A specific radioimmunoassay has been established for a growth hormone-dependent insulinlike growth factor (IGF) binding protein (BP) from human plasma. Although the assay was directed against a 53-kD, acid-stable BP subunit, the main immunoreactive BP in the circulation had an apparent molecular mass of approximately 125 kD. Only higher primate species showed cross-reactivity, and IGF-I, IGF-II, and other peptides were without effect. Circulating BP levels in healthy subjects rose threefold from early childhood to puberty. In 65 adults aged 18 to 65, the mean level (+/- SD) was 6.12 +/- 1.43 micrograms/ml, and declined with age. Strong growth hormone-dependence of BP was also seen; there was a 2.2-fold increase in active acromegaly and a 50-80% reduction in growth hormone deficiency. Poorly controlled diabetic subjects had BP levels 40% below normal, whereas in renal failure and third-term pregnancy a mild elevation was seen. Measurement of BP may provide a useful adjunct to IGF assays in growth disorders.
R C Baxter, J L Martin
Title and authors | Publication | Year |
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Endocrine and cellular physiology and pathology of the insulin-like growth factor acid-labile subunit.
Baxter RC |
Nature reviews. Endocrinology | 2024 |
Doxorubicin induced ROS-dependent HIF1α activation mediates blockage of IGF1R survival signaling by IGFBP3 promotes cardiac apoptosis
Wen SY, Ali A, Huang IC, Liu JS, Chen PY, Padma Viswanadha V, Huang CY, Kuo WW |
Aging | 2023 |
Therapeutic role of growth factors in treating diabetic wound
Zheng SY, Wan XX, Kambey PA, Luo Y, Hu XM, Liu YF, Shan JQ, Chen YW, Xiong K |
World journal of diabetes | 2023 |
IGFs in Dentin Formation and Regeneration: Progress and Remaining Challenges.
He P, Zheng L, Zhou X |
Stem Cells International | 2022 |
Insulin-Like Growth Factor-1 (IGF-1) and Its Monitoring in Medical Diagnostic and in Sports
J Bailes, M Soloviev |
Biomolecules | 2021 |
The IGF/Insulin-IGFBP Axis in Corneal Development, Wound Healing, and Disease
WL Stuard, R Titone, DM Robertson |
Frontiers in Endocrinology | 2020 |
Pregnancy-associated plasma proteins and Stanniocalcin-2 – Novel players controlling IGF-I physiology
J Frystyk, E Teran, MF Gude, M Bjerre, R Hjortebjerg |
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society | 2020 |
Baseline IGFBP - 3 as the Key Element to Predict Growth Response to Growth Hormone and IGF - 1 Therapy in Subjects with Non - GH Deficient Short Stature and IGF - 1 Deficiency
S Perez-Colon, O Lazareva, R Purushothaman, S Malik, S Ten, A Bhangoo |
International Journal of Endocrinology and Metabolism | 2018 |
Changes in Serum Concentrations of Insulin-like Growth Factor Binding Protein-3 after General Anesthesia Using Propofol or Isoflurane
JH Woo, JH Kim, HJ Baik, M Lee, YJ Kim |
The Ewha Medical Journal | 2018 |
Getting closer: contributions of zoo studies to research on the physiology and development of Bonobos Pan paniscus , Chimpanzees Pan troglodytes and other primates
V Behringer, JM Stevens, T Deschner, G Hohmann |
International Zoo Yearbook | 2018 |
Contrasting Effects of IGF Binding Protein-3 Expression in Mammary Tumor Cells and the Tumor Microenvironment
T Scully, CD Scott, SM Firth, JE Pintar, SM Twigg, RC Baxter |
Experimental Cell Research | 2018 |
Combined sprint and resistance training abrogates age differences in somatotropic hormones
M Sellami, W Dhahbi, LD Hayes, J Padulo, F Rhibi, H Djemail, A Chaouachi, A Lucía |
PloS one | 2017 |
Sex Differences in Age-Related Decline of Urinary Insulin-Like Growth Factor-Binding Protein-3 Levels in Adult Bonobos and Chimpanzees
V Behringer, SA Wudy, WF Blum, JM Stevens, T Remer, C Boesch, G Hohmann |
Frontiers in Endocrinology | 2016 |
Endocrinology
C Napier, SH Pearce |
Endocrinology | 2016 |
Involvement of insulin-like growth factor binding protein-3 in peroxisome proliferator-activated receptor gamma-mediated inhibition of breast cancer cell growth
CK Pon, SM Firth, RC Baxter |
Molecular and Cellular Endocrinology | 2015 |
Chesley's Hypertensive Disorders in Pregnancy
SJ Fisher, M McMaster, JM Roberts |
Chesley's Hypertensive Disorders in Pregnancy | 2015 |
Protein Malnutrition Attenuates Bone Anabolic Response to PTH in Female Rats
P Ammann, G Zacchetti, JA Gasser, C Lavet, R Rizzoli |
Endocrinology | 2014 |
IGF binding proteins in cancer: mechanistic and clinical insights
RC Baxter |
Nature Reviews Cancer | 2014 |
Continuous Positive Airway Pressure Increases Pulsatile Growth Hormone Secretion and Circulating Insulin-like Growth Factor-1 in a Time-Dependent Manner in Men With Obstructive Sleep Apnea: A Randomized Sham-Controlled Study
CM Hoyos, R Killick, DM Keenan, RC Baxter, JD Veldhuis, PY Liu |
Sleep | 2014 |
TGF-β-induced expression of IGFBP-3 regulates IGF1R signaling in human osteosarcoma cells
LJ Schedlich, VM Yenson, RC Baxter |
Molecular and Cellular Endocrinology | 2013 |
Effects of raloxifene and estrogen on bioactive IGF1 in GH-deficient women
V Birzniece, NE Magnusson, KK Ho, J Frystyk |
European Journal of Endocrinology | 2013 |
Insulin-like growth factor binding protein-3 inhibits migration of endometrial cancer cells
L Gribben, RC Baxter, DJ Marsh |
Cancer Letters | 2012 |
Breast cancer biomarkers: proteomic discovery and translation to clinically relevant assays
L Chung, RC Baxter |
Expert Review of Proteomics | 2012 |
Differential Effects of Raloxifene and Estrogen on Body Composition in Growth Hormone-Replaced Hypopituitary Women
V Birzniece, UJ Meinhardt, J Gibney, G Johannsson, N Armstrong, RC Baxter, KK Ho |
The Journal of clinical endocrinology and metabolism | 2012 |
Involvement of Insulin-like Growth Factor-binding Protein-3 in the Effects of Histone Deacetylase Inhibitor MS-275 in Hepatoma Cells
WH Lin, JL Martin, DJ Marsh, MM Jack, RC Baxter |
The Journal of biological chemistry | 2011 |
Growth Hormone
VS Herman-Bonert, S Melmed |
The Pituitary | 2011 |
Hormonal status and regulation of glycemia in neonatal calves during the first hours of postnatal life
D Kirovski, M Lazarevic, V Stojic, H Samanc, I Vujanac, O Nedic, R Masnikosa |
Acta veterinaria | 2011 |
Williams Textbook of Endocrinology
DW Cooke, SA Divall, S Radovick |
Williams Textbook of Endocrinology | 2011 |
The Pituitary
X Bertagna, L Guignat, MC Raux-Demay, B Guilhaume, F Girard |
The Pituitary | 2011 |
Physiologically Based Pharmacokinetics of Molecular Imaging Nanoparticles for mRNA Detection Determined in Tumor-Bearing Mice
AW Opitz, E Wickstrom, ML Thakur, NJ Wagner |
Oligonucleotides | 2010 |
The current status of IGF-I assays – A 2009 update
J Frystyk, P Freda, DR Clemmons |
Growth Hormone & IGF Research | 2010 |
Effect of maternal asthma, inhaled glucocorticoids and cigarette use during pregnancy on the newborn insulin-like growth factor axis
VL Clifton, NA Hodyl, VE Murphy, WB Giles, RC Baxter, R Smith |
Growth Hormone & IGF Research | 2010 |
Effect of the Glycemic Index of Carbohydrates on Acne vulgaris
RC Reynolds, S Lee, JY Choi, FS Atkinson, KS Stockmann, P Petocz, JC Brand-Miller |
Nutrients | 2010 |
Vitamins & Hormones
KJ Hare, FK Knop |
Vitamins & Hormones | 2010 |
Modulatory Effect of Raloxifene and Estrogen on the Metabolic Action of Growth Hormone in Hypopituitary Women
V Birzniece, U Meinhardt, J Gibney, G Johannsson, RC Baxter, MJ Seibel, KK Ho |
The Journal of clinical endocrinology and metabolism | 2010 |
Laron Syndrome - From Man to Mouse
Z Laron, J Kopchick |
2010 | |
The current status of IGF-I assays – A 2009 update
J Frystyk, P Freda, DR Clemmons |
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society | 2010 |
Potentiation of growth factor signaling by insulin-like growth factor-binding protein-3 in breast epithelial cells requires sphingosine kinase activity
JL Martin, MZ Lin, EM McGowan, RC Baxter |
The Journal of biological chemistry | 2009 |
Detection of growth hormone responsive proteins using SELDI–TOF mass spectrometry
L Chung, RC Baxter |
Growth Hormone & IGF Research | 2009 |
Endothelial Cell Dysfunction and Oxidative Stress
RN Taylor, ST Davidge, JM Roberts |
Chesley s Hypertensive Disorders in Pregnancy | 2009 |
Effects of endogenous insulin-like growth factor binding protein-3 on cell cycle regulation in breast cancer cells
