Human polymorphonuclear neutrophils rapidly incorporated radiolabeled platelet-activating factor, 1-O-[hexadecyl-9, 10-3H2]-2-acetyl-sn-glycero-3-phosphocholine ([3H]PAF), and then metabolized it into its sn-2-fatty acyl derivative. Fractionation of radiolabel-pretreated cells over Percoll gradients revealed that virtually all of the intact [3H]PAF was located in nongranule membranes that were enriched with alkaline phosphatase and cell surface glycoproteins. While still membrane associated, the ligand was rapidly converted to its acyl derivative and then more slowly transferred to specific granules and, to a lesser extent, azurophilic granules. In contrast, neutrophils did not metabolize [3H]PAF at 4 degrees C but rather gradually accumulated it in their alkaline phosphatase-enriched membrane subfractions. These same subfractions contained receptors for the ligand, as determined by their capacity to bind [3H]PAF specifically. Binding was readily saturated, partially reversible, and fit a two receptor model; dissociation constant (Kd) values for high and low affinity sites were 0.2 and 500 nM, respectively. Receptors with similar affinities were detected in whole cells. Furthermore, the potencies of several structural analogues in inhibiting binding of [3H]PAF to membranes correlated closely with their respective potencies in stimulating degranulation responses. Finally, quantitative studies suggested all or most of the cell's receptors were membrane associated. We conclude that PAF rapidly enters cellular membranes to bind with specific receptors that trigger function. The intramembranous ligand is also deacetylated, acylated, and then transferred to granules. This metabolism may be sufficiently rapid to limit ligand-receptor binding and distort quantitative analyses of receptors.
J T O'Flaherty, J R Surles, J Redman, D Jacobson, C Piantadosi, R L Wykle
Title and authors | Publication | Year |
---|---|---|
Effect of acyl and alkyl analogs of platelet-activating factor on inflammatory signaling
GK Marathe, VH Chaithra, LY Ke, CH Chen |
Prostaglandins & Other Lipid Mediators | 2020 |
Annual Reports in Medicinal Chemistry
JJ Liu, TW Lee |
Annual Reports in Medicinal Chemistry Volume 46 | 2011 |
Kinetic and thermodynamic analyses of adhesion of a peptide, Trp-Lys-Tyr-Met-Val-D-Met (WKYMVm), and human formyl peptide receptor (hFPR)
JH Cho, K Cho, HS Shin |
Biotechnology Letters | 2010 |
Tumor necrosis factor-α causes release of cytosolic interleukin-18 from human neutrophils
CC Silliman, MR Kelher, F Gamboni-Robertson, C Hamiel, KM England, CA Dinarello, TH Wyman, SY Khan, NJ McLaughlin, RS Bercovitz, A Banerjee |
American journal of physiology. Cell physiology | 2010 |
Platelet activating factor stimulates arachidonic acid release in differentiated keratinocytes via arachidonyl non-selective phospholipase A2
KM Jørgensen, HS Felberg, RK Berge, A Laegreid, B Johansen |
Archives of Dermatological Research | 2009 |
Tumor necrosis factor-alpha causes release of cytosolic interleukin-18 from human neutrophils
CC Silliman, MR Kelher, F Gamboni-Robertson, C Hamiel, KM England, CA Dinarello, TH Wyman, SY Khan, NJ McLaughlin, RS Bercovitz, A Banerjee |
American journal of physiology. Cell physiology | 2009 |
Mechanisms underlying the nociceptive responses induced by platelet-activating factor (PAF) in the rat paw
DM Marotta, R Costa, EM Motta, ES Fernandes, R Medeiros, NL Quintão, MM Campos, JB Calixto |
Biochemical Pharmacology | 2009 |
Sepsis
JM O’Brien, NA Ali, SK Aberegg, E Abraham |
