Citations to this article

Metabolic basis of hyperapobetalipoproteinemia. Turnover of apolipoprotein B in low density lipoprotein and its precursors and subfractions compared with normal and familial hypercholesterolemia.
B Teng, … , A K Soutar, G R Thompson
B Teng, … , A K Soutar, G R Thompson
Published March 1, 1986
Citation Information: J Clin Invest. 1986;77(3):663-672. https://doi.org/10.1172/JCI112360.
View: Text | PDF
Research Article

Metabolic basis of hyperapobetalipoproteinemia. Turnover of apolipoprotein B in low density lipoprotein and its precursors and subfractions compared with normal and familial hypercholesterolemia.

Abstract

The turnover of apolipoprotein B (apo B) in very low density, intermediate density, and low density lipoproteins (VLDL, IDL, and LDL) and in the light and heavy fractions of LDL was determined in seven patients with hyperapobetalipoproteinemia (hyperapo B), six normolipidemic subjects, and five patients with heterozygous familial hypercholesterolemia (FH). After receiving an injection of 125I-VLDL, hyperapo B patients were found to have a higher rate of synthesis of VLDL-apo B than controls (40.1 vs. 21.5 mg/kg per d, P less than 0.05) but a reduced fractional catabolic rate (FCR) (0.230 vs. 0.366/h, P less than 0.01). After receiving an injection of 131I-LDL, hyperapo B patients had higher rates of LDL-apo B synthesis than controls (23.1 vs. 13.0 mg/kg per d, P less than 0.001), as did FH patients (22.7 mg/kg per d). The FCR of LDL was similar in hyperapo B patients and controls (0.386 vs. 0.366/d) but was markedly decreased in FH patients (0.192/d). Most subjects exhibited precursor-product relationships between VLDL and IDL, and all did between IDL and light LDL; an analogous relationship between light and heavy LDL was evident in most hyperapo B patients and controls but not in FH patients. Simultaneous injection of differentially labeled LDL fractions and deconvolution analysis showed increased light LDL synthesis with normal conversion into heavy LDL in hyperapo B, whereas in FH conversion of light LDL was reduced and there was independent synthesis of heavy LDL. These data show that the increased concentration of LDL-apo B in hyperapo B is solely due to increased LDL synthesis, which is secondary to increased VLDL synthesis; in contrast, in FH there is both an increase in synthesis of LDL (which is partly VLDL-independent) and reduced catabolism.

Authors

B Teng, A D Sniderman, A K Soutar, G R Thompson

×

Total citations by year

Year: 2022 2021 2020 2016 2015 2014 2012 2011 2010 2009 2008 2007 2006 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 Total
Citations: 2 4 1 1 1 2 1 2 2 3 1 3 4 3 2 2 5 5 8 12 10 12 10 12 14 9 17 21 14 13 13 1 210
Citation information

Citations to this article (210)

Title and authors Publication Year
Macronutrient intake modulates impact of EcoRI polymorphism of ApoB gene on lipid profile and inflammatory markers in patients with type 2 diabetes.
Abaj F, Koohdani F 		Scientific Reports 2022
Physiological Bases for the Superiority of Apolipoprotein B Over Low-Density Lipoprotein Cholesterol and Non-High-Density Lipoprotein Cholesterol as a Marker of Cardiovascular Risk.
Glavinovic T, Thanassoulis G, de Graaf J, Couture P, Hegele RA, Sniderman AD 		Journal of the American Heart Association 2022
High-density lipoproteins, reverse cholesterol transport and atherogenesis
HJ Pownall, C Rosales, BK Gillard, AM Gotto 		Nature Reviews Cardiology 2021
FH through the retrospectoscope
GR Thompson 		Journal of lipid research 2021
Machine learning modelling of blood lipid biomarkers in familial hypercholesterolaemia versus polygenic/environmental dyslipidaemia
M Correia, E Kagenaar, DB van Schalkwijk, M Bourbon, M Gama-Carvalho 		Scientific Reports 2021
The scientific basis and future of lipoprotein apheresis
GR Thompson 		Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 2021
The Clinical Utility of apoB versus LDL-C/non-HDL-C
CN Kohli-Lynch, G Thanassoulis, AE Moran, AD Sniderman 		Clinica chimica acta; international journal of clinical chemistry 2020
Clove bud ( Syzygium aromaticum ) improved blood and hepatic antioxidant indices in laying hens receiving low n-6 to n-3 ratios
MR Alizadeh, AH Mahdavi, HR Rahmani, E Jahanian 		Journal of Animal Physiology and Animal Nutrition 2016
The crucial roles of apolipoproteins E and C-III in apoB lipoprotein metabolism in normolipidemia and hypertriglyceridemia:
FM Sacks 		Current Opinion in Lipidology 2015
The Severe Hypercholesterolemia Phenotype
AD Sniderman, S Tsimikas, S Fazio 		Journal of the American College of Cardiology 2014
Changes in ultracentrifugally separated plasma lipoprotein subfractions in patients with polygenic hypercholesterolemia, familial combined hyperlipoproteinemia, and familial hypercholesterolemia after treatment with atorvastatin
K Homma, Y Homma, T Yoshida, H Ozawa, Y Shiina, S Wakino, K Hayashi, H Itoh, S Hori 		Journal of Clinical Lipidology 2014
Phenotypes of hypertriglyceridemia caused by excess very-low-density lipoprotein
AD Sniderman, A Tremblay, JD Graaf, P Couture 		Journal of Clinical Lipidology 2012
Apolipoproteins: metabolic role and clinical biochemistry applications
MH Dominiczak, MJ Caslake 		Annals of Clinical Biochemistry 2011
Annual Reports in Medicinal Chemistry