MK O'Han, RC Baxter, LJ Schedlich |
Growth Factors | 2009 |
Inhibition of adipocyte differentiation by insulin-like growth factor-binding protein-3
SS Chan, LJ Schedlich, SM Twigg, RC Baxter |
American journal of physiology. Endocrinology and metabolism | 2009 |
Proteomic Profiling of Growth Hormone-Responsive Proteins in Human Peripheral Blood Leukocytes
L Chung, AE Nelson, KK Ho, RC Baxter |
The Journal of clinical endocrinology and metabolism | 2009 |
Activity of Human Pregnancy Insulin-Like Growth Factor Binding Protein-3: Determination by Reconstituting Recombinant Complexes
X Yan, LD Payet, RC Baxter, SM Firth |
Endocrinology | 2009 |
A pilot study to determine the short-term effects of a low glycemic load diet on hormonal markers of acne: A nonrandomized, parallel, controlled feeding trial
R Smith, N Mann, H Mäkeläinen, J Roper, A Braue, G Varigos |
Molecular Nutrition & Food Research | 2008 |
Enrichment of low molecular weight serum proteins using acetonitrile precipitation for mass spectrometry based proteomic analysis
R Kay, C Barton, L Ratcliffe, B Matharoo-Ball, P Brown, J Roberts, P Teale, C Creaser |
Rapid Communications in Mass Spectrometry | 2008 |
Disorders of Growth Hormone/Insulin-like Growth Factor Secretion and Action
RG Rosenfeld, P Cohen |
Pediatric Endocrinology | 2008 |
Pharmacodynamics of Growth Hormone Abuse Biomarkers and the Influence of Gender and Testosterone: A Randomized Double-Blind Placebo-Controlled Study in Young Recreational Athletes
AE Nelson, U Meinhardt, JL Hansen, IH Walker, G Stone, CJ Howe, K Leung, MJ Seibel, RC Baxter, DJ Handelsman, R Kazlauskas, KK Ho |
The Journal of clinical endocrinology and metabolism | 2008 |
Within-Subject Variability and Analytic Imprecision of Insulinlike Growth Factor Axis and Collagen Markers: Implications for Clinical Diagnosis and Doping Tests
TV Nguyen, AE Nelson, CJ Howe, MJ Seibel, RC Baxter, DJ Handelsman, R Kazlauskas, KK Ho |
Clinical chemistry | 2008 |
Polycystic Ovary Syndrome
MA Brown, RJ Chang |
Ultrasound Quarterly | 2007 |
Plasma growth hormones, P300 event-related potential and test of variables of attention (TOVA) are important neuroendocrinological predictors of early cognitive decline in a clinical setting: Evidence supported by structural equation modeling (SEM) parameter estimates
ER Braverman, TJ Chen, TJ Prihoda, W Sonntag, B Meshkin, BW Downs, JF Mengucci, SH Blum, A Notaro, V Arcuri, M Varshavskiy, K Blum |
AGE | 2007 |
Effects of glucose on metabolism and Insulin-like growth factor binding-3 expression in human fibroblasts
HY Ryu, HJ Hwang, IH Kim, HS Ryu, TJ Nam |
Journal of Life Science | 2007 |
Effects of Glucose on Insulin-like Growth Factor Binding-5 Expression in Human Fibroblasts
HY Ryu, HJ Hwang, IH Kim, HS Ryu, TJ Nam |
Journal of Life Science | 2007 |
The effect of a high-protein, low glycemic–load diet versus a conventional, high glycemic–load diet on biochemical parameters associated with acne vulgaris: A randomized, investigator-masked, controlled trial
RN Smith, NJ Mann, A Braue, H Mäkeläinen, GA Varigos |
Journal of the American Academy of Dermatology | 2007 |
Molecular basis of the interaction between IGFBP-3 and retinoid X receptor: Role in modulation of RAR-signaling
LJ Schedlich, LD Graham, MK O’Han, A Muthukaruppan, X Yan, SM Firth, RC Baxter |
Archives of Biochemistry and Biophysics | 2007 |
Expression of Insulin-Like Growth Factor Binding Protein-2 by MCF-7 Breast Cancer Cells Is Regulated through the Phosphatidylinositol 3-Kinase/AKT/Mammalian Target of Rapamycin Pathway
JL Martin, RC Baxter |
Endocrinology | 2007 |
Endocrine Regulation of Human Fetal Growth: The Role of the Mother, Placenta, and Fetus
VE Murphy, R Smith, WB Giles, VL Clifton |
Endocrine reviews | 2006 |
Serum Levels of Insulin-like Growth Factor-I and Insulin-like Growth Factor Binding Protein-3 in Children with Insulin- Dependent Diabetes Mellitus
P Cinaz, M Kendirci, S Kurtoglu, N Gökçora, Ν Buyan, I Yavuz, A Demir |
Journal of Pediatric Endocrinology and Metabolism | 2006 |
The effect of economic status on height, insulin-like growth factor (IGF)-I and IGF binding protein-3 concentrations in healthy Turkish children
S Turan, A Bereket, A Furman, A Omar, M Berber, A Ozen, C Akbenlioglu, G Haklar |
European Journal of Clinical Nutrition | 2006 |
Novel Biomarkers of Human Growth Hormone Action from Serum Proteomic Profiling Using Protein Chip Mass Spectrometry
L Chung, D Clifford, M Buckley, RC Baxter |
The Journal of clinical endocrinology and metabolism | 2006 |
Influence of Demographic Factors and Sport Type on Growth Hormone-Responsive Markers in Elite Athletes
AE Nelson, CJ Howe, TV Nguyen, KC Leung, GJ Trout, MJ Seibel, RC Baxter, DJ Handelsman, R Kazlauskas, KK Ho |
The Journal of clinical endocrinology and metabolism | 2006 |
The Aminoterminal Insulin-Like Growth Factor (IGF) Binding Domain of IGF Binding Protein-3 Cannot Be Functionally Substituted by the Structurally Homologous Domain of CCN3
X Yan, RC Baxter, B Perbal, SM Firth |
Endocrinology | 2006 |
Erythropoietin administration does not influence the GH-IGF axis or makers of bone turnover in recreational athletes
AE Nelson, CJ Howe, TV Nguyen, MJ Seibel, RC Baxter, DJ Handelsman, R Kazlauskas, KK Ho |
Clinical Endocrinology | 2005 |
Cord serum insulin-like growth factor binding protein-1 and -3: effect of maternal diabetes and relationships to fetal growth
S Loukovaara, RJ Kaaja, RA Koistinen |
Diabetes & Metabolism | 2005 |
Aging Somatotropic Axis: Mechanisms and Implications of Insulin-Like Growth Factor–Related Binding Protein Adaptation
J Frystyk |
Endocrinology and metabolism clinics of North America | 2005 |
Segmental Igfbp5 expression is specifically associated with the bent structure of zigzag hairs
T Schlake |
Mechanisms of Development | 2005 |
Pediatric Endocrinology
PS Thornton |
Pediatric Endocrinology | 2005 |
Effects of 9- cis -Retinoic Acid on the Insulin-Like Growth Factor Axis in Former Smokers
HY Lee, YS Chang, JY Han, DD Liu, JJ Lee, R Lotan, MR Spitz, WK Hong |
Journal of Clinical Oncology | 2005 |
Enhancement of Tumor Necrosis Factor-α-Induced Growth Inhibition by Insulin-Like Growth Factor-Binding Protein-5 (IGFBP-5), But Not IGFBP-3 in Human Breast Cancer Cells
AJ Butt, KA Dickson, S Jambazov, RC Baxter |
Endocrinology | 2005 |
Growth Hormone (GH) Responses to GH-Releasing Hormone-Arginine Testing in Human Immunodeficiency Virus Lipodystrophy
P Koutkia, B Canavan, J Breu, S Grinspoon |
The Journal of clinical endocrinology and metabolism | 2005 |
Free insulin-like growth factors – measurements and relationships to growth hormone secretion and glucose homeostasis
J Frystyk |
Growth Hormone & IGF Research | 2004 |
Plant 2-arylobenzofurans demonstrate a selective estrogen receptor modulator profile
Z Papoutsi, E Kassi, D Papaevangeliou, H Pratsinis, V Zoumpourlis, M Halabalaki, S Mitakou, A Kalofoutis, P Moutsatsou |
Steroids | 2004 |
Role of N- and C-terminal Residues of Insulin-like Growth Factor (IGF)-binding Protein-3 in Regulating IGF Complex Formation and Receptor Activation
X Yan, BE Forbes, KA McNeil, RC Baxter, SM Firth |
The Journal of biological chemistry | 2004 |
IGF and Nutrition in Health and Disease
MS Houston, JM Holly, EL Feldman |
2004 | |
Regulation of the Somatotropic Axis by Intensive Insulin Therapy during Protracted Critical Illness
D Mesotten, PJ Wouters, RP Peeters, KV Hardman, JM Holly, RC Baxter, GV den Berghe |
The Journal of clinical endocrinology and metabolism | 2004 |
Insulin-Like Growth Factor Binding Protein-3 Expression Is Associated with Growth Stimulation of T47D Human Breast Cancer Cells: The Role of Altered Epidermal Growth Factor Signaling
AJ Butt, JL Martin, KA Dickson, F McDougall, SM Firth, RC Baxter |
The Journal of clinical endocrinology and metabolism | 2004 |
Circulating levels of insulin-like growth factor-II and IGF-binding protein 3 in cervical cancer
SP Mathur, RS Mathur, PB Underwood, MF Kohler, WT Creasman |
Gynecologic Oncology | 2003 |
Diabetic neuropathy and nerve regeneration
H Yasuda, M Terada, K Maeda, S Kogawa, M Sanada, M Haneda, A Kashiwagi, R Kikkawa |
Progress in Neurobiology | 2003 |
