
Pediatric Nephrology 1996
Serum insulin-like growth factor II levels in normal adolescents and those with insulin dependent diabetes mellitus
CL Acerini, KL Clayton, R Hintz, B Baker, A Watts, JM Holly, DB Dunger
Clinical Endocrinology 1996
Serum Levels of Insulin-like Growth Factor-I and Insulin-like Growth Factor Binding Protein-3 in Children with Insulin-Dependent Diabetes Mellitus
P Cinaz, M Kendirci, S Kurtoglu, N Gökçora, Ν Buyan, I Yavuz, A Demir
Journal of Pediatric Endocrinology and Metabolism 1996
Insulin-like growth factor-I and IGF binding protein-3 remain high after GnRH analogue therapy in girls with central precocious puberty
H Kanety, A Karasik, C Pariente, A Kauschansky
Clinical Endocrinology 1996
Short Stature Caused by a Mutant Growth Hormone
Y Takahashi, H Kaji, Y Okimura, K Goji, H Abe, K Chihara
New England Journal of Medicine 1996
Insulin and insulin-like growth factor-I: their role as risk factors in the development of diabetic cardiovascular disease
B Göke, HC Fehmann
Diabetes Research and Clinical Practice 1996
Insulin-like growth factor-I serum concentrations and patterns of insulin-like growth factor binding proteins in patients with chronic liver disease
JG Scharf, F Schmitz, J Frystyk, C Skjaerbaek, H Moesus, WF Blum, G Ramadori, H Hartmann
Journal of Hepatology 1996
IGF-I, marqueur nutritionnel
M Jeevanandam
Nutrition Clinique et Métabolisme 1996
Insulin-like growth factor bioactivity and its modification in growth hormone resistant states
AJ Donaghy, RC Baxter
Baillière's Clinical Endocrinology and Metabolism 1996
Serum insulin-like growth factor binding protein-3 responds differently to trauma in men and women:
SM Houston-Bolze, MT Downing, AM Sayed, JH Williford
Critical Care Medicine 1996
An Unusual Case of Growth Hormone Receptor Deficiency Syndrome
PY Kwong, JD Teale
Annals of Clinical Biochemistry 1996
Growth hormone, insulin-like growth factor and the kidney
RJ Krieg, F Santos, JC Chan
Kidney International 1995
Abnormal serum IGF-II transport in non-islet cell tumor hypoglycemia results from abnormalities of both IGF binding protein-3 and acid labile subunit and leads to elevation of serum free IGF-II
WH Daughaday, B Trivedi, RC Baxter
Endocrine 1995
Serum zinc in highly trained adolescent gymnasts
JF Brun, C Dieu-Cambrezy, A Charpiat, C Fons, C Fedou, JP Micallef, M Fussellier, L Bardet, A Orsetti
Biological Trace Element Research 1995
IGFBP-3 is a poor parameter for assessment of clinical activity in acromegaly
WW Herder, AJ Lely, JA Janssen, P Uitterlinden, LJ Hofland, SW Lamberts
Clinical Endocrinology 1995
Effects of cholinergic modulation on serum insulin-like growth factor4 and its binding proteins in normal and diabetic subjects
IS Ismall, JP Mlell, MF Scanlon, JR Peters
Clinical Endocrinology 1995
Is IGF binding protein-3 assessment helpful for the diagnosis of GH deficiency?
