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Immunoreactive apolipoprotein E is a widely distributed cellular protein. Immunohistochemical localization of apolipoprotein E in baboon tissues.

C T Lin, … , J Y Wu, L Chan

C T Lin, … , J Y Wu, L Chan

Published October 1, 1986
Citation Information: J Clin Invest. 1986;78(4):947-958. https://doi.org/10.1172/JCI112685.

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Title and authors	Publication	Year
Identification of apolipoprotein E-derived amyloid within cholesterol granulomas of leopard geckos (Eublepharis macularius) Ikeda M, Kondo H, Murakami T, Iwaide S, Itoh Y, Shibuya H	Scientific Reports	2024
Neuronal ApoE4 in Alzheimer’s disease and potential therapeutic targets Zhang L, Xia Y, Gui Y	Frontiers in aging neuroscience	2023
The Apolipoprotein E neutralizing antibody inhibits SARS-CoV-2 infection by blocking cellular entry of lipoviral particles. Cui Q, Jeyachandran AV, Garcia G, Qin C, Zhou Y, Zhang M, Wang C, Sun G, Liu W, Zhou T, Feng L, Palmer C, Li Z, Aziz A, Gomperts BN, Feng P, Arumugaswami V, Shi Y		2023
Simultaneous Mass Spectrometry-Based Apolipoprotein Profiling and Apolipoprotein E Phenotyping in Patients with ASCVD and Mild Cognitive Impairment. Begcevic Brkovic I, Zöhrer B, Scholz M, Reinicke M, Dittrich J, Kamalsada S, Baber R, Beutner F, Teren A, Engel C, Wirkner K, Thiele H, Löffler M, Riedel-Heller SG, Ceglarek U	Nutrients	2022
COVID-19 enters the expanding network of apolipoprotein E4-related pathologies K Gkouskou, T Vasilogiannakopoulou, E Andreakos, N Davanos, M Gazouli, D Sanoudou, AG Eliopoulos	Redox Biology	2021
Generation of APOE knock-down SK-N-SH human neuroblastoma cells using CRISPR/Cas9: a novel cellular model relevant to Alzheimer’s disease research SS Muñoz, B Garner, L Ooi	Bioscience Reports	2021
Apolipoprotein E is a Concentration-dependent Pulmonary Danger Signal that Activates the NLRP3 Inflammasome and IL-1β Secretion by Asthmatic Macrophages Gordon EM, Yao X, Xu H, Karkowsky W, Kaler M, Kalchiem-Dekel O, Barochia AV, Gao M, Keeran KJ, Jeffries KR, Levine SJ	Journal of Allergy and Clinical Immunology	2019
Lipids - two sides of the same coin in lung fibrosis A Mamazhakypov, RT Schermuly, L Schaefer, M Wygrecka	Cellular Signalling	2019
Apolipoprotein E is a concentration-dependent pulmonary danger signal that activates the NLRP3 inflammasome and IL-1β secretion by bronchoalveolar fluid macrophages from asthmatic subjects EM Gordon, X Yao, H Xu, W Karkowsky, M Kaler, O Kalchiem-Dekel, AV Barochia, M Gao, KJ Keeran, KR Jeffries, SJ Levine	Journal of Allergy and Clinical Immunology	2019
The APOE ε4 allele is associated with a reduction in FEV1/FVC in women: A cross-sectional analysis of the Long Life Family Study AM Kulminski, AV Barochia, Y Loika, N Raghavachari, KG Arbeev, MK Wojczynski, B Thyagarajan, BN Vardarajan, K Christensen, AI Yashin, SJ Levine, SD Ginsberg	PloS one	2018
Emerging Roles of Apolipoprotein E and Apolipoprotein A-I in the Pathogenesis and Treatment of Lung Disease X Yao, EM Gordon, DM Figueroa, AV Barochia, SJ Levine	American journal of respiratory cell and molecular biology	2016
Inhibition of Interleukin-10 Signaling Induces Microbiota-dependent Chronic Colitis in Apolipoprotein E Deficient Mice: V Singh, M Kumar, BS Yeoh, X Xiao, P Saha, MJ Kennett, M Vijay-Kumar	Inflammatory Bowel Diseases	2016
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Human apolipoprotein E allele and docosahexaenoic acid intake modulate peripheral cholesterol homeostasis in mice A Pinçon, JD Coulombe, R Chouinard-Watkins, M Plourde	The Journal of Nutritional Biochemistry	2016
Evolutionary analysis of apolipoprotein E by Maximum Likelihood and complex network methods LJ Benevides, DS de Carvalho, RF Andrade, GC Bomfim, FM de Fernandes	Genetics and molecular biology	2016