The circulating IGF system and its relationship with 24-h glucose regulation and insulin sensitivity in healthy subjects
J Frystyk, B Nyholm, C Skjaerbaek, RC Baxter, O Schmitz, H Ørskov |
Clinical Endocrinology | 2003 |
Current concepts in the biochemical assessment of the patient with acromegaly
PU Freda |
Growth Hormone & IGF Research | 2003 |
Evaluation of serum insulin-like growth factor binding proteins (IGFBP) in Angus cattle divergently selected for serum IGF-I concentration
M Pagan |
Domestic Animal Endocrinology | 2003 |
Serum levels of insulin-like growth factor I and its binding proteins in health and disease
A Juul |
Growth Hormone & IGF Research | 2003 |
Optimizing Control of Acromegaly: Integrating a Growth Hormone Receptor Antagonist into the Treatment Algorithm
DR Clemmons, K Chihara, PU Freda, KK Ho, A Klibanski, S Melmed, SM Shalet, CJ Strasburger, PJ Trainer, MO Thorner |
The Journal of clinical endocrinology and metabolism | 2003 |
Effects of Recombinant Human Insulin-Like Growth Factor (IGF)-I and Estrogen Administration on IGF-I, IGF Binding Protein (IGFBP)-2, and IGFBP-3 in Anorexia Nervosa: A Randomized-Controlled Study
S Grinspoon, K Miller, D Herzog, D Clemmons, A Klibanski |
The Journal of clinical endocrinology and metabolism | 2003 |
Insulin-like growth factor-I and analogues increase growth in artificially-reared neonatal pigs
FR Dunshea, CS Chung, PC Owens, JF Ballard, PE Walton |
British Journal of Nutrition | 2002 |
The combined administration of GH-releasing peptide-2 (GHRP-2), TRH and GnRH to men with prolonged critical illness evokes superior endocrine and metabolic effects compared to treatment with GHRP-2 alone
GV Berghe, RC Baxter, F Weekers, P Wouters, CY Bowers, A Iranmanesh, JD Veldhuis, R Bouillon |
Clinical Endocrinology | 2002 |
Insulin-Like Growth Factor-I Inhibits Cell Growth in the A549 Non-Small Lung Cancer Cell Line
Y Kodama, RC Baxter, JL Martin |
American journal of respiratory cell and molecular biology | 2002 |
Habitual physical activity, anabolic hormones, and potassium content of fat-free mass in postmenopausal women
RD Hansen, BJ Allen |
The American journal of clinical nutrition | 2002 |
Impaired Blockade of Insulin-Like Growth Factor I (IGF-I)-Induced Hypoglycemia by IGF Binding Protein-3 Analog with Reduced Ternary Complex-Forming Ability
SM Firth, F McDougall, AJ McLachlan, RC Baxter |
Endocrinology | 2002 |
Supraphysiological Doses of GH Induce Rapid Changes in Cardiac Morphology and Function
A Cittadini, A Berggren, S Longobardi, C Ehrnborg, R Napoli, T Rosén, S Fazio, K Caidahl, BA Bengtsson, L Saccà |
The Journal of clinical endocrinology and metabolism | 2002 |
IGF-Binding Protein-3-Induced Growth Inhibition and Apoptosis Do Not Require Cell Surface Binding and Nuclear Translocation in Human Breast Cancer Cells
AJ Butt, KA Fraley, SM Firth, RC Baxter |
Endocrinology | 2002 |
Utility of insulin-like growth factor-I and its binding protein assays
M Noël, D Chevenne, D Porquet |
Current Opinion in Clinical Nutrition and Metabolic Care | 2001 |
Paradoxical elevations in serum IGF-II and IGF binding protein-2 in acromegaly: insights into the regulation of these peptides
AG Renehan, AA Toogood, WD Ryder, J Jones, CS Potten, ST O'Dwyer, SM Shalet |
Clinical Endocrinology | 2001 |
DHEA-PC Slows the Progression of Type 2 Diabetes (Non–Insulin-Dependent Diabetes Mellitus) in the ZDF/Gmi-fa/fa Rat
JJ Byrne, HL Bradlow |
Diabetes Technology & Therapeutics | 2001 |
Responses of insulin-like growth factor (IGF)-I and IGF-binding proteins to nutritional status in peroxisome proliferator-activated receptor-alpha knockout mice
MS Lewitt, K Brismar, J Wang, IL Wivall-Helleryd, P Sindelar, FJ Gonzalez, T Bergman, GA Bobek |
Growth Hormone & IGF Research | 2001 |
Total and free insulin-like growth factor I, insulin-like growth factor binding protein 3 and acid-labile subunit reflect clinical activity in acromegaly
SB Sneppen, M Lange, LM Pedersen, LØ Kristensen, KM Main, A Juul, NE Skakkebæk, U Feldt-Rasmussen |
Growth Hormone & IGF Research | 2001 |
Influence of Metabolic Control on Growth in Homocystinuria due to Cystathionine B-Synthase Deficiency
AK Topaloglu, C Sansaricq, SE Snyderman |
Pediatric Research | 2001 |
Utility of insulin-like growth factor-I and its binding protein assays:
M Noël, D Chevenne, D Porquet |
Current Opinion in Clinical Nutrition and Metabolic Care | 2001 |
Functional Neurobiology of Aging
PL Thornton, WE Sonntag |
Functional Neurobiology of Aging | 2001 |
Direct measurement of IGF-I and IGFBP-3 in bronchoalveolar lavage fluid from idiopathic pulmonary fibrosis
L Pala, S Giannini, E Rosi, B Cresci, G Scano, S Mohan, R Duranti, CM Rotella |
Journal of Endocrinological Investigation | 2001 |
Effect of acute elevation of IGF-I on circulating GH, TSH, insulin, IGF-II and IGFBP-3 levels in non-endocrine short stature (NESS)
K Hanew, A Tanaka |
Journal of Endocrinological Investigation | 2001 |
Factors regulating insulin-like growth factor binding protein-3 secretion from human hepatoma (HepG2) cells
T Kalme, M Loukovaara, H Koistinen, R Koistinen, M Seppälä, P Leinonen |
The Journal of Steroid Biochemistry and Molecular Biology | 2001 |
Sex Steroids and Bone
JE Compston |
Physiological reviews | 2001 |
Use of Mutagenesis to Probe IGF-Binding Protein Structure/Function Relationships
DR Clemmons |
Endocrine reviews | 2001 |
Five-Day Pulsatile Gonadotropin-Releasing Hormone Administration Unveils Combined Hypothalamic-Pituitary-Gonadal Defects Underlying Profound Hypoandrogenism in Men with Prolonged Critical Illness1
GV den Berghe, F Weekers, RC Baxter, P Wouters, A Iranmanesh, R Bouillon, JD Veldhuis |
The Journal of clinical endocrinology and metabolism | 2001 |
Kinetic analysis of the disposition of insulin-like growth factor 1 in healthy volunteers
N Mizuno, Y Kato, M Iwamoto, A Urae, T Amamoto, T Niwa, Y Sugiyama |
Pharmaceutical Research | 2001 |
Fetal Macrosomia: Etiologic Factors
O Langer |
Clinical Obstetrics and Gynecology | 2000 |
Serum insulin-like growth factor-I and breast cancer
P Toniolo, PF Bruning, A Akhmedkhanov, JM Bonfrer, KL Koenig, A Lukanova, RE Shore, A Zeleniuch-Jacquotte |
International Journal of Cancer | 2000 |
Population PK and PK/PD modelling of microencapsulated octreotide acetate in healthy subjects
H Zhou, TL Chen, M Marino, H Lau, T Miller, G Kalafsky, JF McLeod |
British Journal of Clinical Pharmacology | 2000 |
Characterization of an amino-terminal fragment of insulin-like growth factor binding protein-3 and its effects in MCF-7 breast cancer cells
H Salahifar, SM Firth, RC Baxter, JL Martin |
Growth Hormone & IGF Research | 2000 |
Fonction somatotrope et vieillissement
M Noël, C Coudray-Lucas, D Porquet, B Lesourd |
Nutrition Clinique et Métabolisme | 2000 |
Pharmacokinetics, Pharmacodynamics, and Safety of Microencapsulated Octreotide Acetate in Healthy Subjects
T Chen, TE Miller, P Prasad, J Lee, J Krauss, K Miscik, G Kalafsky, JE McLeod |
The Journal of Clinical Pharmacology | 2000 |
Expression of Epidermal Growth Factor in Transgenic Mice Causes Growth Retardation
SY Chan, RW Wong |
The Journal of biological chemistry | 2000 |
Insulin-like Growth Factor-binding Protein-3 Modulates Expression of Bax and Bcl-2 and Potentiates p53-independent Radiation-induced Apoptosis in Human Breast Cancer Cells
AJ Butt, SM Firth, MA King, RC Baxter |
The Journal of biological chemistry | 2000 |
The Effect of Phosphorylation by Casein Kinase 2 on the Activity of Insulin-Like Growth Factor-Binding Protein-3
JA Coverley, JL Martin, RC Baxter |
Endocrinology | 2000 |
Human Insulin-Like Growth Factor (IGF) Binding Protein-1 Inhibits IGF-I-Stimulated Body Growth but Stimulates Growth of the Kidney in Snell Dwarf Mice
SC van Buul-Offers, M van Kleffens, JG Koster, DJ Lindenbergh-Kortleve, MG Gresnigt, SL Drop, CM Hoogerbrugge, RJ Bloemen, JA Koedam, JW van Neck |
Endocrinology | 2000 |
Insulin-Like Growth Factor Binding Protein-3 Is Regulated by Dihydrotestosterone and Stimulates Deoxyribonucleic Acid Synthesis and Cell Proliferation in LNCaP Prostate Carcinoma Cells*
JL Martin, SL Pattison |
Endocrinology | 2000 |
Endocrinology of Aging
JE Morley, L van den Berg |
2000 | |