The American Journal of Medicine | 2007 |
Ginkgolide B stimulates signaling events in neutrophils and primes defense activities
M Lenoir, O Muntaner, E Pedruzzi, M Roch-Arveiller, M Tissot, K Drieu, A Périanin |
Biochemical and Biophysical Research Communications | 2005 |
Stress-induced platelet-activating factor synthesis in human neutrophils
JS Owen, PR Baker, JT O'Flaherty, MJ Thomas, MP Samuel, RE Wooten, RL Wykle |
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2005 |
Determination of specific receptor sites for platelet activating factor in bovine neutrophils
RA Burgos, MA Hidalgo, SM Matthei, R Hermosilla, H Folch, JL Hancke |
American Journal of Veterinary Research | 2004 |
Activation of extracellular signal-regulated kinase couples platelet-activating factor-induced adhesion and delayed apoptosis of human neutrophils
T Khreiss, L József, JS Chan, JG Filep |
Cellular Signalling | 2004 |
Sensitization of human neutrophil defense activities through activation of platelet-activating factor receptors by ginkgolide B, a bioactive component of the Ginkgo biloba extract EGB 761
M Lenoir, E Pedruzzi, S Rais, K Drieu, A Perianin |
Biochemical Pharmacology | 2002 |
Evidence for the involvement of the NADPH Oxidase enzyme complex in the optimal accumulation of Platelet-activating factor in the human cell line PLB-985
TS Hiran, MC Dinauer, C Johnson, KL Clay, JB Travers |
Prostaglandins & Other Lipid Mediators | 2001 |
Airway receptors
J Widdicombe |
Respiration Physiology | 2001 |
Role of Platelet-Activating Factor in Cardiovascular Pathophysiology
G Montrucchio, G Alloatti, G Camussi |
Physiological reviews | 2000 |
Platelet-Activating Factor Antagonists: Current Status in Asthma
FP Gomez, R Rodriguez-Roisin |
BioDrugs | 2000 |
Integrin-dependent homotypic adhesion of neutrophils. Arachidonic acid activates Raf-1/Mek/Erk via a 5-lipoxygenase- dependent pathway
C Capodici, MH Pillinger, G Han, MR Philips, G Weissmann |
Journal of Clinical Investigation | 1998 |
Continuous binding of the PAF molecule to its receptor is necessary for the long-term aggregation of platelets
M Suzuki, J Sugatani, M Ino, M Shimura, M Akiyama, R Yamazaki, Y Suzuki, M Miwa |
American journal of physiology. Cell physiology | 1998 |
Enhancement of leukotriene B4 release in stimulated asthmatic neutrophils by platelet activating factor
K Shindo, K Koide, M Fukumura |
Thorax | 1997 |
PAF-Induced Eosinophil Chemotaxis Increases during an Asthmatic Attack and Is Inhibited by Prednisolonein Vivoandin Vitro
K Shindo, K Koide, M Fukumura |
Biochemical and Biophysical Research Communications | 1997 |
A Sulphonoglycolipid from the Fern Polypodium decumanum and its Effect on the Platelet Activating-factor Receptor in Human Neutrophils
M Vasänge, W Rolfsen, L Bohlin |
Journal of Pharmacy and Pharmacology | 1997 |
Evidence for platelet-activating factor receptor subtypes on human polymorphonuclear leukocyte membranes
TD LeVan, SB Dow, PB Chase, JW Bloom, JW Regan, E Cunningham, M Halonen |
Biochemical Pharmacology | 1997 |
Comparison of PAF- and fMLP-induced [Ca2+]i transients in human polymorphonuclear leukocytes
D Nowak, P Bialasiewicz, A Antczak, M Krol, G Piasecka |
Journal of Lipid Mediators and Cell Signalling | 1996 |
Protein kinase C inhibitors and PAF stimulate phosphatidylserine synthesis in human leucocytes
B Bleivik, LR White, KS Bjerve |
Journal of Lipid Mediators and Cell Signalling | 1996 |
Characterization of [3H]apafant binding to PAF receptor on rabbit platelet membranes: A comparison of a Microplate Filtration System and a standard method
