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Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible.

J C Drapier, J B Hibbs Jr

J C Drapier, J B Hibbs Jr

Published September 1, 1986
Citation Information: J Clin Invest. 1986;78(3):790-797. https://doi.org/10.1172/JCI112642.

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Converse Modulation of IRP1 and IRP2 by Immunological Stimuli in Murine RAW 264.7 Macrophages C Bouton, L Oliveira, JC Drapier	The Journal of biological chemistry	1998
Heme and the Endothelium: EFFECTS OF NITRIC OXIDE ON CATALYTIC IRON AND HEME DEGRADATION BY HEME OXYGENASE M Juckett, Y Zheng, H Yuan, T Pastor, W Antholine, M Weber, G Vercellotti	The Journal of biological chemistry	1998
Inhibition of Protein Synthesis by Nitric Oxide Correlates with Cytostatic Activity: Nitric Oxide Induces Phosphorylation of Initiation Factor eIF-2α YM Kim, K Son, SJ Hong, A Green, JJ Chen, E Tzeng, C Hierholzer, TR Billiar	Molecular Medicine	1998
Nitric Oxide in Transplant Rejection and Anti-Tumor Defense S Lukiewicz, JL Zweier		1998
Avian macrophage metabolism RR Dietert, KA Golemboski	Poultry science	1998
The inhibition of cytochrome c oxidase by nitric oxide using S-nitrosoglutathione J Torres, N Davies, VM Darley-Usmar, MT Wilson	Journal of Inorganic Biochemistry	1997
Nicotinamide attenuates methamphetamine-induced striatal dopamine depletion in rats NK Huang, FJ Wan, CJ Tseng, CS Tung	NeuroReport	1997
Calcium-independent NO-synthase activity and nitrites/nitrates production in transient focal cerebral ischaemia in mice M Grandati, C Verrecchia, ML Revaud, M Allix, RG Boulu, M Plotkine	British Journal of Pharmacology	1997
Inhibition of Japanese encephalitis virus infection by nitric oxide: antiviral effect of nitric oxide on RNA virus replication YL Lin, YL Huang, SH Ma, CT Yeh, SY Chiou, LK Chen, CL Liao	Journal of virology	1997
Interferon (IFN)-alpha activation of human blood mononuclear cells in vitro and in vivo for nitric oxide synthase (NOS) type 2 mRNA and protein expression: possible relationship of induced NOS2 to the anti-hepatitis C effects of IFN-alpha in vivo AI Sharara, DJ Perkins, MA Misukonis, SU Chan, JA Dominitz, JB Weinberg	Journal of Experimental Medicine	1997
Growth and viability of macrophages continuously stimulated to produce nitric oxide JC Zhuang, GN Wogan	Proceedings of the National Academy of Sciences	1997
Role of nitric oxide on uterine and ovarian prostaglandin synthesis during luteolysis in the rat AB Motta, AM Franchi, MF Gimeno	Prostaglandins, Leukotrienes and Essential Fatty Acids	1997
Nitric oxide inhibits enterocyte mitochondrial phospholipase D M Madesh, KA Balasubramanian	FEBS Letters	1997
Leishmaniaspp.: Mechanisms of Toxicity of Nitrogen Oxidation Products J Mauël, A Ransijn	Experimental Parasitology	1997
Ivermectin-Induced Killing of Microfilariaein Vitroby Neutrophils Mediated by NO H Zahner, D Schmidtchen, JA Mutasa	Experimental Parasitology	1997
Leishmaniaspp.: Nitric Oxide-Mediated Metabolic Inhibition of Promastigote and Axenically Grown Amastigote Forms JL Lemesre, D Sereno, S Daulouède, B Veyret, N Brajon, P Vincendeau	Experimental Parasitology	1997
Interferon (IFN)- Activation of Human Blood Mononuclear Cells In Vitro and In Vivo for Nitric Oxide Synthase (NOS) Type 2 mRNA and Protein Expression: Possible Relationship of Induced NOS2 to the Anti-Hepatitis C Effects of IFN- In Vivo AI Sharara, DJ Perkins, MA Misukonis, SU Chan, JA Dominitz, JB Weinberg	Journal of Experimental Medicine	1997
