JCI - Citations to Gram-negative bacteremia produces both severe systolic and diastolic cardiac dysfunction in a canine model that simulates human septic shock.

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Gram-negative bacteremia produces both severe systolic and diastolic cardiac dysfunction in a canine model that simulates human septic shock.

C Natanson, … , J J Conklin, J E Parrillo

C Natanson, … , J J Conklin, J E Parrillo

Published July 1, 1986
Citation Information: J Clin Invest. 1986;78(1):259-270. https://doi.org/10.1172/JCI112559.

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Cardiac Magnetic Resonance Studies in a Large Animal Model that Simulates the Cardiac Abnormalities of Human Septic Shock Ford VJ, Applefeld WN, Wang J, Sun J, Solomon SB, Sidenko S, Feng J, Sheffield C, Klein HG, Yu ZX, Torabi-Parizi P, Danner RL, Sachdev V, Solomon MA, Chen MY, Natanson C		2024
In a Canine Model of Septic Shock, Cardiomyopathy Occurs Independent of Catecholamine Surges and Cardiac Microvascular Ischemia Ford VJ, Applefeld WN, Wang J, Sun J, Solomon SB, Klein HG, Feng J, Lertora J, Parizi\u2010Torabi P, Danner RL, Solomon MA, Chen MY, Natanson C	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease	2024
Cardiac Magnetic Resonance Studies in a Large Animal Model That Simulates the Cardiac Abnormalities of Human Septic Shock Ford VJ, Applefeld WN, Wang J, Sun J, Solomon SB, Sidenko S, Feng J, Sheffield C, Klein HG, Yu Z, Torabi\u2010Parizi P, Danner RL, Sachdev V, Solomon MA, Chen MY, Natanson C	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease	2024
Advances in Rodent Experimental Models of Sepsis. Cai L, Rodgers E, Schoenmann N, Raju RP	International journal of molecular sciences	2023
Monoclonal antibodies neutralizing alpha-hemolysin, bicomponent leukocidins, and clumping factor A protected against Staphylococcus aureus-induced acute circulatory failure in a mechanically ventilated rabbit model of hyperdynamic septic shock. Nguyen NTQ, Doan TNM, Sato K, Tkaczyk C, Sellman BR, Diep BA	Frontiers in immunology	2023
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American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock: AL Davis, JA Carcillo, RK Aneja, AJ Deymann, JC Lin, TC Nguyen, RS Okhuysen-Cawley, MS Relvas, RA Rozenfeld, PW Skippen, BJ Stojadinovic, EA Williams, TS Yeh, F Balamuth, J Brierley, AR de Caen, IM Cheifetz, K Choong, E Conway, T Cornell, A Doctor, MA Dugas, JD Feldman, JC Fitzgerald, HR Flori, JD Fortenberry, AL Graciano, BM Greenwald, MW Hall, YY Han, LJ Hernan, JE Irazuzta, E Iselin, EW van der Jagt, HE Jeffries, S Kache, C Katyal, NT Kissoon, AA Kon, MC Kutko, G MacLaren, T Maul, R Mehta, F Odetola, K Parbuoni, R Paul, MJ Peters, S Ranjit, KE Reuter-Rice, EJ Schnitzler, HF Scott, A Torres, J Weingarten-Abrams, SL Weiss, JJ Zimmerman, AL Zuckerberg	Critical Care Medicine	2017
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Differential Paradigms in Animal Models of Sepsis SM Kingsley, BV Bhat	Current Infectious Disease Reports	2016
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CD1d- and MR1-Restricted T Cells in Sepsis PA Szabo, RV Anantha, CR Shaler, JK McCormick, SM Haeryfar	Frontiers in immunology	2015
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Diastolic dysfunction and mortality in septic patients: a systematic review and meta-analysis F Sanfilippo, C Corredor, N Fletcher, G Landesberg, U Benedetto, P Foex, M Cecconi	Intensive Care Medicine	2015
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Annual Update in Intensive Care and Emergency Medicine 2014 JL Vincent		2014
