Circulating immune complexes (CIC) containing IgA and C3 were elevated in 48% of IgA nephropathy patients; IgA1 was the predominant subclass. IgA1-IgG CIC were detected in 44%, IgA2-IgG CIC in 7%, and IgM-IgA1 CIC in 16% of the patients. No IgM-IgA2 CIC were detectable. Sucrose gradient ultracentrifugation indicated that IgG-IgA1 CIC were predominantly of intermediate (13-19S) size whereas IgA1-C3 CIC sedimented from 11S to 19S. At acid pH, isolated CIC revealed the presence of substantial amounts of 7S IgA. One third of the patients had elevated serum IgA rheumatoid factor (RF) of both polymeric and monomeric forms despite normal levels of IgM-RF; 87% of patients with elevated IgA-RF had IgA1-IgG CIC. These results indicate that the IgA1 component of CIC in patients with IgA nephropathy is not necessarily of mucosal origin and suggest that a portion of these CIC consists of IgA RF immunologically complexed with autologous IgG.
C Czerkinsky, W J Koopman, S Jackson, J E Collins, S S Crago, R E Schrohenloher, B A Julian, J H Galla, J Mestecky
Title and authors | Publication | Year |
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IgA Nephropathy: Pleiotropic impact of Epstein-Barr virus infection on immunopathogenesis and racial incidence of the disease
Mestecky J, Julian BA, Raska M |
Frontiers in immunology | 2023 |
Challenges in IgA Nephropathy Management: An Era of Complement Inhibition.
Tesař V, Radhakrishnan J, Charu V, Barratt J |
Kidney International Reports | 2023 |
Current Understanding of Complement Proteins as Therapeutic Targets for the Treatment of Immunoglobulin A Nephropathy.
Rajasekaran A, Green TJ, Renfrow MB, Julian BA, Novak J, Rizk DV |
Drugs | 2023 |
Galactose-Deficient IgA1 B cells in the Circulation of IgA Nephropathy Patients Carry Preferentially Lambda Light Chains and Mucosal Homing Receptors
Zachova K, Jemelkova J, Kosztyu P, Ohyama Y, Takahashi K, Zadrazil J, Orsag J, Matousovic K, Galuszkova D, Petejova N, Mestecky J, Raska M |
Journal of the American Society of Nephrology : JASN | 2022 |
Identification and characterization of circulating immune complexes in IgA nephropathy.
Matsumoto Y, Aryal RP, Heimburg-Molinaro J, Park SS, Wever WJ, Lehoux S, Stavenhagen K, van Wijk JAE, Van Die I, Chapman AB, Chaikof EL, Cummings RD |
Science Advances | 2022 |
Collectin11 and Complement Activation in IgA Nephropathy
M Wei, W Guo, B Xu, S Shi, L Liu, X Zhou, J Lv, L Zhu, H Zhang |
Clinical journal of the American Society of Nephrology : CJASN | 2021 |
Single-cell RNA-sequencing reveals distinct immune cell subsets and signaling pathways in IgA nephropathy
H Zeng, L Wang, J Li, S Luo, Q Han, F Su, J Wei, X Wei, J Wu, B Li, J Huang, P Tang, C Cao, Y Zhou, Q Yang |
Cell & Bioscience | 2021 |
Aberrantly Glycosylated IgA1 in IgA Nephropathy: What We Know and What We Don’t Know
Y Ohyama, MB Renfrow, J Novak, K Takahashi |
Journal of Clinical Medicine | 2021 |
Pathogenesis of IgA Nephropathy: Current Understanding and Implications for Development of Disease-Specific Treatment
B Knoppova, C Reily, RG King, BA Julian, J Novak, TJ Green |
Journal of Clinical Medicine | 2021 |
IgA glycosylation and immune complex formation in IgAN
H Suzuki, J Novak |
Seminars in Immunopathology | 2021 |
An Update on the Current State of Management and Clinical Trials for IgA Nephropathy
CK Cheung, A Rajasekaran, J Barratt, DV Rizk |
Journal of Clinical Medicine | 2021 |
Poly-IgA Complexes and Disease Severity in IgA Nephropathy
X Zhang, J Lv, P Liu, X Xie, M Wang, D Liu, H Zhang, J Jin |
Clinical journal of the American Society of Nephrology : CJASN | 2021 |
Glomerular Complement Factor H–Related Protein 5 is Associated with Histologic Injury in Immunoglobulin A Nephropathy
W Guo, L Sun, H Dong, G Wang, X Xu, Z Zhao, H Cheng |
Kidney International Reports | 2021 |
The immune landscape of IgA induction in the gut
C Seikrit, O Pabst |
Seminars in Immunopathology | 2021 |
Proceedings of 16th International Symposium on IgA Nephropathy
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Kidney Diseases | 2021 |
Role of Epstein-Barr Virus in Pathogenesis and Racial Distribution of IgA Nephropathy