S Cianfarani, S Boemi, A Spagnoli, M Cappa, G Argirò, F Vaccaro, ML Bitti, B Boscherlni
Clinical Endocrinology 1995
Insulin-like growth factor-I gene expression in the tibial epiphyseal growth plate of growth hormone-treated uremic rats
JD Hanna, F Santos, JW Foreman, JC Chan, VK Han
Kidney International 1995
Identification of insulin-like growth factor binding proteins from cultured human epidermal keratinocytes
MM Murashita, VC Russo, SR Edmondson, CJ Wraight, GA Werther
Journal of Cellular Physiology 1995
Insulin-like growth-factor-binding protein 3 is decreased in early-stage operable pre-menopausal breast cancer
PF Bruning, JV Doorn, JM Bonfrèr, PA van Noord, CM Korse, TC Linders, AA Hart
International Journal of Cancer 1995
Growth hormone, insulinlike growth factor-1, and insulinlike growth factor binding proteins 1 and 3 in chronic liver disease
A Donaghy, R Ross, A Gimson, SC Hughes, J Holly, R Williams
Hepatology 1995
Defining growth hormone deficiency in adults
KK Ho, DM Hoffman
Metabolism 1995
Plasma levels of insulin-like growth factor binding protein-3 in acute trauma patients
M Jeevanandam, NJ Holaday, SR Petersen
Metabolism 1995
Insulin-like growth factor binding proteins as glucoregulators
RC Baxter
Metabolism 1995
Insulin-like growth factors: Clinical experience in ovarian function
RP Buyalos
The American Journal of Medicine 1995
Modulation of human IGF binding protein-3 activity by structural modification
RC Baxter, SM Firth
Progress in Growth Factor Research 1995
Developmental regulation of circulating insulin-like growth factor-binding proteins in normal pregnancies and in pre-eclampsia
MS Lewitt, FP Scott, NM Clarke, RC Baxter
Progress in Growth Factor Research 1995
The role of glycosylation in the action of IGFBP-3
SM Firth, RC Baxter
Progress in Growth Factor Research 1995
Serum levels of insulin-like growth factor-binding protein-3 in normal pregnancy
HS Wang, BJ Cheng, YK Soong
European Journal of Obstetrics & Gynecology and Reproductive Biology 1995
Serum levels of insulin-like growth factor I and insulin-like growth factor-binding protein-l and -3 in women with regular menstrual cycles**Supported by Medical Research grant CMRP-0426 from Chang-Gung Memorial Hospital, Lin-Kou Medical Center, Taipei, Taiwan, Republic of China
HS Wang, JD Lee, YK Soong
Fertility and Sterility 1995
Insulin regulates circulating insulin-like growth factors and some of their binding proteins in lactating cows
MA McGuire, DA Dwyer, RJ Harrell, DE Bauman
American journal of physiology. Endocrinology and metabolism 1995
In vivo proteolysis of serum insulin-like growth factor (IGF) binding protein-3 results in increased availability of IGF to target cells
C Blat, J Villaudy, M Binoux
Journal of Clinical Investigation 1994
The ratio between serum levels of insulin-like growth factor (IGF)-I and the IGF binding proteins (IGFBP-1, 2 and 3) decreases with age in healthy adults and is increased in acromegalic patients
A Juul, K Main, WF Blum, J Lindholm, MB Ranke, NE Skakkebaek
Clinical Endocrinology 1994
Senescence and cell density of human diploid fibroblasts influence metabolism of insulin-like growth factor binding proteins
VG Grigoriev, EJ Moerman, S Goldstein
Journal of Cellular Physiology 1994
Plasma insulin-like growth factor I and its binding proteins 1 and 3 in postmenopausal patients with breast cancer receiving long term tamoxifen
EI Lahti, M Knip, TJ Laatikainen
Cancer 1994
Growth hormone (GH), insulin-like growth factors (IGFs), and IGF-binding protein-3 (IGFBP-3) in a child with Proteus syndrome
G Rudolph, WF Blum, EW Jenne, M Schöning, H Enders, T Meitinger, JD Murken, A Kampik
American Journal of Medical Genetics 1994