D Balsa, M Merlos, M Giral, R Ferrando, J García-Rafanell, J Forn |
Journal of Pharmacological and Toxicological Methods | 1996 |
Intensive Care in Childhood
D Tibboel, E van der Voort |
1996 | |
Endothelin stimulates platelet-activating factor synthesis by cultured rat Kupffer cells
SB Mustafa, CR Gandhi, SA Harvey, MS Olson |
Hepatology | 1995 |
Effect of lipopolysaccharide on mitogen-activated protein kinases and cytosolic phospholipase A2
SI Fouda, TF Molski, MS Ashour, RI Sha'afi |
Biochemical Journal | 1995 |
Identification of Functional Platelet-Activating Factor Receptors on Human Keratinocytes
JB Travers, JC Huff, M Rola-Pleszczynski, EW Gelfand, JG Morelli, RC Murphy |
Journal of Investigative Dermatology | 1995 |
Platelet-activating factor receptor: gene expression and signal transduction
T Izumi, T Shimizu |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1995 |
Signal sorting by G-protein-linked receptors
G Milligan |
Advances in pharmacology (San Diego, Calif.) | 1995 |
Human umbilical vein endothelial cells: Specific binding of platelet-activating factor and cytosolic calcium flux
RM Korth, M Hirafuji, J Benvenistev, F Russo-Marie |
Biochemical Pharmacology | 1995 |
Airways Smooth Muscle: Neurotransmitters, Amines, Lipid Mediators and Signal Transduction
D Raeburn, MA Giembycz |
1995 | |
Vascular Endothelium
MA Gimbrone, MI Cybulsky, N Kume, T Collins, N Resnick |
Annals of the New York Academy of Sciences | 1994 |
15-Hydroxyeicosatetraenoic acid inhibits neutrophil migration across cytokine-activated endothelium
S Takata, A Papayianni, M Matsubara, W Jimenez, PH Pronovost, HR Brady |
The American Journal of Pathology | 1994 |
Characterization of platelet-activating factor binding to human airway epithelial cells: modulation by fatty acids and ion-channel blockers
JX Kang, SF Man, AJ Hirsh, MT Clandinin |
Biochemical Journal | 1994 |
Functional PAF receptors in glia cells: Binding parameters and regulation of expression
C Brodie |
International Journal of Developmental Neuroscience | 1994 |
Advances in Pharmacology
B Drenger, Y Ginosar, Y Gozal |
Advances in Pharmacology | 1994 |
Comparison of 1-O-alkyl-, 1-O-alk-1'-enyl-, and 1-O-acyl-2-acetyl-sn-glycero-3-phosphoethanolamines and -3-phosphocholines as agonists of the platelet-activating factor family
JT O'Flaherty, T Tessner, D Greene, JR Redman, RL Wykle |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1994 |
Lipid Mediators
JR Vane, RM Botting |
Lipid Mediators | 1994 |
Platelet activating factor (PAF) and lyso-PAF in psoriasis
MR Judge, RM Barr, AI Mallet, F Courtney, AK Black, MW Greaves |
Archives of Dermatological Research | 1994 |
Structural and (patho)physiological diversity of PAF
R N Pinckard, D S Woodard, H J Showell, M J Conklyn, M J Novak, L M McManus |
Clinical Reviews in Allergy | 1994 |
Platelet-activating factor: receptors and signal transduction
W Chao, MS Olson |
Biochemical Journal | 1993 |
Regulation of the receptor for platelet-activating factor on human platelets
JA Burgers, JW Akkerman |
Biochemical Journal | 1993 |
Adsorption and uptake of the alkyllysophospholipid ET-18-OCH3 by HL-60 cells during induction of differentiation by dimethylsulfoxide
EC Heesbeen, LF Verdonck, M Haagmans, HG van Heugten, GE Staal, G Rijksen |
Leukemia Research | 1993 |
Binding of [3H]SR 27417, a novel platelet-activating factor (PAF) receptor antagonist, to rabbit and human platelets and polymorphonuclear leukocytes
JM Herbert, MC Laplace, JP Maffrand |
Biochemical Pharmacology | 1993 |