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Ventricular Dilation Is Associated With Improved Cardiovascular Performance and Survival in Sepsis SL Cavazzoni, M Guglielmi, JE Parrillo, T Walker, RP Dellinger, SM Hollenberg	Chest	2010
Bacterial Flagellin Triggers Cardiac Innate Immune Responses and Acute Contractile Dysfunction J Rolli, N Rosenblatt-Velin, J Li, N Loukili, S Levrand, P Pacher, B Waeber, F Feihl, P Ruchat, L Liaudet, L Tailleux	PloS one	2010
Endotoxin impairs cardiac hemodynamics by affecting loading conditions but not by reducing cardiac inotropism L Jianhui, N Rosenblatt-Velin, N Loukili, P Pacher, F Feihl, B Waeber, L Liaudet	American journal of physiology. Heart and circulatory physiology	2010
Pulmonary surfactant: an immunological perspective ZC Chroneos, Z Sever-Chroneos, VL Shepherd	Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology	2009
Effects of intra-aortic balloon counterpulsation in a model of septic shock* SB Solomon, PC Minneci, KJ Deans, J Feng, PQ Eichacker, SM Banks, RL Danner, C Natanson, MA Solomon	Critical Care Medicine	2009
Clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: 2007 update from the American College of Critical Care Medicine* J Brierley, JA Carcillo, K Choong, T Cornell, A DeCaen, A Deymann, A Doctor, A Davis, J Duff, MA Dugas, A Duncan, B Evans, J Feldman, K Felmet, G Fisher, L Frankel, H Jeffries, B Greenwald, J Gutierrez, M Hall, YY Han, J Hanson, J Hazelzet, L Hernan, J Kiff, N Kissoon, A Kon, J Irazusta, J Lin, A Lorts, M Mariscalco, R Mehta, S Nadel, T Nguyen, C Nicholson, M Peters, R Okhuysen-Cawley, T Poulton, M Relves, A Rodriguez, R Rozenfeld, E Schnitzler, T Shanley, S Skache, P Skippen, A Torres, B Dessauer, J Weingarten, T Yeh, A Zaritsky, B Stojadinovic, J Zimmerman, A Zuckerberg	Critical Care Medicine	2009
Scientific and clinical challenges in sepsis L Ulloa, M Brunner, L Ramos, EA Deitch	Current pharmaceutical design	2009
Severe reversible myocardial depression in a patient with Pseudomonas aeruginosa sepsis suggesting tako-tsubo cardiomyopathy C Palacio, K Nugent, R Alalawi, C Cevik	International Journal of Cardiology	2009
Intensive Care Medicine JL Vincent	Intensive Care Medicine	2009
Isolated and reversible impairment of ventricular relaxation in patients with septic shock* B Bouhemad, A Nicolas-Robin, C Arbelot, M Arthaud, F Féger, JJ Rouby	Critical Care Medicine	2008
Evaluation of platelet count and its association with plateletcrit, mean platelet volume, and platelet size distribution width in a canine model of endotoxemia Z Yilmaz, O Eralp, YO Ilcol	Veterinary Clinical Pathology	2008
EXPERIMENTAL MODELS OF SEPSIS AND THEIR CLINICAL RELEVANCE LF Poli-de-Figueiredo, AG Garrido, N Nakagawa, P Sannomiya	Shock	2008
Linksventrikuläre diastolische Dysfunktion R Meierhenrich, W Schütz, A Gauss	Der Anaesthesist	2008
Decreases in myocardial glucose and increases in pyruvate but not ischaemia are observed during porcine endotoxaemia MS Chew, A Johansson, C Anderson, A Ersson, E Tønnesen	Acta Anaesthesiologica Scandinavica	2008
Modeling sepsis in the laboratory: merging sound science with animal well-being JA Nemzek, KM Hugunin, MR Opp	Comparative medicine	2008
Critical Care Medicine SS Braithwaite	Critical Care Medicine	2008
Yearbook of Intensive Care and Emergency Medicine JL Vincent		2008
Mechanisms of sepsis-induced cardiac dysfunction A Rudiger, M Singer	Critical Care Medicine	2007
Disruption of phospholipase C 1 signalling attenuates cardiac tumor necrosis factor- expression and improves myocardial function during endotoxemia T Peng, E Shen, J Fan, Y Zhang, JM Arnold, Q Feng	Cardiovascular Research	2007
