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Citations to this article

Circulating immune complexes and immunoglobulin A rheumatoid factor in patients with mesangial immunoglobulin A nephropathies.
C Czerkinsky, … , J H Galla, J Mestecky
C Czerkinsky, … , J H Galla, J Mestecky
Published June 1, 1986
Citation Information: J Clin Invest. 1986;77(6):1931-1938. https://doi.org/10.1172/JCI112522.
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Circulating immune complexes and immunoglobulin A rheumatoid factor in patients with mesangial immunoglobulin A nephropathies.

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Abstract

Circulating immune complexes (CIC) containing IgA and C3 were elevated in 48% of IgA nephropathy patients; IgA1 was the predominant subclass. IgA1-IgG CIC were detected in 44%, IgA2-IgG CIC in 7%, and IgM-IgA1 CIC in 16% of the patients. No IgM-IgA2 CIC were detectable. Sucrose gradient ultracentrifugation indicated that IgG-IgA1 CIC were predominantly of intermediate (13-19S) size whereas IgA1-C3 CIC sedimented from 11S to 19S. At acid pH, isolated CIC revealed the presence of substantial amounts of 7S IgA. One third of the patients had elevated serum IgA rheumatoid factor (RF) of both polymeric and monomeric forms despite normal levels of IgM-RF; 87% of patients with elevated IgA-RF had IgA1-IgG CIC. These results indicate that the IgA1 component of CIC in patients with IgA nephropathy is not necessarily of mucosal origin and suggest that a portion of these CIC consists of IgA RF immunologically complexed with autologous IgG.

Authors

C Czerkinsky, W J Koopman, S Jackson, J E Collins, S S Crago, R E Schrohenloher, B A Julian, J H Galla, J Mestecky

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Citations to this article (174)

