Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Feedback regulation of pancreatic enzyme secretion. Suppression of cholecystokinin release by trypsin.
C Owyang, … , D S Louie, D Tatum
C Owyang, … , D S Louie, D Tatum
Published June 1, 1986
Citation Information: J Clin Invest. 1986;77(6):2042-2047. https://doi.org/10.1172/JCI112534.
View: Text | PDF
Research Article

Feedback regulation of pancreatic enzyme secretion. Suppression of cholecystokinin release by trypsin.

  • Text
  • PDF
Abstract

Feedback regulation of pancreatic enzyme secretion occurs in rats. Whether such a system exists in man remains unsettled and the responsible mechanism is unknown. To investigate this question gastrointestinal intubation and perfusion were performed in 12 healthy subjects. Intraduodenal perfusion of trypsin-inhibited phenylalanine-, oleic acid-, and meal-stimulated chymotrypsin and lipase outputs in a dose-related manner. The minimal concentration of bovine trypsin needed to inhibit pancreatic enzyme secretion was 0.5 g/liter. 1 g/liter caused a maximal suppression of 35 +/- 4% of the phenylalanine-stimulated chymotrypsin release. This inhibitory effect was protease-specific. Intraduodenal perfusion of phenylalanine and oleic acid increased plasma cholecystokinin (CCK) from a basal level of 0.9 +/- 0.06 to 5.3 +/- 0.9 pM and 7.2 +/- 1.3 pM, respectively. Addition of bovine trypsin to the perfusates significantly reduced the plasma CCK level to basal values. This inhibitory effect of trypsin on CCK release was dose dependent and specific to proteases. Therefore, the present studies indicate that feedback regulation of pancreatic enzyme secretion is operative in man and it is mediated by release of CCK.

Authors

C Owyang, D S Louie, D Tatum

×

Total citations by year

Year: 2024 2021 2020 2019 2018 2017 2016 2015 2014 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 1975 1964 Total
Citations: 2 2 3 8 2 2 1 2 1 2 2 1 2 2 1 3 3 1 6 7 2 11 8 7 10 5 10 10 9 8 9 11 13 9 1 1 1 1 179
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (179)

Title and authors Publication Year
Basal pancreatic secretion in a comparative aspect in poultry and rodents
Kuzmina IV, Tolpygo SM, Kotov AV, Shoibonov BB, Zamolodchikova TS
Frontiers in physiology 2024
Pancreatic Enzyme Use Reduces Pancreatitis Frequency in Children With Acute Recurrent or Chronic Pancreatitis: A Report From INSPPIRE.
Freeman AJ, Ng K, Wang F, Abu-El-Haija MA, Chugh A, Cress GA, Fishman DS, Gariepy CE, Giefer MJ, Goday P, Gonska TY, Grover AS, Lindblad D, Liu QY, Maqbool A, Mark JA, McFerron BA, Mehta MS, Morinville VD, Noel RA, Ooi CY, Perito ER, Schwarzenberg SJ, Sellers ZM, Wilschanski M, Zheng Y, Yuan Y, Andersen DK, Lowe ME, Uc A
The American journal of gastroenterology 2024
Clinical Pancreatology for Practising Gastroenterologists and Surgeons
JE DomínguezMuñoz
2021
Medical Management of Chronic Pancreatitis in Children: A Position Paper by the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Pancreas Committee
AJ Freeman, A Maqbool, MD Bellin, KR Goldschneider, AS Grover, C Hartzell, TL Piester, F Szabo, BD Kiernan, R Khalaf, R Kumar, M Rios, SZ Husain, VD Morinville, M Abu-El-Haija
Journal of Pediatric Gastroenterology and Nutrition 2021
Targeting obesity with plant-derived pancreatic lipase inhibitors: A comprehensive review
L Rajan, D Palaniswamy, SK Mohankumar
Pharmacological research : the official journal of the Italian Pharmacological Society 2020
Chronic Pancreatitis: Epidemiology, Diagnosis, and Management Updates
A Kichler, S Jang
Drugs 2020
Pancreatobiliary Diversion in the Mouse
X Chen, S Qiu, Q Li, L Hu, C Yao, X Xu, F Wang
European Surgical Research 2020
Therapeutic Enzymes: Function and Clinical Implications
N Labrou
2019
Therapeutic Enzymes: Function and Clinical Implications
N Labrou
2019
Therapeutic Enzymes: Function and Clinical Implications
N Labrou
2019
Therapeutic Enzymes: Function and Clinical Implications
N Labrou
2019
Therapeutic Enzymes: Function and Clinical Implications
N Labrou
2019
Therapeutic Enzymes: Function and Clinical Implications
N Labrou
2019
Therapeutic Enzymes: Function and Clinical Implications
N Labrou
2019
Plasmid DNA nicking- a Novel Activity of Soybean Trypsin Inhibitor and Bovine Aprotinin