Human chemotaxis receptor genes cluster at 19q13.3-13.4. Characterization of the human C5a receptor gene
NP Gerard, L Bao, XP He, RL Eddy, TB Shows, C Gerard |
Biochemistry | 1993 |
Platelet-activating factor receptor-dependent activation of the muscarinic K+ current in bullfrog atrial myocytes
J Ramos-Franco, CF Lo, GE Breitwieser |
Circulation research | 1993 |
Enzymatic studies of lyso platelet-activating factor acylation in human neutrophils and changes upon stimulation
ME Venable, SC Olson, ML Nieto, RL Wykle |
The Journal of biological chemistry | 1993 |
Release of platelet activation factor from activated neutrophils. Transglutaminase-dependent enhancement of transbilayer movement across the plasma membrane
DL Bratton |
The Journal of biological chemistry | 1993 |
Platelet-Activating Factor and Structurally Related Alkyl Ehter Lipids
OP Santos, M Boim, E Barros, E Pirotzky, P Braquet, N Schor |
Platelet-Activating Factor and Structurally Related Alkyl Ehter Lipids | 1992 |
Release of adenosine from human neutrophils stimulated by platelet activating factor, leukotriene B(4) and opsonized zymosan
S Sipka, Z Dinya, M Koltai, P Braquet, G Szegedi |
Mediators of Inflammation | 1992 |
Regulation of platelet-activating-factor receptors and the desensitization response in polymorphonuclear neutrophils
JT O'Flaherty, DP Jacobson, JF Redman |
Biochemical Journal | 1992 |
Inhibition of human neutrophil responses by alpha-cyano-3,4-dihydroxythiocinnamamide; a protein-tyrosine kinase inhibitor
P Dryden, V Duronio, L Martin, AT Hudson, H Salari |
British Journal of Pharmacology | 1992 |
Characterization of specific binding sites of 3H-labelled platelet-activating factor ([3H]PAF) and a new antagonist, [3H]SR 27417, on guinea-pig tracheal epithelial cells
JM Herbert |
Biochemical Journal | 1992 |
Reversible or irreversible modification of [3H]PAF binding on rabbit platelet membranes differentiates various PAF receptor antagonists
MT Domingo, F Piro, C Broquet, E Auclair, PE Chabrier, P Braquet |
Lipids | 1992 |
Induction of high-affinity paf receptor expression during T cell activation
C Calabresse, MC Nguer, O Pellegrini, J Benveniste, Y Richard, YN Thomas |
European Journal of Immunology | 1992 |
Inhibition of human neutrophil responses by α-cyano-3,4-dihydroxythiocinnamamide; a protein-tyrosine kinase inhibitor
P Dryden, V Duronio, L Martin, AT Hudson, H Salari |
British Journal of Pharmacology | 1992 |
Mononuclear Phagocytes
R van Furth |
1992 | |
Regulation of the surface expression of the platelet-activating factor receptor in IC-21 peritoneal macrophages. Effects of lipopolysaccharide
H Liu, W Chao, MS Olson |
The Journal of biological chemistry | 1992 |
The superoxide-generating oxidase of phagocytic cells. Physiological, molecular and pathological aspects
F MOREL, J DOUSSIERE, PV VIGNAIS |
European Journal of Biochemistry | 1991 |
Bioactions of 5-hydroxyicosatetraenoate and its interaction with platelet-activating factor
AG Rossi, JT O'Flaherty |
Lipids | 1991 |
Tumor necrosis factor release by human monocytes stimulated with platelet-activating factor
NM Ruis, JK Rose, FH Valone |
Lipids | 1991 |
Immunoregulatory functions of paf-acether. VI. Dual effect on human B cell proliferation
C Leprince, E Vivier, D Treton, P Galanaud, J Benveniste, Y Richard, Y Thomas |
Lipids | 1991 |
Roles of Ca2+ in human neutrophil responses to receptor agonists
JT O'Flaherty, AG Rossi, DP Jacobson, JF Redman |
Biochemical Journal | 1991 |
Solubilization of a functionally active platelet-activating factor receptor from rabbit platelets