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Clinical & Experimental Immunology 1992
Mesangial cell autoantigens in immunoglobulin A nephropathy and Henoch-Schönlein purpura
DJ O'Donoghue, A Darvill, FW Ballardie
Journal of Clinical Investigation 1991
Effect of cyclosporine a on circulating immune complexes in IgA nephropathy
KN Lai, CW Lam, IK Cheng, JS Tam, FM Lai
International Urology and Nephrology 1991
Complement enhances the clearance of large-sized soluble IgA aggregates in rats
WM Bogers, RK Stad, DJ Janssen, M Rits, H Bazin, LA van Es, MR Daha
European Journal of Immunology 1991
Pathogenic role of polyclonal and polymeric IgA in a murine model of mesangial proliferative glomerulonephritis with IgA deposition
E Muso, H Yoshida, E Takeuchi, T Shimada, M Yashiro, T Sugiyama, C Kawai
Clinical & Experimental Immunology 1991
Selective Elevation of Monomeric IgA1 in IgA Nephropathy Patients With Normal Renal Function
JH Peterman, BA Julian, KA Kirk, S Jackson
American Journal of Kidney Diseases 1991
Macroscopic Hematuria and Proteinuria Preceding Renal IgA Deposition in Patients With IgA Nephropathy
BA Julian, VR Cannon, FB Waldo, J Egido
American Journal of Kidney Diseases 1991
IgA nephropathy in a child with human immunodeficiency virus type 1 infection
H Trachtman, B Gauthier, A Vinograd, E Valderrama
Pediatric Nephrology 1991
Immunology of Renal Disease
CD Pusey
1991
Rheumatoid factors and glomerulonephritis
M Miyazaki, M Endoh, T Suga, N Yano, T Kuramoto, Y Matsumoto, K Eguchi, M Yagame, M Miura, Y Nomoto, H Sakai
Clinical & Experimental Immunology 1990
Monoclonal antibody 6b6.6 defines a cross-reactive kappa light chain idiotope on human monoclonal and polyclonal rheumatoid factors
RE Schrohenloher, MA Accavitti, AS Bhown, WJ Koopman
Arthritis & Rheumatism 1990
IgA polyspecific autoantibodies in IgA nephropathy
P Matsiota, P Dosquet, H Louzir, E Druet, P Druet, S Avrameas
Clinical & Experimental Immunology 1990
Detection and characterization of circulating and glomerular immune complexes in experimental IgA nephropathy
J González-Cabrero, J Egido, A Barat, E González
Immunology 1990
Role of IgA in IgA nephropathy
FB Waldo
The Journal of Pediatrics 1990
Pathology Reviews • 1990
E Rubin, I Damjanov
1990
Inflammatory bowel disease and ankylosing spondylitis associated with cutaneous vasculitis, glomerulonephritis, and circulating IgA immune complexes
AJ Peeters, AW van den Wall Bake, MR Daha, FC Breeveld
Annals of the rheumatic diseases 1990
Humoral immune response to influenza vaccination in patients with primary immunoglobulin A nephropathy. An analysis of isotype distribution and size of the influenza-specific antibodies
AW van Bake, WE Beyer, JH Evers-Schouten, J Hermans, MR Daha, N Masurel, LA van Es
Journal of Clinical Investigation 1989
The liver and IgA: Immunological, cell biological and clinical implications
WR Brown, TM Kloppel
Hepatology 1989
Elevated production of polymeric and monomeric IgA1 by the bone marrow in IgA nephropathy
AW van Bake, MR Daha, JJ Haaijman, J Radl, A der Ark, LA van Es
Kidney International 1989
Retroviral gp70 antigen in spontaneous mesangial glomerulonephritis of ddY mice
E Takeuchi, T Doi, T Shimada, E Muso, N Maruyama, H Yoshida
Kidney International 1989
Polymorphs infiltrate glomeruli in mesangial IgA glomerulonephritis
P Kincaid-Smith, K Nicholls, I Birchall
Kidney International 1989
Vasculitis
JJ Cream
Current Problems in Dermatology 1989
Increased serum levels of IgA1-IgG immune complexes and anti-F(ab')2 antibodies in patients with primary IgA nephropathy
FP Schena, A Pastore, N Ludovico, RA Sinico, S Benuzzi, V Montinaro
Clinical & Experimental Immunology 1989
Characterization of circulating idiotypes containing immune complexes and their presence in the glomerular mesangium in patients with IgA nephropathy
J González-Cabrero, J Egido, F Mampaso, MC Rivas, L Hernando
Clinical & Experimental Immunology 1989
Clearance of Polymeric IgA Aggregates in Humans
D Roccatello, G Picciotto, R Coppo, G Piccoli, A Molino, G Cacace, A Amore, A Amoroso, G Quattrocchio, LM Sena
American Journal of Kidney Diseases 1989
Immune Complex Assays: Diagnostic and Clinical Application
TM Phillips, FA Salinas
Critical Reviews in Clinical Laboratory Sciences 1989
Antibodies to polyclonal IgA, IgA1, and IgA2 and isotype-specific immune complexes in IgA nephropathy
CL Jones, CS Hosking, P Kincaid-Smith, HR Powell, SC Richardson, FH Sennhauser, DM Roberton
Journal of Clinical Immunology 1989
AUTOIMMUNITY IN IgA NEPHROPATHY
FW Ballardie, S Williams, PE Brenchley, DJ O'Donoghue
The Lancet 1988