K Zachova, P Kosztyu, J Zadrazil, K Matousovic, K Vondrak, P Hubacek, BA Julian, Z Moldoveanu, Z Novak, K Kostovcikova, M Raska, J Mestecky |
Frontiers in immunology | 2020 |
The Emerging Role of Complement Proteins as a Target for Therapy of IgA Nephropathy
DV Rizk, N Maillard, BA Julian, B Knoppova, TJ Green, J Novak, RJ Wyatt |
Frontiers in immunology | 2019 |
Serum Levels of Joining Chain-Containing IgA1 Are Not Elevated in Patients with IgA Nephropathy
G Li, X Wang, Z Yang, Q Zhao, Y Wen, X Li, R Gao |
Disease Markers | 2019 |
IgA and FcαRI: Pathological Roles and Therapeutic Opportunities
A Breedveld, M van Egmond |
Frontiers in immunology | 2019 |
Phosphatidylethanolamine binding protein-4 (PEBP4) is increased in IgA nephropathy and is associated with IgA-positive B-cells in affected kidneys
S Taylor, K Pieri, P Nanni, J Tica, J Barratt, A Didangelos |
Journal of Autoimmunity | 2019 |
Circulating complement factor H–related protein 5 levels contribute to development and progression of IgA nephropathy
L Zhu, W Guo, S Shi, L Liu, J Lv, NR Medjeral-Thomas, HJ Lomax-Browne, MC Pickering, H Zhang |
Kidney International | 2018 |
Biomarkers and Precision Medicine in IgA Nephropathy
FP Schena, SN Cox |
Seminars in Nephrology | 2018 |
The Origin and Activities of IgA1-Containing Immune Complexes in IgA Nephropathy
B Knoppova, C Reily, N Maillard, DV Rizk, Z Moldoveanu, J Mestecky, M Raska, MB Renfrow, BA Julian, J Novak |
Frontiers in immunology | 2016 |
Current Understanding of the Role of Complement in IgA Nephropathy
N Maillard, RJ Wyatt, BA Julian, K Kiryluk, A Gharavi, V Fremeaux-Bacchi, J Novak |
Journal of the American Society of Nephrology : JASN | 2015 |
Diagnosis and monitoring of IgA nephropathy: the role of biomarkers as an alternative to renal biopsy
RN Moresco, MM Speeckaert, JR Delanghe |
Autoimmunity Reviews | 2015 |
The genetics and immunobiology of IgA nephropathy
Krzysztof Kiryluk, Jan Novak |
Journal of Clinical Investigation | 2014 |
Serum levels of galactose-deficient immunoglobulin (Ig) A1 and related immune complex are associated with disease activity of IgA nephropathy
Y Suzuki, K Matsuzaki, H Suzuki, K Okazaki, H Yanagawa, N Ieiri, M Sato, T Sato, Y Taguma, J Matsuoka, S Horikoshi, J Novak, O Hotta, Y Tomino |
Clinical and Experimental Nephrology | 2014 |
A panel of serum biomarkers differentiates IgA nephropathy from other renal diseases
H Yanagawa, H Suzuki, Y Suzuki, K Kiryluk, AG Gharavi, K Matsuoka, Y Makita, BA Julian, J Novak, Y Tomino |
PloS one | 2014 |
Enzymatic sialylation of IgA1 o-glycans: implications for studies of IgA nephropathy
K Takahashi, M Raska, MS Horynova, SD Hall, K Poulsen, M Kilian, Y Hiki, Y Yuzawa, Z Moldoveanu, BA Julian, MB Renfrow, J Novak |
PloS one | 2014 |
Variants in Complement Factor H and Complement Factor H-Related Protein Genes, CFHR3 and CFHR1, Affect Complement Activation in IgA Nephropathy
L Zhu, YL Zhai, FM Wang, P Hou, JC Lv, DM Xu, SF Shi, LJ Liu, F Yu, MH Zhao, J Novak, AG Gharavi, H Zhang |
Journal of the American Society of Nephrology : JASN | 2014 |
O-Linked Glycosylation Determines the Nephritogenic Potential of IgA Rheumatoid Factor
M Kihara, K Ito, J Nakata, M Otani, NL Tran, N Morito, S Takahashi, Y Wada, S Izui |
Journal of the American Society of Nephrology : JASN | 2014 |
Specificity of two monoclonal antibodies against a synthetic glycopeptide, an analogue to the hypo-galactosylated IgA1 hinge region
Y Hiki, H Hori, K Yamamoto, Y Yamamoto, Y Yuzawa, N Kitaguchi, K Takahashi |
Journal of Nephrology | 2014 |
Enzymatic Sialylation of IgA1 O-Glycans: Implications for Studies of IgA Nephropathy
K Takahashi, M Raska, MS Horynova, SD Hall, K Poulsen, M Kilian, Y Hiki, Y Yuzawa, Z Moldoveanu, BA Julian, MB Renfrow, J Novak, IC Moura |
PloS one | 2014 |
Biomarkers in IgA nephropathy: relationship to pathogenetic hits
MC Hastings, Z Moldoveanu, H Suzuki, F Berthoux, BA Julian, JT Sanders, MB Renfrow, J Novak, RJ Wyatt |
Expert Opinion on Medical Diagnostics | 2013 |
IgA Nephropathy: Molecular Mechanisms of the Disease
J Mestecky, M Raska, BA Julian, AG Gharavi, MB Renfrow, Z Moldoveanu, L Novak, K Matousovic, J Novak |
Annual review of pathology | 2013 |
In vitro-generated immune complexes containing galactose-deficient IgA1 stimulate proliferation of mesangial cells