JJ Liu, TW Lee 		Annual Reports in Medicinal Chemistry Volume 46 2011
Diagnosis and treatment of apolipoprotein B dyslipoproteinemias
A Sniderman, P Couture, J Graaf 		Nature Reviews Endocrinology 2010
Diagnosis and treatment of apolipoprotein B dyslipoproteinemias
A Sniderman, P Couture, J de Graaf 		Nature Reviews Endocrinology 2010
Regulation of plasma LDL: the apoB paradigm
AD Sniderman, JD Graaf, P Couture, K Williams, RS Kiss, GF Watts 		Clinical Science 2009
Low-density lipoprotein clearance in patients with chronic renal failure
H Kastarinen, S Horkko, H Kauma, A Karjalainen, MJ Savolainen, YA Kesaniemi 		Nephrology Dialysis Transplantation 2009
Fenofibrate ameliorates diabetic and dyslipidemic profiles in KKAy mice partly via down-regulation of 11β-HSD1, PEPCK and DGAT2
RA Srivastava 		European Journal of Pharmacology 2009
Diabetes, abdominal adiposity, and atherogenic dyslipoproteinemia in women compared with men
K Williams, A Tchernof, KJ Hunt, LE Wagenknecht, SM Haffner, AD Sniderman 		Diabetes 2008
The effects of second-hand smoke on biological processes important in atherogenesis
H Yuan, LS Wong, M Bhattacharya, C Ma, M Zafarani, M Yao, M Schneider, RE Pitas, M Martins-Green 		BMC Cardiovascular Disorders 2007
CETP and oxidized LDL levels increase in dyslipidemic subjects
J Wang, Q Gu, K Li, C Zhang 		Clinical Biochemistry 2007
Tissue-specific stable isotope measurements of postprandial lipid metabolism in familial combined hyperlipidaemia
K Evans, GC Burdge, SA Wootton, JM Collins, ML Clark, GD Tan, F Karpe, KN Frayn 		Atherosclerosis 2007
Significance of Small Dense Low-Density Lipoprotein as a Risk Factor for Coronary Artery Disease and Acute Coronary Syndrome
SW Kwon, SJ Yoon, TS Kang, HM Kwon, JH Kim, J Rhee, SJ Lee, JK Park, JY Lim, YW Yoon, BK Hong 		Yonsei Medical Journal 2006
Simultaneous expression of apolipoprotein B mRNA editing enzyme and scavenger receptor BI mediated by a therapeutic gene expression system
S Zhong, C Liu, D Haviland, PA Doris, BB Teng 		Atherosclerosis 2006
The Relationship between Visceral & Subcutaneous Fat and Small Dense Low Density Lipoprotein Cholesterol Concentration in Type 2 Diabetic Patients
WS Shim, SK Kim, HJ Kim, ES Kang, CW Ahn, SK Lim, HC Lee, BS Cha 		The Journal of Korean Diabetes Association 2006
The Relationship between the Leptin Concentration and the Small Dense Low Density Lipoprotein Cholesterol Concentration in Korean Type 2 Diabetic Patients
WS Shim, HJ Kim, ES Kang, YM Rhee, CW Ahn, SK Lim, HC Lee, BS Cha 		Journal of Korean Endocrine Society 2006
Associations of low density lipoprotein particle composition with atherogenicity
AT Lada, LL Rudel 		Current Opinion in Lipidology 2004
How more effective diagnosis of familial combined hyperlipidemia could lead to more effective therapy
AD Sniderman, JC Engert, MC Cabezas 		Drug Discovery Today: Disease Mechanisms 2004
In vivo metabolism of LDL subfractions in patients with heterozygous FH on statin therapy: rebound analysis of LDL subfractions after LDL apheresis
HC Geiss, S Bremer, PH Barrett, C Otto, KG Parhofer 		Journal of lipid research 2004
Effects of atorvastatin versus fenofibrate on apoB-100 and apoA-I kinetics in mixed hyperlipidemia
S Bilz, S Wagner, M Schmitz, A Bedynek, U Keller, T Demant 		Journal of lipid research 2003
Improved Cardiovascular Risk Profile and Renal Function in Renal Transplant Patients after Randomized Conversion from Cyclosporine to Tacrolimus
MA Artz, JM Boots, G Ligtenberg, JI Roodnat, MH Christiaans, PF Vos, HJ Blom, FC Sweep, PN Demacker, LB Hilbrands 		Journal of the American Society of Nephrology : JASN 2003
LDL concentration is correlated with the removal from the plasma of a chylomicron-like emulsion in subjects with coronary artery disease
AC Sposito, RD Santos, W Hueb, LI Ventura, CC Vinagre, JA Ramires, RC Maranhão 		Atherosclerosis 2002
Clinical relevance of the biochemical, metabolic, and genetic factors that influence low-density lipoprotein heterogeneity
PO Kwiterovich 		The American Journal of Cardiology 2002
Hypertriglyceridemia: new insights and new approaches to pharmacologic therapy
HN Ginsberg 		The American Journal of Cardiology 2001
Post-transcriptional Stimulation of the Assembly and Secretion of Triglyceride-rich Apolipoprotein B Lipoproteins in a Mouse with Selective Deficiency of Brown Adipose Tissue, Obesity, and Insulin Resistance
P Siri, N Candela, YL Zhang, C Ko, S Eusufzai, HN Ginsberg, LS Huang 		The Journal of biological chemistry 2001
Apolipoprotein B as the best predictor of coronary artery disease in Iranian normolipidemic patients
M Haidari, M Moghadam, M Chinicar, A Ahmadieh, M Doosti 		Clinical Biochemistry 2001
Effect of Low-Density Lipoprotein Apheresis on Kinetics of Apolipoprotein B in Heterozygous Familial Hypercholesterolemia1
C Maugeais, K Ouguerram, R Frénais, P Maugère, B Charbonnel, T Magot, M Krempf 		The Journal of clinical endocrinology and metabolism 2001
Two novel quantitative trait loci on mouse chromosomes 6 and 4 independently and synergistically regulate plasma apoB levels
C Ko, TL Lee, PW Lau, J Li, BT Davis, E Voyiaziakis, DB Allison, SC Chua, LS Huang 		Journal of lipid research 2001
Hammerhead Ribozyme as a Therapeutic Agent for Hyperlipidemia: Production of Truncated Apolipoprotein B and Hypolipidemic Effects in a Dyslipidemia Murine Model