MR Islam, K Ihenacho, JW Park, IS Islam
Scientific Reports 2019
Identification and characterization of a calcium dependent bacillopeptidase from Bacillus subtilis CFR5 with novel kunitz trypsin inhibitor degradation activity
GR Sharmila, PM Halami, G Venkateswaran
Food research international (Ottawa, Ont.) 2018
The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery
HG Beger, AL Warshaw, RH Hruban, MW Büchler, MM Lerch, JP Neoptolemos, T Shimosegawa, DC Whitcomb, C Groß
2018
Inhibition effect of food preservatives on endoproteinases
EN Esimbekova, AA Asanova, AA Deeva, VA Kratasyuk
Food Chemistry 2017
Guidelines for the understanding and management of pain in chronic pancreatitis
AM Drewes, SA Bouwense, CM Campbell, GO Ceyhan, M Delhaye, IE Demir, PK Garg, H Goor, C Halloran, S Isaji, JP Neoptolemos, SS Olesen, T Palermo, PJ Pasricha, A Sheel, T Shimosegawa, E Szigethy, DC Whitcomb, D Yadav
Pancreatology 2017
Management of pain in chronic pancreatitis with emphasis on exogenous pancreatic enzymes
PM Hobbs, WG Johnson, DY Graham
World journal of gastrointestinal pharmacology and therapeutics 2016
Hawthorn Nectar Enhances Gastrointestinal Motility as Well as Stimulates Intestinal Am-ylase and Lipase Activities in Mice
S Zou, J Li, C Ma, J Chen, PK Leong, HY Leung, WM Chan, HS Wong, KM Ko
Chinese medicine 2015
Yamada' s Textbook of Gastroenterology
DK Podolsky, M Camilleri, JG Fitz, AN Kalloo, F Shanahan, TC Wang
Yamada' s Textbook of Gastroenterology 2015
Comprehensive Physiology
SN Cheuvront, RW Kenefick
Comprehensive Physiology 2014
Modern Treatment of Patients with Chronic Pancreatitis
G Trikudanathan, U Navaneethan, SS Vege
Gastroenterology Clinics of North America 2012
Regulation of pancreatic exocrine secretion in goats: differential effects of short- and long-term duodenal phenylalanine treatment : Phenylalanine affects pancreatic exocrine secretion of goats
ZP Yu, M Xu, JH Yao, K Liu, F Li, Y Liu, F Wang, FF Sun, NN Liu
Journal of Animal Physiology and Animal Nutrition 2012
The Exocrine Pancreas
SJ Pandol
Colloquium Series on Integrated Systems Physiology: From Molecule to Function 2011
Amino acids stimulate cholecystokinin release through the Ca 2+ -sensing receptor
Y Wang, R Chandra, LA Samsa, B Gooch, BE Fee, JM Cook, SR Vigna, AO Grant, RA Liddle
AJP Gastrointestinal and Liver Physiology 2011
Physiological parameters governing the action of pancreatic lipase
IA Brownlee, DJ Forster, MD Wilcox, PW Dettmar, CJ Seal, JP Pearson
Nutrition Research Reviews 2010
Hormones, Brain and Behavior
J Bernal
Hormones, Brain and Behavior 2009
Microbiota-triggered colonic delivery: Robustness of the polysaccharide approach in the fed state in man
AW Basit, MD Short, EL McConnell
Journal of Drug Targeting 2009
Negative Control of Human Pancreatic Secretion
J Morisset
Pancreas 2008
Pain management in chronic pancreatitis
C Gachago, PV Draganov
World journal of gastroenterology : WJG 2008
Ileal exposure to pig pancreatic juice and bile inhibit exocrine pancreatic secretion in pigs
SG Pierzynowski, V Sileikiene, JL Piedra, S Szymanczyk, PC Gregory, D Kruszewska, R Mosenthin, A Rzasa, S Kowalik, R Zabielski, B Weström
Livestock Science 2007
Postprandial Gastrointestinal Hormone Production Is Different, Depending on the Type of Reconstruction Following Total Gastrectomy
K Kalmár, J Németh, D Kelemen, A Kelemen, E Agoston, OP Horváth
Annals of Surgery 2006
Role of cholecystokinin in the gastric motor response to a meal in horses
M Lorenzo-Figueras, AM Merritt
American Journal of Veterinary Research 2006
Biochemistry and Biology of SPINK-PSTI and Monitor Peptide
R Graf, D Bimmler
Endocrinology and metabolism clinics of North America 2006
Human pancreatic exocrine response to nutrients in health and disease
J Keller, P Layer
Gut 2005
Fisiopatología, diagnóstico y tratamiento de la insuficiencia pancreática exocrina tras pancreatitis aguda
JM Sempere, M Pérez-Mateo
Gastroenterología y Hepatología 2005
Pancreatitis: Advances in Pathobiology, Diagnosis and Treatment
RW Ammann, G Adler, MW Büchler, EP DiMagno, M Sarner
2005
Encyclopedia of Endocrine Diseases
J Borén, O Wiklund
Encyclopedia of Endocrine Diseases 2004
Tropical chronic pancreatitis
KK Barman, G Premalatha, V Mohan