T Yanagihara, R Brown, S Hall, Z Moldoveanu, A Goepfert, M Tomana, BA Julian, J Mestecky, J Novak |
Results in Immunology | 2012 |
Brenner and Rector's The Kidney
C Brugnara, KU Eckardt |
Brenner and Rector's The Kidney | 2012 |
IgA1 immune complexes from pediatric patients with IgA nephropathy activate cultured human mesangial cells
J Novak, LR Kafkova, H Suzuki, M Tomana, K Matousovic, R Brown, S Hall, JT Sanders, TM Eison, Z Moldoveanu, L Novak, Z Novak, R Mayne, BA Julian, J Mestecky, RJ Wyatt |
Nephrology Dialysis Transplantation | 2011 |
Galectin-8 in IgA Nephritis: Decreased Binding of IgA by Galectin-8 Affinity Chromatography and Associated Increased Binding in Non-IgA Serum Glycoproteins
MC Carlsson, O Bakoush, L Tengroth, O Kilsgård, J Malmström, T Hellmark, M Segelmark, H Leffler |
Journal of Clinical Immunology | 2011 |
O -Glycosylated IgA Rheumatoid Factor Induces IgA Deposits and Glomerulonephritis
M Otani, J Nakata, M Kihara, V Leroy, S Moll, Y Wada, S Izui |
Journal of the American Society of Nephrology : JASN | 2011 |
Immune complexes in acute adult-onset Henoch-Schonlein nephritis
M Hilhorst, P Paassen, PB Vriesman, JW Tervaert |
Nephrology Dialysis Transplantation | 2011 |
Galactosylation of Serum IgA1 O-Glycans in Celiac Disease
K Lindfors, H Suzuki, J Novak, P Collin, P Saavalainen, LL Koskinen, M Mäki, K Kaukinen |
Journal of Clinical Immunology | 2010 |
CTLA4Ig Alters the Course of Autoimmune Disease Development in Lyn-/- Mice
SA Oracki, E Tsantikos, C Quilici, A Light, T Schmidt, AM Lew, JE Martin, KG Smith, ML Hibbs, DM Tarlinton |
Journal of immunology (Baltimore, Md. : 1950) | 2009 |
Macromolecular IgA1 taken from patients with familial IgA Nephropathy or their asymptomatic relatives have higher reactivity to mesangial cells in vitro
KY Tam, JC Leung, LY Chan, MF Lam, SC Tang, KN Lai |
Kidney International | 2009 |
Pathogenetic Analyses of IgA nephropathy from the aspect of O-glycans in IgA1 hinge region
Y Hiki |
Nihon Shoni Jinzobyo Gakkai Zasshi | 2009 |
Genetic Diseases of the Kidney
K Ichida, M Hosoyamada, T Hosoya, H Endou |
Genetic Diseases of the Kidney | 2009 |
O-linked oligosaccharides of the IgA1 hinge region: roles of its aberrant structure in the occurrence and/or progression of IgA nephropathy
Y Hiki |
Clinical and Experimental Nephrology | 2009 |
IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly-glycosylated IgA1
Hitoshi Suzuki, Zina Moldoveanu, Stacy Hall, Rhubell Brown, Huong L. Vu, Lea Novak, Bruce A. Julian, Milan Tomana, Robert J. Wyatt, Jeffrey C. Edberg, Graciella S. Alarcón, Robert P. Kimberly, Yasuhiko Tomino, Jiri Mestecky, Jan Novak |
Journal of Clinical Investigation | 2008 |
IgA glycosylation and IgA immune complexes in the pathogenesis of IgA nephropathy
J Novak, BA Julian, M Tomana, J Mestecky |
Seminars in Nephrology | 2008 |
Role of Aberrant Glycosylation of IgA1 Molecules in the Pathogenesis of IgA Nephropathy
J Mestecky, M Tomana, Z Moldoveanu, BA Julian, H Suzuki, K Matousovic, MB Renfrow, L Novak, RJ Wyatt, J Novak |
Kidney and Blood Pressure Research | 2008 |
Secretory IgA mediates retrotranscytosis of intact gliadin peptides via the transferrin receptor in celiac disease
T Matysiak-Budnik, IC Moura, M Arcos-Fajardo, C Lebreton, S Ménard, C Candalh, K Ben-Khalifa, C Dugave, H Tamouza, G Niel, Y Bouhnik, D Lamarque, S Chaussade, G Malamut, C Cellier, N Cerf-Bensussan, RC Monteiro, M Heyman |
Journal of Experimental Medicine | 2008 |
Increased and prolonged production of specific polymeric IgA after systemic immunization with tetanus toxoid in IgA nephropathy
L Layward, AC Allen, SJ Harper, JM Hattersley, J FEEHAhLY |
Clinical & Experimental Immunology | 2008 |
Patients with IgA nephropathy have increased serum galactose-deficient IgA1 levels
Z Moldoveanu, RJ Wyatt, JY Lee, M Tomana, BA Julian, J Mestecky, WQ Huang, SR Anreddy, S Hall, MC Hastings, KK Lau, WJ Cook, J Novak |
Kidney International | 2007 |
Hypercomplementemia in adult patients with IgA nephropathy
K Onda, H Ohi, M Tamano, I Ohsawa, M Wakabayashi, S Horikoshi, T Fujita, Y Tomino |
Journal of Clinical Laboratory Analysis | 2007 |
Th1 polarization in murine IgA nephropathy directed by bone marrow-derived cells