M Enjoji, F Wang, M Nakamuta, L Chan, BB Teng 		Human Gene Therapy 2000
APOLIPOPROTEINB: mRNA Editing, Lipoprotein Assembly, and Presecretory Degradation
NO Davidson, GS Shelness 		Annual Review of Nutrition 2000
Influence of triglyceride concentration on the relationship between lipoprotein cholesterol and apolipoprotein B and A-I levels
G Leroux, I Lemieux, B Lamarche, B Cantin, GR Dagenais, PJ Lupien, JP Després 		Metabolism 2000
Governance of the concentration of plasma LDL: a reevaluation of the LDL receptor paradigm
A D Sniderman, X J Zhang, K Cianflone 		Atherosclerosis 2000
Apolipoprotein B metabolism and the distribution of VLDL and LDL subfractions
CJ Packard, T Demant, JP Stewart, D Bedford, MJ Caslake, G Schwertfeger, A Bedynek, J Shepherd, D Seidel 		Journal of lipid research 2000
MCP-1 deficiency reduces susceptibility to atherosclerosis in mice that overexpress human apolipoprotein B
J Gosling, S Slaymaker, L Gu, S Tseng, CH Zlot, SG Young, BJ Rollins, IF Charo 		Journal of Clinical Investigation 1999
A critical evaluation of the putative role of C3adesArg (ASP) in lipid metabolism and hyperapobetalipoproteinemia
J Kildsgaard, E Zsigmond, L Chan, RA Wetsel 		Molecular Immunology 1999
Regulation of HepG2 cell apolipoprotein B metabolism by the citrus flavanones hesperetin and naringenin
NM Borradaile, KK Carroll, EM Kurowska 		Lipids 1999
Genetic deficiency of acylation stimulating protein (ASP(C3ades-Arg)) does not cause hyperapobetalipoproteinemia in mice
RA Wetsel, J Kildsgaard, E Zsigmond, W Liao, L Chan 		The Journal of biological chemistry 1999
Sialic acid content of LDL and lipoprotein metabolism in combined hyperlipidemia and primary moderate hypercholesterolemia
N Lindbohm, H Gylling, TE Miettinen, TA Miettinen 		Clinica Chimica Acta 1999
Hammerhead Ribozyme Cleavage of Apolipoprotein B mRNA Generates a Truncated Protein
JP Wang, M Enjoji, M Tiebel, S Ochsner, L Chan, BB Teng 		The Journal of biological chemistry 1999
Effects of an oral and intravenous fat load on adipose tissue and forearm lipid metabolism
K Evans, ML Clark, KN Frayn 		American journal of physiology. Endocrinology and metabolism 1999
Uptake of type IV hypertriglyceridemic VLDL by cultured macrophages is enhanced by interferon-γ
SC Whitman, CA Argmann, CG Sawyez, DB Miller, RA Hegele, MW Huff 		Journal of lipid research 1999
GENETICS OF LIPOPROTEIN DISORDERS
J Davignon, J Genest 		Endocrinology & Metabolism Clinics of North America 1998
Defects of lipoprotein metabolism in familial combined hyperlipidaemia
J Graaf, AF Stalenhoef 		Current Opinion in Lipidology 1998
LIPOPROTEIN PHYSIOLOGY
HN Ginsberg 		Endocrinology & Metabolism Clinics of North America 1998
Lipoprotein disorder in brain infarction and hemorrhage
A Sato, Y Asakura, C Yokota, M Suzuki, M Tsushima, Y Kuriyama, T Sawada, T Yamaguchi, M Kobayashi, Y Harano 		International Journal of Clinical & Laboratory Research 1998
Dyslipidemias associated with heterozygous lipoprotein lipase mutations in the French-Canadian population
P Julien, C Gagné, MR Murthy, G Lévesque, S Moorjani, F Cadelis, MR Hayden, PJ Lupien 		Human Mutation 1998
Inhibition of cholesterol esterification by DuP 128 decreases hepatic apolipoprotein B secretion in vivo: effect of dietary fat and cholesterol
JR Burnett, LJ Wilcox, DE Telford, SJ Kleinstiver, PH Barrett, MW Huff 		Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1998
Three-fold effect of lovastatin treatment on low density lipoprotein metabolism in subjects with hyperlipidemia: increase in receptor activity, decrease in apoB production, and decrease in particle affinity for the receptor. Results from a novel triple-tracer approach
L Berglund, JL Witztum, NF Galeano, AS Khouw, HN Ginsberg, R Ramakrishnan 		Journal of lipid research 1998
Differential Effect of Genistein on the Stimulation of Cholesterol Production by Basic Protein II in Normal and HyperapoB Fibroblasts
PO Kwiterovich, M Motevalli 		Arteriosclerosis, thrombosis, and vascular biology 1998
The Adipocyte, Fatty Acid Trapping, and Atherogenesis
AD Sniderman, K Cianflone, P Arner, LK Summers, KN Frayn 		Arteriosclerosis, thrombosis, and vascular biology 1998
The assembly of triacylglycerol-rich lipoproteins: an essential role for the microsomal triacylglycerol transfer protein
DA White, AJ Bennett, MA Billett, AM Salter 		British Journal of Nutrition 1998
Glucose does not stimulate apoprotein B secretion from HepG2 cells because of insufficient stimulation of triglyceride synthesis
H Jiang, HN Ginsberg, X Wu 		Journal of lipid research 1998
VLDL and IDL apolipoprotein B-100 kinetics in familial hypercholesterolemia due to impaired LDL receptor function or to defective apolipoprotein B-100
H Zulewski, R Ninnis, AR Miserez, MW Baumstark, U Keller 		Journal of lipid research 1998
Use of cyclodextrin to deliver lipids and to modulate apolipoprotein B-100 production in HepG2 cells
MR Peluso, JL Dixon 		Lipids 1997
The acylation stimulating protein pathway: Clinical implications
K Cianflone 		Clinical Biochemistry 1997
The acylation-stimulating protein pathway and regulation of postprandial metabolism
AD Sniderman, K Cianflone, L Summers, B Fielding, K Frayn 		Proceedings of the Nutrition Society 1997
Abnormal Protein Tyrosine Phosphorylation in Fibroblasts from Hyperapobetalipoproteinemia Subjects