Postgraduate medical journal 2003
Encyclopedia of Hormones
RA DeFronzo, LJ Mandarino
Encyclopedia of Hormones 2003
Inhibition of endogenous pancreatic enzyme secretion by oral pancreatic enzyme treatment
J Walkowiak, H Witmanowski, K Strzykala, B Bychowiec, T Songin, K Borski, KH Herzig
European Journal of Clinical Investigation 2003
Pancreatitis
RM Mitchell, MF Byrne, J Baillie
The Lancet 2003
Development of the Pancreas and Small Intestine in Rat
S NAKAMATA, S OZAWA, H YOSHIDA, S TANAKA, K MITAMURA
The Showa University Journal of Medical Sciences 2003
Differential mechanism and site of action of CCK on the pancreatic secretion and growth in rats
M Yamamoto, M Otani, DM Jia, KI Fukumitsu, H Yoshikawa, T Akiyama, M Otsuki
AJP Gastrointestinal and Liver Physiology 2003
Clinical Evaluation of Oral Administration of a Cholecystokinin-A Receptor Antagonist (Loxiglumide) to Patients with Acute, Painful Attacks of Chronic Pancreatitis: A Multicenter Dose–Response Study in Japan
K Shiratori, T Takeuchi, K Satake, S Matsuno
Pancreas 2002
Conservative treatment of chronic pancreatitis
A Khalid, DC Whitcomb
European Journal of Gastroenterology & Hepatology 2002
Chronic pancreatitis: Asia-Pacific consensus report
RK Tandon, N Sato, PK Garg
Journal of Gastroenterology and Hepatology 2002
Persistent decreased plasma cholecystokinin levels in celiac patients under gluten-free diet: respective roles of histological changes and nutrient hydrolysis
P Deprez, C Sempoux, BE van Beers, A Jouret, A Robert, J Rahier, A Geubel, S Pauwels, P Mainguet
Regulatory Peptides 2002
Pathological evaluation, clinical chemistry and plasma cholecystokinin in neonatal and young miniature swine fed soy trypsin inhibitor from 1 to 39 weeks of age
LH Garthoff, GR Henderson, AO Sager, TJ Sobotka, DW Gaines, MW O'Donnell, R Chi, SJ Chirtel, CN Barton, LH Brown, FA Hines, T Solomon, J Turkleson, D Berry, H Dick, F Wilson, MA Khan
Food and Chemical Toxicology 2002
Biliary acute pancreatitis:a review
Osvaldo M Tiscornia, Susana Hamamura, Enriqueta S Lehmann, Graciela Otero, Hipolito Waisman, Patricia Tiscornia-Wasserman, Simmy Bank
World journal of gastroenterology : WJG 2002
Luminal CCK-releasing factor stimulates CCK release from human intestinal endocrine and STC-1 cells
Y Wang, V Prpic, GM Green, JR Reeve, RA Liddle
AJP Gastrointestinal and Liver Physiology 2002
Pancreatic enzyme replacement therapy
L Peter, K Jutta, PG Lankisch
Current Gastroenterology Reports 2001
Feedback control of pancreatic exocrine secretion: its relationship to the management of the abdominal pain associated with chronic pancreatitis
PP Toskes
Transactions of the American Clinical and Climatological Association 2001
Diazepam-binding inhibitor mediates feedback regulation of pancreatic secretion and postprandial release of cholecystokinin
Y Li, Y Hao, C Owyang
Journal of Clinical Investigation 2000
Pathophysiological role of cholecystokinin in humans
M Otsuki
Journal of Gastroenterology and Hepatology 2000
Adaptation of the exocrine pancreas to dietary fats
MD Yago, E Martínez-Victoria, RJ Díaz, MA Martínez, J Singh, M Mañas
Journal of Physiology and Biochemistry 2000
A secretin releasing peptide exists in dog pancreatic juice
P Li, Y Song, KY Lee, TM Chang, WY Chey
Life Sciences 2000
Biliary acute pancreatitis: A review
Osvaldo M. Tiscornia, Susana Hamamura, Enriqueta S. de Lehmann, Graciela Otero, Hipólito Waisman, Patricia Tiscornia-Wasserman, Simmy Bank
World journal of gastroenterology : WJG 2000
Pathogenesis and managenent of pain in chronic pancreatitis
C.S.Pitchumoni
World journal of gastroenterology : WJG 2000
Cellular mechanism of sodium oleate-stimulated secretion of cholecystokinin and secretin
CH Chang, WY Chey, TM Chang
AJP Gastrointestinal and Liver Physiology 2000
Effects of Intraluminal Trypsin and Bile on the Exocrine and Endocrine Pancreas After Pancreaticobiliary Diversion and Biliodigestive Shunt:
B Ohlsson, T Yusa, JF Rehfeld, I Lundquist, I Ihse, J Axelson
Pancreas 2000
Drug Development
TS Gaginella, A Guglietta
2000
Assessment of Pancreatic Enzyme Secretory Capacity by a Modified Lundh Test
L Czakó, F Hajnal, J Németh, J Lonovics
International Journal of Gastrointestinal Cancer 2000
Pathogenesis and managenent of pain in chronic pancreatitis.