Ca2+-Independent Permeabilization of the Inner Mitochondrial Membrane by Peroxynitrite Is Mediated by Membrane Protein Thiol Cross-Linking and Lipid Peroxidation FR Gadelha, L Thomson, MM Fagian, AD Costa, R Radi, AE Vercesi	Archives of Biochemistry and Biophysics	1997
The addition of nitric oxide to 1,5-dimethylhexa-2,4-diene; X-ray crystal structure determination of the major product, (E)-2,5-dimethyl-2,5-dinitrohex-3-ene DR Kelly, S Jones, JO Adigun, KS Koh, DE Hibbs, MB Hursthouse, SK Jackson	Tetrahedron	1997
Interplay between NO and [Fe-S] Clusters: Relevance to Biological Systems JC Drapier	Methods	1997
The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells DR Richardson, P Ponka	Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes	1997
Nitric Oxide Increases Tumor Necrosis Factor Production in Differentiated U937 Cells by Decreasing Cyclic AMP S Wang, L Yan, RA Wesley, RL Danner	The Journal of biological chemistry	1997
An EPR Investigation of the Products of the Reaction of Cytosolic and Mitochondrial Aconitases with Nitric Oxide MC Kennedy, WE Antholine, H Beinert	The Journal of biological chemistry	1997
Potential of iron chelators as effective antiproliferative agents DR Richardson	Canadian Journal of Physiology and Pharmacology	1997
Nitric Oxide Sensitivity of the Aconitases PR Gardner, G Costantino, C Szabó, AL Salzman	The Journal of biological chemistry	1997
Redox Modulation of Iron Regulatory Proteins by Peroxynitrite C Bouton, H Hirling, JC Drapier	The Journal of biological chemistry	1997
Nitric Oxide Synthases and Cardiac Muscle: Autocrine and Paracrine Influences JL Balligand, PJ Cannon	Arteriosclerosis, thrombosis, and vascular biology	1997
Expression of Inducible Nitric Oxide Synthase in Rat Experimental Autoimmune Myocarditis With Special Reference to Changes in Cardiac Hemodynamics S Hirono, MO Islam, M Nakazawa, Y Yoshida, M Kodama, A Shibata, T Izumi, S Imai	Circulation research	1997
Nitric Oxide and the Kidney MS Goligorsky, SS Gross		1997
Irreversible Inhibition of Metabolic Function and Islet Destruction after a 36-Hour Exposure to Interleukin-1β* AL Scarim, MR Heitmeier, JA Corbett	Endocrinology	1997
Sialic acids in molecular and cellular interactions S Kelm, R Schauer	International Review of Cytology	1997
NMDA Receptor antagonists prevent acute ammonia toxicity in mice C Hermenegildo, G Marcaida, C Montoliu, S Grisolía, MD Miñana, V Felipo	Neurochemical Research	1996
Immunology of murine leishmaniasis S Mcsorley, L Proudfoot, CA O'Donnell, FY Liew	Clinics in Dermatology	1996
Modulation by nitric oxide of metalloprotein regulatory activities JC Drapier, CC Bouton	BioEssays	1996
Relationship of iron to oligondendrocytes and myelination JR Connor, SL Menzies	Glia	1996
Nitric oxide and bone DM Evans, SH Ralston	Journal of Bone and Mineral Research	1996
Murine encephalitogenic lymphoid cells induce nitric oxide synthase in primary astrocytes SJ Hewett, TP Misko, RM Keeling, MM Behrens, DW Choi, AH Cross	Journal of Neuroimmunology	1996
Modification of macrophage glyceraldehyde-3-phosphate dehydrogenase in response to nitric oxide UK Meßmer, B Brüne	European Journal of Pharmacology	1996
Methods in Neurosciences V Rybin, HM Han, SF Steinberg	Methods in Neurosciences	1996
Protective effect of an inhibitor of nitric oxide synthase on sulphur mustard toxicity in vitro TW Sawyer, PM Lundy, MT Weiss	Toxicology and Applied Pharmacology	1996
Suppression of TCA cycle activity in the cardiac muscle cell by hydroperoxide-induced oxidant stress DR Janero, D Hreniuk	American journal of physiology. Cell physiology	1996
Modulation of Iron Regulatory Protein Functions: FURTHER INSIGHTS INTO THE ROLE OF NITROGEN- AND OXYGEN-DERIVED REACTIVE SPECIES C Bouton, M Raveau, JC Drapier	The Journal of biological chemistry	1996