M Motevalli, PJ Goldschmidt-Clermont, D Virgil, PO Kwiterovich 		The Journal of biological chemistry 1997
Specific reduction of plasma large, light low-density lipoprotein by a bile acid sequestering resin, cholebine (MCI-196) in type II hyperlipoproteinemia
Y Homma, T Kobayashi, H Yamaguchi, H Ozawa, H Sakane, H Nakamura 		Atherosclerosis 1997
Decreased intracellular degradation and increased secretion of apo B-100 in Hep G2 cells after inhibition of cholesteryl ester synthesis
C Ooyen 		Atherosclerosis 1997
Inhibiting Δ9-Desaturase Activity Impairs Triacylglycerol Secretion in Cultured Chicken Hepatocytes
P Legrand, D Catheline, MC Fichot, P Lemarchal 		The Journal of nutrition 1997
Lipoprotein Heterogeneity and Apolipoprotein B Metabolism
CJ Packard, J Shepherd 		Arteriosclerosis, thrombosis, and vascular biology 1997
A Familial Combined Hyperlipidemic Kindred With Impaired Apolipoprotein B Catabolism: Kinetics of Apolipoprotein B During Placebo and Pravastatin Therapy
CA Aguilar-Salinas, PH Barrett, J Pulai, XL Zhu, G Schonfeld 		Arteriosclerosis, thrombosis, and vascular biology 1997
Associations Between Diet and the Hyperapobetalipoproteinemia Phenotype Expression in Children and Young Adults: The Cardiovascular Risk in Young Finns Study
IO Nuotio, OT Raitakari, KV Porkka, L Räsänen, T Moilanen, JS Viikari 		Arteriosclerosis, thrombosis, and vascular biology 1997
A diet containing myristoleic plus palmitoleic acids elevates plasma cholesterol in young growing swine
DR Smith, DA Knabe, HR Cross, SB Smith 		Lipids 1996
Association of lipoprotein cholesterol and triglycerides with the severity of coronary artery disease in men and women
T Korhonen, MJ Savolainen, MJ Koistinen, M Ikäheimo, MK Linnaluoto, K Kervinen, YA Kesäniemi 		Atherosclerosis 1996
Prevalence of hyperapobetalipoproteinemia and factors affecting the phenotype expression in children and young adults The Cardiovascular Risk in Young Finns Study
IO Nuotio, KV Porkka, OT Raitakari, T Lehtimäki, J Marniemi, S Taimela, L Suurinkeroinen, JS Viikari 		Atherosclerosis 1996
The atherogenic role of triglycerides and small, dense low density lipoproteins: impact of ciprofibrate therapy
MJ Chapman, E Bruckert 		Atherosclerosis 1996
Prevention and Regression of Atherosclerosis: Effects of Hmg-CoA Reductase Inhibitors
A Bjelajac, AK Goo, CW Weart 		The Annals of pharmacotherapy 1996
Demonstration of a Physical Interaction between Microsomal Triglyceride Transfer Protein and Apolipoprotein B during the Assembly of ApoB-containing Lipoproteins
X Wu, M Zhou, LS Huang, J Wetterau, HN Ginsberg 		The Journal of biological chemistry 1996
Fenofibrate Reduces Plasma Cholesteryl Ester Transfer From HDL to VLDL and Normalizes the Atherogenic, Dense LDL Profile in Combined Hyperlipidemia
M Guérin, E Bruckert, PJ Dolphin, G Turpin, MJ Chapman 		Arteriosclerosis, thrombosis, and vascular biology 1996
Dietary and Genetic Effects on LDL Size Measures in Baboons
AT Singh, DL Rainwater, CM Kammerer, RM Sharp, M Poushesh, WR Shelledy, JL VandeBerg 		Arteriosclerosis, thrombosis, and vascular biology 1996
Analysis of Apolipoproteins
MF Laker, K Evans 		Annals of Clinical Biochemistry 1996
Role of cholesterol in regulating apolipoprotein B secretion by the liver
GR Thompson, RP Naoumova, GF Watts 		Journal of lipid research 1996
Lack of association of the apolipoprotein A-I-C-III-A-IV gene XmnI and SstI polymorphisms and of the lipoprotein lipase gene mutations in familial combined hyperlipoproteinemia in French Canadian subjects
M Marcil, B Boucher, E Gagné, J Davignon, M Hayden, J Genest 		Journal of lipid research 1996
Inhibition of apolipoprotein B and triglyceride secretion in human hepatoma cells (HepG2)
M Haghpassand, D Wilder, JB Moberly 		Journal of lipid research 1996
Autoantibodies against malondialdehyde-modified LDL are elevated in subjects with an LDL subclass pattern B
H Jansen, H Ghanem, JH Kuypers, JC Birkenhäger 		Atherosclerosis 1995
Effects of simvastatin on plasma lipoprotein subfractions, cholesterol esterification rate, and cholesteryl ester transfer protein in type II hyperlipoproteinemia
Y Homma, H Ozawa, T Kobayashi, H Yamaguchi, H Sakane, H Nakamura 		Atherosclerosis 1995
Regulation of Apolipoprotein B Biogenesis in Human Hepatocytes: Posttranscriptional Control Mechanisms That Determine the Hepatic Production of Apolipoprotein B-Containing Lipoproteins
K Adeli 		Clinical Biochemistry 1995
Impact of a common mutation of the LDL receptor gene, in French-Canadian patients with familial hypercholesterolemia, on means, variances and correlations among traits of lipid metabolism
M Roy, CF Sing, C Betard, J Davignon 		Clinical Genetics 1995
Compositions of very low density lipoprotein subfractions from patients with polydisperse low density lipoproteins
S Saheki, Y Hitsumoto, S Bando, M Murase, N Takeuchi, K Uchida 		Clinica Chimica Acta 1995
Overexpression of Human Apolipoprotein B-100 in Transgenic Rabbits Results in Increased Levels of LDL and Decreased Levels of HDL
J Fan, SP McCormick, RM Krauss, S Taylor, R Quan, JM Taylor, SG Young 		Arteriosclerosis, thrombosis, and vascular biology 1995
Predominance of Large LDL and Reduced HDL 2 Cholesterol in Normolipidemic Men With Coronary Artery Disease
H Campos, GO Roederer, S Lussier-Cacan, J Davignon, RM Krauss 		Arteriosclerosis, thrombosis, and vascular biology 1995