Diagnosis of growth-hormone deficiency in adults
DM Hoffman, AJ O'Sullivan, KK Ho, RC Baxter
The Lancet 1994
Insulin-like growth factor binding proteins and their regulation
RG Rosenfeld, H Pham, P Cohen, P Fielder, SE Gargosky, H Muller, L Nonoshita, Y Oh
Acta Paediatrica 1994
Improvement of diagnostic criteria in growth hormone insensitivity syndrome: solutions and pitfalls
WF Blum, AM Cotterill, MC Postel-Vinay, MB Ranke, MO Savage, P Wilton
Acta Paediatrica 1994
Insulin-like growth factors (IGF)-I and -II and IGF binding protein-1, -2, and -3 in patients with acromegaly before and after adenomectomy
JO Jørgensen, N Møller, J Møller, J Weeke, WF Blum
Metabolism 1994
Insulin-like growth factors and binding proteins in patients with recent-onset type 1 (insulin-dependent) diabetes mellitus: Influence of diabetes control and intraportal insulin infusion
PI Shishko, AV Dreval, IA Abugova, IU Zajarny, VC Goncharov
Diabetes Research and Clinical Practice 1994
The influence of endurance training on insulin-like growth factor-1 in older individuals
ET Poehlman, CJ Rosen, KC Copeland
Metabolism 1994
Insulin-like growth factor I as an indicator of protein-energy undernutrition among metabolically stable hospitalized elderly
DH Sullivan, WJ Carter
Journal of the American College of Nutrition 1994
Vitreal insulin-like growth factor binding proteins (IGFBPs) are increased in human and animal diabetics
RJ Waldbillig, BE Jones, TJ Schoen, P Moshayedi, S Heidersbach, MS Bitar, FJ van Kuijk, E Juan, P Kador, GJ Chader
Current Eye Research 1994
IGF-I and IGF-binding protein gene expressions in spontaneous dwarf rat
H Nogami, T Watanabe, S Kobayashi
American journal of physiology. Endocrinology and metabolism 1994
Diseases of the Pituitary
SL Asa
Neurosurgery Clinics of North America 1994
Regulation of insulin-like growth factors by antiestrogen
R Winston, PC Kao, DT Kiang
Breast Cancer Research and Treatment 1994
Circulating levels of insulin-like growth factor binding protein 3 (IGFBP-3) and insulin-like growth factor I (IGF-I) in perimenopausal women
E Romagnoli, S Minisola, V Carnevale, R Rosso, MT Pacitti, A Scarda, L Scarnecchia, G Mazzuoli
Osteoporosis International 1994
The insulin-like growth factor-I/binding protein axis: physiology, pathophysiology and therapeutic manipulation
KS Langford, JP Miell
European Journal of Clinical Investigation 1993
Plasma IGFBP-3 and its relationship with quantitative growth hormone secretion in short children
M Phillip, SA Chalew, AA Kowarski, MA Stene
Clinical Endocrinology 1993
Accumulation of insulin-like growth factor binding protein-3 in conditioned medium of human fibroblasts increases with chronologic age of donor and senescence in vitro
S Goldstein, EJ Moerman, RC Baxter
Journal of Cellular Physiology 1993
Levels of insulin-like growth factor-I and insulin-like growth factor-binding protein-1 in pregnancy with preterm delivery
HS Wang, CL Lee, T Chard
BJOG: An International Journal of Obstetrics and Gynaecology 1993
Circulating binding proteins for the insulinlike growth factors
RC Baxter
Trends in Endocrinology & Metabolism 1993
Contributory roles of circulatory glucagon and growth hormone to increased renal haemodynamics in type 1 (insulin-dependent) diabetes mellitus
K Hoogenberg, RP Dullaart, NJ Freling, S Meijer, WJ Sluiter
Scandinavian Journal of Clinical & Laboratory Investigation 1993
Growth hormone insensitivity syndromes: a preliminary report on changes in insulin-like growth factors and their binding proteins during treatment with recombinant insulin-like growth factor I
WF Blum, K Hall, MB Ranke, P Wilton
Acta Paediatrica 1993