H Suzuki, Y Suzuki, M Aizawa, T Yamanaka, M Kihara, H Pang, S Horikoshi, Y Tomino |
Kidney International | 2007 |
The pathogenic role of IgA1 O-linked glycosylation in the pathogenesis of IgA nephropathy (Review Article)
J Barratt, AC Smith, J Feehally |
Nephrology | 2007 |
Glomerulonephropathy in ankylosing spondylitis
YC CHAO, ST TSAI, DF HUANG |
APLAR Journal of Rheumatology | 2007 |
Mucosal Immune Defense: Immunoglobulin A
CS Kaetzel |
2007 | |
IgA-containing immune complexes in the urine of IgA nephropathy patients
K Matousovic, J Novak, T Yanagihara, M Tomana, Z Moldoveanu, R Kulhavy, BA Julian, K Konecny, J Mestecky |
Nephrology Dialysis Transplantation | 2006 |
IgA1-containing immune complexes in IgA nephropathy differentially affect proliferation of mesangial cells
J Novak, M Tomana, K Matousovic, R Brown, S Hall, L Novak, BA Julian, RJ Wyatt, J Mestecky |
Kidney International | 2005 |
Role of macromolecular IgA in IgA nephropathy
PJ van der Boog, C Kooten, JW de Fijter, MR Daha |
Kidney International | 2005 |
Mucosal Immunology
WR Brown |
Mucosal Immunology | 2005 |
Use of corticosteroids, other immunosuppressive therapies, and tonsillectomy in the treatment of IgA nephropathy
O Hotta |
Seminars in Nephrology | 2004 |
Interactions of human mesangial cells with IgA and IgA-containing immune complexes1
J Novak, HL Vu, L Novak, BA Julian, J Mestecky, M Tomana |
Kidney International | 2002 |
What is the difference between IgA nephropathy and Henoch-Schönlein purpura nephritis?
JC Davin, IJ Berge, JJ Weening |
Kidney International | 2001 |
Mesangial IgA2 deposits and lectin pathway-mediated complement activation in IgA glomerulonephritis
S Hisano, M Matsushita, T Fujita, Y Endo, S Takebayashi |
American Journal of Kidney Diseases | 2001 |
Progress in molecular and genetic studies of IgA nephropathy
J Novak, B A Julian, M Tomana, J Mesteck |
Journal of Clinical Immunology | 2001 |
Adult Henoch-Schönlein purpura associated with malignancy
E Pertuiset, F Lioté, E Launay-Russ, F Kemiche, I Cerf-Payrastre, AM Chesneau |
Seminars in Arthritis and Rheumatism | 2000 |
Fcalpha receptor (CD89) mediates the development of immunoglobulin A (IgA) nephropathy (Berger's disease). Evidence for pathogenic soluble receptor-Iga complexes in patients and CD89 transgenic mice
P Launay, B Grossetête, M Arcos-Fajardo, E Gaudin, SP Torres, L Beaudoin, NP de Serre, A Lehuen, RC Monteiro |
Journal of Experimental Medicine | 2000 |
Fc Receptor (Cd89) Mediates the Development of Immunoglobulin a (Iga) Nephropathy (Berger's Disease): Evidence for Pathogenic Soluble Receptor-Iga Complexes in Patients and Cd89 Transgenic Mice
P Launay, B Grossetete, M Arcos-Fajardo, E Gaudin, SP Torres, L Beaudoin, NP de Serre, A Lehuen, RC Monteiro |
Journal of Experimental Medicine | 2000 |
Circulating immune complexes in IgA nephropathy consist of IgA1 with galactose-deficient hinge region and antiglycan antibodies
M Tomana, J Novak, BA Julian, K Matousovic, K Konecny, J Mestecky |
Journal of Clinical Investigation | 1999 |
IgA nephropathy
TE Hunley, V Kon |
Current Opinion in Pediatrics | 1999 |
Elevation of serum IgA in spondyloarthropathies and IgA nephropathy and its pathogenic role
V Montenegro, RC Monteiro |
Current Opinion in Rheumatology | 1999 |
Elevation of serum IgA in spondyloarthropathies and IgA nephropathy and its pathogenic role:
V Montenegro, RC Monteiro |
Current Opinion in Rheumatology | 1999 |
Study of the Relationship between Sticky Human Serum IgA1 and Its O-Glycan Glycoform
H Iwase, S Ohkawa, I Ishii-Karakasa, Y Hiki, T Kokubo, T Sano, A Tanaka, K Toma, Y Kobayashi, K Hotta |
Biochemical and Biophysical Research Communications | 1999 |
Down-regulation of Fcalpha receptors on blood cells of IgA nephropathy patients: Evidence for a negative regulatory role of serum IgA
B Grossetete, P Launay, A Lehuen, P Jungers, JF Bach, RC Monteiro |
Kidney International | 1998 |
Experimental Murine IgA Nephropathy following Passive Administration of Vomitoxin-induced IgA Monoclonal Antibodies
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Food and Chemical Toxicology | 1998 |
Is There IgA from Gut Mucosal Origin in the Serum of Children with Henoch–Schönlein Purpura?