Clinical trials in spontaneous disease in dogs: a new paradigm for investigations of sepsis CM Otto	Journal of Veterinary Emergency and Critical Care	2007
Review of hypocalcemia in septic patients MK Holowaychuk, LG Martin	Journal of Veterinary Emergency and Critical Care	2007
Sepsis JM O’Brien, NA Ali, SK Aberegg, E Abraham	The American Journal of Medicine	2007
A canine model of septic shock: balancing animal welfare and scientific relevance PC Minneci, KJ Deans, B Hansen, C Parent, C Romines, DA Gonzales, SX Ying, P Munson, AF Suffredini, J Feng, MA Solomon, SM Banks, SJ Kern, RL Danner, PQ Eichacker, C Natanson, SB Solomon	American journal of physiology. Heart and circulatory physiology	2007
Septic shock: a heart story since the 1960s C Rabuel, A Mebazaa	Intensive Care Medicine	2006
Nitric oxide involvement in the hemodynamic response to fluid resuscitation in endotoxic shock in rats MR Losser, AP Forget, D Payen	Critical Care Medicine	2006
Critical Heart Disease in Infants and Children BA Fivush, AM Neu, R Parekh, LG Maxwell, LC Racusen, JR White, DG Nichols	Critical Heart Disease in Infants and Children	2006
MOUSE MODELS OF RESUSCITATED SHOCK SM Hollenberg	Shock	2005
Short-lasting systemic and regional benefits of early crystalloid infusion after intravenous inoculation of dogs with live Escherichia coli AG Garrido, LF de Figueiredo, RJ Cruz, E Silva, MR Silva	Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.]	2005
Serum troponin detection suggests myocardial injury in pediatric sepsis…What next?* V Nadkarni	Pediatric Critical Care Medicine	2004
EVALUATING MYOCARDIAL DEPRESSION IN SEPSIS RJ Levy, CS Deutschman	Shock	2004
Experimental models of sepsis and septic shock: an overview AG Garrido, LF de Figueiredo, MR Silva	Acta Cirurgica Brasileira	2004
Differing effects of epinephrine, norepinephrine, and vasopressin on survival in a canine model of septic shock PC Minneci, KJ Deans, SM Banks, R Costello, G Csako, PQ Eichacker, RL Danner, C Natanson, SB Solomon	American journal of physiology. Heart and circulatory physiology	2004
Challenges of implementing pharmacogenetics in the critical care environment BD Freeman, HL McLeod	Nature Reviews Drug Discovery	2004
The role of tumor necrosis factor-α (TNF-α) and the sphingosine pathway in sepsis-induced myocardial dysfunction MF Costello, CM Otto, LJ Rubin	Journal of Veterinary Emergency and Critical Care	2003
Doppler-based Hemodynamic Monitoring MA Turner	AACN Clinical Issues: Advanced Practice in Acute and Critical Care	2003
Sympathetic Blockade in a Canine Model of Gram-Negative Bacterial Peritonitis: SB Solomon, SM Banks, E Gerstenberger, G Csako, JD Bacher, ML Thomas, R Costello, PQ Eichacker, RL Danner, C Natanson	Shock	2003
Clinical practice parameters for hemodynamic support of pediatric and neonatal patients in septic shock* JA Carcillo, AI Fields	Critical Care Medicine	2002
Myocardial dysfunction in the patient with sepsis S Krishnagopalan, A Kumar, JE Parrillo, A Kumar	Current Opinion in Critical Care	2002
Animal and human models for sepsis MJ Schultz, T der Poll	Annals of Medicine	2002
The Sepsis Text JL Vincent, J Carlet, SM Opal		2002
Sepsis: State of the art PE Marik, J Varon	Disease-a-Month	2001
Left Ventricular Dysfunction Related to Septic Shock Masquerading as Postpartum Cardiomyopathy IF Bukharovich, E Harrison, TH le Jemtel	Congestive Heart Failure	2001
Myocardial dysfunction in septic shock: Part I. Clinical manifestation of cardiovascular dysfunction A Kumar, C Haery, JE Parrillo	Journal of Cardiothoracic and Vascular Anesthesia	2001
