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Citations to this article

Use of alpha 2 adrenoreceptor agonists and antagonists in the functional assessment of the sympathetic nervous system.
D Robertson, … , A S Hollister, R M Robertson
D Robertson, … , A S Hollister, R M Robertson
Published August 1, 1986
Citation Information: J Clin Invest. 1986;78(2):576-581. https://doi.org/10.1172/JCI112611.
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Research Article

Use of alpha 2 adrenoreceptor agonists and antagonists in the functional assessment of the sympathetic nervous system.

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Abstract

We studied the effects of clonidine, an alpha 2-adrenoreceptor agonist, and yohimbine, an alpha 2-adrenoreceptor antagonist, on blood pressure, heart rate, and plasma catecholamines in 12 patients with autonomic dysfunction. Clonidine (0.1 mg, orally) lowered blood pressure 18 +/- 3 torr in six subjects and raised it 5 +/- 1 torr in six. The change in blood pressure in response to this dose of clonidine was inversely proportional to the supine level of norepinephrine (P less than 0.05). Yohimbine (4-64 micrograms/kg) raised plasma norepinephrine and blood pressure in six patients with degenerative autonomic dysfunction. Yohimbine also attenuated by 50% (P less than 0.05) the hypotensive response to head-up tilt of patients with degenerative autonomic dysfunction. Clonidine depends upon postjunctional hypersensitivity and the degree of autonomic insufficiency to elicit its pressor response. In contrast, the pressor response to yohimbine is related to the capacity of the sympathetic nervous system to be activated and release norepinephrine. If plasma norepinephrine levels following yohimbine administration are monitored, the biochemical and hemodynamic response to the drug may provide a sensitive indication of the capacity of the sympathetic nervous system to be activated in patients with autonomic dysfunction.

Authors

D Robertson, M R Goldberg, C S Tung, A S Hollister, R M Robertson

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Total citations by year

Year: 2023 2018 2017 2016 2015 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1997 1996 1995 1994 1992 1991 1990 1989 Total
Citations: 1 1 1 1 1 3 2 3 1 1 1 4 2 1 2 5 2 2 2 2 2 2 5 2 4 1 1 55
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2010 (3)

Title and authors Publication Year
Catecholamines 101
DS Goldstein
Clinical Autonomic Research 2010
A Novel Pharmacological Approach to Determining Parasympathetic Heart Rate Reserve in Human Subjects
J Tank, K Heusser, A Diedrich, FC Luft, J Jordan
Clinical Pharmacology & Therapeutics 2010
Neurocardiology: Therapeutic Implications for Cardiovascular Disease: Neurocardiology
DS Goldstein
Cardiovascular Therapeutics 2010

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