Characterization of the binding defect in insulin-like growth factor binding protein-3 from pregnancy serum
RC Baxter, AM Suikkari, JL Martin
Biochemical Journal 1993
Evaluation of plasma insulin-like growth factor-binding protein-3 as a potential predictor of preeclampsia
M Varma, CJ de Groot, S Lanyi, RN Taylor
American Journal of Obstetrics and Gynecology 1993
Effect of hypophysectomy on insulin-like growth factor (IGF)-1 binding activity of serum in chickens
D Morishita, M Wakita, S Hoshino
Comparative Biochemistry and Physiology Part A: Physiology 1993
The serum insulin-like growth factor-II/mannose-6-phosphate receptor in normal and diabetic pregnancy
MC Gelato, C Rutherford, G San-Roman, S Shmoys, A Monheit
Metabolism 1993
Differential Regulation of IGF-1 and IGF-Binding Protein-1 by Dietary Composition in Humans
VC Musey, S Goldstein, PK Farmer, PB Moore, LS Phillips
The American Journal of the Medical Sciences 1993
Physiology and Pharmacology of Bone
GR Mundy, TJ Martin
1993
Growth Hormone and Somatomedins during Lifespan
EE Müller, D Cocchi, V Locatelli
1993
Insulin-like growth factor binding protein-3 protease activity in the urine of children with chronic renal failure
DY Lee, P Cohen, AM Krensky, RG Rosenfeld, PD Yorgin
Pediatric Nephrology 1993
Effects of insulin-like growth factor-I on glucose tolerance, insulin levels, and insulin secretion
PD Zenobi, S Graf, H Ursprung, ER Froesch
Journal of Clinical Investigation 1992
Insulin-like growth factor-I improves glucose and lipid metabolism in type 2 diabetes mellitus
PD Zenobi, SE Jaeggi-Groisman, WF Riesen, ME Røder, ER Froesch
Journal of Clinical Investigation 1992
Alternative Methods of Diagnosis of Growth Hormone Deficiency
AT Silink
Journal of Pediatric Endocrinology and Metabolism 1992
Insulin-like growth factor-1, growth hormone-dependent insulin-like growth factor-binding protein and growth in children with chronic renal failure
EM Hodson, AS Brown, LP Roy, AR Rosenberg
Pediatric Nephrology 1992
Insulin-like growth factors and diabetes
LA Bach, MM Rechler
Diabetes / Metabolism Reviews 1992
Administration of human recombinant insulin-like growth factor-I to patients following major gastrointestinal surgery
JP Miell, AM Taylor, J Jones, CR Buchanan, J Rennie, R Sherwood, R Leicester, RJ Ross
Clinical Endocrinology 1992
IGF binding protein 3 in patients with Laron type dwarfism: effect of exogenous rIGF-I
Z Laron, B Klinger, WF Blum, A Silbergeld, MB Ranke
Clinical Endocrinology 1992
Cloning and sequence determination of bovine insulin-like growth factor binding protein-2 (IGFBP-2): Comparison of its structral and functional properties with IGFBP-1
WH Busby, RH McCusker, DR Clemmons, MJ Bourner, NR Siegel, GG Krivi
Journal of Cellular Biochemistry 1992
Developmental regulation of insulin-like growth factor binding protein production: Studies in fetal, postnatal, and pregnant sheep
J Fowlkes, M Freemark
Journal of Cellular Physiology 1992
11 Growth failure in renal disease
O Mehls, WF Blum, F Schaefer, B Tönshoff, K Schärer
Baillière's Clinical Endocrinology and Metabolism 1992
The endocrine regulation of growth during early life: a nutritional perspective
JM Bassett
BSAP Occasional Publication 1992
Human osteoblast-derived insulin-like growth factor (IGF) binding protein-5 stimulates osteoblast mitogenesis and potentiates IGF action
DL Andress, RS Birnbaum
The Journal of biological chemistry 1992
Structural determinants for binary and ternary complex formation between insulin-like growth factor-I (IGF-I) and IGF binding protein-3
RC Baxter, ML Bayne, MA Cascieri
The Journal of biological chemistry 1992
Insulin-like growth factor-binding protein-1: A role in glucose counterregulation?