Role of Endothelium-Derived Nitric Oxide in the Modulation of Canine Myocardial Mitochondrial Respiration In Vitro: Implications for the Development of Heart Failure YW Xie, W Shen, G Zhao, X Xu, MS Wolin, TH Hintze	Circulation research	1996
Nitric Oxide Research from Chemistry to Biology YA Henry, A Guissani, B Ducastel		1996
Control of Skeletal Muscle Blood Flow During Dynamic Exercise: Contribution of Endothelium-Derived Nitric Oxide DJ Green, G OʼDriscoll, BA Blanksby, RR Taylor	Sports Medicine	1996
Suppressor macrophages in Trypanosoma brucei infection: nitric oxide is related to both suppressive activity and lifespan in vivo NA Mabbott, IA Sutherland, JM Sternberg	Parasite Immunology	1995
Nitric-Oxide-Mediated Activation of Iron-Regulatory Protein Controls Hepatic Iron Metabolism During Acute Inflammation G Cairo, A Pietrangelo	European Journal of Biochemistry	1995
Iron: Mammalian defense systems, mechanisms of disease, and chelation therapy approaches GJ Kontoghiorghes, ED Weinberg	Blood Reviews	1995
Nitric Oxide RA Schroeder, PC Kuo	Anesthesia & Analgesia	1995
Nitric oxide as a mediator of inflammation?-You had better believe it MJ Miller, MB Grisham	Mediators of Inflammation	1995
Inhibition of viral replication by nitric oxide and its reversal by ferrous sulfate and tricarboxylic acid cycle metabolites G Karupiah, N Harris	Journal of Experimental Medicine	1995
Gamma interferon-induced, nitric oxide-mediated inhibition of vaccinia virus replication N Harris, RM Buller, G Karupiah	Journal of virology	1995
Inducible nitric oxide synthase activity and expression in a human colonic epithelial cell line, HT-29 G Kolios, Z Brown, RL Robson, DA Robertson, J Westwick	British Journal of Pharmacology	1995
Role of nitric oxide in parasitic infections SL James	Microbiological reviews	1995
Nitric oxide. Novel biology with clinical relevance TR Billiar	Annals of Surgery	1995
Inhibition of cytochrome c oxidase in turnover by nitric oxide: mechanism and implications for control of respiration J Torres, V Darley-Usmar, MT Wilson	Biochemical Journal	1995
Role of nitric oxide in cell-mediated tumor cytotoxicity MG Cifone, L Cironi, MA Meccia, P Roncaioli, C Festuccia, GD Nuntiis, S D'Aló, A Santoni	Advances in Neuroimmunology	1995
Nitrogen oxide-induced autoprotection in isolated rat hepatocytes YM Kim, H Bergonia, JR Lancaster	FEBS Letters	1995
The antiviral role of nitric oxide JB Mannick	Research in Immunology	1995
Nitric oxide: An ancestral immunocyte effector molecule A Franchini, A Conte, E Ottaviani	Advances in Neuroimmunology	1995
Neuroprotective and deleterious effects of nitric oxide on focal cerebral ischemia-induced neurone death C Verrecchia, RG Boulu, M Plotkine	Advances in Neuroimmunology	1995
Nitrogen monoxide decreases iron uptake from transferrin but does not mobilise iron from prelabelled neoplastic cells D R Richardson, V Neumannova, P Ponka	Biochimica et Biophysica Acta	1995
Impact of nitric oxide on macrophage glucose metabolism and glyceraldehyde-3-phosphate dehydrogenase activity RB Mateo, JS Reichner, B Mastrofrancesco, D Kraft-Stolar, JE Albina	American journal of physiology. Cell physiology	1995
Nitric Oxide: An Important Signaling Mechanism Between Vascular Endothelium and Parenchymal Cells in the Regulation of Oxygen Consumption W Shen, TH Hintze, MS Wolin	Circulation	1995
Role of Nitric Oxide in Sepsis and ADRS MP Fink, D Payen		1995
Chirurgisches Forum ’95 für experimentelle und klinische Forschung HG Beger, G Hierholzer, J Seifert, W Hartel		1995