Pitchumoni CS
World Journal of Gastroenterology 2000
Pancreatic Enzymes: Secretion and Luminal Nutrient Digestion in Health and Disease
P Layer, J Keller
Journal of Clinical Gastroenterology 1999
Chronic Pancreatitis: Complications and Management
MV Apte, GW Keogh, JS Wilson
Journal of Clinical Gastroenterology 1999
Pain Management in chronic pancreatitis
DL Conwell, G Zuccaro
Current Treatment Options in Gastroenterology 1999
ENZYMATIC THERAPY IN PATIENTS WITH CHRONIC PANCREATITIS
NJ Greenberger
Gastroenterology Clinics of North America 1999
PALLIATION OF PAIN IN CHRONIC PANCREATITIS
J Mössner
Surgical Clinics of North America 1999
Inhibition of digestive proteases by vegetable meals in three fish species; seabream (Sparus aurata), tilapia (Oreochromis niloticus) and African sole (Solea senegalensis)
FJ López, IM Dı́az, MD López, FJ López
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 1999
Radiology of the Pancreas
AL Baert, G Delorme, LV Hoe
1999
Darmkrankheiten
WF Caspary, J Stein
1999
Adaptation of the human pancreas to inhibition of luminal proteolytic activity
H Friess, J Kleeff, R Isenmann, P Malfertheiner, MW Büchler
Gastroenterology 1998
Regulation of the action of the novel cholecystokinin-releasing peptide diazepam binding inhibitor by inhibitory hormones and taurocholate
KH Herzig, C Wilgus, I Schön, K Tatemoto, UR Fölsch
Regulatory Peptides 1998
Chronic Pancreatitis
CS Pitchumoni
Journal of Clinical Gastroenterology 1998
AGA technical review: Treatment of pain in chronic pancreatitis
AL Warshaw, PA Banks, CF Castillo
Gastroenterology 1998
Involvement of Endogenous Cholecystokinin and Somatostatin in Gastroprotection Induced by Intraduodenal Fat
T Brzozowski, PC Konturek, SJ Konturek, S Kwiecień, R Pajdo, I Brzozowska, EG Hahn
Journal of Clinical Gastroenterology 1998
CCK-, secretin-, and cholinergic-independent pancreatic fluid hypersecretion in protease inhibitor-treated rats
M Yamamoto, H Shirohara, M Otsuki
AJP Gastrointestinal and Liver Physiology 1998
Influence of High-Dose Pancreatic Enzyme Treatment on Pancreatic Function in Healthy Volunteers
H Friess, J Kleeff, P Malfertheiner, MW Müller, K Homuth, MW Büchler
International Journal of Gastrointestinal Cancer 1998
Cholecystokinin-A receptor antagonists: therapies for gastrointestinal disorders
M D'Amato, LC Rovati
Expert Opinion on Investigational Drugs 1997
CHOLECYSTOKININ CELLS
RA Liddle
Annual Review of Physiology 1997
The potency of dietary amino acids in elevating plasma cholecystokinin immunoreactivity in cats is related to amino acid hydrophobicity
RC Backus, KA Howard, QR Rogers
Regulatory Peptides 1997
Plasma cholecystokinin and its precursors in hepatic cirrhosis
LI Paloheimo, O Clemmesen, K Dalhoff, JF Rehfeld
Journal of Hepatology 1997
Clinical Studies of Human Pancreatic Enzyme Synthesis
SJ O'Keefe
The Yale journal of biology and medicine 1997
Plasma Concentrations of Cholecystokinin and Neurotensin in Patients with Cystic Fibrosis
KH Herzig, J Domagk, R Nustede, M Stern, B Bewig, WK Cichy, UR Fölsch
Scandinavian Journal of Gastroenterology 1997
Feedback Regulation of Pancreatic Exocrine Secretion in Minipigs
T Houe, SS Sætre, P Svendsen, O Olsen, JF Rehfeld, OB de Muckadell
Scandinavian Journal of Gastroenterology 1997
Distribution and Localization of a Novel Cholecystokinin-Releasing Factor in the Rat Gastrointestinal Tract*
N Tarasova, AW Spannagel, GM Green, G Gomez, JT Reed, JC Thompson, MR Hellmich, JR Reeve, RA Liddle, GH Greeley
Endocrinology 1997
Clinical Pathology of Pancreatic Disorders
JA Lott
1997
Diagnostic Procedures in Pancreatic Disease
P Malfertheiner, JE Domínguez-Muñoz, HU Schulz, H Lippert
1997
Purification and characterization of a luminal cholecystokinin-releasing factor from rat intestinal secretion