Activation of cardiac endothelium as a compensatory component in endotoxin-induced cardiomyopathy: role of endothelin, prostaglandins, and nitric oxide A Mebazaa, GW de Keulenaer, X Paqueron, LJ Andries, P Ratajczak, S Lanone, C Frelin, D Longrois, D Payen, DL Brutsaert, SU Sys	Circulation	2001
Characterization of a Hyperdynamic Murine Model of Resuscitated Sepsis Using Echocardiography SM Hollenberg, A Dumasius, C Easington, SA Colilla, A Neumann, JE Parrillo	American journal of respiratory and critical care medicine	2001
Systemic Inflammatory Response Syndrome, Sepsis, and Multiple Organ Dysfunction CA Brady, CM Otto	Veterinary Clinics of North America Small Animal Practice	2001
Acute G-CSF therapy is not protective during lethal E. coli sepsis Z Quezado, C Parent, W Karzai, M Depietro, C Natanson, W Hammond, RL Danner, X Cui, Y Fitz, SM Banks, E Gerstenberger, PQ Eichacker	American Journal of Physiology - Regulatory, Integrative and Comparative Physiology	2001
Dexamethasone Blocks Sepsis-Induced Protection of the Heart from Ischemia Reperfusion Injury AJ Spanier, KH McDonough	Proceedings of the Society for Experimental Biology and Medicine	2000
Laparoscopic Pneumoperitoneum in Acute Peritonitis Does Not Increase Bacteremia or Aggravate Metabolic or Hemodynamic Disturbances FS Silva, RC Ramos, LF Zantut, RS Poggetti, B Fontes, D Birolini	Surgical Laparoscopy, Endoscopy & Percutaneous Techniques	2000
Effects of N-methyl-L-arginine on cardiac and regional blood flow in a dog endotoxin shock model MF Doursout, RG Kilbourn, CJ Hartley, JE Chelly	Journal of Critical Care	2000
MYOCARDIAL DYSFUNCTION IN SEPTIC SHOCK A Kumar, C Haery, JE Parrillo	Critical Care Clinics	2000
Role of the Heart in the Loss of Aeration Characterizing Lower Lobes in Acute Respiratory Distress Syndrome LM Malbouisson, CJ Busch, L Puybasset, Q Lu, P Cluzel, JJ Rouby	American journal of respiratory and critical care medicine	2000
Shortening of cardiac action potentials in endotoxic shock in guinea pigs is caused by an increase in nitric oxide activity and activation of the adenosine triphosphate-sensitive potassium channel: CC Chen, YC Lin, SA Chen, HN Luk, PY Ding, MS Chang, CE Chiang	Critical Care Medicine	2000
Endotoxin induces a dose-dependent myocardial cross-tolerance to ischemia-reperfusion injury: RR Neviere, FY Li, T Singh, ML Myers, W Sibbald	Critical Care Medicine	2000
Inhaled NO reduces leukocyte-endothelial cell interactions and myocardial dysfunction in endotoxemic rats R Nevière, B Guery, S Mordon, F Zerimech, S Charré, F Wattel, C Chopin	American journal of physiology. Heart and circulatory physiology	2000
Nitric oxide modulation of TNF-α-induced cardiac contractile dysfunction is concentration dependent JW Horton, D Maass, J White, B Sanders	American journal of physiology. Heart and circulatory physiology	2000
Surgical Laparoscopy, Endoscopy & Percutaneous Techniques J Vracko, KL Wiechel	Surgical Laparoscopy, Endoscopy & Percutaneous Techniques	1999
Myocardial dysfunction in sepsis: Injury or depression? MM Parker	Critical Care Medicine	1999
End-Diastolic Pressure-Volume Relationship in Sepsis: Relative Contributions of Compliance and Equilibrium Chamber Volume Differ S Farias, FM Powers, WR Law	Journal of Surgical Research	1999
FULMINANT HEPATIC FAILURE AO Shakil, GV Mazariegos, DJ Kramer	Surgical Clinics of North America	1999
Pulmonary Artery Catheterization and Esophageal Doppler Monitoring in the ICU PE Marik	Chest	1999
Digestion of Streptococcus pneumoniae Cell Walls with Its Major Peptidoglycan Hydrolase Releases Branched Stem Peptides Carrying Proinflammatory Activity PA Majcherczyk, H Langen, D Heumann, M Fountoulakis, MP Glauser, P Moreillon	The Journal of biological chemistry	1999