Cardiovascular Disease 2
LL Gallo 		1995
Role of the neutral lipid accessible pool in the regulation of secretion of apoB-100 lipoprotein particles by HepG2 cells
RK Avramoglu, K Cianflone, AD Sniderman 		Journal of lipid research 1995
ACAT inhibitors decrease secretion of cholesteryl esters and apolipoprotein B by perfused livers of African green monkeys
TP Carr, RL Hamilton, LL Rudel 		Journal of lipid research 1995
Serum cholesterol and cholesterol and lipoprotein metabolism in hypercholesterolaemic NIDDM patients before and during sitostanol ester-margarine treatment
H Gylling, TA Miettinen 		Diabetologia 1994
Hepatic lipase and lipoprotein lipase are not major determinants of the low density lipoprotein subclass pattern in human subjects with coronary heart disease
H Jansen, W Hop, A Tol, AV Bruschke, JC Birkenhäger 		Atherosclerosis 1994
Effects of bezafibrate therapy on subfractions of plasma low-density lipoprotein and high-density lipoprotein, and on activities of lecithin: cholesterol acyltransferase and cholesteryl ester transfer protein in patients with hyperlipoproteinemia
Y Homma, H Ozawa, T Kobayashi, H Yamaguchi, H Sakane, Y Mikamia, Y Mikami, H Nakamura 		Atherosclerosis 1994
Effects of albumin on lipid synthesis, apo B-100 secretion, and LDL catabolism in HepG2 cells
K Cianflone, H Vu, ZJ Zhang, AD Sniderman 		Atherosclerosis 1994
Lipoprotein lipase activity in patients with combined hyperlipidaemia
M Seed, F Mailly, D Vallance, E Doherty, A Winder, P Talmud, SE Humphries 		Journal of Molecular Medicine 1994
ApoB metabolism in familial hypercholesterolemia. Inconsistencies with the LDL receptor paradigm
WR Fisher, LA Zech, PW Stacpoole 		Arteriosclerosis Thrombosis and Vascular Biology 1994
Inhibition of hepatic ACAT decreases ApoB secretion in miniature pigs fed a cholesterol-free diet
MW Huff, DE Telford, PH Barrett, JT Billheimer, PJ Gillies 		Arteriosclerosis Thrombosis and Vascular Biology 1994
The effect of three serum basic proteins on the mass of lipids in normal and hyperapoB fibroblasts
PO Kwiterovich, M Motevalli, M Miller 		Arteriosclerosis Thrombosis and Vascular Biology 1994
Cotranslational inhibition of apoB-100 synthesis by cyclosporin A in the human hepatoma cell line HepG2
A Kaptein, EC de Wit, HM Princen 		Arteriosclerosis Thrombosis and Vascular Biology 1994
Genetic factors in coronary heart disease
U Goldbourt, U de Faire, K Berg 		1994
Vascular Diagnostics
P Lanzer, J Rösch 		1994
Exogenous VLDL stimulates apolipoprotein B secretion from HepG2 cells by both pre- and post-translational mechanisms
X Wu, N Sakata, J Dixon, HN Ginsberg 		Journal of lipid research 1994
The adipsin-acylation stimulating protein system and regulation of intracellular triglyceride synthesis
A Baldo, AD Sniderman, S St-Luce, RK Avramoglu, M Maslowska, B Hoang, JC Monge, A Bell, S Mulay, K Cianflone 		Journal of Clinical Investigation 1993
Effect of hyperapo B LDL on cholesterol esterification in THP-1 macrophages
SD Kafonek, I Raikhel, PS Bachorik, PO Kwiterovich 		Atherosclerosis 1993
Regulation of hepatic secretion of apolipoprotein B-containing lipoproteins: information obtained from cultured liver cells
M Pravenec, V Zidek, M Simakova, V Kren, D Krenova, K Horky, M Jachymova, B Mikova, L Kazdova, TJ Aitman, PC Churchill, RC Webb, NH Hingarh, Y Yang, JM Wang, EM Lezin, TW Kurtz 		Nature Genetics 1993
Lipid transfer protein-mediated distribution of HDL-derived cholesteryl esters among plasma apo B-containing lipoprotein subpopulations
CA Marzetta, TJ Meyers, JJ Albers 		Arteriosclerosis Thrombosis and Vascular Biology 1993
Substrate delivery as a determinant of hepatic apoB secretion
AD Sniderman, K Cianflone 		Arteriosclerosis Thrombosis and Vascular Biology 1993
Familial hypoalphalipoproteinemia in premature coronary artery disease
J Genest, JM Bard, JC Fruchart, JM Ordovas, EJ Schaefer 		Arteriosclerosis Thrombosis and Vascular Biology 1993
Increased production rates of LDL are common in individuals with low plasma levels of HDL cholesterol, independent of plasma triglyceride concentrations
HN Ginsberg, C Ngai, XJ Wang, R Ramakrishnan 		Arteriosclerosis Thrombosis and Vascular Biology 1993
Plasma lipid, lipoprotein cholesterol, and apoprotein distributions in selected US communities. The Atherosclerosis Risk in Communities (ARIC) Study
SA Brown, R Hutchinson, J Morrisett, E Boerwinkle, CE Davis, AM Gotto, W Patsch 		Arteriosclerosis Thrombosis and Vascular Biology 1993
Dietary fat saturation modifies the metabolism of LDL subfractions in guinea pigs
ML Fernandez, G Abdel-Fattah, DJ McNamara 		Arteriosclerosis Thrombosis and Vascular Biology 1993
Stable isotopes show a direct relation between VLDL apoB overproduction and serum triglyceride levels and indicate a metabolically and biochemically coherent basis for familial combined hyperlipidemia
S Venkatesan, P Cullen, P Pacy, D Halliday, J Scott 		Arteriosclerosis Thrombosis and Vascular Biology 1993
Association of plasma triglyceride concentration and LDL particle diameter, density, and chemical composition with premature coronary artery disease in men and women
J Coresh, PO Kwiterovich, HH Smith, PS Bachorik 		Journal of lipid research 1993
Dense low density lipoprotein subspecies with diminished oxidative resistance predominate in combined hyperlipidemia
S Dejager, E Bruckert, MJ Chapman 		Journal of lipid research 1993