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IgA Nephropathy—Human Disease and Animal Model
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Structural heterogeneity of glycans in IgA molecules: Implications for IgA nephropathy
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Nephrology | 1997 |
Heterogeneity of carbohydrate moieties of IgA1 molecules from IgA nephropathy patients and normal individuals
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Nephrology | 1997 |
Immunological aspects of IgA nephropathy
MJ KIM, SP HONG |
Nephrology | 1997 |
Altered immunity in circulation of patients with IgA nephropathy
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Nephrology | 1997 |
Galactose-deficient IgA1 in sera of IgA nephropathy patients is present in complexes with IgG
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Kidney International | 1997 |
IgA nephropathy-specific expression of the IgA Fc receptors (CD89) on blood phagocytic cells
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Clinical & Experimental Immunology | 1997 |
Effect of Anti-DNA Autoantibodies on the Gene Expression of Interleukin 8, Transforming Growth Factor-β, and Nitric Oxide Synthase in Cultured Endothelial Cells
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Scandinavian Journal of Rheumatology | 1997 |
Increased binding of polymeric λ-IgA to cultured human mesangial cells in IgA nephropathy
KN Lai, WY To, PK Li, JC Leung |
Kidney International | 1996 |
Deficient IgA1 immune response to nasal cholera toxin subunit B in primary IgA nephropathy
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Kidney International | 1996 |
Polyethylene Glycol Precipitates of Serum Contain a Large Proportion of Uncomplexed Immunoglobulins and C3
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Immunological Investigations | 1996 |
Immunoglobulin-A and the pathogenesis of schistosomal glomerulopathy
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Kidney International | 1996 |
IgA multiple myeloma presenting as Henoch-Schönlein purpura/polyarteritis nodosa overlap syndrome
D Birchmore, C Sweeney, D Choudhury, MF Konwinski, K Carnevale, V D'Agati |
Arthritis & Rheumatism | 1996 |
Serologic study of immunoglobulin A-fibronectin aggregates in immunoglobulin a nephropathy
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American Journal of Kidney Diseases | 1996 |
Determination of IgA- and IgM-rheumatoid factors in patients with rheumatoid arthritis with and without nephropathy
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Annals of the rheumatic diseases | 1996 |
IgA and IgG immune complexes increase human macrophage C3 biosynthesis
J Laufer, H Boichis, N Farzam, JH Passwell |
Immunology | 1995 |
Advances in Mucosal Immunology
J Mestecky, MW Russell, S Jackson, SM Michalek, H Tlaskalová-Hogenová, J Šterzl |
1995 | |
Anti-immunoglobulin antibodies in children with Schönlein-Henoch syndrome. Absence of serum anti-IgA antibodies
AB Quirós, C Blanco, J Alvarez, P Solis, F Conde, S Gomez |
European Journal of Pediatrics | 1994 |
Etiology of IgA nephropathy syndrome
Y Endo, H Kanbayashi |
Pathology International | 1994 |
Immunopathological features of palatine tonsil characteristic of IgA nephropathy: IgA1 localization in follicular dendritic cells
C Kusakari, M Nose, T Takasaka, R Yuasa, M Kato, K Miyazonou, T Fujitaij, M Kyogoku |
Clinical & Experimental Immunology | 1994 |
IgA anticardiolipin antibodies associated with Henoch-Schönlein purpura
AD Burden, IW Gibson, RS Rodger, DM Tillman |
Journal of the American Academy of Dermatology | 1994 |
Handbook of Mucosal Immunology
D Nadal, CP Braegger, P Knoflach, B Albini |
Handbook of Mucosal Immunology | 1994 |
Charge distribution of serum IgA ln IgA nephropathy
K Sugimoto, Y Kakizaki, S Waga |
Nihon Shoni Jinzobyo Gakkai Zasshi | 1994 |
Experimental IgA nephropathy: factors influencing IgA-immune complex deposition in the glomerulus
A Chen, CH Wei, WH Lee, CY Lin |
Springer Seminars in Immunopathology | 1994 |
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CY Lin |
Springer Seminars in Immunopathology | 1994 |
Immunopathological features of palatine tonsil characteristic of IgA nephropathy: IgA1 localization in follicular dendritic cells.