Push-pull Sorbent-Based Pheresis Treatment in an Experimental Canine Endotoxemia Model: Preliminary Report AT Peter, SR Ash, J Steczko, JJ Turek, DE Blake, DJ Carr, WR Knab, RH Bosley	The International Journal of Artificial Organs	1999
Fachübergreifende Aspekte der Hämostaseologie IV E Martin, P Nawroth		1999
Effects of l -NMMA and Fluid Loading on TNF-induced Cardiovascular Dysfunction in Dogs ZM Quezado, W Karzai, RL Danner, BD Freeman, L Yan, PQ Eichacker, SM Banks, J Perren Cobb, RE Cunnion, MJ Quezado, JE Sevransky, C Natanson	American journal of respiratory and critical care medicine	1998
Reversal of Hypocalcemia and Decreased Afterload in Sepsis: Effect on Myocardial Systolic and Diastolic Function A Kovacs, MR Courtois, B Barzilai, IE Karl, PA Ludbrook, RS Hotchkiss	American journal of respiratory and critical care medicine	1998
Septic Shock B Klosterhalfen, RS Bhardwaj	General Pharmacology: The Vascular System	1998
Response of the septic vasculature to prolonged vasopressor therapy with N (omega-monomethyl-L-arginine) and epinephrine in canines: BD Freeman, F Zeni, SM Banks, PQ Eichacker, JD Bacher, EP Garvey, JV Tuttle, CH Jurgensen, C Natanson, RL Danner	Critical Care Medicine	1998
The Hemodynamic Derangements in Sepsis PE Marik, J Varon	Chest	1998
Cardiopulmonary effects of inhaled nitric oxide in normal dogs and during E. coli pneumonia and sepsis ZM Quezado, C Natanson, W Karzai, RL Danner, CA Koev, Y Fitz, DP Dolan, S Richmond, SM Banks, L Wilson, PQ Eichacker	Journal of applied physiology	1998
Cardiac Failure in Transgenic Mice With Myocardial Expression of Tumor Necrosis Factor-α D Bryant, L Becker, J Richardson, J Shelton, F Franco, R Peshock, M Thompson, B Giroir	Circulation	1998
Critical Care Nephrology C Ronco, R Bellomo		1998
Systemic pressure-flow reactivity to norepinephrine in rabbits: impact of endotoxin and fluid loading A Ricard-Hibon, , R Kong, S Belouci, B Teisseire, D Pay	Intensive Care Medicine	1998
Tyrphostin AG 556 improves survival and reduces multiorgan failure in canine Escherichia coli peritonitis JE Sevransky, G Shaked, A Novogrodsky, A Levitzki, A Gazit, A Hoffman, RJ Elin, ZM Quezado, BD Freeman, PQ Eichacker, RL Danner, SM Banks, J Bacher, ML 3rd, C Natanson	Journal of Clinical Investigation	1997
The role of the vasculature in regulating venous return and cardiac output: historical and graphical approach E Jacobsohn, R Chorn, M O’Connor	Canadian Journal of Anaesthesia	1997
Intervention in endotoxin shock by sulfatide (I3SO3-GalCer) with a concomitant reduction in tumor necrosis factor alpha production H Higashi, Y Suzuki, N Mukaida, N Takahashi, D Miyamoto, K Matsushima	Infection and immunity	1997
Platelet-activating factor antagonism improves ventricular contractility in endotoxemia: MJ Herbertson, HA Werner, KR Walley	Critical Care Medicine	1997
Myocardial collagen changes and edema in rats with hyperdynamic sepsis: P Yu, DR Boughner, WJ Sibbald, J Keys, J Dunmore, CM Martin	Critical Care Medicine	1997
A murine model of pulmonary damage induced by lipopolysaccharide via intranasal instillation RJ Szarka, N Wang, L Gordon, PN Nation, RH Smith	Journal of Immunological Methods	1997
rG-CSF reduces endotoxemia and improves survival during E. coli pneumonia BD Freeman, Z Quezado, F Zeni, C Natanson, RL Danner, S Banks, M Quezado, Y Fitz, J Bacher, PQ Eichacker	Journal of applied physiology	1997
Yearbook of Intensive Care and Emergency Medicine 1997 JL Vincent		1997
Noninvasive monitoring of hemodynamic changes in acute pancreatitis in rabbits M Gyöngyösi, T Takács, L Czakó, Z Jambrik, K Boda, A Farkas, T Forster, M Csanády	Digestive Diseases and Sciences	1997