Perspective on future role of biological markers in clinical therapy trials of Alzheimer's disease: A long-range point of view beyond 2020 H Hampel, S Lista, SJ Teipel, F Garaci, R Nisticò, K Blennow, H Zetterberg, L Bertram, C Duyckaerts, H Bakardjian, A Drzezga, O Colliot, S Epelbaum, K Broich, S Lehéricy, A Brice, ZS Khachaturian, PS Aisen, B Dubois	Biochemical Pharmacology	2014
Primary genetic investigation of a hyperlipidemia model: molecular characteristics and variants of the apolipoprotein e gene in mongolian gerbil Y Liu, J Wu, Q Shi, H Guo, H Ying, N Xu	BioMed Research International	2014
Fatty Acid Metabolism in Carriers of Apolipoprotein E Epsilon 4 Allele: Is It Contributing to Higher Risk of Cognitive Decline and Coronary Heart Disease? R Chouinard-Watkins, M Plourde	Nutrients	2014
Immunoexpression of gelatinase and apolipoprotein E in induced glomerulosclerosis in adult male albino rat: AE Mansy, MA el Hamid	The Egyptian Journal of Histology	2013
Apolipoproteína E e Doença de Alzheimer D Prado, IL Cardoso	Revista Neurociências	2013
LDL Receptor Knock-Out Mice Are a Physiological Model Particularly Vulnerable to Study the Onset of Inflammation in Non-Alcoholic Fatty Liver Disease V Bieghs, PJ van Gorp, K Wouters, T Hendrikx, MJ Gijbels, M Bilsen, J Bakker, CJ Binder, D Lütjohann, B Staels, MH Hofker, R Shiri-Sverdlov, WK Syn	PloS one	2012
Cerebral amyloid β(42) deposits and microvascular pathology in ageing baboons: Brain amyloid and microvascular pathology in baboons M Ndung'u, W Härtig, F Wegner, JM Mwenda, RW Low, RO Akinyemi, RN Kalaria	Neuropathology and Applied Neurobiology	2012
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Macrophage-Specific ApoE Gene Repair Reduces Diet-Induced Hyperlipidemia and Atherosclerosis in Hypomorphic Apoe Mice N Gaudreault, N Kumar, VR Olivas, D Eberlé, JH Rapp, RL Raffai, M Lisanti	PloS one	2012
All-trans retinoic acid regulates the expression of apolipoprotein E in rats with glomerulosclerosis induced by Adriamycin TB Zhou, YH Qin, FY Lei, LN Su, YJ Zhao, WF Huang	Experimental and Molecular Pathology	2011
Cholesterol metabolism in neurons and astrocytes FW Pfrieger, N Ungerer	Progress in Lipid Research	2011
All-trans retinoic acid can regulate the expressions of gelatinases and apolipoprotein E in glomerulosclerosis rats TB Zhou, YH Qin, C Ou, FY Lei, LN Su, WF Huang, YJ Zhao	Vascular Pharmacology	2011
Lessons from genome-wide association studies findings in Alzheimer's disease : Genomics of Alzheimer's disease CF MORAES, TC LINS, EF CARMARGOS, JO NAVES, RW PEREIRA, OT NÓBREGA	Psychogeriatrics	2011
The effect of APOE genotype on brain levels of oxysterols in young and old human APOE ε2, ε3 and ε4 knock-in mice AM Jenner, WL Lim, MP Ng, MR Wenk, G Shui, MJ Sharman, SE Gandy, RN Martins	Neuroscience	2010
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The effect of aging on the immunohistochemistry of apolipoprotein E in the liver SN Hilmer, A Warren, VC Cogger, R Fraser, AJ McLean, D Sullivan, DG Couteur	Experimental Gerontology	2004
Expanding the association between theAPOEgene and the risk of Alzheimer's disease: possible roles forAPOEpromoter polymorphisms and alterations inAPOEtranscription SM Laws, E Hone, S Gandy, RN Martins	Journal of Neurochemistry	2003
Human apoE3 but not apoE4 rescues impaired astrocyte activation in apoE null mice G Ophir, S Meilin, M Efrati, J Chapman, D Karussis, A Roses, DM Michaelson	Neurobiology of Disease	2003
Essential role for the (hepatic) LDL receptor in macrophage apolipoprotein E-induced reduction in serum cholesterol levels and atherosclerosis MV Eck	Atherosclerosis	2001
Accelerated atherosclerosis in C57Bl/6 mice transplanted with ApoE-deficient bone marrow MV Eck, N Herijgers, M Vidgeon-Hart, NJ Pearce, PM Hoogerbrugge, PH Groot, TJ van Berkel	Atherosclerosis	2000
