Citations to this article

Human monoclonal autoantibodies that react with both pancreatic islets and thyroid.
C Garzelli, … , F Ginsberg-Fellner, A L Notkins
C Garzelli, … , F Ginsberg-Fellner, A L Notkins
Published May 1, 1986
Citation Information: J Clin Invest. 1986;77(5):1627-1631. https://doi.org/10.1172/JCI112479.
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Human monoclonal autoantibodies that react with both pancreatic islets and thyroid.

Abstract

Transformation of human peripheral blood lymphocytes with Epstein-Barr virus and rapid screening on rat insulinoma cells by an enzyme-linked immunosorbent assay were used to identify monoclonal autoantibodies that reacted with human pancreatic islets. Six such monoclonal autoantibodies were isolated and cloned. All six also were found to react with human thyroid. It is concluded that lymphocytes able to make autoantibodies that react with both the pancreas and thyroid are common in the human B cell repertoire.

Authors

C Garzelli, F E Taub, M C Jenkins, D W Drell, F Ginsberg-Fellner, A L Notkins

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Year: 1997 1996 1993 1992 1991 1990 1989 1988 1987 1975 Total
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Citations to this article (20)

Title and authors Publication Year
Idiotypes in Medicine: Autoimmunity, Infection and Cancer
TJ Kunicki, DJ Nugent 		Idiotypes in Medicine: Autoimmunity, Infection and Cancer 1997
Microorganisms and Autoimmune Diseases
H Friedman, NR Rose, M Bendinelli 		1996
Further Analyses of Epitopes for Human Monoclonal Anti-Basement Membrane Zone Antibodies Produced by Stable Human Hybridoma Cell Lines Constructed with Epstein-Barr Virus Transformants
T Hashimoto, M Amagai, T Ebihara, S Gamou, N Shimizu, T Tsubata, A Hasegawa, K Miki, T Nishikawa 		Journal of Investigative Dermatology 1993
Low titer, competitive insulin autoantibodies are spontaneously produced in autoimmune diseases of the thyroid
P Vardi, D Modan-Mozes, S Ish-Shalom, L Soloveitzik, D Barzilai, M Modan 		Diabetes Research and Clinical Practice 1993
Increased specificity and sensitivity of insulin antibody measurements in autoimmune thyroid disease and type I diabetes
MJ Hegewald, SL Schoenfeld, DK McCulloch, CJ Greenbaum, LJ Klaff, JP Palmer 		Journal of Immunological Methods 1992
DETECTION OF AN IDIOTOPE ON A HUMAN MONOCLONAL AUTOANTIBODY BY MONOCLONAL ANTI-IDIOTYPIC ANTIBODY AND ITS RELATIONSHIP TO EPSTEIN-BARR VIRUS-INDUCED AUTOIMMUNITY
C Garzelli, M Incaprera, A Bazzichi, G Falcone 		Autoimmunity 1992
Clinical chemistry
DJ Anderson, FV Lente, FS Apple, SC Kazmierczak, JA Lott, MK Gupta, N McBride, WE Katzin, RE Scott, al. 		Analytical Chemistry 1991
Monoclonal autoantibodies from insulin-dependent diabetic patients: autoantibodies against β-cell surface or cytoplasmic antigens
E Houssaint, S Pogu, M Ouary, P Sai 		Clinical & Experimental Immunology 1990
Monoclonal autoantibodies from insulin-dependent diabetic patients: autoantibodies against beta-cell surface or cytoplasmic antigens
E Houssaint, S Pogu, M Ouary, P Sai 		Clinical & Experimental Immunology 1990
Production of human monoclonal anti-basement membrane zone (BMZ) antibodies from a patient with bullous pemphigoid (BP) by Epstein-Barr virus transformation. Analyses of the heterogeneity of anti-BMZ antibodies in BP sera using them
T Sugi, T Hashimoto, T Hibi, T Nishikawa 		Journal of Clinical Investigation 1989
Immunological aspects of diabetes mellitus: Prospects for pharmacological modification
M Itoh 		Pharmacology & Therapeutics 1989
Reactivity of monoclonal islet cell antibodies on normal hyperplastic and neoplastic thyroid C-cells
N Neuhold, M Wimmer, OM Braun, G Horvat, K Krisch 		Cell and Tissue Research 1989
Human Nesidioblastosis Tissue as an Immunogen for Generation of Islet Cell Specific Monoclonal Antibodies
KD Gerbitz, B Boenke, A Paprotta, U Chemnitz, G Hübner 		Clinical Chemistry and Laboratory Medicine 1988
Identification of monoclonal antibodies to pancreatic islet cells by immunoperoxidase staining
KD Kohnert, K Fält, S Witt, B Ziegler, M Ziegler 		Acta Histochemica 1988
Probing the human B-cell repertoire: Isolation of Epstein-Barr virus (EBV)-transformed human B lymphocytes making antibodies with a common idiotope that have different antigen-binding specificities
Y Uchigata, BS Prabhakar, AL Notkins 		Journal of Clinical Immunology 1988
Viral Etiology of Polymyositis/Dermatomyositis
DENMAN AM 		Polymyositis and Dermatomyositis 1988
Human monoclonal antibodies as cellular and molecular probes: a review
MJ O'Hare, CY Yiu 		Molecular and Cellular Probes 1987
Multiple organ-reactivity of monoclonal autoantibodies to mouse erythrocytes
C Garzelli, F Basolo, C Puglisi, A Pacciardi 		Experientia 1987
Thyroid Autoimmunity
A Pinchera, SH Ingbar, JM McKenzie, GF Fenzi 		1987
Polymyositis and Dermatomyositis
A Bohan, JB Peter 		New England Journal of Medicine 1975

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