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Citations to this article

Kinetic constants for receptor-dependent and receptor-independent low density lipoprotein transport in the tissues of the rat and hamster.
D K Spady, … , J B Meddings, J M Dietschy
D K Spady, … , J B Meddings, J M Dietschy
Published May 1, 1986
Citation Information: J Clin Invest. 1986;77(5):1474-1481. https://doi.org/10.1172/JCI112460.
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Kinetic constants for receptor-dependent and receptor-independent low density lipoprotein transport in the tissues of the rat and hamster.

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Abstract

In this study, carried out in the rat and hamster, the receptor-dependent low density lipoprotein (LDL) transport process in each organ was characterized in terms of its maximal uptake rate (Jm) and Michaelis constant (Km), while the rate of receptor-independent uptake was defined in terms of its proportionality constant (P). The highest Jm values of 50-126 micrograms/h per g were found in the liver and endocrine glands in both species and receptor-dependent uptake also was detected in other organs like spleen, kidney, and intestine. The Km values were essentially the same in all of the organs and equaled approximately 90 mg/dl in both species. The receptor-independent uptake constants also were similar in the two species and were highest in the spleen, liver, and intestine. From these values for Jm, Km, and P, it was possible to construct theoretical curves that predict the plasma LDL-cholesterol concentration and fractional catabolic rate given any alteration in LDL-cholesterol production or the magnitude of receptor-dependent LDL transport in any organ of the rat or hamster.

Authors

D K Spady, J B Meddings, J M Dietschy

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Year: 2017 2016 2014 2013 2012 2010 2009 2007 2006 2005 2004 2003 2002 2000 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 Total
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