The Role of Nitric Oxide in Physiology and Pathophysiology H Koprowski, H Maeda		1995
Biochemical, Pharmacological, and Clinical Aspects of Nitric Oxide BA Weissman, N Allon, S Shapira		1995
Apoptosis in Immunology G Kroemer, C Martinez-A.		1995
New Approaches to the Prevention of Atherosclerosis: M Naito, T Hayashi, A Iguchi	Drugs	1995
Selective potentiation of NMDA-induced neuronal injury following induction of astrocytic iNOS SI Hewett, CA Csernansky, DW Choi	Neuron	1994
From Apoptosis to Autoimmunity: Insights from the Signaling Pathways Leading to Proliferation or to Programmed Cell Death E Baixeras, L Bosca, C Stauber, A Gonzalez, AC Carrera, JA Gonzalo, C Martinez-A	Immunological Reviews	1994
Assembly and regulation of NADPH oxidase and nitric oxide synthase NR Bastian, JB Hibbs	Current Opinion in Immunology	1994
THE INDUCIBLE FORM OF NITRIC OXIDE SYNTHASE (NOS2) ISOLATED FROM MURINE MACROPHAGES MAPS NEAR THE NUDE MUTATION ON MOUSE CHROMOSOME 11 BA Mock, MM Krall, LG Byrd, H Chin, CH Barton, I Charles, FY Liew, J Blackwell	European Journal of Immunogenetics	1994
Abrogation of gamma interferon-induced inhibition of Ehrlichia chaffeensis infection in human monocytes with iron-transferrin RE Barnewall, Y Rikihisa	Infection and immunity	1994
Antihistoplasma effect of activated mouse splenic macrophages involves production of reactive nitrogen intermediates TE Lane, BA Wu-Hsieh, DH Howard	Infection and immunity	1994
Role of nitric oxide in eicosanoid synthesis and uterine motility in estrogen-treated rat uteri AM Franchi, M Chaud, V Rettori, A Suburo, SM McCann, M Gimeno	Proceedings of the National Academy of Sciences	1994
The iron-responsive element binding protein: a target for synaptic actions of nitric oxide SR Jaffrey, NA Cohen, TA Rouault, RD Klausner, SH Snyder	Proceedings of the National Academy of Sciences	1994
Reversibility of interleukin-1 beta-induced islet destruction and dysfunction by the inhibition of nitric oxide synthase JA Corbett, ML McDaniel	Biochemical Journal	1994
Mutational analysis of the [4Fe-4S]-cluster converting iron regulatory factor from its RNA-binding form to cytoplasmic aconitase H Hirling, BR Henderson, LC Kühn	The EMBO Journal	1994
Nitric oxide: A signal for ADP-ribosylation of proteins B Brüne, S Dimmeler, LM Vedia, EG Lapetina	Life Sciences	1994
Advances in Pharmacology B Drenger, Y Ginosar, Y Gozal	Advances in Pharmacology	1994
Elevated temperature accelerates and amplifies the induction of nitric oxide synthesis in rat macrophages C Bernard, R Merval, B Esposito, A Tedgui	European Journal of Pharmacology: Environmental Toxicology and Pharmacology	1994
p53 expression in nitric oxide-induced apoptosis UK Meßmer, M Ankarcrona, P Nicotera, B Brüne	FEBS Letters	1994
Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide MW Cleeter, JM Cooper, VM Darley-Usmar, S Moncada, AH Schapira	FEBS Letters	1994
Modulation of glyceraldehyde-3-phosphate dehydrogenase in Salmonella abortus equi lipopolysaccharide-treated mice S Dimmeler, UK Meßmer, G Tiegs, B Brüne	European Journal of Pharmacology: Molecular Pharmacology	1994
Endotoxin-stimulated alveolar macrophages impair lung epithelial Na+ transport by an L-Arg-dependent mechanism CG Compeau, OD Rotstein, H Tohda, Y Marunaka, B Rafii, AS Slutsky, H O'Brodovich	American journal of physiology. Cell physiology	1994
Modualation of inducible nitric oxide synthase in RINm5F cells UK Meβmer, B Brüne	Cellular Signalling	1994
Nω-monomethyl-l-arginine inhibits nitric oxide production in murine cardiac allografts but does not affect graft rejection NR Bastian, S Xu, XL Shao, J Shelby, DL Granger, JB Hibbs	Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease	1994