Kusakari C, Nose M, Takasaka T, Yuasa R, Kato M, Miyazono K, Fujita T, Kyogoku M |
Clinical & Experimental Immunology | 1994 |
Abnormalities of the IgA immune system in members of unrelated pedigrees from patients with IgA nephropathy
FP Schena, V Scivittaro, E Ranieri, R Sinico, S Benuzzi, M Cillo, L Aventaggiato |
Clinical & Experimental Immunology | 1993 |
Cross-linking of monocyte plasma membrane Fc alpha, Fc gamma or mannose receptors induces TNF production
GL Polat, J Laufer, I Fabian, JH Passwell |
Immunology | 1993 |
Pathogenesis of idiopathic IgA nephropathy
DG Williams |
Pediatric Nephrology | 1993 |
Henoch-Schoenlein purpura due to streptokinase
AP Zilliox, DT Domoto, PS Hutcheson, CC Tsai, RG Slavin |
Journal of Clinical Immunology | 1993 |
Abnormalities of the IgA immune system in members of unrelated pedigrees from patients with IgA nephropathy.
Schena FP, Scivittaro V, Ranieri E, Sinico R, Benuzzi S, Di Cillo M, Aventaggiato L |
Clinical & Experimental Immunology | 1993 |
Binding of serum immunoglobulins to collagens in IgA nephropathy and HIV infection
AW van Bake, KA Kirk, RE Gay, LM Switalski, BA Julian, S Jackson, S Gay, J Mestecky |
Kidney International | 1992 |
IgA-containing immune complexes after challenge with food antigens in patients with IgA nephropathy
S Jackson, Z Moldoveanu, KA Kirk, BA Julian, TF Patterson, AL Mullins, T Jilling, J Mestecky, JH Galla |
Clinical & Experimental Immunology | 1992 |
In vivo activation of complement by IgA in a rat model
RK Stad, WM Bogers, ME der Sluys, LA Es, MR Daha |
Clinical & Experimental Immunology | 1992 |
Abnormalities of mucosal immune system and human disease
W Strober |
Clinical Immunology Newsletter | 1992 |
Both Kupffer cells and liver endothelial cells play an important role in the clearance of IgA and IgG immune complexes
WM Bogers, RK Stad, LA Es, MR Daha |
Research in Immunology | 1992 |
Mucosal immune dysfunction associated with alcoholic IgA nephropathy
SM Smith, S Tokuda, H Tsukamoto |
Clinical Immunology and Immunopathology | 1992 |
Heavy and light chain composition of serum IgA and IgA rheumatoid factor in henoch-schönlein purpura: IgA IN HENOCH-SCHÖNLEIN PURPURA
FT Saulsbury |
Arthritis & Rheumatism | 1992 |
Systemic immune response after mucosal immunization in patients with IgA nephropathy
FB Waldo |
Journal of Clinical Immunology | 1992 |
IgA-containing immune complexes after challenge with food antigens in patients with IgA nephropathy.
Jackson S, Moldoveanu Z, Kirk KA, Julian BA, Patterson TF, Mullins AL, Jilling T, Mestecky J, Galla JH |
Clinical & Experimental Immunology | 1992 |
In vivo activation of complement by IgA in a rat model.
Stad RK, Bogers WM, Thoomes-van der Sluys ME, Van Es LA, Daha MR |
Clinical & Experimental Immunology | 1992 |
Increased and prolonged production of specific polymeric IgA after systemic immunization with tetanus toxoid in IgA nephropathy.