Proteolysis and lipid-facilitated translocation are distinct but competitive processes that regulate secretion of apolipoprotein B in Hep G2 cells
N Sakata, X Wu, JL Dixon, HN Ginsberg 		The Journal of biological chemistry 1993
Effects of ketoconazole on cholesterol precursors and low density lipoprotein kinetics in hypercholesterolemia
H Gylling, H Vanhanen, TA Miettinen 		Journal of lipid research 1993
Alcohol dose and low density lipoprotein heterogeneity in squirrel monkeys (Saimiri sciureus)
JL Hojnacki, JE Cluette-Brown, M Dawson, RN Deschenes, JJ Mulligan 		Atherosclerosis 1992
Both inherited susceptibility and environmental exposure determine the low-density lipoprotein-subfraction pattern distribution in healthy Dutch families
J Graaf, DW Swinkels, AF de Haan, PN Demacker, AF Stalenhoef 		The American Journal of Human Genetics 1992
Effects of lovastatin therapy on very-low-density lipoprotein triglyceride metabolism in subjects with combined hyperlipidemia: Evidence for reduced assembly and secretion of triglyceride-rich lipoproteins
Y Arad, R Ramakrishnan, HN Ginsberg 		Metabolism 1992
Hypertriglyceridemia: Risks and perspectives
AM Gotto 		The American Journal of Cardiology 1992
Abnormalities of low density lipoproteins in normolipidemic type II diabetic and nondiabetic patients with coronary artery disease
M Tilly-Kiesi, M Syvänne, T Kuusi, S Lahdenperä, Taskinen 		Journal of lipid research 1992
Transgenic mice expressing full-length human apolipoprotein B-100. Full-length human apolipoprotein B mRNA is essentially not edited in mouse intestine or liver
W Xiong, E Zsigmond, AM Gotto, LW Reneker, L Chan 		The Journal of biological chemistry 1992
Cholesteryl ester storage disease: complex molecular effects of chronic lovastatin therapy
R Levy, RE Ostlund, G Schonfeld, P Wong, CF Semenkovich 		Journal of lipid research 1992
Studies of the sites of intracellular degradation of apolipoprotein B in Hep G2 cells
S Furukawa, N Sakata, HN Ginsberg, JL Dixon 		The Journal of biological chemistry 1992
Regulation of guinea pig plasma low density lipoprotein kinetics by dietary fat saturation
ML Fernandez, EC Lin, DJ McNamara 		Journal of lipid research 1992
Effect of moderate hypertriglyceridemia on the relation of plasma total and LDL apo B levels
A Sniderman, H Vu, K Cianflone 		Atherosclerosis 1991
Plasma Lipid and Lipoprotein Levels in Childhood
PO Kwiterovich 		Annals of the New York Academy of Sciences 1991
Effects of probucol on plasma lipoprotein subfractions and activities of lipoprotein lipase and hepatic triglyceride lipase
Y Homma, EH Moriguchi, H Sakane, H Ozawa, H Nakamura, Y Goto 		Atherosclerosis 1991
Influence of lovastatin therapy on metabolism of low density lipoproteins in mixed hyperlipidaemia
GL Vega, SM Grundy 		Journal of Internal Medicine 1991
Relationships of low density lipoprotein subfractions to angiographically defined coronary artery disease in young survivors of myocardial infarction
P Tornvall, F Karpe, LA Carlson, A Hamsten 		Atherosclerosis 1991
Effects of fluvastatin (XU 62-320), an HMG-CoA reductase inhibitor, on the distribution and composition of low density lipoprotein subspecies in humans
J Yuan, MY Tsai, J Hegland, DB Hunninghake 		Atherosclerosis 1991
Familial combined hyperlipoproteinemia
J Genest 		CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 1991
Differential low density lipoprotein hydrated density distribution in female and male patients with familial hypercholesterolemia
MK Tilly-Kiesi, MJ Tikkanen 		Clinica Chimica Acta 1991
3. Genetic (primary) forms of hypertriglceridemia
G Assmann, HB Brewer 		The American Journal of Cardiology 1991
Clinical chemistry
DJ Anderson, FV Lente, FS Apple, SC Kazmierczak, JA Lott, MK Gupta, N McBride, WE Katzin, RE Scott, al. 		Analytical Chemistry 1991
George Lyman Duff Memorial Lecture. Multifactorial etiology of hypercholesterolemia. Implications for prevention of coronary heart disease
SM Grundy 		Arteriosclerosis Thrombosis and Vascular Biology 1991
Metabolic basis of primary hypercholesterolemia
GL Vega, MA Denke, SM Grundy 		Circulation 1991
Overproduction of a buoyant low density lipoprotein subspecies in spontaneously hypercholesterolemic mutant pigs
WJ Checovich, RJ Aiello, AD Attie 		Arteriosclerosis Thrombosis and Vascular Biology 1991
Clinical Value of Apolipoprotein Measurement
D Bhatnagar, PN Durrington 		Annals of Clinical Biochemistry 1991
Metabolic pathways of apolipoprotein B in heterozygous familial hypercholesterolemia: studies with a [3H]leucine tracer
WR Fisher, LA Zech, LL Kilgore, PW Stacpoole 		Journal of lipid research 1991
Discrete subspecies of human low density lipoproteins are heterogeneous in their interaction with the cellular LDL receptor
F Nigon, P Lesnik, M Rouis, MJ Chapman 		Journal of lipid research 1991
Oleate stimulates secretion of apolipoprotein B-containing lipoproteins from Hep G2 cells by inhibiting early intracellular degradation of apolipoprotein B
JL Dixon, S Furukawa, HN Ginsberg 		The Journal of biological chemistry 1991
Impaired response of fibroblasts from patients with hyperapobetalipoproteinemia to acylation-stimulating protein
KM Cianflone, MH Maslowska, AD Sniderman 		Journal of Clinical Investigation 1990