Tumor necrosis factor alpha and interleukin 1beta are responsible for in vitro myocardial cell depression induced by human septic shock serum A Kumar, V Thota, L Dee, J Olson, E Uretz, JE Parrillo	Journal of Experimental Medicine	1996
Role of endotoxemia in cardiovascular dysfunction and lethality: virulent and nonvirulent Escherichia coli challenges in a canine model of septic shock WD Hoffman, RL Danner, ZM Quezado, SM Banks, RJ Elin, JM Hosseini, C Natanson	Infection and immunity	1996
Circuit factors in the high cardiac output of sepsis S Magder, G Vanelli	Journal of Critical Care	1996
Indications du remplissage vasculaire dans le choc septique C Frot, D Payen	Réanimation Urgences	1996
Myocardial dysfunction after successful resuscitation from cardiac arrest: RJ Gazmuri, MH Weil, J Bisera, W Tang, M Fukui, DA McKee	Critical Care Medicine	1996
Hemodynamic Effects of IV Milrinone Lactate in Pediatric Patients With Septic Shock P Barton, J Garcia, A Kouatli, L Kitchen, A Zorka, C Lindsay, S Lawless, B Giroir	Chest	1996
Tumor Necrosis Factor-α Induces a Biphasic Effect on Myocardial Contractility in Conscious Dogs DR Murray, GL Freeman	Circulation research	1996
Prevention of endotoxin-induced acute lethality in Propionibacterium acnes-primed rabbits by an antibody to leukocyte integrin beta 2 with concomitant reduction of cytokine production N Ikeda, N Mukaida, S Kaneko, N Fujioka, S Su, H Nariuchi, M Unoura, K Harada, Y Nakanuma, K Kobayashi	Infection and immunity	1995
Role of alpha-2-macroglobulin and bacterial elastase in guinea-pig pseudomonal septic shock MM Khan, Y Shibuya, T Kambara, T Yamamoto	International Journal of Experimental Pathology	1995
Current understanding of sepsis: criticism and a proposal R Rabinovici, LF Neville, G Feuerstein	Journal of Endotoxin Research	1995
Role of Nitric Oxide in Sepsis and ADRS MP Fink, D Payen		1995
Shock, Sepsis, and Organ Failure — Nitric Oxide G Schlag, H Redl		1995
The third component of complement protects against Escherichia coli endotoxin-induced shock and multiple organ failure ZM Quezado, WD Hoffman, JA Winkelstein, I Yatsiv, CA Koev, LC Cork, RJ Elin, PQ Eichacker, C Natanson	Journal of Experimental Medicine	1994
Effects of N-acetylcysteine in endotoxic shock J Bakker, H Zhang, M Depierreux, S Asbeck, JL Vincent	Journal of Critical Care	1994
Regional blood flow distribution in endotoxin-treated dogs: Modification by ibuprofen C Winslow, PM Dorinsky	Journal of Critical Care	1994
Ultrasonographic evaluation of central and end-organ hemodynamics in antepartum pyelonephritis DM Twickler, MJ Lucas, L Bowe, DD McIntire, J Barron, FG Cunningham	American Journal of Obstetrics and Gynecology	1994
Systemic Inflammatory Response Syndrome: Septic Shock D Purvis, R Kirby	Veterinary Clinics of North America Small Animal Practice	1994
Mediator-Specific Therapies for the Systemic Inflammatory Response Syndrome, Sepsis, Severe Sepsis, and Septic Shock: Present and Future Approaches MF Hazinski	Critical Care Nursing Clinics of North America	1994
Oxygen Transport to Tissue XV P Vaupel, R Zander, DF Bruley		1994
The immunocytochemical localization of tumour necrosis factor and leukotriene in the rat heart and lung during endotoxin shock N Tanaka, T Kita, K Kasai, T Nagano	Virchows Archiv	1994
Endotoxin-induced pulmonary dysfunction is prevented by C1-esterase inhibitor R Guerrero, F Velasco, M Rodriguez, A Lopez, R Rojas, MA Alvarez, R Villalba, V Rubio, A Torres, D Castillo	Journal of Clinical Investigation	1993
