Citations to this article

Antibody-mediated killing of suppressor T lymphocytes as a possible cause of macroglobulinemia in the tropical splenomegaly syndrome.
W F Piessens, … , H A Marwoto, L L Laughlin
W F Piessens, … , H A Marwoto, L L Laughlin
Published June 1, 1985
Citation Information: J Clin Invest. 1985;75(6):1821-1827. https://doi.org/10.1172/JCI111895.
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Antibody-mediated killing of suppressor T lymphocytes as a possible cause of macroglobulinemia in the tropical splenomegaly syndrome.

Abstract

To investigate the pathogenesis of macroglobulinemia in the tropical splenomegaly syndrome (TSS), we assessed the functional activity of B lymphocytes and T cell subsets in a pokeweed mitogen-driven assay of immunoglobulin synthesis. Mononuclear cells from patients with TSS produced more IgM than cells from village or from distant controls. This appeared to result from a decrease in the number and/or activity of suppressor T cells of the T8+ phenotype. The lack of functional suppressor T lymphocytes was associated with the presence in sera from patients with TSS of IgM antibodies that specifically killed T8+, 9.3-, 60.1+ T cells from normal donors. These results support the hypothesis that macroglobulinemia in TSS results from defective immunoregulatory control of B cell function, and that this may be caused by lysis of suppressor T cells by specific lymphocytotoxic antibodies produced by patients with this syndrome.

Authors

W F Piessens, S L Hoffman, A A Wadee, P W Piessens, S Ratiwayanto, L Kurniawan, J R Campbell, H A Marwoto, L L Laughlin

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Citations to this article (18)

Title and authors Publication Year
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Hyper-reactive malarial splenomegaly: Rare cause of pyrexia of unknown origin
S Verma, A Aggarwal 		The Indian Journal of Pediatrics 2007
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Hyperreactive Malarial Splenomegaly in Europeans: Report of Five Cases
S Puente, M Subirats, A Benito, JM Rubio, JM González-Lahoz 		Journal of Travel Medicine 2001
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J Ende, A Gompel, E Enden, H Taelman, G Vanham, T Vervoort 		Tropical Medicine and International Health 2000
The use of PCR in the diagnosis of hyper-reactive malarial splenomegaly (HMS)
S Puente, JM Rubio, M Subirats, M Lago, J Gonzalez-Lahoz, A Benito 		Annals of Tropical Medicine and Parasitology 2000
Splénomégalie malarique hyperréactive chez un Européen revenant d'Afrique
H Granier, R Vatan, X Nicolas, M Richecœur, J Martin 		La Revue de Médecine Interne 1999
Hyperreactive Malarial Splenomegaly Syndrome in a European Patient
J Orús, A Martinez, M Corachán, ME Valls 		Tropical Doctor 1996
Use of immunoglobulin gene rearrangements to show clonal lymphoproliferation in hyper-reactive malarial splenomegaly
I Bates, DH Bevan, TR Rutherford, G Bedu-Addo 		The Lancet 1991
Cell surface antibodies in Type 1 (insulin-dependent) diabetic patients: II. Presence of immunoglobulins M which bind to lymphocytes
O Segers, F Gorus, G Somers, MV Winkel, M Vercammen, D Pipeleers 		Diabetologia 1989
Immunopathological mechanisms in the induction of parasitic diseases with particular reference to type III hypersensitivity reactions
MW Steward 		Parasitology 1987
6 Tropical splenomegaly syndrome (TSS) and other diseases of the spleen
D Hewlett, CS Pitchumoni 		Bailliere's Clinical Gastroenterology 1987
Asymptomatic malaria infections — Do they matter?
BM Greenwood 		Parasitology Today 1987
Hyperreactive malarious splenomegaly (tropical splenomegaly syndrome)
GG Crane 		Parasitology Today 1986

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