Citations to this article

Suppressor and cytolytic cell function in multiple sclerosis. Effects of cyclosporine A and interleukin 2.
M B Bania, … , M K Nicholas, B G Arnason
M B Bania, … , M K Nicholas, B G Arnason
Published August 1, 1986
Citation Information: J Clin Invest. 1986;78(2):582-586. https://doi.org/10.1172/JCI112612.
View: Text | PDF
Research Article

Suppressor and cytolytic cell function in multiple sclerosis. Effects of cyclosporine A and interleukin 2.

Abstract

Patients with progressive multiple sclerosis (MS) demonstrated persistent reductions in levels of concanavalin A (Con A)-induced suppressor activity and heightened levels of in vitro pokeweed mitogen (PWM)-induced IgG secretion. The reduced Con A suppressor activity could not be reversed by addition of interleukin 2 (IL-2). Cyclosporine A (CsA) treatment did not alter the defect in Con A-induced suppressor activity, but did markedly inhibit T8+ cell-mediated alloantigen directed cytolytic activity; this latter defect was reversible by in vitro addition of IL-2. CsA-treated patients did not differ from placebo-treated patients with regard to levels of PWM-induced IgG secretion or proliferative responses of their mononuclear cells to Con A. The results indicate that CsA treatment of MS patients reduces cytolytic function from baseline normal values, but does not alter aberrant suppressor cell function.

Authors

M B Bania, J P Antel, A T Reder, M K Nicholas, B G Arnason

×

Total citations by year

Year: 2016 2015 2014 2011 2010 2009 2008 1999 1991 1990 1989 1988 Total
Citations: 1 1 1 1 1 1 2 1 2 1 2 5 19
Citation information

Citations to this article (19)

Title and authors Publication Year
Treatment of Multiple Sclerosis
M Nadeem, O Mufti, I Ahsan, R Naheed, SM Faheem 		Neuroscience and medicine 2016
CD8+ T-Cells as Immune Regulators of Multiple Sclerosis
S Sinha, AW Boyden, FR Itani, MP Crawford, NJ Karandikar 		Frontiers in immunology 2015
Immune regulation of multiple sclerosis by CD8+ T cells
S Sinha, FR Itani, NJ Karandikar 		Immunologic Research 2014
Role of CD8 T cell subsets in the pathogenesis of multiple sclerosis
A Saxena, G Martin-Blondel, LT Mars, RS Liblau 		FEBS Letters 2011
Exploring the roles of CD8+ T lymphocytes in the pathogenesis of autoimmune demyelination
TA Johnson, FR Jirik, S Fournier 		Seminars in Immunopathology 2010
Pathogenic CD8+T cells in multiple sclerosis
MA Friese, L Fugger 		Annals of Neurology 2009
Isolation and characterization of CD8+ regulatory T cells in multiple sclerosis
J Correale, A Villa 		Journal of Neuroimmunology 2008
The role of CD8 suppressors versus destructors in autoimmune central nervous system inflammation
AL Zozulya, H Wiendl 		Human Immunology 2008
Interferon-? secretion by peripheral blood T-cell subsets in multiple sclerosis: Correlation with disease phase and interferon-? therapy
B Becher, PS Giacomini, D Pelletier, E McCrea, A Prat, JP Antel 		Annals of Neurology 1999
CD21+ (B2 antigen+) cell decrement and CD4+ CD29+ (helper-inducer) cell increment suggest an activation of cell immune reactivity in multiple sclerosis
D Gambi, AM Porrini, A Giampietro, S Macor 		Journal of Neuroimmunology 1991
Phenotypic and functional characteristics of activated CD8+ cells: A CD11b−CD28− subset mediates noncytolytic functional suppression
MS Freedman, TC Ruijs, M Blain, JP Antel 		Clinical Immunology and Immunopathology 1991
Serial studies of serum interleukin-2 in chronic progressive multiple sclerosis patients: occurrence of ‘bursts’ and effect of cyclosporine
JL Trotter, RC van der Veen, DB Clifford 		Journal of Neuroimmunology 1990
Activated suppressor cell function in severely disabled patients with multiple sclerosis
JP Antel, MS Freedman, S Brodovsky, GS Francis, P Duquette 		Annals of Neurology 1989
Correlation of immunological studies and disease progression in chronic progressive multiple sclerosis
JL Trotter, DB Clifford, JE McLnnis, RC Griffeth, KA Bruns, MS Perlmutter, CB Anderson, KG Collins, G Banks, BC Hicks 		Annals of Neurology 1989
Immunoregulatory circuits in multiple sclerosis: Is there a ?short??
MS Freeman, JP Antel 		Annals of Neurology 1988
Immunoregulation in Rapidly Progressive Multiple Sclerosis
BG Arnason, AB Noronha, AT Reder 		Annals of the New York Academy of Sciences 1988
Serial immune evaluation of cyclosporine- and placebo-treated multiple sclerosis patients
RH Kerman, JS Wolinsky, A Nath, ES Sears 		Journal of Neuroimmunology 1988
Hypertension in cyclosporine-treated renal transplant recipients is sodium dependent
JJ Curtis, RG Luke, P Jones, AG Diethelm 		The American Journal of Medicine 1988
Virology and Immunology in Multiple Sclerosis: Rationale for Therapy
CL Cazzullo, D Caputo, A Ghezzi, M Zaffaroni 		1988

Advertisement