Layward L, Allen AC, Harper SJ, Hattersley JM, Feehally J |
Clinical & Experimental Immunology | 1992 |
Mesangial cell autoantigens in immunoglobulin A nephropathy and Henoch-Schönlein purpura
DJ O'Donoghue, A Darvill, FW Ballardie |
Journal of Clinical Investigation | 1991 |
Effect of cyclosporine a on circulating immune complexes in IgA nephropathy
KN Lai, CW Lam, IK Cheng, JS Tam, FM Lai |
International Urology and Nephrology | 1991 |
Complement enhances the clearance of large-sized soluble IgA aggregates in rats
WM Bogers, RK Stad, DJ Janssen, M Rits, H Bazin, LA van Es, MR Daha |
European Journal of Immunology | 1991 |
Pathogenic role of polyclonal and polymeric IgA in a murine model of mesangial proliferative glomerulonephritis with IgA deposition
E Muso, H Yoshida, E Takeuchi, T Shimada, M Yashiro, T Sugiyama, C Kawai |
Clinical & Experimental Immunology | 1991 |
Selective Elevation of Monomeric IgA1 in IgA Nephropathy Patients With Normal Renal Function
JH Peterman, BA Julian, KA Kirk, S Jackson |
American Journal of Kidney Diseases | 1991 |
Macroscopic Hematuria and Proteinuria Preceding Renal IgA Deposition in Patients With IgA Nephropathy
BA Julian, VR Cannon, FB Waldo, J Egido |
American Journal of Kidney Diseases | 1991 |
IgA nephropathy in a child with human immunodeficiency virus type 1 infection
H Trachtman, B Gauthier, A Vinograd, E Valderrama |
Pediatric Nephrology | 1991 |
Immunology of Renal Disease
CD Pusey |
1991 | |
Rheumatoid factors and glomerulonephritis
M Miyazaki, M Endoh, T Suga, N Yano, T Kuramoto, Y Matsumoto, K Eguchi, M Yagame, M Miura, Y Nomoto, H Sakai |
Clinical & Experimental Immunology | 1990 |
Monoclonal antibody 6b6.6 defines a cross-reactive kappa light chain idiotope on human monoclonal and polyclonal rheumatoid factors
RE Schrohenloher, MA Accavitti, AS Bhown, WJ Koopman |
Arthritis & Rheumatism | 1990 |
IgA polyspecific autoantibodies in IgA nephropathy
P Matsiota, P Dosquet, H Louzir, E Druet, P Druet, S Avrameas |
Clinical & Experimental Immunology | 1990 |
Detection and characterization of circulating and glomerular immune complexes in experimental IgA nephropathy
J González-Cabrero, J Egido, A Barat, E González |
Immunology | 1990 |
Role of IgA in IgA nephropathy
FB Waldo |
The Journal of Pediatrics | 1990 |
Pathology Reviews • 1990
E Rubin, I Damjanov |
1990 | |
Inflammatory bowel disease and ankylosing spondylitis associated with cutaneous vasculitis, glomerulonephritis, and circulating IgA immune complexes
AJ Peeters, AW van den Wall Bake, MR Daha, FC Breeveld |
Annals of the rheumatic diseases | 1990 |
Humoral immune response to influenza vaccination in patients with primary immunoglobulin A nephropathy. An analysis of isotype distribution and size of the influenza-specific antibodies
AW van Bake, WE Beyer, JH Evers-Schouten, J Hermans, MR Daha, N Masurel, LA van Es |
Journal of Clinical Investigation | 1989 |
The liver and IgA: Immunological, cell biological and clinical implications
WR Brown, TM Kloppel |
Hepatology | 1989 |
Elevated production of polymeric and monomeric IgA1 by the bone marrow in IgA nephropathy
AW van Bake, MR Daha, JJ Haaijman, J Radl, A der Ark, LA van Es |
Kidney International | 1989 |
Retroviral gp70 antigen in spontaneous mesangial glomerulonephritis of ddY mice
E Takeuchi, T Doi, T Shimada, E Muso, N Maruyama, H Yoshida |
Kidney International | 1989 |
Polymorphs infiltrate glomeruli in mesangial IgA glomerulonephritis
P Kincaid-Smith, K Nicholls, I Birchall |
Kidney International | 1989 |
Vasculitis
JJ Cream |
Current Problems in Dermatology | 1989 |
Increased serum levels of IgA1-IgG immune complexes and anti-F(ab')2 antibodies in patients with primary IgA nephropathy
FP Schena, A Pastore, N Ludovico, RA Sinico, S Benuzzi, V Montinaro |
Clinical & Experimental Immunology | 1989 |
Characterization of circulating idiotypes containing immune complexes and their presence in the glomerular mesangium in patients with IgA nephropathy
J González-Cabrero, J Egido, F Mampaso, MC Rivas, L Hernando |
Clinical & Experimental Immunology | 1989 |
Clearance of Polymeric IgA Aggregates in Humans
D Roccatello, G Picciotto, R Coppo, G Piccoli, A Molino, G Cacace, A Amore, A Amoroso, G Quattrocchio, LM Sena |
American Journal of Kidney Diseases | 1989 |
Immune Complex Assays: Diagnostic and Clinical Application
TM Phillips, FA Salinas |
Critical Reviews in Clinical Laboratory Sciences | 1989 |
Antibodies to polyclonal IgA, IgA1, and IgA2 and isotype-specific immune complexes in IgA nephropathy
CL Jones, CS Hosking, P Kincaid-Smith, HR Powell, SC Richardson, FH Sennhauser, DM Roberton |
Journal of Clinical Immunology | 1989 |
AUTOIMMUNITY IN IgA NEPHROPATHY
FW Ballardie, S Williams, PE Brenchley, DJ O'Donoghue |