AW Spannagel, GM Green, D Guan, RA Liddle, K Faull, JR Reeve
Proceedings of the National Academy of Sciences 1996
Effects of intravenous infusion of amino acids on cholecystokinin release and gallbladder contraction in humans
H Shirohara, A Tabaru, M Otsuki
Journal of Gastroenterology 1996
Effects of nafamostat mesilate, somatostatin, and glucagon on caerulein-induced acute pancreatitis in rats
K Mori, Y Marugami, Y Sakurai, M Ochiai, S Hasegawa, H Imazu, T Matsubara, M Suganuma, A Shikata, T Funabiki
Journal of Hepato-Biliary-Pancreatic Surgery 1996
Chronic Bile Diversion to the Urinary Bladder Enhances Cholecystokinin Release and Suppresses Gastric Inhibitory Polypeptide Release in Dogs
M Takahashi, I Sasaki, H Naito, Y Funayama, C Shibata, S Matsuno
The Tohoku Journal of Experimental Medicine 1996
Bile-pancreatic juice replacement not cholinergic-and cholecystokinin-receptor blockade reverses acinar cell hyperstimulation after bile-pancreatic duct ligation
I Samuel, RJ Joehl
The American Journal of Surgery 1996
Adaptation to high-fat diets: effects on eating behaviour and plasma cholecystokinin
SJ French, B Murray, RD Rumsey, R Fadzlin, NW Read
British Journal of Nutrition 1995
Decreased plasma levels of cholecystokinin in healthy males after chronic ingestion of a heat-treated soya product
LJ Lu, KE Anderson, G Gomez, WH Nealon
Cancer Letters 1995
No Effect of Long-Term Treatment with Pancreatic Extract on Recurrent Abdominal Pain in Patients with Chronic Pancreatitis
A Malesci, E Gaia, A Fioretta, P Bocchia, G Ciravegna, P Cantor, I Vantini
Scandinavian Journal of Gastroenterology 1995
Pain in Chronic Pancreatitis
JB Jansen, JH Kuijpers, FJ Zitman, R Dongen
Scandinavian Journal of Gastroenterology 1995
Effect of predigested fat on intestinal stimulation of plasma cholecystokinin and gall bladder motility in coeliac disease
WP Hopman, G Rosenbusch, MP Hectors, JB Jansen
Gut 1995
Profound duodenogastric reflux causes pancreatic growth in rats
T Gasslander, H Mukaida, MK Herrington, RA Hinder, TE Adrian
Gut 1995
Chirurgisches Forum ’95 für experimentelle und klinische Forschung
HG Beger, G Hierholzer, J Seifert, W Hartel
1995
On the role of cholecystokinin in pancreatic cancer
MK Herrington, TE Adrian
International Journal of Gastrointestinal Cancer 1995
Time-course of the pancreatic changes following long-term stimulation or inhibition of the CCK-A receptor
B Ohlsson, J Axelson, B Sternby, JF Rehfeld, I Ihse
International Journal of Gastrointestinal Cancer 1995
No negative feedback regulation between plasma CCK levels and luminal tryptic activities in patients with pancreatic insufficiency
T Nakamura, K Takebe, K Kudoh, M Ishii, K Imamura, H Kikuchi, F Kasai, Y Tandoh, N Yamada, Y Arai, A Terada, K Machida
International Journal of Gastrointestinal Cancer 1995
Feedback Inhibition of Cholecystokinin Secretion by Bile Acids and Pancreatic Proteases
GM Green
Annals of the New York Academy of Sciences 1994
Biological actions of cholecystokinin
JN Crawley, RL Corwin
Peptides 1994
Regulation of Cholecystokinin Gene Expression in Rat Intestine
RA Liddle
Annals of the New York Academy of Sciences 1994
Relationship between postprandial release of CCK and PP in health and in chronic pancreatitis
B Glasbrenner, JE Dominguez-Muñoz, DK Nelson, RL Riepl, M Büchler, P Malfertheiner
Regulatory Peptides 1994
Effect of bile salt binding or protease inactivation on plasma cholecystokinin and gallbladder responses to bombesin
PW Thimister, WP Hopman, CE Sloots, G Rosenbusch, A Tangerman, HL Willems, CB Lamers, JB Jansen
Gastroenterology 1994
Roles of gut hormones in negative-feedback regulation of pancreatic exocrine secretion in humans
