Citations to this article

Evidence for the presence of xenopsin-related peptide(s) in the gastric mucosa of mammals.
G E Feurle, … , E Rix, W Knauf
G E Feurle, … , E Rix, W Knauf
Published July 1, 1985
Citation Information: J Clin Invest. 1985;76(1):156-162. https://doi.org/10.1172/JCI111940.
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Research Article

Evidence for the presence of xenopsin-related peptide(s) in the gastric mucosa of mammals.

Abstract

Using immunohistochemistry and radioimmunoassay, substance(s) related to the amphibian octapeptide xenopsin (XP) were demonstrated in the gastric mucosa of humans and dogs. Immunohistochemistry localized XP-immunoreactive epithelial cells in the gastric antral mucosa. The reaction was abolished by preabsorption of the antiserum with XP but not by neurotensin or other peptides. Immunoreactive XP (iXP) was found by radioimmunoassay in extracts of both the antrum and body of the stomach prepared with acid/acetone or acetic acid. A study of its distribution in the dog indicated that the level of iXP was highest in the stomach, lower in the pancreas and duodenum, and not measurable in the jejunoileum and colon. Gel chromatography on Sephadex G-25 indicated the presence of at least two forms of iXP, one larger and the other about the same size as XP. Reverse-phase high pressure liquid chromatography on mu-Bondapak C-18 yielded several peaks of iXP, one of which eluted at the position of synthetic XP. The results of immunochemical analyses using four different antisera towards XP were consistent with structures for canine iXPs that were closely related to XP only in their C-terminal regions. These results suggest that mammalian counterparts to amphibian XP reside within endocrine cells of the gastric mucosa. It seems possible that these peptides function as gastrointestinal signals.

Authors

G E Feurle, R E Carraway, E Rix, W Knauf

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Year: 2022 2014 2012 2000 1993 1992 1991 1990 1989 1988 1987 1986 Total
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Citations to this article (28)

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Adsorption of neurotensin-family peptides on SERS-active Ag substrates: Adsorption of neurotensin-family peptides
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Pro-xenopsin(s) in vesicles of mammalian brain, liver, stomach and intestine is apparently released into blood and cerebral spinal fluid
RE Carraway, SP Mitra, DE Cochrane 		Regulatory Peptides 2000
Effects of GTP analogs and metal ions on the binding of neurotensin to porcine brain membranes
RE Carraway, SP Mitra, TW Honeyman 		Peptides 1993
Isolation and primary structure of an amphibian neurotensin
C Shaw, DM McKay, DW Halton, L Thim, KD Buchanan 		Regulatory Peptides 1992
Identification of xenin, a xenopsin-related peptide, in the human gastric mucosa and its effect on exocrine pancreatic secretion
GE Feurle, G Hamscher, R Kusiek, HE Meyer, JW Metzger 		The Journal of biological chemistry 1992
Xenopsin-related peptide(s) are formed from xenopsin precursor by leukocyte protease(s) and cathepsin D
RE Carraway, SP Mitra, K Muraki 		Peptides 1991
The Neuroendocrine System OF the Gut—AN Update
F Sundler, E Ekblad, R Hakanson 		Acta Oncologica 1991
Generation of xenopsin-related peptides from tissue precursors by media conditioned by endotoxin-stimulated rat peritoneal macrophages
DE Cochrane, RE Carraway, W Boucher 		Inflammation 1991
Characterisation and visualisation of [3H]dermorphin binding to mu opioid receptors in the rat brain. Combined high selectivity and affinity in a natural peptide agonist for the morphine (mu) receptor
M AMICHE, S SAGAN, A MOR, D PELAPRAT, W ROSTENE, A DELFOUR, P NICOLAS 		European Journal of Biochemistry 1990
Neurotensin-related peptides inhibit spontaneous longitudinal contractions of porcine distal jejunum
DR Brown, RE Carraway, AM Parsons, SP Mitra 		Peptides 1990
Isolation and sequence of canine xenopsin and an extended fragment from its precursor
RE Carraway, SP Mitra 		Peptides 1990
Isolation and structures of xenopsin-related peptides from rat stomach, liver and brain
RE Carraway, SP Mitra, K Muraki 		Regulatory Peptides 1990
Characterisation of xenopsin immunoreactivity derived from pepsinised human skin and possible mechanism of in vivo generation
DJ Eedy, C Shaw, CF Johnston, KD Buchanan 		Regulatory Peptides 1990
Dissimilar trophic effects of cerulein and xenopsin on the rat pancreas
GE Feurle, G Ohnheiser, C Löser 		International Journal of Gastrointestinal Cancer 1990
Species-specific effects of neurotensin on gallbladder contractionin vitro
, P Singh, JR Upp, JC Thompson 		Digestive Diseases and Sciences 1989
Immunocytochemical evidence for the colocalization of neurotensin/xenopsin- and gastrin/caerulein-immunoreactive substances in Xenopus laevis gastrointestinal tract
BE Flucher, C Lenglachner-Bachinger, GE Feurle 		General and Comparative Endocrinology 1988
The neurotensin analog xenopsin excites nigral dopamine neurons
MF Pozza, E Küng, S Bischoff, HR Olpe 		European Journal of Pharmacology 1988
Neurotensin and prostaglandin interactions in smooth muscle of the guinea pig stomach
S Katsoulis, JM Conlon 		European Journal of Pharmacology 1988
Xenopsin-related peptide generated in avian gastric extracts
RE Carraway, DE Cochrane, SP Mitra 		Regulatory Peptides 1988
Xenopsin immunoreactivity in antral G-cells may reside in the N-terminus of gastrin 17
CF Johnston, C Shaw, JE Ardill, JM Sloan, KD Buchanan 		Histochemistry 1988
Xenopsin- and neurotensin-like peptides in gastric juice from patients with duodenal ulcers
C Shaw, F Stöckmann, JM Conlon 		European Journal of Clinical Investigation 1987
Structure of a biologically active neurotensin-related peptide obtained from pepsin-treated albumin(s)
RE Carraway, SP Mitra, DE Cochrane 		The Journal of biological chemistry 1987
Skin peptides in Xenopus laevis: morphological requirements for precursor processing in developing and regenerating granular skin glands
BE Flucher, C Lenglachner-Bachinger, K Pohlhammer, H Adam, C Mollay 		The Journal of Cell Biology 1986
LANT-6, xenopsin and neuromedin N stimulate cyclic GMP at neurotensin receptors
JA Gilbert, E Richelson 		European Journal of Pharmacology 1986
Co-localization of xenopsin and gastrin immunoreactivity in gastric antral G-cells
EW Rix, GE Feurle, RE Carraway 		Histochemistry 1986

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