The Lancet | 1988 |
Tonsillar Distribution of IgA and IgG Immunocytes and Production of IgA Subclasses and J Chain in Tonsillitis Vary with the Presence or Absence of IgA Nephropathy
J Nagy, P Brandtzaeg |
Scandinavian Journal of Immunology | 1988 |
IgA-mediated clearance and tissue deposition of dinitrophenylated human serum albumin at various DNP:HSA ratios
JM Epps, JO Phillips, J Mestecky |
Molecular Immunology | 1988 |
Activation of complement by human serum IgA, secretory IgA and IgA1 fragments
PS Hiemstra, J Biewenga, A Gorter, ME Stuurman, A Faber, LA van Es, MR Daha |
Molecular Immunology | 1988 |
The bone marrow as production site of the IgA deposited in the kidneys of patients with IgA nephropathy
AW van Bake, MR Daha, J Radl, JJ Haaijman, AV der Ark, RM Valentijn, LA van Es |
Clinical & Experimental Immunology | 1988 |
Serum levels and in vitro production of IgA subclasses in patients with primary IgA nephropathy
AW van Bake, MR Daha, A der Ark, PS Hiemstra, J Radl, LA van Es |
Clinical & Experimental Immunology | 1988 |
Serum IgA preferentially binds to cationic polypeptides in IgA nephropathy
RC Monteiro, A Chevailler, LH Noel, P Lesavre |
Clinical & Experimental Immunology | 1988 |
Recent progress in renal immunopathology
G Andres, Y Yuzawa, F Cavalot |
Human Pathology | 1988 |
IgA nephropathy, the most common glomerulonephritis worldwide
BA Julian, FB Waldo, A Rifai, J Mestecky |
The American Journal of Medicine | 1988 |
Binding of IgA to erythrocytes from patients with IgA nephropathy
S Matsuda, FB Waldo, C Czerkinsky, Z Moldoveanu, J Mestecky |
Clinical Immunology and Immunopathology | 1988 |
Disposition of IgA-Containing Circulating Immune Complexes
LA Hebert |
American Journal of Kidney Diseases | 1988 |
Serum IgA and the Production of IgA by Peripheral Blood and Bone Marrow Lymphocytes in Patients With Primary IgA Nephropathy: Evidence for the Bone Marrow as the Source of Mesangial IgA
AW Bake, MR Daha, J Evers-Schouten, LA Es |
American Journal of Kidney Diseases | 1988 |
Composition of IgA-Containing Circulating Immune Complexes in IgA Nephropathy
LA Es, AW Bake, RM Valentijn, MR Daha |
American Journal of Kidney Diseases | 1988 |
Immunobiology of IgA
J Mestecky |
American Journal of Kidney Diseases | 1988 |
The Role of Polymeric IgA in Complement-Mediated Solubilization of IgG and IgA Immune Complexes
FP Schena, A Pastore, V Montinaro |
American Journal of Kidney Diseases | 1988 |
Immunoglobulin-Antiimmunoglobulin Interactions and Immune Complexes in IgA Nephropathy
S Jackson |
American Journal of Kidney Diseases | 1988 |
Occurrence of polymeric IgA1 rheumatoid factor in the acquired immune deficiency syndrome
S Jackson, A Tarkowski, JE Collins, LM Dawson, RE Schrohenloher, DP Kotler, WJ Koopman |
Journal of Clinical Immunology | 1988 |
Anti-IgA antibodies in IgA-deficient children
FH Sennhauser, CS Hosking, CL Jones, RA Macdonald, N Mermelstein, DM Roberton |
Journal of Clinical Immunology | 1988 |
IgA1 is the major immunoglobulin component of immune complexes in the acquired immune deficiency syndrome
S Jackson, LM Dawson, DP Kotler |
Journal of Clinical Immunology | 1988 |
IgA Immune Complexes in Patients With Dermatitis Herpetiformis Occur in the Absence of IgA Rheumatoid Factor
RP Hall, RW Eyre |
Journal of Investigative Dermatology | 1987 |
Presence of shared idiotypes in serum and immune complexes in patients with IgA nephropathy
J González-Cabrero, J Egido, J Sancho, F Moldenhauer |
Clinical & Experimental Immunology | 1987 |
IgA-antigliadin antibodies in IgA mesangial nephropathy (Berger's disease)
A Fornasieri, RA Sinico, P Maldifassi, P Bernasconi, M Vegni, G D'Amico |
British medical journal (Clinical research ed.) | 1987 |
Analysis of serum and synovial fluid IgA in Reiter's syndrome and reactive arthritis
RD Inman, ME Johnston, MH Klein |
Clinical Immunology and Immunopathology | 1987 |
Aberrant synthesis of antibodies directed at the Fab fragment of IgA in patients with IgA nephropathies
S Jackson, RI Montgomery, BA Julian, JH Galla, C Czerkinsky |
Clinical Immunology and Immunopathology | 1987 |
Striking Elevation of Serum IgA, IgA-Containing Immune Complexes, and IgA Rheumatoid Factor in Clinically Silent Dermatitis Herpetiformis
BA Julian, C Czerkinsky, MW Russell, JH Galla, WJ Koopman, J Mestecky, Z Moldoveanu, S Jackson |
American Journal of Kidney Diseases | 1987 |
Recent Advances in Mucosal Immunology
J Mestecky, JR McGhee, J Bienenstock, PL Ogra |
1987 | |
Molecular forms of IgA rheumatoid factor in serum and synovial fluid of patients with rheumatoid arthritis
RE Schrohenloher, WJ Koopman, GS Alarcón |
Arthritis & Rheumatism | 1986 |
Glomerulonephritis
JS Cameron |
British medical journal | 1970 |