Is NO an endogenous antiatherogenic molecule? JP Cooke, PS Tsao	Arteriosclerosis Thrombosis and Vascular Biology	1994
Role of nitric oxide in the regulation of oxygen consumption in conscious dogs W Shen, X Xu, M Ochoa, G Zhao, MS Wolin, TH Hintze	Circulation research	1994
Progress in Iron Research C Hershko, AM Konijn, P Aisen		1994
Cell Signal Transduction, Second Messengers, and Protein Phosphorylation in Health and Disease AM Municio, MT Miras-Portugal		1994
Nitric Oxide Activation of Poly(ADP-Ribose) Synthetase in Neurotoxicity J Zhang, VL Dawson, TM Dawson, SH Snyder	Science	1994
Iron regulates cytoplasmic levels of a novel iron-responsive element-binding protein without aconitase activity B Guo, Y Yu, EA Leibold	The Journal of biological chemistry	1994
Induction of iron-derived EPR signals in murine cancers by nitric oxide. Evidence for multiple intracellular targets NR Bastian, CY Yim, JB Hibbs, WE Samlowski	The Journal of biological chemistry	1994
Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide L Castro, M Rodriguez, R Radi	The Journal of biological chemistry	1994
Quenching of the tyrosyl free radical of ribonucleotide reductase by nitric oxide. Relationship to cytostasis induced in tumor cells by cytotoxic macrophages M Lepoivre, JM Flaman, P Bobé, G Lemaire, Y Henry	The Journal of biological chemistry	1994
Biosynthesis of nitric oxide activates iron regulatory factor in macrophages JC Drapier, H Hirling, J Wietzerbin, P Kaldy, LC Kühn	The EMBO Journal	1993
Iron regulatory factor expressed from recombinant baculovirus: conversion between the RNA-binding apoprotein and Fe-S cluster containing aconitase A Emery-Goodman, H Hirling, L Scarpellino, B Henderson, LC Kühn	Nucleic Acids Research	1993
Gamma interferon cooperates with lipopolysaccharide to activate mouse splenic macrophages to an antihistoplasma state TE Lane, BA Wu-Hsieh, DH Howard	Infection and immunity	1993
Neutralization of gamma interferon and tumor necrosis factor alpha blocks in vivo synthesis of nitrogen oxides from L-arginine and protection against Francisella tularensis infection in Mycobacterium bovis BCG-treated mice SJ Green, CA Nacy, RD Schreiber, DL Granger, RM Crawford, MS Meltzer, AH Fortier	Infection and immunity	1993
Gamma interferon-induced nitric oxide production reduces Chlamydia trachomatis infectivity in McCoy cells J Mayer, ML Woods, Z Vavrin, JB Hibbs	Infection and immunity	1993
Pronounced enhancement of .NO-dependent antimicrobial action by an .NO-oxidizing agent, imidazolineoxyl N-oxide K Yoshida, T Akaike, T Doi, K Sato, S Ijiri, M Suga, M Ando, H Maeda	Infection and immunity	1993
Translational regulation via iron-responsive elements by the nitric oxide/NO-synthase pathway G Weiss, B Goossen, W Doppler, D Fuchs, K Pantopoulos, G Werner-Felmayer, H Wachter, MW Hentze	The EMBO Journal	1993
Nitric oxide is a mediator of the decrease in cytochrome P450-dependent metabolism caused by immunostimulants OG Khatsenko, SS Gross, AB Rifkind, JR Vane	Proceedings of the National Academy of Sciences	1993
Neuronal toxicity by macrophages in mixed brain cell culture is augmented by antineuronal IgG and dependent upon nitric oxide synthesis RH Fabian, HC Rea	Journal of Neuroimmunology	1993
Reaction of nitric oxide with hydrogen peroxide to produce potentially cytotoxic singlet oxygen as a model for nitric oxide-mediated killing AA Noronha-Dutra, MM Epperlein, N Woolf	FEBS Letters	1993
Nitric oxide preferentially stimulates auto-ADP-ribosylation of glyceraldehyde-3-phosphate dehydrogenase compared to alcohol or lactate dehydrogenase S Dimmeler, B Brüne	FEBS Letters	1993