Hemodynamic changes associated with thermodilution cardiac output determination in canine acute blood loss or endotoxemia T Nishikawa	Acta Anaesthesiologica Scandinavica	1993
Metabolic basis for management of the septic surgical patient JH Shaw, JB Koea	World Journal of Surgery	1993
Pathogenetic Mechanisms of Septic Shock FH Epstein, JE Parrillo	New England Journal of Medicine	1993
Acute mesenteric ischemia: Pathophysiology, diagnosis, and treatment E Benjamin, JM Oropello	Disease-a-Month	1993
Endotoxin in Human Disease CA Manthous, JB Hall, RW Samsel	Chest	1993
Pseudomonal elastase injection causes low vascular resistant shock in guinea pigs MH Mohammad, T Yamamoto, H Araki, Y Ijiri, Y Shibuya, M Okamoto, T Kambara	Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease	1993
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N omega-amino-L-arginine, an inhibitor of nitric oxide synthase, raises vascular resistance but increases mortality rates in awake canines challenged with endotoxin JP Cobb, C Natanson, WD Hoffman, RF Lodato, S Banks, CA Koev, MA Solomon, RJ Elin, JM Hosseini, RL Danner	Journal of Experimental Medicine	1992
Altered ryanodine receptor of canine cardiac sarcoplasmic reticulum and its underlying mechanism in endotoxin shock LL Wu, MS Liu	Journal of Surgical Research	1992
Systemic Hemodynamic Abnormalities and Vasopressor Therapy in Sepsis and Septic Shock ZM Quezado, C Natanson	American Journal of Kidney Diseases	1992
Cytokines induce stress protein formation in cultured cardiac myocytes I Lw-Friedrich, D Weisensee, P Mitrou, W Schoeppe	Basic Research in Cardiology	1992
Function of Isolated Hearts from Septic, Saline-Infused, and Septic, Alcohol-Infused Rats AE Muniz, KH McDonough	Alcoholism, clinical and experimental research	1991
Right ventricular pump dysfunction with acute experimental septic shock JL Zellner, FG Spinale, FA Crawford, JA Cook	Journal of Surgical Research	1991
Effets hémodynamiques de la dobutamine dans le choc septique hyperkinétique traité par noradrénaline C Lejus, Y Blanloeil, T François, P Michel, M Pinaud, P Desjars	Annales Françaises d’Anesthésie et de Réanimation	1991
Reduction in the Ca2+-induced Ca2+ release from canine cardiac sarcoplasmic reticulum following endotoxin administration MS Liu, LL Wu	Biochemical and Biophysical Research Communications	1991
Endotoxemia in Human Septic Shock RL Danner, RJ Elin, JM Hosseini, RA Wesley, JM Reilly, JE Parillo	Chest	1991
Southwestern Internal Medicine Conference: Septic Shock AR Nogare	The American Journal of the Medical Sciences	1991
Impaired calcium uptake by cardiac sarcoplasmic reticulum and its underlying mechanism in endotoxin shock LL Wu, MS Liu	Molecular and Cellular Biochemistry	1991
Endotoxin-induced myocardial depression in rats: Effect of ibuprofen and SDZ 64-688, a platelet activating factor receptor antagonist TD Baum, SO Heard, HS Feldman, CA Latka, MP Fink	Journal of Surgical Research	1990
LY171883 preserves mesenteric perfusion in porcine endotoxic shock SM Cohn, MP Fink, PC Lee, H Wang, HR Rothschild, YF Deniz, T Baum	Journal of Surgical Research	1990
Laboratory models of sepsis and septic shock MP Fink, SO Heard	Journal of Surgical Research	1990
Myocardial function in septic shock MM Parker, JE Parrillo	Journal of Critical Care	1990
The heart and circulation in sepsis RF Raper, MM Fisher	Baillière's Clinical Anaesthesiology	1990
Pseudomonas aeruginosa Compared with Escherichia coli Produces Less Endotoxemia but More Cardiovascular Dysfunction and Mortality in a Canine Model of Septic Shock RL Danner, C Natanson, RJ Elin, JM Hosseini, S Banks, TJ MacVittie, JE Parrillo	Chest	1990