Characterization of LDL binding in TR 715-19 cells A high capacity, stable line for evaluating the binding of LDL to the human LDL receptor
H Hara, BV Howard 		Atherosclerosis 1990
Mechanisms of hypercholesterolaemia in glycogen storage disease type I: defective metabolism of low density lipoprotein in cultured skin fibroblasts
E Levy, L Thibault, CC Roy, J Letarte, M Lambert, EG Seidman 		European Journal of Clinical Investigation 1990
Apolipoproteins and metabolism in atherosclerosis
AM Gotto 		Transactions of the American Clinical and Climatological Association 1990
Acylation-stimulatory activity in hyperapobetalipoproteinemic fibroblasts: enhanced cholesterol esterification with another serum basic protein, BP II
P Kwiterovich, M Motevalli, M Miller 		Proceedings of the National Academy of Sciences 1990
Modulation of chylomicron remnant metabolism by an hepatic hydroxymethylglutaryl coenzyme A reductase inhibitor
K Cianflone, M Bilodeau, J Davignon, AD Sniderman 		Metabolism 1990
Differences in metabolism of three low density lipoprotein subfractions in Hep G2 cells
DW Swinkels, JC Hendriks, PN Demacker, AF Stalenhoef 		Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1990
9 Hypertriglyceridaemia, triglyceride-rich lipoproteins and coronary heart disease
A Hamsten 		Baillière's Clinical Endocrinology and Metabolism 1990
Cholesterol Metabolism, Ldl, and the Ldl Receptor
NB Myant 		Cholesterol Metabolism, Ldl, and the Ldl Receptor 1990
Lipoprotein (A)
EF Plow, LA Miles 		Lipoprotein (A) 1990
Diagnosis and Management of Familial Dyslipoproteinemia in Children and Adolescents
PO Kwiterovich 		Pediatric Clinics of North America 1990
Lipoprotein Physiology and Its Relationship to Atherogenesis
HN Ginsberg 		Endocrinology and metabolism clinics of North America 1990
Causes of high blood cholesterol
SM Grundy, GL Vega 		Circulation 1990
Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, in Vivo Kinetics
CL Malmendier, P Alaupovic, HB Brewer 		1990
Atherosclerosis and Cardiovascular Disease
G Descovich, A Gaddi, G Magri, S Lenzi 		1990
Regulation of apoB secretion from HepG2 cells: evidence for a critical role for cholesteryl ester synthesis in the response to a fatty acid challenge
KM Cianflone, Z Yasruel, MA Rodriguez, D Vas, AD Sniderman 		Journal of lipid research 1990
Lovastatin therapy reduces low density lipoprotein apoB levels in subjects with combined hyperlipidemia by reducing the production of apoB-containing lipoproteins: implications for the pathophysiology of apoB production
Y Arad, R Ramakrishnan, HN Ginsberg 		Journal of lipid research 1990
Studies on the metabolism of apolipoprotein B in hypertriglyceridemic subjects using simultaneous administration of tritiated leucine and radioiodinated very low density lipoprotein
WF Beltz, YA Kesäniemi, NH Miller, WR Fisher, SM Grundy, LA Zech 		Journal of lipid research 1990
Conversion of plasma VLDL and IDL precursors into various LDL subpopulations using density gradient ultracentrifugation
CA Marzetta, DM Foster, JD Brunzell 		Journal of lipid research 1990
Apolipoprotein B messenger RNA editing is developmentally regulated and widely expressed in human tissues
B Teng, M Verp, J Salomon, NO Davidson 		The Journal of biological chemistry 1990
Human low density lipoprotein subfractions separated by gradient gel electrophoresis: composition, distribution, and alterations induced by cholesteryl ester transfer protein
P Gambert, C Bouzerand-Gambert, A Athias, M Farnier, C Lallemant 		Journal of lipid research 1990
Estimation of turnover of low density lipoproteins by simplified methods
GL Vega, SM Grundy 		Atherosclerosis 1989
Restriction fragment length polymorphisms in the apo B gene in relation to coronary artery disease
NB Myant, J Gallagher, M Barbir, GR Thompson, D Wile, SE Humphries 		Atherosclerosis 1989
Genetic influences on susceptibility to atherosclerosis in the young
PO Kwiterovich 		Bulletin of the New York Academy of Medicine 1989
Regulation of low density lipoprotein apoprotein B metabolism by lovastatin and cholestyramine in miniature pigs: Effects on LDL composition and synthesis of LDL subfractions
MW Huff, DE Telford 		Metabolism 1989
Reduction in plasma low-density lipoprotein cholesterol and urinary mevalonic acid by lovastatin in patients with heterozygous familial hypercholesterolemia
AS Pappu, DR Illingworth, S Bacon 		Metabolism 1989
The Hyperlipoproteinemias
W Patsch, JR Patsch, AM Gotto 		Medical Clinics of North America 1989
Pathophysiology of reverse cholesterol transport. Insights from inherited disorders of lipoprotein metabolism
D Reichl, NE Miller 		Arteriosclerosis (Dallas, Tex.) 1989
Relation of cholesterol to apolipoprotein B in low density lipoproteins of children. The Bogalusa Heart Study
SR Srinivasan, W Wattigney, LS Webber, GS Berenson 		Arteriosclerosis (Dallas, Tex.) 1989
Lipoprotein Subfractions Omega-3 Fatty Acids
HU Klör 		1989
Colestipol-induced changes in LDL composition and metabolism. II. Studies in humans
SG Young, JL Witztum, TE Carew, RW Krauss, FT Lindgren 		Journal of lipid research 1989
Relationships between LDL density and kinetic heterogeneity in subjects with normolipidemia and familial combined hyperlipidemia using density gradient ultracentrifugation
CA Marzetta, DM Foster, JD Brunzell 		Journal of lipid research 1989
Metabolic behavior of hepatic VLDL and plasma LDL apoB-100 in African green monkeys