JE Rogers, V Duronio, SI Wong, M McNeil, H Salari |
Biochemical Journal | 1991 |
The effect of inhibitors of platelet aggregation on the metabolism of platelet-activating factor (PAF) in washed rabbit platelets
C O'Neill, AJ Ammit, R Korth, S Fleming, X Wells |
Lipids | 1991 |
L-659,989: A useful probe in the detection of multiple conformational states of PAF receptors
SB Hwang, MH Lam |
Lipids | 1991 |
Pharmacological characterization of the Raji lymphoblast platelet-activating factor receptor
JB Travers, Q Li, RH Fertel |
Drug Development Research | 1991 |
High affinity receptor binding of platelet-activating factor in rat peritoneal polymorphonuclear leukocytes
SB Hwang |
European Journal of Pharmacology | 1991 |
Evidence for platelet-activating factor receptors in several B lymphoblastoid cell lines
JB Travers, JE Shaw, Q Li, DA Kniss, RH Fertel |
Life Sciences | 1991 |
Role of free radicals and platelet-activating factor in the genesis of intestinal motor disturbances induced by Escherichia coli endotoxins in rats
L Pons, MT Droy-Lefaix, P Braquet, L Bueno |
Gastroenterology | 1991 |
Modulation of leukotriene B4 and platelet-activating factor binding to neutrophils
M Yamazaki, TF Molski, T Stevens, CK Huang, EL Becker, RI Sha'afi |
American journal of physiology. Cell physiology | 1991 |
Inflammatory activities
PJ Barnes |
Nature | 1991 |
Prostaglandins, Leukotrienes, Lipoxins, and PAF
JM Bailey |
1991 | |
Pharmacology of Asthma
CP Page, PJ Barnes |
1991 | |
EJB Reviews 1991
P Christen, E Hofmann |
1991 | |
Platelet-activating factor induces tyrosine phosphorylation in human neutrophils
J Gomez-Cambronero, E Wang, G Johnson, CK Huang, RI Sha'afi |
The Journal of biological chemistry | 1991 |
Cyclical binding, processing, and functional interactions of neutrophils with leukotriene B4
JT O'Flaherty, JF Redman, DP Jacobson |
Journal of Cellular Physiology | 1990 |
Effect of Staphylococcus aureus delta-toxin on human granulocyte functions and platelet-activating-factor metabolism
S Kasimir, W Schönfeld, JE Alouf, W König |
Infection and immunity | 1990 |
Evidence for a platelet-activating factor receptor on human lymphoblastoid B cells: Activation of the phosphatidylinositol cycle and induction of calcium mobilization
PG Schulam, G Putcha, J Franklin-Johnson, WT Shearer |
Biochemical and Biophysical Research Communications | 1990 |
Synthesis and use of a novel N-formyl peptide derivative to isolate a human N-formyl peptide receptor cDNA
F Boulay, M Tardif, L Brouchon, P Vignais |
Biochemical and Biophysical Research Communications | 1990 |
Inhibition by calcium channel blockers of the binding of platelet-activating factor to human neutrophil granulocytes
JG Filep, É Földes-Filep |
European Journal of Pharmacology | 1990 |
Translocation of exogenous platelet-activating factor and its lyso-compound through plasma membranes is a rate-limiting step for their metabolic conversions into alkylacylglycerophosphocholines in rabbit platelets and guinea-pig leukocytes
A Tokumura, T Tsutsumi, JI Yoshida, H Tsukatani |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1990 |
Conversion of alkylacetylglycerol to platelet-activating factor in HL-60 cells and subcellular localization of the mediator
DS Vallari, M Record, F Snyder |
Archives of Biochemistry and Biophysics | 1990 |
Regulation of platelet-activating factor receptor and PAF receptor-mediated arachidonic acid release by protein kinase C activation in rat Kupffer cells
W Chao, H Liu, DJ Hanahan, MS Olson |