Growth and Insulin-Like Growth Factors (IGFs) in Children with Insulin-Dependent Diabetes Mellitus at the Onset of Disease: Evidence for Normal Growth, Age Dependency of the IGF System Alterations, and Presence of a Small (Approximately 18-Kilodalton) IGF-Binding Protein-3 Fragment in Serum
S Cianfarani, R Bonfanti, ML Bitti, D Germani, S Boemi, G Chiumello, B Boscherini |
The Journal of clinical endocrinology and metabolism | 2000 |
Estrogens Exert Route- and Dose-Dependent Effects on Insulin-Like Growth Factor (IGF)-Binding Protein-3 and the Acid-Labile Subunit of the IGF Ternary Complex*
GY Kam, KC Leung, RC Baxter, KK Ho |
The Journal of clinical endocrinology and metabolism | 2000 |
Hypoglycaemia associated with the production of insulin-like growth factor II and insulin-like growth factor binding protein 6 by a haemangiopericytoma
K Hoekman, J Doorn, T Gloudemans, JA Maassen, AG Schuller, HM Pinedo |
Clinical Endocrinology | 1999 |
Initial characterization of the GH-IGF axis and nutritional status of the Ati Negritos of the Philippines
AB Clavano-Harding, GR Ambler, CT Cowell, SP Garnett, B Al-Toumah, JC Coakley, KK Ho, RC Baxter |
Clinical Endocrinology | 1999 |
GH Response to Exercise: Assessment of the Pituitary Refractory Period, and Relationship with Circulating Components of the GH-IGF-I Axis in Adolescent Females
A Eliakim, JA Brasel, DM Cooper |
Journal of Pediatric Endocrinology and Metabolism | 1999 |
Moderate Doses of Porcine Somatotropin do not Increase Plasma Insulin-Like Growth factor-I (IGF-I) or IGF Binding Protein-3
FR Dunshea, RH King, PC Owens, PE Walton |
Domestic Animal Endocrinology | 1999 |
Reactivation of pituitary hormone release and metabolic improvement by infusion of growth hormone-releasing peptide and thyrotropin-releasing hormone in patients with protracted critical illness
GV Berghe, P Wouters, F Weekers, S Mohan, RC Baxter, JD Veldhuis, CY Bowers, R Bouillon |
The Journal of clinical endocrinology and metabolism | 1999 |
The search for trans-acting factors controlling messenger RNA decay
GM Wilson, G Brewer |
Progress in nucleic acid research and molecular biology | 1999 |
Evaluation of disease activity by IGF-I and IGF binding protein-3 (IGFBP3) in acromegaly patients distributed according to a clinical score
H Jasper, P Pennisi, M Vitale, A Mella, G Ropelato, A Chervin |
Journal of Endocrinological Investigation | 1999 |
Serum IGF-I and IGFBP-3 levels for the assessment of disease activity of acromegaly
HS Chen, HD Lin |
Journal of Endocrinological Investigation | 1999 |
Liver-specific and proliferation-induced deoxyribonuclease I hypersensitive sites in the mouse insulin-like growth factor binding protein-1 gene
MA Crissey, JI Leu, RA de Angelis, LE Greenbaum, LM Scearce, K Kovalovich, R Taub |
Hepatology | 1999 |
Monoclonal antibodies to growth hormone (GH) prolong liver GH binding and GH-induced IGF-I/IGFBP-3 synthesis
V Beauloye, SM Muaku, P Lause, D Portetelle, R Renaville, AR Robert, JM Ketelslegers, D Maiter |
American journal of physiology. Endocrinology and metabolism | 1999 |
Oncogenic ras Causes Resistance to the Growth Inhibitor Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) in Breast Cancer Cells
JL Martin, RC Baxter |
The Journal of biological chemistry | 1999 |
Maternal serum insulin-like growth factor binding protein-2 and -3 and fetal growth
RP Holmes, JM Holly, PW Soothill |
Human Reproduction | 1999 |
The IGF System
RG Rosenfeld, CT Roberts |
1999 | |
Effect of Severe Growth Hormone (GH) Deficiency due to a Mutation in the GH-Releasing Hormone Receptor on Insulin-Like Growth Factors (IGFs), IGF-Binding Proteins, and Ternary Complex Formation Throughout Life1
MH Aguiar-Oliveira, MS Gill, ES de, A Barretto, MR Alcântara, F Miraki-Moud, CA Menezes, AH Souza, CE Martinelli, FA Pereira, R Salvatori, MA Levine, SM Shalet, C Camacho-Hubner, PE Clayton |
The Journal of clinical endocrinology and metabolism | 1999 |
Interactions between Growth Hormone, Insulin-Like Growth Factor I, and Basic Fibroblast Growth Factor in Melanocyte Growth1
SR Edmondson, VC Russo, AC McFarlane, CJ Wraight, GA Werther |
The Journal of clinical endocrinology and metabolism | 1999 |
The relationship between the growth hormone and insulin-like growth factor axis in long-term survivors of childhood brain tumours
JC Achermann, PC Hindmarsh, CG Brook |
Clinical Endocrinology | 1998 |
Growth Hormone Resistance and Somatomedins in Children with End-Stage Liver Disease Awaiting Transplantation
RM Greer, P Quirk, GJ Cleghorn, RW Shepherd |
Journal of Pediatric Gastroenterology & Nutrition | 1998 |
Tamoxifen alters levels of serum insulin-like growth factors and binding proteins in postmenopausal breast cancer patients: A prospective paired cohort study
GH Ho, CY Ji, BH Phang, KO Lee, KC Soo, EH Ng |
Annals of Surgical Oncology | 1998 |
Ongoing Assessment of Nutritional Status in Children with Malignant Disease
SP Attard-Montalto, J Hadley, JE Kingston, OB Eden, V Saha |
Pediatric Hematology-Oncology | 1998 |
Thrity-day monitoring of insulin-like growth factors and their binding proteins in intensive care unit patients
RC Baxter, FH Hawker, C To, PM Stewart, SR Holman |
Growth Hormone & IGF Research | 1998 |
Effect of aging on growth hormone-induced insulin-like growth factor-I secretion from cultured rat chondrocytes
N Rousseau, P Brazeau, H Lapierre, T Abribat |
Growth Hormone & IGF Research | 1998 |
Expression of Insulin-like Growth Factor Binding Proteins in Bronchoalveolar Lavage Fluid of Patients with Pulmonary Sarcoidosis
JT Allen, CA Bloor, RA Knight, MA Spiteri |
American journal of respiratory cell and molecular biology | 1998 |
Development of Resistance to Insulin-like Growth Factor Binding Protein-3 in Transfected T47D Breast Cancer Cells
SM Firth, S Fanayan, D Benn, RC Baxter |
Biochemical and Biophysical Research Communications | 1998 |
Follicular fluid insulin-like growth factor-I and insulin-like growth factor-binding protein-1 and -3 vary as a function of ovarian reserve and ovarian stimulation
L Stadtmauer, A Vidali, SR Lindheim, MV Sauer |
Journal of Assisted Reproduction and Genetics | 1998 |
Role of insulin-like growth factor binding proteins in human post-nephrectomy proximal tubule cells
DW Johnson, HJ Saunders, MJ Field, CA Pollock |
The Journal of Physiology | 1998 |
Follicular Fluid Insulin-like Growth Factor-I and Insulin-like Growth Factor–Binding Protein-1 and -3 Vary as a Function of Ovarian Reserve and Ovarian Stimulation
L Stadtmauer, A Vidali, SR Lindheim, MV Sauer |
Journal of Assisted Reproduction and Genetics | 1998 |
Long-Term Effect of Recombinant Human Insulin-Like Growth Factor I on Metabolic and Growth Control in a Patient with Leprechaunism
J Nakae, M Kato, M Murashita, N Shinohara, T Tajima, K Fujieda |
The Journal of clinical endocrinology and metabolism | 1998 |
Developmental Changes in Serum Levels of Free and Total Insulin-Like Growth Factor I (IGF-I), IGF-Binding Protein-1 and -3, and the Acid-Labile Subunit in Rats 1
J Frystyk, H Grønbæk, C Skjærbæk, A Flyvbjerg, H Ørskov, RC Baxter |
Endocrinology | 1998 |
Insulin-like Growth Factor-binding Protein (IGFBP)-3 and IGFBP-5 Share a Common Nuclear Transport Pathway in T47D Human Breast Carcinoma Cells
LJ Schedlich, TF Young, SM Firth, RC Baxter |
The Journal of biological chemistry | 1998 |
Structural Determinants of Ligand and Cell Surface Binding of Insulin-like Growth Factor-binding Protein-3
SM Firth, U Ganeshprasad, RC Baxter |
The Journal of biological chemistry | 1998 |
Insulin-Like Growth Factor Binding Protein-3: A Novel Biomarker for the Assessment of the Synthetic Capacity of Hepatocytes in Liver Cirrhosis
M Shaarawy, MA Fikry, BA Massoud, S Lotfy |
The Journal of clinical endocrinology and metabolism | 1998 |
Insulin-Like Growth Factor-I Resistance*
S Jain, DW Golde, R Bailey, ME Geffner |
Endocrine reviews | 1998 |
Age-Related Differences in Serum Insulin-like Growth Factor-I (IGF-I) and IGF-Binding Protein-3 Levels in Congenital Hypothyroidism
N Kandemir, N Yordam, H Oguz |
Journal of Pediatric Endocrinology and Metabolism | 1997 |
Insulin-Like Growth Factor-I and Its Binding Protein-3 in Serum: Are They Good Screening Properties for the Diagnosis of Growth Hormone Deficiency?