Tonsillar Distribution of IgA and IgG Immunocytes and Production of IgA Subclasses and J Chain in Tonsillitis Vary with the Presence or Absence of IgA Nephropathy
J Nagy, P Brandtzaeg
Scandinavian Journal of Immunology 1988
IgA-mediated clearance and tissue deposition of dinitrophenylated human serum albumin at various DNP:HSA ratios
JM Epps, JO Phillips, J Mestecky
Molecular Immunology 1988
Activation of complement by human serum IgA, secretory IgA and IgA1 fragments
PS Hiemstra, J Biewenga, A Gorter, ME Stuurman, A Faber, LA van Es, MR Daha
Molecular Immunology 1988
The bone marrow as production site of the IgA deposited in the kidneys of patients with IgA nephropathy
AW van Bake, MR Daha, J Radl, JJ Haaijman, AV der Ark, RM Valentijn, LA van Es
Clinical & Experimental Immunology 1988
Serum levels and in vitro production of IgA subclasses in patients with primary IgA nephropathy
AW van Bake, MR Daha, A der Ark, PS Hiemstra, J Radl, LA van Es
Clinical & Experimental Immunology 1988
Serum IgA preferentially binds to cationic polypeptides in IgA nephropathy
RC Monteiro, A Chevailler, LH Noel, P Lesavre
Clinical & Experimental Immunology 1988
Recent progress in renal immunopathology
G Andres, Y Yuzawa, F Cavalot
Human Pathology 1988
IgA nephropathy, the most common glomerulonephritis worldwide
BA Julian, FB Waldo, A Rifai, J Mestecky
The American Journal of Medicine 1988
Binding of IgA to erythrocytes from patients with IgA nephropathy
S Matsuda, FB Waldo, C Czerkinsky, Z Moldoveanu, J Mestecky
Clinical Immunology and Immunopathology 1988
Disposition of IgA-Containing Circulating Immune Complexes
LA Hebert
American Journal of Kidney Diseases 1988
Serum IgA and the Production of IgA by Peripheral Blood and Bone Marrow Lymphocytes in Patients With Primary IgA Nephropathy: Evidence for the Bone Marrow as the Source of Mesangial IgA
AW Bake, MR Daha, J Evers-Schouten, LA Es
American Journal of Kidney Diseases 1988
Composition of IgA-Containing Circulating Immune Complexes in IgA Nephropathy
LA Es, AW Bake, RM Valentijn, MR Daha
American Journal of Kidney Diseases 1988
Immunobiology of IgA
J Mestecky
American Journal of Kidney Diseases 1988
The Role of Polymeric IgA in Complement-Mediated Solubilization of IgG and IgA Immune Complexes
FP Schena, A Pastore, V Montinaro
American Journal of Kidney Diseases 1988
Immunoglobulin-Antiimmunoglobulin Interactions and Immune Complexes in IgA Nephropathy
S Jackson
American Journal of Kidney Diseases 1988
Occurrence of polymeric IgA1 rheumatoid factor in the acquired immune deficiency syndrome
S Jackson, A Tarkowski, JE Collins, LM Dawson, RE Schrohenloher, DP Kotler, WJ Koopman
Journal of Clinical Immunology 1988
Anti-IgA antibodies in IgA-deficient children
FH Sennhauser, CS Hosking, CL Jones, RA Macdonald, N Mermelstein, DM Roberton
Journal of Clinical Immunology 1988
IgA1 is the major immunoglobulin component of immune complexes in the acquired immune deficiency syndrome
S Jackson, LM Dawson, DP Kotler
Journal of Clinical Immunology 1988
IgA Immune Complexes in Patients With Dermatitis Herpetiformis Occur in the Absence of IgA Rheumatoid Factor
RP Hall, RW Eyre
Journal of Investigative Dermatology 1987
Presence of shared idiotypes in serum and immune complexes in patients with IgA nephropathy
J González-Cabrero, J Egido, J Sancho, F Moldenhauer
Clinical & Experimental Immunology 1987
IgA-antigliadin antibodies in IgA mesangial nephropathy (Berger's disease)
A Fornasieri, RA Sinico, P Maldifassi, P Bernasconi, M Vegni, G D'Amico
British medical journal (Clinical research ed.) 1987
Analysis of serum and synovial fluid IgA in Reiter's syndrome and reactive arthritis
RD Inman, ME Johnston, MH Klein
Clinical Immunology and Immunopathology 1987
Aberrant synthesis of antibodies directed at the Fab fragment of IgA in patients with IgA nephropathies
S Jackson, RI Montgomery, BA Julian, JH Galla, C Czerkinsky
Clinical Immunology and Immunopathology 1987
Striking Elevation of Serum IgA, IgA-Containing Immune Complexes, and IgA Rheumatoid Factor in Clinically Silent Dermatitis Herpetiformis
BA Julian, C Czerkinsky, MW Russell, JH Galla, WJ Koopman, J Mestecky, Z Moldoveanu, S Jackson
American Journal of Kidney Diseases 1987
Recent Advances in Mucosal Immunology
J Mestecky, JR McGhee, J Bienenstock, PL Ogra
1987
Molecular forms of IgA rheumatoid factor in serum and synovial fluid of patients with rheumatoid arthritis
RE Schrohenloher, WJ Koopman, GS Alarcón
Arthritis & Rheumatism 1986
Glomerulonephritis
JS Cameron
British medical journal 1970

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