Archives of Biochemistry and Biophysics | 1990 |
Binding of platelet activating factor to albumin
KL Clay, C Johnson, P Henson |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1990 |
The metabolism of platelet-activating factor in human T-lymphocytes
JB Travers, H Sprecher, RH Fertel |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1990 |
Characterization of Receptors for Platelet-activating Factor in Guinea Pig Lung Membranes
J Gomez, JW Bloom, HI Yamamura, M Halonen |
American journal of respiratory cell and molecular biology | 1990 |
The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors
F Boulay, M Tardif, L Brouchon, P Vignais |
Biochemistry | 1990 |
Stimulation and priming of protein kinase C translocation by a Ca2+ transient-independent mechanism. Studies in human neutrophils challenged with platelet-activating factor and other receptor agonists
JT O'Flaherty, JF Redman, DP Jacobson, AG Rossi |
The Journal of biological chemistry | 1990 |
Development of specific functionally active receptors for platelet-activating factor in HL-60 cells following granulocytic differentiation
DS Vallari, R Austinhirst, F Snyder |
The Journal of biological chemistry | 1990 |
Phorbol 12-myristate 13-acetate inhibits binding of leukotriene B4 and platelet-activating factor and the responses they induce in neutrophils: site of action
M Yamazaki, J Gomez-Cambronero, M Durstin, TF Molski, EL Becker, RI Sha'afi |
Proceedings of the National Academy of Sciences | 1989 |
Platelet-activating factor regulates phospholipid metabolism in human neutrophils
J Tou |
Lipids | 1989 |
Protein kinase C blockers and neutrophil receptors for leukotriene B4
JT O'Flaherty, D Jacobson |
Biochemical and Biophysical Research Communications | 1989 |
Effects of C-reactive protein on human neutrophil granulocytes challenged with N-formyl-methionyl-leucyl-phenylalanine and platelet-activating factor
J Filep, É Földes-Filep |
Life Sciences | 1989 |
Prostaglandin binding sites in human polymorphonuclear neutrophils
AG Rossi, JT O'Flaherty |
Prostaglandins | 1989 |
Characterization of PAF receptors on human neutrophils using the specific antagonist, WEB 2086 Correlation between receptor binding and function
G Dent, D Ukena, P Chanez, G Sybrecht, P Barnes |
FEBS Letters | 1989 |
Receptor-independent metabolism of platelet-activating factor by myelogenous cells
JT O'Flaherty, MC Chabot, J Redman, D Jacobson, RL Wykle |
FEBS Letters | 1989 |
Airway Smooth Muscle in Health and Disease
RF Coburn |
1989 | |
Stimulation of Platelet-activating Factor Synthesis by a Nonmetabolizable Bioactive Analog of Platelet-activating Factor and Influence of Arachidonic Acid Metabolites
TG Tessner, JT O'Flaherty, RL Wykle |
The Journal of biological chemistry | 1989 |
Distribution of arachidonic acid in choline- and ethanolamine-containing phosphoglycerides in subfractionated human neutrophils
JI MacDonald, H Sprecher |
The Journal of biological chemistry | 1989 |
Bidirectional Effects of Protein Kinase C Activators
JT O'Flaherty, DP Jacobson, JF Redman |
The Journal of biological chemistry | 1989 |
Identification of Receptors for Platelet-Activating Factor in Rat Kupffer Cells
W Chao, H Liu, M DeBuysere, DJ Hanahan, MS Olson |
The Journal of biological chemistry | 1989 |
Calcium is necessary but not sufficient for the platelet-activating factor release in human neutrophils stimulated by physiological stimuli
J Gomez-Cambronero, M Durstin, TF Molski, PH Naccache, RI Sha'afi |
The Journal of biological chemistry | 1989 |
Airway receptors.