A Koch, HG Dörr |
Clinical Chemistry and Laboratory Medicine | 1997 |
Serum Levels of Insulin-like Growth Factor-I and Insulin-like Growth Factor Binding Protein-3 in Obese Children
A Bideci, P Cinaz, A Hasanoglu, S Elbeg |
Journal of Pediatric Endocrinology and Metabolism | 1997 |
Modulation of growth factors by growth hormone in children with chronic renal failure
DR Powell, F Liu, BK Baker, RL Hintz, PD Lee, SK Durham, ED Brewer, JW Frane, SL Watkins, RJ Hogg |
Kidney International | 1997 |
Insulin-like growth factor binding proteins and their role in controlling IGF actions
DR Clemmons |
Cytokine & Growth Factor Reviews | 1997 |
Effects of single nightly injections of growth hormone—releasing hormone (GHRH 1–29) in healthy elderly men
J Vittone, MR Blackman, J Busby-Whitehead, C Tsiao, KJ Stewart, J Tobin, T Stevens, MF Bellantoni, MA Rogers, G Baumann, J Roth, SM Harman, RG Spencer |
Metabolism | 1997 |
Bioactivity of a 29-Kilodalton Insulin-Like Growth Factor Binding Protein-3 Fragment Present in Excess in Chronic Renal Failure Serum
SK Durham, S Mohan, F Liu, BK Baker, PD Lee, RL Hintz, CA Conover, DR Powell |
Pediatric Research | 1997 |
Growth hormone secretion in the elderly: Ageing and the somatopause
FC Martin, AL Yeo, PH Sonksen |
Baillière's Clinical Endocrinology and Metabolism | 1997 |
The pathogenesis of growth failure in paediatric liver disease
RI Holt, AJ Baker, JP Miell |
Journal of Hepatology | 1997 |
Comparative study of insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 (IGFBP-3) level and ratio measurements and their relationship with an index of clinical activity in the management of patients with acromegaly
C Páramo, MA O, E Fluiters, R Luna, J la Fuente, RV García-Mayor |
Metabolism | 1997 |
Growth Factors and Cytokines in Health and Disease
P Martin, J McCluskey, P Mallucci, S Nodder |
Growth Factors and Cytokines in Health and Disease | 1997 |
Advances in Molecular and Cellular Endocrinology
MR Pollak, EM Brown |
Advances in Molecular and Cellular Endocrinology | 1997 |
Growth and hormone characteristics of pubertal development in the hamadryas baboon
BA Crawford, WJ Harewood, DJ Handelsman |
Journal of Medical Primatology | 1997 |
Human renal fibroblasts modulate proximal tubule cell growth and transport via the IGF-I axis
DW Johnson, HJ Saunders, BK Brew, A Ganesan, RC Baxter, P Poronnik, DI Cook, AZ Györy, MJ Field, CA Pollock |
Kidney International | 1997 |
Simulation of IGF-I pharmacokinetics after infusion of recombinant IGF-I in human subjects
MA Boroujerdi, RH Jones, PH Sonksen, DL Russell-Jones |
American journal of physiology. Endocrinology and metabolism | 1997 |
Weight loss and wrestling training: effects on growth-related hormones
JN Roemmich, WE Sinning |
Journal of applied physiology | 1997 |
Evidence for Insulin-Like Growth Factor (IGF)-Independent Transcriptional Regulation of IGF Binding Protein-3 by Growth Hormone in SKHEP-1 Human Hepatocarcinoma Cells*
ZS Gucev, Y Oh, KM Kelley, JI Labarta, P Vorwerk, RG Rosenfeld |
Endocrinology | 1997 |
Insulin-Like Growth Factor-Binding Proteins in Serum and Other Biological Fluids: Regulation and Functions*
S Rajaram, DJ Baylink, S Mohan |
Endocrine reviews | 1997 |
Effect of Aging on the Sensitivity of Growth Hormone Secretion to Insulin-Like Growth Factor-I Negative Feedback*
IM Chapman, ML Hartman, SS Pezzoli, FE Harrell, RL Hintz, KG Alberti, MO Thorner |
The Journal of clinical endocrinology and metabolism | 1997 |
Adjunctive Growth Hormone during Ovarian Hyperstimulation Increases Levels of Insulin-Like Growth Factor Binding Proteins in Follicular Fluid: A Randomized, Placebo-Controlled, Cross-Over Study*
J Rabinovici, NA Cataldo, P Dandekar, SM Rosenthal, SE Gargosky, N Gesundheit, MC Martin |
The Journal of clinical endocrinology and metabolism | 1997 |
Metabolic effects of recombinant human insulin-like growth factor-I in humans: comparison with recombinant human growth hormone
N Mauras, MW Haymond |
Pediatric Nephrology | 1996 |
Collection of blood in heparinized tubes does not alter the molecular distribution or forms of IGFBP-3 and IGF
S Mandel, E Moreland, RG Rosenfeld, SE Gargosky |
Endocrine | 1996 |
Insulin-like growth factor binding proteins as growth inhibitors in children with chronic renal failure
DR Powell, F Liu, BK Baker, PD Lee, RL Hintz |
Pediatric Nephrology | 1996 |
Serum insulin-like growth factor II levels in normal adolescents and those with insulin dependent diabetes mellitus
CL Acerini, KL Clayton, R Hintz, B Baker, A Watts, JM Holly, DB Dunger |
Clinical Endocrinology | 1996 |
Serum Levels of Insulin-like Growth Factor-I and Insulin-like Growth Factor Binding Protein-3 in Children with Insulin-Dependent Diabetes Mellitus
P Cinaz, M Kendirci, S Kurtoglu, N Gökçora, Ν Buyan, I Yavuz, A Demir |
Journal of Pediatric Endocrinology and Metabolism | 1996 |
Insulin-like growth factor-I and IGF binding protein-3 remain high after GnRH analogue therapy in girls with central precocious puberty
H Kanety, A Karasik, C Pariente, A Kauschansky |
Clinical Endocrinology | 1996 |
Short Stature Caused by a Mutant Growth Hormone
Y Takahashi, H Kaji, Y Okimura, K Goji, H Abe, K Chihara |
New England Journal of Medicine | 1996 |
Insulin and insulin-like growth factor-I: their role as risk factors in the development of diabetic cardiovascular disease
B Göke, HC Fehmann |
Diabetes Research and Clinical Practice | 1996 |
Insulin-like growth factor-I serum concentrations and patterns of insulin-like growth factor binding proteins in patients with chronic liver disease
JG Scharf, F Schmitz, J Frystyk, C Skjaerbaek, H Moesus, WF Blum, G Ramadori, H Hartmann |
Journal of Hepatology | 1996 |
IGF-I, marqueur nutritionnel
M Jeevanandam |
Nutrition Clinique et Métabolisme | 1996 |
Insulin-like growth factor bioactivity and its modification in growth hormone resistant states
AJ Donaghy, RC Baxter |
Baillière's Clinical Endocrinology and Metabolism | 1996 |
Serum insulin-like growth factor binding protein-3 responds differently to trauma in men and women:
SM Houston-Bolze, MT Downing, AM Sayed, JH Williford |
Critical Care Medicine | 1996 |
An Unusual Case of Growth Hormone Receptor Deficiency Syndrome
PY Kwong, JD Teale |
Annals of Clinical Biochemistry | 1996 |
Growth hormone, insulin-like growth factor and the kidney
RJ Krieg, F Santos, JC Chan |
Kidney International | 1995 |
Abnormal serum IGF-II transport in non-islet cell tumor hypoglycemia results from abnormalities of both IGF binding protein-3 and acid labile subunit and leads to elevation of serum free IGF-II
WH Daughaday, B Trivedi, RC Baxter |
Endocrine | 1995 |
Serum zinc in highly trained adolescent gymnasts
JF Brun, C Dieu-Cambrezy, A Charpiat, C Fons, C Fedou, JP Micallef, M Fussellier, L Bardet, A Orsetti |
Biological Trace Element Research | 1995 |
IGFBP-3 is a poor parameter for assessment of clinical activity in acromegaly
WW Herder, AJ Lely, JA Janssen, P Uitterlinden, LJ Hofland, SW Lamberts |
Clinical Endocrinology | 1995 |
Effects of cholinergic modulation on serum insulin-like growth factor4 and its binding proteins in normal and diabetic subjects
IS Ismall, JP Mlell, MF Scanlon, JR Peters |
Clinical Endocrinology | 1995 |
Is IGF binding protein-3 assessment helpful for the diagnosis of GH deficiency?