Pancreatic islet cells are highly susceptible towards the cytotoxic effects of chemically generated nitric oxide KD Kröncke, HH Brenner, ML Rodriguez, K Etzkorn, EA Noack, H Kolb, V Kolb-Bachofen	Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease	1993
Nutrition and Immunology DM Klurfeld		1993
Cytotoxicity of activated rat macrophages against syngeneic islet cells is arginine-dependent, correlates with citrulline and nitrite concentrations and is identical to lysis by the nitric oxide donor nitroprusside , , H Kolb, V Kolb-Bachofen	Diabetologia	1993
Cytotoxic Cells: Recognition, Effector Function, Generation, and Methods MV Sitkovsky, PA Henkart		1993
Iron in Central Nervous System Disorders P Riederer, MB Youdim		1993
The immunologic insult in type 1 diabetes MC Honeyman, LC Harrison	Springer Seminars in Immunopathology	1993
Nitric oxide, an endothelial cell relaxation factor, inhibits neutrophil superoxide anion production via a direct action on the NADPH oxidase RM Clancy, J Leszczynska-Piziak, SB Abramson	Journal of Clinical Investigation	1992
Interleukin 1 beta induces the formation of nitric oxide by beta-cells purified from rodent islets of Langerhans. Evidence for the beta-cell as a source and site of action of nitric oxide JA Corbett, JL Wang, MA Sweetland, JR Lancaster, ML McDaniel	Journal of Clinical Investigation	1992
A novel neuronal messenger molecule in brain: The free radical, nitric oxide TM Dawson, VL Dawson, SH Snyder	Annals of Neurology	1992
Immunomodulatory agents in the laboratory and clinic AK Nüssler, AW Thomson	Parasitology	1992
Neutrophils, Nitrogen Oxides, and Inflammatory Bowel Disease MB Grisham, T Yamada	Annals of the New York Academy of Sciences	1992
Ferritin as a source of iron for oxidative damage DW Reif	Free radical biology & medicine	1992
Protective effects of inhibitors of nitric oxide synthase in immune complex-induced vasculitis MS Mulligan, S Moncada, PA Ward	British Journal of Pharmacology	1992
Extracellular superoxide dismutase, nitric oxide, and central nervous system O2 toxicity TD Oury, YS Ho, CA Piantadosi, JD Crapo	Proceedings of the National Academy of Sciences	1992
Macrophage activation for intracellular killing as induced by a Ca2+ ionophore. Dependence on L-arginine-derived nitrogen oxidation products Y Buchmüller-Rouiller, SB Corradin, J Mauël	Biochemical Journal	1992
Nitric oxide and cyclic GMP formation induced by interleukin 1 beta in islets of Langerhans. Evidence for an effector role of nitric oxide in islet dysfunction JA Corbett, JL Wang, JH Hughes, BA Wolf, MA Sweetland, JR Lancaster, ML McDaniel	Biochemical Journal	1992
L-arginine-dependent killing of intracellular Ehrlichia risticii by macrophages treated with gamma interferon J Park, Y Rikihisa	Infection and immunity	1992
Iron depletion: A defense against intracellular infection and neoplasia ED Weinberg	Life Sciences	1992
Lipopolysaccharide and cytokines induce a macrophage-type of nitric oxide synthase in bovine retinal pigmented epithelial cells O Goureau, M Lepoivre, Y Courtois	Biochemical and Biophysical Research Communications	1992
Activated mouse macrophages kill Entamoeba histoloytica trophozoites by releasing reactive nitrogen intermediates M Denis, E Ghadirian	Microbial Pathogenesis	1992
Inverse relation in the de novo arginase synthesis and nitric oxide production in murine and rat peritoneal macrophages in long-term cultures in vitro A Hrabák, Temesi, I Csuka, F Antoni	Comparative Biochemistry and Physiology Part B: Comparative Biochemistry	1992