MS Lewitt, RC Baxter
Molecular and Cellular Endocrinology 1991
The presence of cation-dependent proteases for insulin-like growth factor binding proteins does not alter the size distribution of insulin-like growth factors in pregnancy
SC Davies, JM Holly, VJ Coulson, AM Cotterill, AF Abdulla, PG Whlttakert, T Chard, JA Wass
Clinical Endocrinology 1991
Insulin-Like Growth Factor (IGF) Binding Proteins: the Role of Serum IGFBPs in Regulating IGF Availability
RC Baxter
Acta Paediatrica 1991
Cytochalasin B stimulates insulin-like growth factor-binding protein-1 production by Hep G2 cells
MS Lewitt, RC Baxter
Molecular and Cellular Endocrinology 1991
Insulin-like Growth Factor-II (IGF-II) and IGF Binding Proteins in Human Endometrium
LC Giudice, G Lamson, RG Rosenfeld, JC Irwin
Annals of the New York Academy of Sciences 1991
Insulin-like growth factor binding protein 3 accumulates to high levels in culture medium of senescent and quiescent human fibroblasts
S Goldstein, EJ Moerman, RA Jones, RC Baxter
Proceedings of the National Academy of Sciences 1991
Synthesis of the acid-labile subunit of the growth-hormone-dependent insulin-like-growth-factor-binding protein complex by rat hepatocytes in culture
CD Scott, RC Baxter
Biochemical Journal 1991
Function of the growth hormone-insulin-like growth factor I axis in the profoundly growth-retarded diabetic child: Evidence for defective target organ responsiveness in the Mauriac syndrome
N Mauras, T Merimee, AD Rogol
Metabolism 1991
Evaluation of interference by insulin-like growth factor I (IGF-I) binding proteins in a radioimmunoassay for IGF-I in serum from dairy cows
K Plaut, WS Cohick, DE Bauman, RC Baxter
Domestic Animal Endocrinology 1991
Plasma IGF-I binding proteins in sheep: Effect of recombinant growth hormone treatment and nutritional status
SC Hodgkinson, JJ Bass, PD Gluckman
Domestic Animal Endocrinology 1991
Insulin-like growth factors: biochemistry and physiology
AC Herington
Baillière's Clinical Endocrinology and Metabolism 1991
Identification and molecular characterization of insulin-like growth factor binding proteins (IGFBP-1, -2, -3, -4, -5 and -6)
S Shimasaki, N Ling
Progress in Growth Factor Research 1991
Peptide Growth Factors and Their Receptors I
MB Sporn, AB Roberts
1991
Growth hormone resistance and inhibition of somatomedin activity by excess of insulin-like growth factor binding protein in uraemia
WF Blum, MB Ranke, K Kietzmann, B Tnshoff, O Mehls
Pediatric Nephrology 1991
Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors
MK Raizada, D LeRoith
1991
Growth, Growth Hormone and the Somatomedins: A Historical Perspective and Current Concepts
BT Rudd
Annals of Clinical Biochemistry 1991
Growth Factors and Diabetic Complications
A Flyvbjerg
Diabetic Medicine 1990
Molecular biology of the insulin-like growth factors
JE Hepler, PK Lund
Molecular Neurobiology 1990
Grundlagen und klinische Bedeutung der Insulin-like Growth Factors/Somatomedine
E Weimann, W Kiess
Klinische Wochenschrift 1990
THE GROWTH HORMONE INDEPENDENT INSULIN-LIKE GROWTH FACTOR-I BINDING PROTEIN BP-28 IS ASSOCIATED WITH SERUM INSULIN-LIKE GROWTH FACTOR-I INHIBITORY BIOACTIVITY IN ADOLESCENT INSULIN-DEPENDENT DIABETICS
AM Taylor, DB Dunger, MA Preece, JM Holly, CP Smith, JA Wass, S Patel, VE Tate
Clinical Endocrinology 1990
Endogenous mediators of growth
N Loveridge, C Farquharson, BA Scheven