S Cianfarani, S Boemi, A Spagnoli, M Cappa, G Argirò, F Vaccaro, ML Bitti, B Boscherlni |
Clinical Endocrinology | 1995 |
Insulin-like growth factor-I gene expression in the tibial epiphyseal growth plate of growth hormone-treated uremic rats
JD Hanna, F Santos, JW Foreman, JC Chan, VK Han |
Kidney International | 1995 |
Identification of insulin-like growth factor binding proteins from cultured human epidermal keratinocytes
MM Murashita, VC Russo, SR Edmondson, CJ Wraight, GA Werther |
Journal of Cellular Physiology | 1995 |
Insulin-like growth-factor-binding protein 3 is decreased in early-stage operable pre-menopausal breast cancer
PF Bruning, JV Doorn, JM Bonfrèr, PA van Noord, CM Korse, TC Linders, AA Hart |
International Journal of Cancer | 1995 |
Growth hormone, insulinlike growth factor-1, and insulinlike growth factor binding proteins 1 and 3 in chronic liver disease
A Donaghy, R Ross, A Gimson, SC Hughes, J Holly, R Williams |
Hepatology | 1995 |
Defining growth hormone deficiency in adults
KK Ho, DM Hoffman |
Metabolism | 1995 |
Plasma levels of insulin-like growth factor binding protein-3 in acute trauma patients
M Jeevanandam, NJ Holaday, SR Petersen |
Metabolism | 1995 |
Insulin-like growth factor binding proteins as glucoregulators
RC Baxter |
Metabolism | 1995 |
Insulin-like growth factors: Clinical experience in ovarian function
RP Buyalos |
The American Journal of Medicine | 1995 |
Modulation of human IGF binding protein-3 activity by structural modification
RC Baxter, SM Firth |
Progress in Growth Factor Research | 1995 |
Developmental regulation of circulating insulin-like growth factor-binding proteins in normal pregnancies and in pre-eclampsia
MS Lewitt, FP Scott, NM Clarke, RC Baxter |
Progress in Growth Factor Research | 1995 |
The role of glycosylation in the action of IGFBP-3
SM Firth, RC Baxter |
Progress in Growth Factor Research | 1995 |
Serum levels of insulin-like growth factor-binding protein-3 in normal pregnancy
HS Wang, BJ Cheng, YK Soong |
European Journal of Obstetrics & Gynecology and Reproductive Biology | 1995 |
Serum levels of insulin-like growth factor I and insulin-like growth factor-binding protein-l and -3 in women with regular menstrual cycles**Supported by Medical Research grant CMRP-0426 from Chang-Gung Memorial Hospital, Lin-Kou Medical Center, Taipei, Taiwan, Republic of China
HS Wang, JD Lee, YK Soong |
Fertility and Sterility | 1995 |
Insulin regulates circulating insulin-like growth factors and some of their binding proteins in lactating cows
MA McGuire, DA Dwyer, RJ Harrell, DE Bauman |
American journal of physiology. Endocrinology and metabolism | 1995 |
In vivo proteolysis of serum insulin-like growth factor (IGF) binding protein-3 results in increased availability of IGF to target cells
C Blat, J Villaudy, M Binoux |
Journal of Clinical Investigation | 1994 |
The ratio between serum levels of insulin-like growth factor (IGF)-I and the IGF binding proteins (IGFBP-1, 2 and 3) decreases with age in healthy adults and is increased in acromegalic patients
A Juul, K Main, WF Blum, J Lindholm, MB Ranke, NE Skakkebaek |
Clinical Endocrinology | 1994 |
Senescence and cell density of human diploid fibroblasts influence metabolism of insulin-like growth factor binding proteins
VG Grigoriev, EJ Moerman, S Goldstein |
Journal of Cellular Physiology | 1994 |
Plasma insulin-like growth factor I and its binding proteins 1 and 3 in postmenopausal patients with breast cancer receiving long term tamoxifen
EI Lahti, M Knip, TJ Laatikainen |
Cancer | 1994 |
Growth hormone (GH), insulin-like growth factors (IGFs), and IGF-binding protein-3 (IGFBP-3) in a child with Proteus syndrome
G Rudolph, WF Blum, EW Jenne, M Schöning, H Enders, T Meitinger, JD Murken, A Kampik |
American Journal of Medical Genetics | 1994 |
Diagnosis of growth-hormone deficiency in adults
DM Hoffman, AJ O'Sullivan, KK Ho, RC Baxter |
The Lancet | 1994 |
Insulin-like growth factor binding proteins and their regulation
RG Rosenfeld, H Pham, P Cohen, P Fielder, SE Gargosky, H Muller, L Nonoshita, Y Oh |
Acta Paediatrica | 1994 |
Improvement of diagnostic criteria in growth hormone insensitivity syndrome: solutions and pitfalls
WF Blum, AM Cotterill, MC Postel-Vinay, MB Ranke, MO Savage, P Wilton |
Acta Paediatrica | 1994 |
Insulin-like growth factors (IGF)-I and -II and IGF binding protein-1, -2, and -3 in patients with acromegaly before and after adenomectomy
JO Jørgensen, N Møller, J Møller, J Weeke, WF Blum |
Metabolism | 1994 |
Insulin-like growth factors and binding proteins in patients with recent-onset type 1 (insulin-dependent) diabetes mellitus: Influence of diabetes control and intraportal insulin infusion
PI Shishko, AV Dreval, IA Abugova, IU Zajarny, VC Goncharov |
Diabetes Research and Clinical Practice | 1994 |
The influence of endurance training on insulin-like growth factor-1 in older individuals
ET Poehlman, CJ Rosen, KC Copeland |
Metabolism | 1994 |
Insulin-like growth factor I as an indicator of protein-energy undernutrition among metabolically stable hospitalized elderly
DH Sullivan, WJ Carter |
Journal of the American College of Nutrition | 1994 |
Vitreal insulin-like growth factor binding proteins (IGFBPs) are increased in human and animal diabetics
RJ Waldbillig, BE Jones, TJ Schoen, P Moshayedi, S Heidersbach, MS Bitar, FJ van Kuijk, E Juan, P Kador, GJ Chader |
Current Eye Research | 1994 |
IGF-I and IGF-binding protein gene expressions in spontaneous dwarf rat
H Nogami, T Watanabe, S Kobayashi |
American journal of physiology. Endocrinology and metabolism | 1994 |
Diseases of the Pituitary
SL Asa |
Neurosurgery Clinics of North America | 1994 |
Regulation of insulin-like growth factors by antiestrogen
R Winston, PC Kao, DT Kiang |
Breast Cancer Research and Treatment | 1994 |
Circulating levels of insulin-like growth factor binding protein 3 (IGFBP-3) and insulin-like growth factor I (IGF-I) in perimenopausal women
E Romagnoli, S Minisola, V Carnevale, R Rosso, MT Pacitti, A Scarda, L Scarnecchia, G Mazzuoli |
Osteoporosis International | 1994 |
The insulin-like growth factor-I/binding protein axis: physiology, pathophysiology and therapeutic manipulation
KS Langford, JP Miell |
European Journal of Clinical Investigation | 1993 |
Plasma IGFBP-3 and its relationship with quantitative growth hormone secretion in short children
M Phillip, SA Chalew, AA Kowarski, MA Stene |
Clinical Endocrinology | 1993 |
Accumulation of insulin-like growth factor binding protein-3 in conditioned medium of human fibroblasts increases with chronologic age of donor and senescence in vitro
S Goldstein, EJ Moerman, RC Baxter |
Journal of Cellular Physiology | 1993 |
Levels of insulin-like growth factor-I and insulin-like growth factor-binding protein-1 in pregnancy with preterm delivery
HS Wang, CL Lee, T Chard |
BJOG: An International Journal of Obstetrics and Gynaecology | 1993 |
Circulating binding proteins for the insulinlike growth factors
RC Baxter |
Trends in Endocrinology & Metabolism | 1993 |
Contributory roles of circulatory glucagon and growth hormone to increased renal haemodynamics in type 1 (insulin-dependent) diabetes mellitus
K Hoogenberg, RP Dullaart, NJ Freling, S Meijer, WJ Sluiter |
Scandinavian Journal of Clinical & Laboratory Investigation | 1993 |
Growth hormone insensitivity syndromes: a preliminary report on changes in insulin-like growth factors and their binding proteins during treatment with recombinant insulin-like growth factor I
WF Blum, K Hall, MB Ranke, P Wilton |
Acta Paediatrica | 1993 |
Characterization of the binding defect in insulin-like growth factor binding protein-3 from pregnancy serum
RC Baxter, AM Suikkari, JL Martin |
Biochemical Journal | 1993 |