Interferon-gamma and tumor necrosis factor synergize to induce nitric oxide production and inhibit mitochondrial respiration in vascular smooth muscle cells Y Geng, GK Hansson, E Holme	Circulation research	1992
Mononuclear Phagocytes R van Furth		1992
Early loss of the tyrosyl radical in ribonucleotide reductase of adenocarcinoma cells producing nitric oxide M Lepoivre, JM Flaman, Y Henry	The Journal of biological chemistry	1992
Nitric oxide causes ADP-ribosylation and inhibition of glyceraldehyde-3-phosphate dehydrogenase S Dimmeler, F Lottspeich, B Brüne	The Journal of biological chemistry	1992
Roles of iron in neoplasia: Promotion, prevention, and therapy ED Weinberg	Biological Trace Element Research	1992
Leber's hereditary optic neuropathy and complex I deficiency in muscle NG Larsson, O Andersen, E Holme, A Oldfors, J Wahlstr�m	Annals of Neurology	1991
Role of nitric oxide synthesis in macrophage antimicrobial activity CF Nathan, JB Hibbs	Current Opinion in Immunology	1991
Nitric oxide derived from L-arginine impairs cytoplasmic pH regulation by vacuolar-type H+ ATPases in peritoneal macrophages CJ Swallow, S Grinstein, RA Sudsbury, OD Rotstein	Journal of Experimental Medicine	1991
Role of inorganic nitrogen oxides and tumor necrosis factor alpha in killing Leishmania donovani amastigotes in gamma interferon-lipopolysaccharide-activated macrophages from Lshs and Lshr congenic mouse strains TI Roach, AF Kiderlen, JM Blackwell	Infection and immunity	1991
Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide NS Kwon, DJ Stuehr, CF Nathan	Journal of Experimental Medicine	1991
Genetic regulation of macrophage priming/activation: the Lsh gene story JM Blackwell, TI Roach, SE Atkinson, JW Ajioka, CH Barton, MA Shaw	Immunology Letters	1991
International Review of Cytology RA Miller	International Review of Cytology	1991
Nitric oxide and host defence RG Kilbourn	Research in Immunology	1991
Synthesis of nitric oxide from L-arginine: a recently discovered pathway induced by cytokines with antitumour and antimicrobial activity JB Hibbs	Research in Immunology	1991
Cytokines that regulate macrophage production of nitrogen oxides and expression of antileishmanial activities CA Nacy, BJ Nelson, MS Meltzer, SJ Green	Research in Immunology	1991
Antiproliferative effects of NO synthase products M Lepoivre, K Raddassi, I Oswald, JP Tenu, G Lemaire	Research in Immunology	1991
Alteration of physiological activity of activated macrophages through L-arginine metabolism M Takema, K Inaba, K Okazaki, K Uno, K Tawara, S Muramatsu	Japanese journal of cancer research : Gann	1991
Molecular Aspects of Inflammation H Sies, L Flohé, G Zimmer		1991
Interleukin-1 beta-induced formation of EPR-detectable iron-nitrosyl complexes in islets of Langerhans. Role of nitric oxide in interleukin-1 beta-induced inhibition of insulin secretion JA Corbett, JR Lancaster, MA Sweetland, ML McDaniel	The Journal of biological chemistry	1991
Generation of EPR-detectable nitrosyl-iron complexes in tumor target cells cocultured with activated macrophages JC Drapier, C Pellat, Y Henry	The Journal of biological chemistry	1991
Nitric oxide, a biological effector: Electron paramagnetic resonance detection of nitrosyl-iron-protein complexes in whole cells Y Henry, C Ducrocq, JC Drapier, D Servent, C Pellat, A Guissani	European Biophysics Journal	1991
Alteration of Physiological Activity of Activated Macrophages through L‐Arginine Metabolism Takema M, Inaba K, Okazaki K, Uno K, Tawara K, Muramatsu S	Japanese journal of cancer research : Gann	1991
Metabolic fate of L-arginine in relation to microbiostatic capability of murine macrophages DL Granger, JB Hibbs, JR Perfect, DT Durack	Journal of Clinical Investigation	1990
