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Citations to this article

Binding of fibrinogen to human monocytes.
D C Altieri, … , P M Mannucci, A M Capitanio
D C Altieri, … , P M Mannucci, A M Capitanio
Published October 1, 1986
Citation Information: J Clin Invest. 1986;78(4):968-976. https://doi.org/10.1172/JCI112687.
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Research Article Article has an altmetric score of 6

Binding of fibrinogen to human monocytes.

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Abstract

The interaction of fibrinogen with monocytes was studied. After stimulation with ADP (10 microM) or thrombin (1 U/ml), platelet-free suspensions of human monocytes bind 125I-fibrinogen with two different affinities in a specific and Ca2+-dependent reaction with saturation at 5.80-7.35 X 10(-7) M of added protein. The binding of fibrinogen to specific receptors on monocytes induces the procoagulant activity of these cells. Thrombasthenic cells or normal monocytes preincubated with a monoclonal antibody to the platelet glycoprotein IIb/IIIa complex (10E5) do not bind fibrinogen and have no procoagulant activity. Metabolic studies with [35S]methionine revealed that cultured monocytes actually synthesize a surface antigen precipitated by 10E5 antibody as a major band with 92,000 relative molecular weight. Our data indicate that monocytes express receptors for fibrinogen only in part related to the platelet glycoprotein IIb/IIIa complex. Furthermore, the binding of fibrinogen to monocytes enhances the cooperation of these cells in hemostasis.

Authors

D C Altieri, P M Mannucci, A M Capitanio

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Year: 2024 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1994 1993 1992 1991 1990 1989 1988 1987 1986 Total
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