HO Jin, CW Song, TM Chang, WY Chey
Gastroenterology 1994
Endogenous cholecystokinin stimulates pancreatic enzyme secretion via vagal afferent pathway in rats
Y Li, C Owyang
Gastroenterology 1994
Facing the Pancreatic Dilemma
P Pederzoli, G Cavallini, C Bassi, M Falconi
1994
Pancreatic enzymes in chronic pancreatitis
P Layer, G Holtmann
International Journal of Gastrointestinal Cancer 1994
Gastrin-releasing peptide and CCK after intraduodenal inhibition of proteases in dogs
R Nustede, WE Schmidt, M Jäger, F Stöckmann, H Köhler, UR Fölsch, HJ Peiper
International Journal of Gastrointestinal Cancer 1994
Effect of jejunal infusion of different caloric loads on pancreatic enzyme secretion and gastro-intestinal hormone response in man
A Pfeiffer, N Vidon, GE Feurle, JA Chayvialle, JJ Bernier
European Journal of Clinical Investigation 1993
Effect of duodenal juice on bombesin-stimulated cholecystokinin release during loxigIumide administration in man
MC Jebbink, JB Jansen, FG van der Kleij, DM Mooy, LC Rovatit, CB Lamers
European Journal of Clinical Investigation 1993
Endogenous somatostatin possibly controls pancreatic growth: Further evidence for feedback regulation
M Rünzi, MK Müller, H Goebell
Regulatory Peptides 1993
Role of secretin in negative feedback regulation of postprandial pancreatic secretion in dogs
M Imamura, KY Lee, Y Song, M Moriyasu, TM Chang, WY Chey
Gastroenterology 1993
Standards in Pancreatic Surgery
HG Beger, M Büchler, P Malfertheiner
1993
Ökosystem Darm V
M Zeitz, WF Caspary, J Bockemühl, G Lux
1993
Duodenal juice total protein and pancreatic enzyme synthesis, turnover, and secretion in patients after acute pancreatitis
JM Ogden, SJ O'Keefe, JA Louw, G Adams, IN Marks
Gut 1993
Ökosystem Darm IV
J Bockemühl, R Ottenjann, M Zeitz, G Lux
1993
The influence of bile acids on the regulation of exocrine pancreatic secretion and on the plasma concentrations of neurotensin and CCK in dogs
R Nustede, WE Schmidt, H Köhler, UR Fölsch, A Schafmayer
International Journal of Gastrointestinal Cancer 1993
Cholecystokinin cells purified by fluorescence-activated cell sorting respond to monitor peptide with an increase in intracellular calcium
RA Liddle, MA Misukonis, L Pacy, AE Balber
Proceedings of the National Academy of Sciences 1992
Trypsin inhibitor and maternal reunion increase plasma cholecystokinin in neonatal rats
A Weller, ES Corp, A Tyrka, RC Ritter, L Brenner, J Gibbs, GP Smith
Peptides 1992
Evidence against autocrine feedback regulation of cholecystokinin secretion in man
MC Jebbink, JB Jansen, DM Mooy, CM Schouten, CB Lamers
Peptides 1992
Effect of chymotrypsin on human cholecystokinin release: use of clostripain in the validation of a new radioimmunoassay
K Beardshall, P Deprez, RJ Playford, M Alexander, J Calam
Regulatory Peptides 1992
Influence of dietary protein concentrations or of duodenal amino acid infusion on cholecystokinin release in goats
M Furuse, M Kato, SI Yang, K Asakura, J Okumura
Comparative Biochemistry and Physiology Part A: Physiology 1992
The effect of the cholecystokinin receptor antagonist MK-329 on meal-stimulated pancreaticobiliary output in humans
P Cantor, PE Mortensen, J Myhre, I Gjorup, H Worning, E Stahl, TT Survill
Gastroenterology 1992
A New Twist in the Brain-Gut Axis
DC Whitcomb, IL Taylor
The American Journal of the Medical Sciences 1992
Pancreatic Fistulas
P Pederzoli, C Bassi, S Vesentini
1992
Cholecystokinin receptor antagonist loxiglumide modulates plasma levels of gastro-entero-pancreatic hormones in man Feedback control of cholecystokinin and gastrin secretion
WE Schmidt, W Creutzfeldt, M Höcker, R Nustede, AR Choudhury, A Schleser, LC Rovati, UR Fölsch
European Journal of Clinical Investigation 1991