Proceedings of the Nutrition Society 1990
Insulinlike growth factor binding proteins
DR Clemmons
Trends in Endocrinology & Metabolism 1990
The gene for insulin-like growth factor-binding protein-1 is localized to human chromosomal region 7p14-p12
J Ekstrand, E Ehrenborg, I Stern, B Stellan, L Zech, H Luthman
Genomics 1990
Effect of dietary proteins on the plasma immunoreactive insulin-like growth factor-1/somatomedin C concentration in the rat
S Takahashi, M Kajikawa, T Umezawa, SI Takahashi, H Kato, Y Miura, TJ Nam, T Noguchi, H Naito
British Journal of Nutrition 1990
INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS IN FOLLICULAR FLUID FROM NORMAL DOMINANT AND COHORT FOLLICLES, POLYCYSTIC AND MULTICYSTIC OVARIES
JM Holly, JA Eden, J Alaghband-Zadeh, GD Carter, RC Jemmott, S Cianfarani, T Chard, JA Wass
Clinical Endocrinology 1990
Insulin-Like Growth Factor Binding Proteins (IGFBPs) with Special Reference to IGFBPS
W Blum, M Ranke
Acta Paediatrica 1990
Insulin-like Growth Factor Binding Protein-1 Levels in Diabetic Adolescents and their Relationship to Metabolic Control
JM Holly, DB Dunger, JA Edge, CP Smith, T Chard, JA Wass
Diabetic Medicine 1990
Glycosaminoglycans inhibit formation of the 140 kDa insulin-like growth factor-binding protein complex
RC Baxter
Biochemical Journal 1990
Recognition of insulin-like-growth-factor-binding proteins in serum and amniotic fluid by an antiserum against a low-molecular-mass insulin-like-growth-factor-inhibitor/binding protein
GT Ooi, AC Herington
Biochemical Journal 1990
Radioimmunoassay for Insulin-Like Growth Factor (IGF). II: Interference by Pure IGF-Binding Proteins
RC Baxter
Journal of Immunoassay 1990
Molecular biology of the insulin-like growth factors: Relevance to nervous system function
JE Hepler, PK Lund
Molecular Neurobiology 1990
Circulating levels of insulin-like growth factors increase and molecular forms of their serum binding proteins change with human pregnancy
SE Gargosky, KJ Moyse, PE Walton, JA Owens, JC Wallace, JS Robinson, PC Owens
Biochemical and Biophysical Research Communications 1990
Proceedings of the 1989 Laurentian Hormone Conference
RG Rosenfeld, G Lamson, H Pham, Y Oh, C Conover, DD de Leon, SM Donovan, I Ocrant, L Giudice
Proceedings of the 1989 Laurentian Hormone Conference 1990
Cloning and Expression of Human Insulin-Like Growth Factor Binding Protein 3
SK Spratt, GP Tatsuno, MK Yamanaka, BC Ark, J Detmer, D Mascarenhas, J Flynn, C Talkington-verser, EM Spencer
Growth Factors 1990
GnRH Analogues in Cancer and Human Reproduction
BH Vickery, B Lunenfeld
1990
Purification and properties of a novel insulin-like growth factor-II binding protein from transformed human fibroblasts
JL Martin, KE Willetts, RC Baxter
The Journal of biological chemistry 1990
Insulin-like growth factor binding protein-3. Organization of the human chromosomal gene and demonstration of promoter activity
ML Cubbage, A Suwanichkul, DR Powell
The Journal of biological chemistry 1990
Insulin-like growth factor binding proteins from cultured human fibroblasts. Characterization and hormonal regulation
CA Conover, F Liu, D Powell, RG Rosenfeld, RL Hintz
Journal of Clinical Investigation 1989
The somatomedin-insulin-like growth factors
K Hall, M Tally
Journal of Internal Medicine 1989
Somatomedin-binding proteins: What role do they play in the growth process?