Mechanisms of macrophage-mediated tumor cell killing: A comparative analysis of the roles of reactive nitrogen intermediates and tumor necrosis factor R Keller, R Keist, A Wechsler, TP Leist, PH van der Meide	International Journal of Cancer	1990
EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages JR Lancaster, JB Hibbs	Proceedings of the National Academy of Sciences	1990
Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts G Werner-Felmayer, ER Werner, D Fuchs, A Hausen, G Reibnegger, H Wachter	Journal of Experimental Medicine	1990
Cellular mechanisms of nonspecific immunity to intracellular infection: Cytokine-induced synthesis of toxic nitrogen oxides from l-arginine by macrophages and hepatocytes SJ Green, S Mellouk, SL Hoffman, MS Meltzer, CA Nacy	Immunology Letters	1990
FAD and GSH participate in macrophage synthesis of nitric oxide DJ Stuehr, NS Kwon, CF Nathan	Biochemical and Biophysical Research Communications	1990
IFN-γ-activated macrophages: Detection by electron paramagnetic resonance of complexes between L-Arginine-derived nitric oxide and non-heme iron proteins C Pellat, Y Henry, JC Drapier	Biochemical and Biophysical Research Communications	1990
Macrophage and endothelial cell nitric oxide synthesis: Cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine SS Gross, DJ Stuehr, K Aisaka, EA Jaffe, R Levi, OW Griffith	Biochemical and Biophysical Research Communications	1990
Nitric oxide mediates iron release from ferritin DW Reif, RD Simmons	Archives of Biochemistry and Biophysics	1990
The role of nitrogen oxides as effector molecules of parasite killing SL James, JB Hibbs	Parasitology Today	1990
Cellular Iron Metabolism in Health and Diseased ED Weinberg	Drug Metabolism Reviews	1990
Alterations of ribonucleotide reductase activity following induction of the nitrite-generating pathway in adenocarcinoma cells M Lepoivre, B Chenais, A Yapo, G Lemaire, L Thelander, JP Tenu	The Journal of biological chemistry	1990
Current concepts in Cryptococcosis TF Patterson, VT Andriole	European Journal of Clinical Microbiology & Infectious Diseases	1989
Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells DJ Stuehr, CF Nathan	Journal of Experimental Medicine	1989
Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide DJ Stuehr, SS Gross, I Sakuma, R Levi, CF Nathan	Journal of Experimental Medicine	1989
An L-arginine-dependent mechanism mediates Kupffer cell inhibition of hepatocyte protein synthesis in vitro TR Billiar, RD Curran, DJ Stuehr, MA West, BG Bentz, RL Simmons	Journal of Experimental Medicine	1989
L-Arginine independent macrophage tumor cytotoxicity J Klostergaard, ME Leroux	Biochemical and Biophysical Research Communications	1989
Specific amino acid (L-arginine) requirement for the microbiostatic activity of murine macrophages DL Granger, JB Hibbs, JR Perfect, DT Durack	Journal of Clinical Investigation	1988
Interferon-γ and tumor necrosis factor induce the L-arginine-dependent cytotoxic effector mechanism in murine macrophages* JC Drapier, J Wietzerbin, JB Hibbs	European Journal of Immunology	1988
Nitric oxide: A cytotoxic activated macrophage effector molecule JB Hibbs, RR Taintor, Z Vavrin, EM Rachlin	Biochemical and Biophysical Research Communications	1988
Effects of inhibitors of tumoricidal activity upon schistosomulum killing by activated macrophages SL James, JA Glaven	Infection and immunity	1987
Macrophage Cytotoxicity: Role for L-Arginine Deiminase and Imino Nitrogen Oxidation to Nitrite JB Hibbs, RR Taintor, Z Vavrin	Science	1987

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