Barnes PJ |
Postgraduate medical journal | 1989 |
Agonist-induced calcium flux, phosphoinositide metabolism, aggregation and enzyme secretion in human neutrophils
AG Rossi, RM McMillan, DE MacIntyre |
Agents and Actions | 1988 |
Exudate polymorphonuclear leukocytes isolated from skin chambers are primed for enhanced response to subsequent stimulation with chemoattractant f-Met-Leu-Phe and C3-opsonized yeast particles
G Briheim, B Coble, O Stendahl, C Dahlgren |
Inflammation | 1988 |
Activation of the respiratory burst oxidase in neutrophils: On the role of membrane-derived second messengers, Ca++, and protein kinase C
JD Lambeth |
Journal of Bioenergetics and Biomembranes | 1988 |
Specific binding of platelet-activating factor (PAF) by human peripheral blood mononuclear leukocytes
DS Ng, K Wong |
Biochemical and Biophysical Research Communications | 1988 |
Comparison of three paf-acether receptor antagonist ginkgolides
R Korth, D Nunez, J Bidault, J Benveniste |
European Journal of Pharmacology | 1988 |
Effect of sulfhydryl reagents on PAF binding to human neutrophils and platelets
DS Ng, K Wong |
European Journal of Pharmacology | 1988 |
Platelet-activating factor binding and metabolism during human platelet aggregation
FH Valone |
Thrombosis Research | 1988 |
Effects of plasma kallikrein infusions into pigs on haemodynamic and haemostatic variables
N Egberg, MJ Gallimore, J Jakobsson |
Fibrinolysis | 1988 |
Evidence for protein-catalyzed transfer of platelet activating factor by macrophage cytosol
JB Banks, RL Wykle, JT O'Flaherty, RH Lumb |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1988 |
Identification of a second putative receptor of platelet-activating factor from human polymorphonuclear leukocytes
SB Hwang |
The Journal of biological chemistry | 1988 |
PAF Antagonists: Their Potential Therapeutic Role in Asthma
KF Chung, PJ Barnes |
Drugs | 1988 |
Antitumor activity of synthetic alkylphospholipids with or without PAF activity
I Kudo, S Nojima, HW Chang, R Yanoshita, H Hayashi, E Kondo, H Nomura, K Inoue |
Lipids | 1987 |
Inhibition by BN 52021 (Ginkgolide B) of the binding of [3h]- Platelet-activating factor to human neutrophil granulocytes
E Füldes-Filep, P Braquet, J Filep |
Biochemical and Biophysical Research Communications | 1987 |
1-0-alkyl-2-N-methylcarbamyl-glycerophosphocholine: A biologically potent, non-metabolizable analog of platelet-activating factor
JT O'Flaherty, JF Redman, JD Schmitt, JM Ellis, JR Surles, MH Marx, C Piantadosi, RL Wykle |
Biochemical and Biophysical Research Communications | 1987 |
Platelet-activating factor (PAF) receptor antagonists inhibit mitogen-induced human peripheral blood T-cell proliferation
P Patrignani, S Valitutti, F Aiello, P Musiani |
Biochemical and Biophysical Research Communications | 1987 |
BN 52021 displaces [3H]paf-acether from, and inhibits its binding to intact human platelets
R Korth, J Benveniste |
European Journal of Pharmacology | 1987 |
Phospholipid metabolism and stimulus-response coupling
JT O'Flaherty |
Biochemical Pharmacology | 1987 |
Platelet-activating factor and cellular immune responses
P Braquet, M Rola-Pleszcynski |
Immunology Today | 1987 |
Desensitization and antagonism of rat polymorphonuclear leukocytes stimulated with PAF acether
M Beureau, D Joseph, BB Vargaftig |
Prostaglandins | 1987 |
Lipid Mediators in the Immunology of Shock
M Paubert-Braquet, P Braquet, B Demling, JR Fletcher, M Foegh |
1987 | |
PAF, Platelets, and Asthma
M Schmitz-Schumann, G Menz, CP Page |
1987 | |
Platelet-Activating Factor and Related Lipid Mediators
F Snyder |
1987 | |
Binding and internalization of platelet-activating factor 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine in washed rabbit platelets
H Homma, A Tokumura, DJ Hanahan |
The Journal of biological chemistry | 1987 |
GTP regulation of platelet-activating factor binding to human neutrophil membranes
DS Ng, K Wong |
Biochemical and Biophysical Research Communications | 1986 |
Advances in Lipid Research
AM Scanu |
Advances in Lipid Research | 1965 |