A note on plasma cholecystokinin concentration in dairy cows
M Furuse, SI Yang, YH Choi, N Kawamura, A Takahashi, J Okumura
Animal Production 1991
The importance of gastric secretion in the feedback control of interdigestive and postprandial pancreatic secretion in rats
SJ Konturek, E Krzyzek, J Bilski
Regulatory Peptides 1991
Factors Influencing the Release of Cholecystokinin Induced by Gastrin-Releasing Peptide in Man
L Lundell, P Cantor, M Sjövall, JF Rehfeld, L Olbe
Scandinavian Journal of Gastroenterology 1991
Pancreatic Enzymes in Health and Disease
PG Lankisch
1991
Regulation of pancreatic exocrine secretion
WY Chey
International Journal of Gastrointestinal Cancer 1991
Perspectives of CCK antagonists in pancreatic research: Part II. Experimental studies
T Takács, Á Pap
International Journal of Gastrointestinal Cancer 1991
Perspectives of CCK antagonists in pancreatic research and clinical use: Part I
LC Rovati
International Journal of Gastrointestinal Cancer 1991
Is there a duodenum-pancreas negative feedback?: Views: Pro and con
DF Magee
International Journal of Gastrointestinal Cancer 1991
Interactions of pancreatic secretory trypsin inhibitor in small intestinal juice: Its hydrolysis and protection by intraluminal factors
TC Freeman, R Davies, J Calam
Clinica Chimica Acta 1990
Oral administration of proteinase inhibitor II from potatoes reduces energy intake in man
AJ Hill, SR Peikin, CA Ryan, JE Blundell
Physiology & Behavior 1990
Feedback regulation of pancreatic exocrine secretion in animal and man
UR Fölsch
European Journal of Clinical Investigation 1990
Gastrointestinal Endocrinology
CC Wang, YH Tu, WY Zhu
Gastrointestinal Endocrinology 1990
Role of Cholecystokinin in the Regulation of Pancreatic Enzyme Secretion in the Rat
AJ de Jong, JB Jansen, CB Lamers
Scandinavian Journal of Gastroenterology 1990
Enhanced Release of Cholecystokinin by Soya-Bean Trypsin Inhibitor in Chickens
M Furuse, SI Yang, T Muramatsu, J Okumura
Scandinavian Journal of Gastroenterology 1990
Feedback Regulation of Human Pancreatic Secretion
P Layer, JB Jansen, L Cherian, CB Lamers, H Goebell
Gastroenterology 1990
Effect of pancreatic proteases on plasma cholecystokinin, secretin, and pancreatic exocrine secretion in response to sodium oleate
P Li, KY Lee, XS Ren, TM Chang, WY Chey
Gastroenterology 1990
Effect of partial gastrectomy with Billroth II or Roux-en-Y anastomosis on postprandial and cholecystokinin-stimulated gallbladder contraction and secretion of cholecystokinin and pancreatic polypeptide
PN Rieu, JB Jansen, WP Hopman, HJ Joosten, CB Lamers
Digestive Diseases and Sciences 1990
Hyperlipidemic Pancreatitis
PP Toskes
Gastroenterology Clinics of North America 1990
A critical appraisal of studies of the pancreas: Animal models used in pancreas research: Studies on feedback regulations of the pancreas
B Göke
International Journal of Gastrointestinal Cancer 1990
Effects of a novel cholecystokinin (CCK) receptor antagonist, MK-329, on gallbladder contraction and gastric emptying in humans. Implications for the physiology of CCK
RA Liddle, BJ Gertz, S Kanayama, L Beccaria, LD Coker, TA Turnbull, ET Morita
Journal of Clinical Investigation 1989
Endogenous cholecystokinin regulates growth of human cholangiocarcinoma
BM Evers, G Gomez, CM Townsend, S Rajaraman, JC Thompson
Annals of Surgery 1989
Down-regulation of pancreatic growth and gallbladder contractility by bile salts
G Gomez, CM Townsend, R Maani, P Singh, GG Greeley, JC Thompson
The American Journal of Surgery 1989
Effect of pancreatic enzyme supplementation on postprandial plasma cholecystokinin secretion in patients with pancreatic insufficiency
JB Jansen, MC Jebbink, HJ Mulders, CB Lamers
Regulatory Peptides 1989