Prominent expression of the selenoprotein thioredoxin reductase in the medullary rays of the rat kidney and thioredoxin reductase mRNA variants differing at the 5' untranslated region AK Rundlöf, M Carlsten, MM Giacobini, ES Arnér	Biochemical Journal	2000
Role of macrophage-derived lipoprotein lipase in lipoprotein metabolism and atherosclerosis MV Eck, R Zimmermann, PH Groot, R Zechner, TJ van Berkel	Arteriosclerosis, thrombosis, and vascular biology	2000
Les gènes d'apolipoprotéines Régulation de leur expression A Ribeiro, JM Lacorte, P Cardot, J Chambaz	Annales de l'Institut Pasteur/Actualités	2000
Differential Gene Expression in the Initiation and Progression of Nickel-Induced Acute Lung Injury SA McDowell, K Gammon, CJ Bachurski, JS Wiest, JE Leikauf, DR Prows, GD Leikauf	American journal of respiratory cell and molecular biology	2000
Effect of Macrophage-Derived Mouse ApoE, Human ApoE3-Leiden, and Human ApoE2 (Arg158→Cys) on Cholesterol Levels and Atherosclerosis in ApoE-Deficient Mice MV Eck, N Herijgers, KW Dijk, LM Havekes, MH Hofker, PH Groot, TJ Berkel	Arteriosclerosis, thrombosis, and vascular biology	2000
Effect of Macrophage-Derived Apolipoprotein E on Established Atherosclerosis in Apolipoprotein E–Deficient Mice W Shi, X Wang, NJ Wang, WH McBride, AJ Lusis	Arteriosclerosis, thrombosis, and vascular biology	2000
Lipid and apolipoprotein concentrations in prenodal leg lymph of fasted humans: associations with plasma concentrations in normal subjects, lipoprotein lipase deficiency, and LCAT deficiency MN Nanjee, CJ Cooke, WL Olszewski, NE Miller	Journal of lipid research	2000
Specific Regional Transcription of Apolipoprotein E in Human Brain Neurons PT Xu, JR Gilbert, HL Qiu, J Ervin, TR Rothrock-Christian, C Hulette, DE Schmechel	The American Journal of Pathology	1999
Serum lipoproteins and apolipoprotein E in infants with congenital hypothyroidism TA Ciomartan, TA Uchiyama	Pediatrics International	1999
Mouse Models in the Study of Genetic Neurological Disorders B Popko		1999
Regulated turnover of a cell surface-associated pool of newly synthesized apolipoprotein E in HepG2 cells M Schmitt, T Grand-Perret	Journal of lipid research	1999
Competition of Aβ amyloid peptide and apolipoprotein E for receptor-mediated endocytosis K Winkler, H Scharnagl, U Tisljar, H Hoschützky, I Friedrich, MM Hoffmann, M Hüttinger, H Wieland, W März	Journal of lipid research	1999
Molecular mechanisms that underlie structural and functional changes atthe postsynaptic membrane duringsynaptic plasticity HV Wheal, Y Chen, J Mitchell, M Schachner, W Maerz, H Wieland, D Rossum, J Kirsch	Progress in Neurobiology	1998
Regionally specific neuronal expression of human APOE gene in transgenic mice P Xu	Neuroscience Letters	1998
Secretion of apoB- and apoA-I-containing lipoproteins by chick kidney P Tarugi, G Ballarini, B Pinotti, A Franchini, E Ottaviani, S Calandra	Journal of lipid research	1998
Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages S Fazio, VR Babaev, AB Murray, AH Hasty, KJ Carter, LA Gleaves, JB Atkinson, MF Linton	Proceedings of the National Academy of Sciences	1997
Bone Marrow Transplantation in Apolipoprotein E–Deficient Mice: Effect of ApoE Gene Dosage on Serum Lipid Concentrations, (β)VLDL Catabolism, and Atherosclerosis MV Eck, N Herijgers, J Yates, NJ Pearce, PM Hoogerbrugge, PH Groot, TJ Berkel	Arteriosclerosis, thrombosis, and vascular biology	1997
APOLIPOPROTEIN E IS ASSOCIATED WITH ISLET AMYLOID AND OTHER AMYLOIDOSES: IMPLICATIONS FOR ALZHEIMER'S DISEASE SB Chargé, MM Esiri, CA Bethune, BC Hansen, A Clark	The Journal of Pathology	1996
Murine bone marrow transplantation as a novel approach to studying the role of macrophages in lipoprotein metabolism and atherogenesis S Fazio, MR Linton	Trends in Cardiovascular Medicine	1996
Apolipoprotein E and Alzheimer’s Disease AD Roses, K Weisgraber, Y Christen		1996