CA Marzetta, FL Johnson, LA Zech, DM Foster, LL Rudel 		Journal of lipid research 1989
High carbohydrate fat-free diet modulates epitope expression of LDL-apoB-100 and interaction of LDL with human fibroblasts
S Keidar, AC Goldberg, K Cook, J Bateman, G Schonfeld 		Journal of lipid research 1989
Purification and Characterization of Acylation Stimulating Protein
KM Cianflone, AD Sniderman, MJ Walsh, HT Vu, J Gagnon, MA Rodriguez 		The Journal of biological chemistry 1989
Characterization of low-density lipoproteins from patients with recessive X-linked ichthyosis
T Nakamura, Y Matsuzawa, M Okano, Y Kitano, T Funahashi, S Yamashita, S Tarui 		Atherosclerosis 1988
Biochemical, clinical, genetic and metabolic studies of hyperapo-β-lipoproteinaemia
PO Kwiterovich 		Journal of Inherited Metabolic Disease 1988
Apolipoproteins, Dyslipoproteinaemia and Premature Coronary Heart Disease
A Hamsten 		Acta Medica Scandinavica 1988
Plasma apolipoprotein B in middle-aged Finnish men Evidence for a regional gradient of apo B and lack of negative correlation between apo B and dietary linoleate in hyperapobetalipoproteinemia
T Solakivi, MK Salo, P Puska, T Nikkari 		Atherosclerosis 1988
Apolipoprotein measurements in clinical biochemistry and their utility vis-a-vis conventional assays
PS Bachorik, PO Kwiterovich 		Clinica Chimica Acta 1988
Some metabolic characteristics of low-density lipoprotein subfractions, LDL-1 and LDL-2: in vitro and in vivo studies
DW Swinkels, PN Demacker, HL Hak-Lemmers, MJ Mol, SH Yap, A Laar 		Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1988
Modelling of LDL-apheresis: System efficacy and rebound kinetics
F Kochinke, H Baeyer, I Schwaner, H Gräfenhahn, A Nold, R Schwerdtfeger, W Schwartzkopff 		Plasma Therapy and Transfusion Technology 1988
HMG-CoA Reductase Inhibitors for Treatment of Hypercholesterolemia
JA Oates, AJ Wood, SM Grundy 		New England Journal of Medicine 1988
High prevalence of hypertriglyceridaemia and apolipoprotein abnormalities in coronary artery disease
M Barbir, D Wile, I Trayner, VR Aber, GR Thompson 		Heart (British Cardiac Society) 1988
Studies in Inherited Metabolic Disease
RJ Pollitt, RA Harkness, GM Addison 		1988
Guinea pig low density lipoproteins: structural and metabolic heterogeneity
G Luc, MJ Chapman 		Journal of lipid research 1988
Genetic factors affecting blood lipoproteins: the candidate gene approach
AJ Lusis 		Journal of lipid research 1988
Defective receptor binding of low density lipoprotein from pigs possessing mutant apolipoprotein B alleles
SW Lowe, WJ Checovich, J Rapacz, AD Attie 		The Journal of biological chemistry 1988
Low density lipoprotein metabolism in non-insulin-dependent diabetes mellitus
AH Kissebah 		Diabetes / Metabolism Reviews 1987
The Fao cell. A tissue culture model for lipoprotein synthesis and secretion
ML Scarino, KE Howell 		Experimental Cell Research 1987
Hyperapobetalipoproteinemia: the major dyslipoproteinemia in patients with chronic renal failure treated with chronic ambulatory peritoneal dialysis
A Sniderman, K Cianflone, PO Kwiterovich, T Hutchinson, P Barre, S Prichard 		Atherosclerosis 1987
Comparison of selectivity of LDL removal by double filtration and dextran-sulfate cellulose column plasmapheresis, and changes of subfractionated plasma lipoproteins after plasmapheresis in heterozygous familial hypercholesterolemia
Y Homma, Y Mikami, H Tamachi, N Nakaya, H Nakamura, Y Goto 		Metabolism 1987
Integrated study of low density lipoprotein metabolism and very low density lipoprotein metabolism in non-insulin-dependent diabetes
BV Howard, WG Abbott, WF Beltz, IT Harper, RM Fields, SM Grundy, MR Taskinen 		Metabolism 1987
1 Lipid transport through the plasma: the metabolic basis of hyperlipidaemia
J Shepherd, CJ Packard 		Baillière's Clinical Endocrinology and Metabolism 1987
Metabolic consequences of genetic heterogeneity of lipoprotein composition (lipoprotein heterogeneity)
JD Brunzell, A Chait, JJ Albers, DM Foster, RA Failor, EL Bierman 		American Heart Journal 1987
Relationship of intermediate and low-density lipoprotein subspecies to risk of coronary artery disease
RM Krauss 		American Heart Journal 1987
Kinetics of LDL subfractions
GR Thompson, B Teng, AD Sniderman 		American Heart Journal 1987
Plasma lipoprotein distribution of apolipoprotein E in familial hypercholesterolemia
JC Gibson, RB Goldberg, A Rubinstein, HN Ginsberg, WV Brown, S Baker, BI Joffe, HC Seftel 		Arteriosclerosis (Dallas, Tex.) 1987
Hyperapobetalipoproteinemia in a kindred with familial combined hyperlipidemia and familial hypercholesterolemia
PO Kwiterovich, S White, T Forte, PS Bachorik, H Smith, A Sniderman 		Arteriosclerosis (Dallas, Tex.) 1987
Effects of MK‐733 on plasma lipid and lipoprotein levels in subjects with hypercholesterolaemia
LA Simons, PJ Nestel, GD Calvert, CL lennings 		The Medical Journal of Australia 1987
Hypolipidemic therapy modulates expression of apolipoprotein B epitopes on low density lipoproteins. Studies in mild to moderate hypertriglyceridemic patients
Y Kleinman, G Schonfeld, D Gavish, Y Oschry, S Eisenberg 		Journal of lipid research 1987
Paradoxical elevation of LDL apoprotein B levels in hypertriglyceridaemic patients and normal subjects ingesting fish oil
DR Sullivan, TA Sanders, IM Trayner, GR Thompson 		Atherosclerosis 1986

Advertisement