Evaluation of plasma insulin-like growth factor-binding protein-3 as a potential predictor of preeclampsia
M Varma, CJ de Groot, S Lanyi, RN Taylor |
American Journal of Obstetrics and Gynecology | 1993 |
Effect of hypophysectomy on insulin-like growth factor (IGF)-1 binding activity of serum in chickens
D Morishita, M Wakita, S Hoshino |
Comparative Biochemistry and Physiology Part A: Physiology | 1993 |
The serum insulin-like growth factor-II/mannose-6-phosphate receptor in normal and diabetic pregnancy
MC Gelato, C Rutherford, G San-Roman, S Shmoys, A Monheit |
Metabolism | 1993 |
Differential Regulation of IGF-1 and IGF-Binding Protein-1 by Dietary Composition in Humans
VC Musey, S Goldstein, PK Farmer, PB Moore, LS Phillips |
The American Journal of the Medical Sciences | 1993 |
Physiology and Pharmacology of Bone
GR Mundy, TJ Martin |
1993 | |
Growth Hormone and Somatomedins during Lifespan
EE Müller, D Cocchi, V Locatelli |
1993 | |
Insulin-like growth factor binding protein-3 protease activity in the urine of children with chronic renal failure
DY Lee, P Cohen, AM Krensky, RG Rosenfeld, PD Yorgin |
Pediatric Nephrology | 1993 |
Effects of insulin-like growth factor-I on glucose tolerance, insulin levels, and insulin secretion
PD Zenobi, S Graf, H Ursprung, ER Froesch |
Journal of Clinical Investigation | 1992 |
Insulin-like growth factor-I improves glucose and lipid metabolism in type 2 diabetes mellitus
PD Zenobi, SE Jaeggi-Groisman, WF Riesen, ME Røder, ER Froesch |
Journal of Clinical Investigation | 1992 |
Alternative Methods of Diagnosis of Growth Hormone Deficiency
AT Silink |
Journal of Pediatric Endocrinology and Metabolism | 1992 |
Insulin-like growth factor-1, growth hormone-dependent insulin-like growth factor-binding protein and growth in children with chronic renal failure
EM Hodson, AS Brown, LP Roy, AR Rosenberg |
Pediatric Nephrology | 1992 |
Insulin-like growth factors and diabetes
LA Bach, MM Rechler |
Diabetes / Metabolism Reviews | 1992 |
Administration of human recombinant insulin-like growth factor-I to patients following major gastrointestinal surgery
JP Miell, AM Taylor, J Jones, CR Buchanan, J Rennie, R Sherwood, R Leicester, RJ Ross |
Clinical Endocrinology | 1992 |
IGF binding protein 3 in patients with Laron type dwarfism: effect of exogenous rIGF-I
Z Laron, B Klinger, WF Blum, A Silbergeld, MB Ranke |
Clinical Endocrinology | 1992 |
Cloning and sequence determination of bovine insulin-like growth factor binding protein-2 (IGFBP-2): Comparison of its structral and functional properties with IGFBP-1
WH Busby, RH McCusker, DR Clemmons, MJ Bourner, NR Siegel, GG Krivi |
Journal of Cellular Biochemistry | 1992 |
Developmental regulation of insulin-like growth factor binding protein production: Studies in fetal, postnatal, and pregnant sheep
J Fowlkes, M Freemark |
Journal of Cellular Physiology | 1992 |
11 Growth failure in renal disease
O Mehls, WF Blum, F Schaefer, B Tönshoff, K Schärer |
Baillière's Clinical Endocrinology and Metabolism | 1992 |
The endocrine regulation of growth during early life: a nutritional perspective
JM Bassett |
BSAP Occasional Publication | 1992 |
Human osteoblast-derived insulin-like growth factor (IGF) binding protein-5 stimulates osteoblast mitogenesis and potentiates IGF action
DL Andress, RS Birnbaum |
The Journal of biological chemistry | 1992 |
Structural determinants for binary and ternary complex formation between insulin-like growth factor-I (IGF-I) and IGF binding protein-3
RC Baxter, ML Bayne, MA Cascieri |
The Journal of biological chemistry | 1992 |
Insulin-like growth factor-binding protein-1: A role in glucose counterregulation?
MS Lewitt, RC Baxter |
Molecular and Cellular Endocrinology | 1991 |
The presence of cation-dependent proteases for insulin-like growth factor binding proteins does not alter the size distribution of insulin-like growth factors in pregnancy
SC Davies, JM Holly, VJ Coulson, AM Cotterill, AF Abdulla, PG Whlttakert, T Chard, JA Wass |
Clinical Endocrinology | 1991 |
Insulin-Like Growth Factor (IGF) Binding Proteins: the Role of Serum IGFBPs in Regulating IGF Availability
RC Baxter |
Acta Paediatrica | 1991 |
Cytochalasin B stimulates insulin-like growth factor-binding protein-1 production by Hep G2 cells
MS Lewitt, RC Baxter |
Molecular and Cellular Endocrinology | 1991 |
Insulin-like Growth Factor-II (IGF-II) and IGF Binding Proteins in Human Endometrium
LC Giudice, G Lamson, RG Rosenfeld, JC Irwin |
Annals of the New York Academy of Sciences | 1991 |
Insulin-like growth factor binding protein 3 accumulates to high levels in culture medium of senescent and quiescent human fibroblasts
S Goldstein, EJ Moerman, RA Jones, RC Baxter |
Proceedings of the National Academy of Sciences | 1991 |
Synthesis of the acid-labile subunit of the growth-hormone-dependent insulin-like-growth-factor-binding protein complex by rat hepatocytes in culture
CD Scott, RC Baxter |
Biochemical Journal | 1991 |
Function of the growth hormone-insulin-like growth factor I axis in the profoundly growth-retarded diabetic child: Evidence for defective target organ responsiveness in the Mauriac syndrome
N Mauras, T Merimee, AD Rogol |
Metabolism | 1991 |
Evaluation of interference by insulin-like growth factor I (IGF-I) binding proteins in a radioimmunoassay for IGF-I in serum from dairy cows
K Plaut, WS Cohick, DE Bauman, RC Baxter |
Domestic Animal Endocrinology | 1991 |
Plasma IGF-I binding proteins in sheep: Effect of recombinant growth hormone treatment and nutritional status
SC Hodgkinson, JJ Bass, PD Gluckman |
Domestic Animal Endocrinology | 1991 |
Insulin-like growth factors: biochemistry and physiology
AC Herington |
Baillière's Clinical Endocrinology and Metabolism | 1991 |
Identification and molecular characterization of insulin-like growth factor binding proteins (IGFBP-1, -2, -3, -4, -5 and -6)
S Shimasaki, N Ling |
Progress in Growth Factor Research | 1991 |
Peptide Growth Factors and Their Receptors I
MB Sporn, AB Roberts |
1991 | |
Growth hormone resistance and inhibition of somatomedin activity by excess of insulin-like growth factor binding protein in uraemia
WF Blum, MB Ranke, K Kietzmann, B Tnshoff, O Mehls |
Pediatric Nephrology | 1991 |
Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors
MK Raizada, D LeRoith |
1991 | |
Growth, Growth Hormone and the Somatomedins: A Historical Perspective and Current Concepts
BT Rudd |
Annals of Clinical Biochemistry | 1991 |
Growth Factors and Diabetic Complications
A Flyvbjerg |
Diabetic Medicine | 1990 |
Molecular biology of the insulin-like growth factors
JE Hepler, PK Lund |
Molecular Neurobiology | 1990 |
Grundlagen und klinische Bedeutung der Insulin-like Growth Factors/Somatomedine
E Weimann, W Kiess |
Klinische Wochenschrift | 1990 |
THE GROWTH HORMONE INDEPENDENT INSULIN-LIKE GROWTH FACTOR-I BINDING PROTEIN BP-28 IS ASSOCIATED WITH SERUM INSULIN-LIKE GROWTH FACTOR-I INHIBITORY BIOACTIVITY IN ADOLESCENT INSULIN-DEPENDENT DIABETICS
AM Taylor, DB Dunger, MA Preece, JM Holly, CP Smith, JA Wass, S Patel, VE Tate |
Clinical Endocrinology | 1990 |
Endogenous mediators of growth
N Loveridge, C Farquharson, BA Scheven |
Proceedings of the Nutrition Society | 1990 |
Insulinlike growth factor binding proteins
DR Clemmons |
Trends in Endocrinology & Metabolism | 1990 |
The gene for insulin-like growth factor-binding protein-1 is localized to human chromosomal region 7p14-p12
J Ekstrand, E Ehrenborg, I Stern, B Stellan, L Zech, H Luthman |
Genomics | 1990 |
Effect of dietary proteins on the plasma immunoreactive insulin-like growth factor-1/somatomedin C concentration in the rat
S Takahashi, M Kajikawa, T Umezawa, SI Takahashi, H Kato, Y Miura, TJ Nam, T Noguchi, H Naito |
British Journal of Nutrition | 1990 |
INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS IN FOLLICULAR FLUID FROM NORMAL DOMINANT AND COHORT FOLLICLES, POLYCYSTIC AND MULTICYSTIC OVARIES
JM Holly, JA Eden, J Alaghband-Zadeh, GD Carter, RC Jemmott, S Cianfarani, T Chard, JA Wass |
Clinical Endocrinology | 1990 |
Insulin-Like Growth Factor Binding Proteins (IGFBPs) with Special Reference to IGFBPS
W Blum, M Ranke |
Acta Paediatrica | 1990 |
Insulin-like Growth Factor Binding Protein-1 Levels in Diabetic Adolescents and their Relationship to Metabolic Control
JM Holly, DB Dunger, JA Edge, CP Smith, T Chard, JA Wass |
Diabetic Medicine | 1990 |
Glycosaminoglycans inhibit formation of the 140 kDa insulin-like growth factor-binding protein complex
RC Baxter |
Biochemical Journal | 1990 |
Recognition of insulin-like-growth-factor-binding proteins in serum and amniotic fluid by an antiserum against a low-molecular-mass insulin-like-growth-factor-inhibitor/binding protein
GT Ooi, AC Herington |
Biochemical Journal | 1990 |
Radioimmunoassay for Insulin-Like Growth Factor (IGF). II: Interference by Pure IGF-Binding Proteins
RC Baxter |
Journal of Immunoassay | 1990 |
Molecular biology of the insulin-like growth factors: Relevance to nervous system function
JE Hepler, PK Lund |
Molecular Neurobiology | 1990 |
Circulating levels of insulin-like growth factors increase and molecular forms of their serum binding proteins change with human pregnancy
SE Gargosky, KJ Moyse, PE Walton, JA Owens, JC Wallace, JS Robinson, PC Owens |
Biochemical and Biophysical Research Communications | 1990 |
Proceedings of the 1989 Laurentian Hormone Conference
RG Rosenfeld, G Lamson, H Pham, Y Oh, C Conover, DD de Leon, SM Donovan, I Ocrant, L Giudice |
Proceedings of the 1989 Laurentian Hormone Conference | 1990 |
Cloning and Expression of Human Insulin-Like Growth Factor Binding Protein 3
SK Spratt, GP Tatsuno, MK Yamanaka, BC Ark, J Detmer, D Mascarenhas, J Flynn, C Talkington-verser, EM Spencer |
Growth Factors | 1990 |
GnRH Analogues in Cancer and Human Reproduction
BH Vickery, B Lunenfeld |
1990 | |
Purification and properties of a novel insulin-like growth factor-II binding protein from transformed human fibroblasts
JL Martin, KE Willetts, RC Baxter |
The Journal of biological chemistry | 1990 |
Insulin-like growth factor binding protein-3. Organization of the human chromosomal gene and demonstration of promoter activity
ML Cubbage, A Suwanichkul, DR Powell |
The Journal of biological chemistry | 1990 |
Insulin-like growth factor binding proteins from cultured human fibroblasts. Characterization and hormonal regulation
CA Conover, F Liu, D Powell, RG Rosenfeld, RL Hintz |
Journal of Clinical Investigation | 1989 |
The somatomedin-insulin-like growth factors
K Hall, M Tally |
Journal of Internal Medicine | 1989 |
Somatomedin-binding proteins: What role do they play in the growth process?
S Cianfarani, JM Holly |
European Journal of Pediatrics | 1989 |
Human insulin-like growth-factor-binding protein. Low-molecular-mass form: protein sequence and cDNA cloning
H LUTHMAN, J SODERLING-BARROS, B PERSSON, C ENGBERG, I STERN, M LAKE, SA FRANZEN, M ISRAELSSON, B RADEN, B LINDGREN, L HJELMQVIST, S ENERBACK, P CARLSSON, G BJURSELL, G POVOA, K HALL, H JORNVALL |
European Journal of Biochemistry | 1989 |
Increased secretion of insulin-like growth factor I into milk of cows treated with recombinantly derived bovine growth hormone
CG Prosser, IR Fleet, AN Corps |
Journal of Dairy Research | 1989 |
Structure of the Mr 140,000 growth hormone-dependent insulin-like growth factor binding protein complex: determination by reconstitution and affinity-labeling
RC Baxter, JL Martin |
Proceedings of the National Academy of Sciences | 1989 |
Significance of abnormal serum binding of insulin-like growth factor II in the development of hypoglycemia in patients with non-islet-cell tumors
WH Daughaday, M Kapadia |
Proceedings of the National Academy of Sciences | 1989 |
Isolation from human cerebrospinal fluid of a new insulin-like growth factor-binding protein with a selective affinity for IGF-II
M Roghani, P Hossenlopp, P Lepage, A Balland, M Binoux |
FEBS Letters | 1989 |
Binding proteins for the insulin-like growth factors: Structure, regulation and function
RC Baxter, JL Martin |
Progress in Growth Factor Research | 1989 |
Purification of the serum acid-stable insulin-like growth factor binding protein from the pig (Sus scrofa)
PE Walton, RC Baxter, BD Burleigh, TD Etherton |
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry | 1989 |
Insulin-like growth factor (IGF-I) and its low molecular weight binding protein in human milk
AM Suikkari |
European Journal of Obstetrics & Gynecology and Reproductive Biology | 1989 |
Circulating insulin-like growth factor I in Type 1 (insulin-dependent) diabetic patients with retinopathy
P Arner, S Sjberg, M Gjtterberg, A Skottner |
Diabetologia | 1989 |
Advances in Growth Hormone and Growth Factor Research
EE MÜller, D Cocchi, V Locatelli |
1989 | |
Molecular and Cellular Biology of Insulin-like Growth Factors and Their Receptors
D LeRoith, MK Raizada |
1989 | |
Structure and Activity Dependence of Recombinant Human Insulin-like Growth Factor II on Disulfide Bond Pairing
MC Smith, JA Cook, TC Furman, JL Occolowitz |
The Journal of biological chemistry | 1989 |
High molecular weight insulin-like growth factor binding protein complex
RC Baxter, JL Martin, VA Beniac |
The Journal of biological chemistry | 1989 |
Nucleotide Sequence and Expression of a cDNA Clone Encoding a Fetal Rat Binding Protein for Insulin-like Growth Factors
AL Brown, L Chiariotti, CC Orlowski, T Mehlman, WH Burgess, EJ Ackerman, CB Bruni, MM Rechler |
The Journal of biological chemistry | 1989 |
ORCADIAN VARIATION OF GH-INDEPENDENT IGF-BINDING PROTEIN IN DIABETES MELLITUS AND ITS RELATIONSHIP TO INSULIN. A NEW ROLE FOR INSULIN?
JM Holly, RA Biddlecombe, DB Dunger, JA Edge, SA Amiel, R Howell, T Chard, LH Rees, JA Wass |
Clinical Endocrinology | 1988 |
Isolation and characterization of a cDNA encoding the low molecular weight insulin-like growth factor binding protein (IBP-1)
A Brinkman, C Groffen, DJ Kortleve, AG van Kessel, SL Drop |
The EMBO Journal | 1988 |
Isolation of a biologically active fragment from the carboxy terminus of the fetal rat binding protein for insulin-like growth factors
JF Wang, B Hampton, T Mehlman, WH Burgess, MM Rechler |
Biochemical and Biophysical Research Communications | 1988 |
Recognition of insulin-like growth factor (IGF) serum binding proteins by an antibody raised against a specific IGF-inhibitor
GT Ooi, AC Herington |
Biochemical and Biophysical Research Communications | 1988 |
Growth hormone-dependent insulin-like growth factor (IGF) binding protein both inhibits and potentiates IGF-I-stimulated DNA synthesis in human skin fibroblasts
JS de Mellow, RC Baxter |
Biochemical and Biophysical Research Communications | 1988 |
Clinical Significance of Somtomedins and Somatomedin Binding Proteins
K Hall, P Bang, K Brismar, M Degerblad, M Tally |
Scandinavian Journal of Clinical & Laboratory Investigation | 1988 |
Basic and Clinical Aspects of Growth Hormone
BB Bercu |
1988 | |
Effects of growth hormone therapy and malnutrition on the growth of rats with renal failure.
Powell DR, Rosenfeld RG, Hintz RL |
Pediatric nephrology (Berlin, Germany) | 1988 |
Heterogeneity of insulin-like growth factor binding proteins and relationships between structure and affinity. 1. Circulating forms in man
S HARDOUIN, P HOSSENLOPP, B SEGOVIA, D SEURIN, G PORTOLAN, C LASSARRE, M BINOUX |
European Journal of Biochemistry | 1987 |
Binding proteins for insulin-like growth factors in adult rat serum. Comparison with other human and rat binding proteins
RC Baxter, JL Martin |
Biochemical and Biophysical Research Communications | 1987 |