Lysosomal degradation and sorting of apolipoprotein E in macrophages J Deng, V Rudick, L Dory	Journal of lipid research	1996
Treatment of severe hypercholesterolemia in apolipoprotein E-deficient mice by bone marrow transplantation WA Boisvert, J Spangenberg, LK Curtiss	Journal of Clinical Investigation	1995
Hepatic apolipoprotein and LDL receptor gene expression in the genetically hypercholesterolemic (RICO) rat C Felgines, C Sérougne, A Mazur, J Férézou, C Lutton, Y Rayssiguier	Atherosclerosis	1995
Concentrations of apolipoproten AI, AII, and E in plasma and lipoprotein fractions of alcoholic patients: Gender differences in the effects of alcohol RC Lin, BA Miller, TJ Kelly	Hepatology	1995
Cell surface “blanket” of apolipoprotein E on rat adrenocortical cells DL Williams, JS Wong, SL Wissig, RL Hamilton	Journal of lipid research	1995
Oxidative-modified and acetylated low-density lipoproteins differ in their effects on cholesterol synthesis and stimulate synthesis of apolipoprotein E in rat peritoneal macrophages by different mechanisms MY Zhang, RC Lin	Metabolism	1994
Apolipoprotein E Expression in Y1 Adrenal Cells Is Associated with Increased Intracellular Cholesterol Content and Reduced Free Cholesterol Efflux MM Prack, GH Rothblat, SK Erickson, ME Reyland, DL Williams	Biochemistry	1994
Acceleration of uptake of LDL but not chylomicrons or chylomicron remnants by cells that secrete apoE and hepatic lipase SY Choi, MC Komaromy, J Chen, LG Fong, AD Cooper	Journal of lipid research	1994
Production of cholesterol-enriched nascent high density lipoproteins by human monocyte-derived macrophages is a mechanism that contributes to macrophage cholesterol efflux HS Kruth, SI Skarlatos, PM Gaynor, W Gamble	The Journal of biological chemistry	1994
Post-transcriptional regulation of apolipoprotein E expression in mouse macrophages by phorbol ester L Dory	Biochemical Journal	1993
Cloning of a cDNA encoding a putative human very low density lipoprotein/apolipoprotein E receptor and assignment of the gene to chromosome 9pter-p23 ME Gfvels, M Caird, D Britt, CL Jackson, D Patterson, JF Strauss	Somatic Cell and Molecular Genetics	1993
A far-downstream hepatocyte-specific control region directs expression of the linked human apolipoprotein E and C-I genes in transgenic mice WS Simonet, N Bucay, SJ Lauer, JM Taylor	The Journal of biological chemistry	1993
Inhibition of apolipoprotein E degradation in a post-Golgi compartment by a cysteine protease inhibitor SQ Ye, CA Reardon, GS Getz	The Journal of biological chemistry	1993
Heparin releases newly synthesized cell surface-associated apolipoprotein E from HepG2 cells M Lilly-Stauderman, TL Brown, A Balasubramaniam, JA Harmony	Journal of lipid research	1993
Effects of Alcohol Feeding on Synthesis and Secretion of Apolipoproteins by Regenerating Rat Sciatic Nerve RC Lin, BA Miller, MH Mei, S Ochs, L Lumeng	Alcoholism, clinical and experimental research	1992
Two coding regions closely linked to the rat apolipoprotein E gene: Nucleotide sequences of rat apolipoprotein C-I and ECL cDNA P Shen, GJ Howlett	Archives of Biochemistry and Biophysics	1992
Human plasma lipoproteins regulate apolipoprotein E secretion from a post-Golgi compartment SQ Ye, LM Olson, CA Reardon, GS Getz	The Journal of biological chemistry	1992
Apolipoprotein (apo) E inhibits the capacity of monosodium urate crystals to stimulate neutrophils. Characterization of intraarticular apo E and demonstration of apo E binding to urate crystals in vivo RA Terkeltaub, CA Dyer, J Martin, LK Curtiss	Journal of Clinical Investigation	1991
Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantation MF Linton, R Gish, ST Hubl, E Bütler, C Esquivel, WI Bry, JK Boyles, MR Wardell, SG Young	Journal of Clinical Investigation	1991
Dexamethasone modulates α2-macroglobulin and apolipoprotein E gene expression in cultured rat liver fat-storing (Ito) cells G Ramadori, T Knittel, S Schwögler, F Bieber, H Rieder, KH Büschenfelde	Hepatology	1991
Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesioning J Poirier, M Hess, PC May, CE Finch	Molecular Brain Research	1991
Apolipoproteins in rat cerebrospinal fluid: A comparison with plasma lipoprotein metabolism and effect of aging H Chiba, T Mitamura, S Fujisawa, A Ogata, Y Aimoto, K Tashiro, K Kobayashi	Neuroscience Letters	1991
The effect of apo E secretion on lipoprotein uptake in transfected cells H Shimano, C Fukazawa, Y Shibasaki, N Mori, T Gotoda, K Harada, M Shimada, N Yamada, Y Yazaki, F Takaku	Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism	1991
Structure and function of lamellar bodies, lipid-protein complexes involved in storage and secretion of cellular lipids G Schmitz, G Müller	Journal of lipid research	1991
Locating a low density lipoprotein-targeting domain of human apolipoprotein B-100 by expressing a minigene construct in transgenic mice WJ Xiong, E Zsigmond, AM Gotto, KY Lei, L Chan	The Journal of biological chemistry	1991
Regulation of apolipoprotein E secretion by high density lipoprotein 3 in mouse macrophages L Dory	Journal of lipid research	1991
Only multimers of a synthetic peptide of human apolipoprotein E are biologically active CA Dyer, RS Smith, LK Curtiss	The Journal of biological chemistry	1991
Apolipoprotein E localization in rat hepatocytes by immunogold labeling of cryothin sections RL Hamilton, JS Wong, LS Guo, S Krisans, RJ Havel	Journal of lipid research	1990
In the absence of a downstream element, the apolipoprotein E gene is expressed at high levels in kidneys of transgenic mice WS Simonet, N Bucay, SJ Lauer, DO Wirak, ME Stevens, KH Weisgraber, RE Pitas, JM Taylor	The Journal of biological chemistry	1990
Changes of genetic apolipoprotein phenotypes caused by liver transplantation. Implications for apolipoprotein synthesis HG Kraft, HJ Menzel, F Hoppichler, W Vogel, G Utermann	Journal of Clinical Investigation	1989
Synthesis and Secretion of Apolipoprotein E by Cultured Human Keratinocytes DA Gordon, ES Fenjves, DL Williams, LB Taichrnan	Journal of Investigative Dermatology	1989
Fat-storing (Ito) cells of rat liver synthesize and secrete apolipoproteins: comparison with hepatocytes G Ramadori, H Rieder, F Theiss, KH Büschenfelde	Gastroenterology	1989
Relationship between serum estrogen and level of apolipoprotein E in human ovarian follicular fluid SA Brown, RV Hay, JR Schreiber	Fertility and Sterility	1989
Structure and expression of dog apolipoprotein A-I, E, and C-I mRNAs: implications for the evolution and functional constraints of apolipoprotein structure CC Luo, WH Li, L Chan	Journal of lipid research	1989
Quantification and regulation of apolipoprotein E expression in rat Kupffer cells PA Dawson, LM Lukaszewski, PF Ells, CC Malbon, DL Williams	Journal of lipid research	1989
Rat granulosa cell apolipoprotein E secretion KL Wyne, JR Schreiber, AL Larsen, GS Getz	The Journal of biological chemistry	1989
Endothelial Cell Biology in Health and Disease N Simionescu, M Simionescu		1988
Apoprotein E-rich high density lipoproteins inhibit ovarian androgen synthesis CA Dyer, LK Curtiss	The Journal of biological chemistry	1988
Macrophage free cholesterol content regulates apolipoprotein E synthesis T Mazzone, H Gump, P Diller, GS Getz	The Journal of biological chemistry	1987
Structure and expression of dog apolipoprotein C-II and C-III mRNAs. Implications for the evolution and functional constraints of apolipoprotein structure S Datta, WH Li, I Ghosh, CC Luo, L Chan	The Journal of biological chemistry	1987
Monoclonal antibodies to the low density lipoprotein receptor as probes for study of receptor-mediated endocytosis and the genetics of familial hypercholesterolemia RW Mahley	The Journal of biological chemistry	1981

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