S Cianfarani, JM Holly
European Journal of Pediatrics 1989
Human insulin-like growth-factor-binding protein. Low-molecular-mass form: protein sequence and cDNA cloning
H LUTHMAN, J SODERLING-BARROS, B PERSSON, C ENGBERG, I STERN, M LAKE, SA FRANZEN, M ISRAELSSON, B RADEN, B LINDGREN, L HJELMQVIST, S ENERBACK, P CARLSSON, G BJURSELL, G POVOA, K HALL, H JORNVALL
European Journal of Biochemistry 1989
Increased secretion of insulin-like growth factor I into milk of cows treated with recombinantly derived bovine growth hormone
CG Prosser, IR Fleet, AN Corps
Journal of Dairy Research 1989
Structure of the Mr 140,000 growth hormone-dependent insulin-like growth factor binding protein complex: determination by reconstitution and affinity-labeling
RC Baxter, JL Martin
Proceedings of the National Academy of Sciences 1989
Significance of abnormal serum binding of insulin-like growth factor II in the development of hypoglycemia in patients with non-islet-cell tumors
WH Daughaday, M Kapadia
Proceedings of the National Academy of Sciences 1989
Isolation from human cerebrospinal fluid of a new insulin-like growth factor-binding protein with a selective affinity for IGF-II
M Roghani, P Hossenlopp, P Lepage, A Balland, M Binoux
FEBS Letters 1989
Binding proteins for the insulin-like growth factors: Structure, regulation and function
RC Baxter, JL Martin
Progress in Growth Factor Research 1989
Purification of the serum acid-stable insulin-like growth factor binding protein from the pig (Sus scrofa)
PE Walton, RC Baxter, BD Burleigh, TD Etherton
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry 1989
Insulin-like growth factor (IGF-I) and its low molecular weight binding protein in human milk
AM Suikkari
European Journal of Obstetrics & Gynecology and Reproductive Biology 1989
Circulating insulin-like growth factor I in Type 1 (insulin-dependent) diabetic patients with retinopathy
P Arner, S Sjberg, M Gjtterberg, A Skottner
Diabetologia 1989
Advances in Growth Hormone and Growth Factor Research
EE MÜller, D Cocchi, V Locatelli
1989
Molecular and Cellular Biology of Insulin-like Growth Factors and Their Receptors
D LeRoith, MK Raizada
1989
Structure and Activity Dependence of Recombinant Human Insulin-like Growth Factor II on Disulfide Bond Pairing
MC Smith, JA Cook, TC Furman, JL Occolowitz
The Journal of biological chemistry 1989
High molecular weight insulin-like growth factor binding protein complex
RC Baxter, JL Martin, VA Beniac
The Journal of biological chemistry 1989
Nucleotide Sequence and Expression of a cDNA Clone Encoding a Fetal Rat Binding Protein for Insulin-like Growth Factors
AL Brown, L Chiariotti, CC Orlowski, T Mehlman, WH Burgess, EJ Ackerman, CB Bruni, MM Rechler
The Journal of biological chemistry 1989
ORCADIAN VARIATION OF GH-INDEPENDENT IGF-BINDING PROTEIN IN DIABETES MELLITUS AND ITS RELATIONSHIP TO INSULIN. A NEW ROLE FOR INSULIN?
JM Holly, RA Biddlecombe, DB Dunger, JA Edge, SA Amiel, R Howell, T Chard, LH Rees, JA Wass
Clinical Endocrinology 1988
Isolation and characterization of a cDNA encoding the low molecular weight insulin-like growth factor binding protein (IBP-1)
A Brinkman, C Groffen, DJ Kortleve, AG van Kessel, SL Drop
The EMBO Journal 1988
Isolation of a biologically active fragment from the carboxy terminus of the fetal rat binding protein for insulin-like growth factors
JF Wang, B Hampton, T Mehlman, WH Burgess, MM Rechler
Biochemical and Biophysical Research Communications 1988
Recognition of insulin-like growth factor (IGF) serum binding proteins by an antibody raised against a specific IGF-inhibitor
GT Ooi, AC Herington
Biochemical and Biophysical Research Communications 1988
Growth hormone-dependent insulin-like growth factor (IGF) binding protein both inhibits and potentiates IGF-I-stimulated DNA synthesis in human skin fibroblasts
JS de Mellow, RC Baxter
Biochemical and Biophysical Research Communications 1988
Clinical Significance of Somtomedins and Somatomedin Binding Proteins
K Hall, P Bang, K Brismar, M Degerblad, M Tally
Scandinavian Journal of Clinical & Laboratory Investigation 1988
Basic and Clinical Aspects of Growth Hormone
BB Bercu
1988
Effects of growth hormone therapy and malnutrition on the growth of rats with renal failure.
Powell DR, Rosenfeld RG, Hintz RL
Pediatric nephrology (Berlin, Germany) 1988
Heterogeneity of insulin-like growth factor binding proteins and relationships between structure and affinity. 1. Circulating forms in man
S HARDOUIN, P HOSSENLOPP, B SEGOVIA, D SEURIN, G PORTOLAN, C LASSARRE, M BINOUX
European Journal of Biochemistry 1987
Binding proteins for insulin-like growth factors in adult rat serum. Comparison with other human and rat binding proteins
RC Baxter, JL Martin
Biochemical and Biophysical Research Communications 1987

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