Sepsis and the Trauma Patient GP McGuire, RG Pearl	Critical Care Clinics	1990
Shock in the Pediatric Patient MF Hazinski	Critical Care Nursing Clinics of North America	1990
Update 1990 JL Vincent		1990
Mechanical Heart-Lung Interaction in the Adult Respiratory Distress Syndrome JW Biondi, DS Schulman, HP Wiedemann, RA Matthay	Clinics in Chest Medicine	1990
Role of endotoxemia in cardiovascular dysfunction and mortality. Escherichia coli and Staphylococcus aureus challenges in a canine model of human septic shock C Natanson, RL Danner, RJ Elin, JM Hosseini, KW Peart, SM Banks, TJ MacVittie, RI Walker, JE Parrillo	Journal of Clinical Investigation	1989
Endotoxin and tumor necrosis factor challenges in dogs simulate the cardiovascular profile of human septic shock C Natanson, PW Eichenholz, RL Danner, PQ Eichacker, WD Hoffman, GC Kuo, SM Banks, TJ MacVittie, JE Parrillo	Journal of Experimental Medicine	1989
Early systolic and diastolic dysfunction during sepsis in rats BE Field, EC Rackow, ME Astiz, MH Weil	Journal of Critical Care	1989
Relative myocardial depression in normotensive sepsis R Raper, WJ Sibbald, AA Driedger, K Gerow	Journal of Critical Care	1989
Pitfalls in interpretation of pulmonary artery catheter data KJ Tuman, GC Carroll, AD Ivankovich	Journal of Cardiothoracic Anesthesia	1989
The Cardiovascular Response of Normal Humans to the Administration of Endotoxin AF Suffredini, RE Fromm, MM Parker, M Brenner, JA Kovacs, RA Wesley, JE Parrillo	New England Journal of Medicine	1989
Inotropic Response to Digoxin and Dopamine in Patients with Severe Sepsis, Cardiac Failure, and Systemic Hypoperfusion SA Nasraway, EC Rackow, ME Astiz, G Karras, MH Weil	Chest	1989
Myocardial Dysfunction in Sepsis Recent Insights RE Cunnion, JE Parrillo	Chest	1989
Myocardial Dysfunction in Sepsis RE Cunnion, JE Parrillo	Critical Care Clinics	1989
Clinical Aspects of O2 Transport and Tissue Oxygenation K Reinhart, K Eyrich		1989
Preanesthetic Assessment 2 EA Frost		1989
Bacterial Septic Shock WD Hoffman, C Natanson	Anesthesiology Clinics of North America	1989
Assessment of the intrinsic contractile status of the heart during sepsis by myocardial pressure-dimension analysis MK Pasque, PV Trigt, GL Pellom, BM Freedman, AS Wechsler	Annals of Surgery	1988
Neutrophil aggregating activity and septic shock in humans: Neutrophil aggregation by a C5a-like material occurs more frequently than complement component depletion and correlates with depression of systemic vascular resistance FP Ognibene, MM Parker, C Burch-Whitman, C Natanson, JH Shelhamer, T Schlesinger, P Roach, JE Parrillo	Journal of Critical Care	1988
Depressed Left Ventricular Performance FP Ognibene, MM Parker, C Natanson, JH Shelhamer, JE Parrillo	Chest	1988
Interleukin-2 Administration Causes Reversible Hemodynamic Changes and Left Ventricular Dysfunction Similar to Those Seen in Septic Shock FP Ognibene, SA Rosenberg, M Lotze, J Skibber, MM Parker, JH Shelhamer, JE Parrillo	Chest	1988
Review: Cardiopulmonary Toxicity of Adoptive Immunotherapy FL Glauser, G DeBlois, D Bechard, AA Fowler, R Merchant, RP Fairman	The American Journal of the Medical Sciences	1988
Cardiovascular Dysfunction in Multisystem Organ Failure: Focus on Septic Shock D Kramer, V Kvetan, J Askanazi, E Lazar	Anesthesiology Clinics of North America	1988
Diverticulitis T Pohlman	Gastroenterology Clinics of North America	1988
Effects of Acid Base Disturbance, Septic Shock, and Calcium and Phosphorous Abnormalities on Cardiovascular Function PM Mehta, RA Kloner	Critical Care Clinics	1987
Care of the Critically Ill Patient J Tinker, M Rapin		1983

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