Enhanced release of cholecystokinin by dietary amino acids in chicks (Gallus domesticus)
SI Yang, F Mitsuhiro, M Tatsuo, O Jun-Ichi
Comparative Biochemistry and Physiology Part A: Physiology 1989
Responses of the pancreatic digestive enzyme secretion to various combinations of amino acids and cholecystokinin in chicks (Gallus domesticus)
SI Yang, F Mitsuhiro, M Tatsuo, O Jun-Ichi
Comparative Biochemistry and Physiology Part A: Physiology 1989
Pancreatic Secretion and the Release of Cholecystokinin after a Meal in Dogs with and without Exclusion of Pancreatic Juice
M Kogire, K Inoue, R Hosotani, YS Huang, JC Thompson, T Tobe
Scandinavian Journal of Gastroenterology 1989
Differential effects of atropine and a cholecystokinin receptor antagonist on pancreatic secretion
G Adler, M Reinshagen, I Koop, B Göke, A Schafmayer, LC Rovati, R Arnold
Gastroenterology 1989
Effect of pancreatic juice diversion on secretin release in rats
G Sun, KY Lee, TM Chang, WY Chey
Gastroenterology 1989
Effect of Pancreatic juice and Trypsin on Oleic Acid-Stimulated Pancreatic Secretion and Plasma Secretin in Dogs
K Shiratori, YH Jo, KY Lee, TM Chang, WY Chey
Gastroenterology 1989
Influence of treatment with pancreatic extracts on pancreatic enzyme secretion
J Mossner, HP Wresky, W Kestel, J Zeeh, U Regner, W Fischbach
Gut 1989
Integrated Actions of Cholecystokinin on the Gastrointestinal Tract: Use of the Cholecystokinin Bioassay
RA Liddle
Gastroenterology Clinics of North America 1989
Gastrointestinal Peptides
DW Green, G Gomez, GH Greeley
Gastroenterology Clinics of North America 1989
Feedback regulation of stimulated pancreatic enzyme secretion during intraduodenal perfusion of trypsin in man
J Dlugosz, UR Fölsch, A Czajkowski, A Gabryelewicz
European Journal of Clinical Investigation 1988
Stimulation of pancreatic secretion in man by a protease inhibitor (camostate)
G Adler, A Müllenhoff, I Koop, T Bozkurt, B Göke, C Beglinger, R Arnold
European Journal of Clinical Investigation 1988
Participation of gastric mechanoreceptors and intestinal chemoreceptors in the gastrocolonic response
J Wiley, D Tatum, R Keinath, C Owyang
Gastroenterology 1988
Regulation of the release of cholecystokinin by bile salts in dogs and humans
G Gomez, JR Upp, F Lluis, RW Alexander, GJ Poston, GH Greeley, JC Thompson
Gastroenterology 1988
Temporal relationships of cholecystokinin release, pancreatobiliary secretion, and gastric emptying of a mixed meal
M Fried, EA Mayer, JB Jansen, CB Lamers, IL Taylor, SR Bloom, JH Meyer
Gastroenterology 1988
Pancreatic secretory response to ordinary meals: Studies with pure pancreatic juice
L Gullo, P Priori, R Pezzilli, G Biliotti, G Mattioli, L Barbara
Gastroenterology 1988
Effect of Trypsin on the Hormonal Regulation of the Fat-Stimulated Human Exocrine Pancreas
O Olsen, OB de Muckadell, P Cantor, C Erlanson-Albertsson, CP Hansen, H Worning
Scandinavian Journal of Gastroenterology 1988
Plasma CCK levels in patients with pancreatic insufficiency
T Bozkurt, G Adler, I Koop, H Koop, W Trmer, R Arnold
Digestive Diseases and Sciences 1988
Lack of insulinotropic effect of endogenous and exogenous cholecystokinin in man
J Reimers, M Nauck, W Creutzfeldt, J Strietzel, R Ebert, P Cantor, G Hoffmann
Diabetologia 1988
Raw soya-bean flour increases cholecystokinin release in man
J Calam, JC Bojarski, CJ Springer
British Journal of Nutrition 1987
Trypsin suppression of pancreatic enzyme secretion
C Owyang, D May, DS Louie
Gastroenterology 1986
Pancreatic Disease
EC Kafka, MH Kalser
Postgraduate Medicine 1975
Advances in Metabolic Disorders
G Aurbach, JT Potts
Advances in Metabolic Disorders 1964

← Previous 1 2 3 … 7 8 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts