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Citations to this article

Hyperinsulinemia. A link between hypertension obesity and glucose intolerance.
M Modan, … , A Shitrit, Z Fuchs
M Modan, … , A Shitrit, Z Fuchs
Published March 1, 1985
Citation Information: J Clin Invest. 1985;75(3):809-817. https://doi.org/10.1172/JCI111776.
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Research Article Article has an altmetric score of 13

Hyperinsulinemia. A link between hypertension obesity and glucose intolerance.

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Abstract

Hypertension and glucose intolerance, determined in a random population sample (n = 2,475), showed a highly significant (P less than 0.001) association from the mildest levels of both conditions, independent of the confounding effects of age, sex, obesity, and antihypertensive medications. Summary rate ratios for hypertension were 1.48 (1.18-1.87) in abnormal tolerance and 2.26 (1.69-2.84) in diabetes compared with normal tolerance. Altogether, 83.4% of the hypertensives were either glucose-intolerant or obese--both established insulin-resistant conditions. Fasting and post-load insulin levels in a representative subgroup (n = 1,241) were significantly elevated in hypertension independent of obesity, glucose intolerance, age, and antihypertensive medications. The mean increment in summed 1- and 2-h insulin levels (milliunits per liter) compared with nonobese normotensives with normal tolerance was 12 for hypertension alone, 47 for obesity alone, 52 for abnormal tolerance alone, and 124 when all three conditions were present. The prevalence of concentrations (milliequivalents per liter) of erythrocyte Na+ greater than or equal to 7.0, K+ less than 92.5, and plasma K+ greater than or equal to 4.5 in a subsample of 59 individuals with all combinations of abnormal tolerance obesity and hypertension was compared with those in 30 individuals free of these conditions. Altogether, 88.1% of the former vs. 40.0% of the latter group presented at least one of these three markers of internal cation imbalance (P less than 0.001). We conclude that insulin resistance and/or hyperinsulinemia (a) are present in the majority of hypertensives, (b) constitute a common pathophysiologic feature of obesity, glucose intolerance, and hypertension, possibly explaining their ubiquitous association, and (c) may be linked to the increased peripheral vascular resistance of hypertension, which is putatively related to elevated intracellular sodium concentration.

Authors

M Modan, H Halkin, S Almog, A Lusky, A Eshkol, M Shefi, A Shitrit, Z Fuchs

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Total citations by year

Year: 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 1982 1967 Total
Citations: 2 3 5 7 15 15 11 14 13 8 15 13 19 117 9 16 19 25 23 18 25 26 25 26 43 38 61 46 42 60 68 81 67 68 38 27 38 21 8 1 1 1177
Citation information
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Citations to this article in year 2016 (13)

Title and authors Publication Year
Endocrinology: Adult and Pediatric
M Gurnell, TJ Visser, P Beck-Peccoz, VK Chatterjee
Endocrinology: Adult and Pediatric 2016
Rubus crataegifolius Bunge regulates adipogenesis through Akt and inhibits high-fat diet-induced obesity in rats
MS Jung, SJ Lee, Y Song, SH Jang, W Min, CK Won, HD Kim, TH Kim, JH Cho
Nutrition & Metabolism 2016
The joint association of self-rated health and diabetes status on 14-year mortality in elderly men and women
R Dankner, L Olmer, G Kaplan, A Chetrit
Quality of Life Research 2016
Hyperinsulinemia adversely affects lung structure and function
S Singh, M Bodas, NK Bhatraju, B Pattnaik, A Gheware, PK Parameswaran, M Thompson, M Freeman, U Mabalirajan, R Gosens, B Ghosh, C Pabelick, A Linneberg, YS Prakash, A Agrawal
American journal of physiology. Lung cellular and molecular physiology 2016
Principles of Diabetes Mellitus
A Ohri, S Vergano, R Bhambri, SH Schneider
Principles of Diabetes Mellitus 2016
Effect of High-Insulin on MUC4, MUC5AC, and MUC5B Expression in Airway Epithelial Cells
HG Na, CH Bae, YS Choi, SY Song, HJ Jin, YD Kim
Journal of Rhinology 2016
Medicago sativa L., a functional food to relieve hypertension and metabolic disorders in a spontaneously hypertensive rat model
R Martínez, G Kapravelou, JM Porres, AM Melesio, L Heras, S Cantarero, FM Gribble, H Parker, P Aranda, M López-Jurado
Journal of Functional Foods 2016
Calbindin-D9k Ablation Disrupt Glucose/Pancreatic Insulin Homeostasis
C Ahn, D Lee, JH Lee, H Yang, BS An, EB Jeung, B Singh
PloS one 2016
The Hypertension of Hemophilia Is Not Explained by the Usual Cardiovascular Risk Factors: Results of a Cohort Study
RF Barnes, TJ Cramer, AS Sait, R Kruse-Jarres, DV Quon, A Drygalski
International Journal of Hypertension 2016
Blood pressure in Warmblood horses before and during a euglycemic-hyperinsulinemic clamp
KE Nostell, SS Lindåse, JT Bröjer
Acta veterinaria Scandinavica 2016
Endocrinology
C Napier, SH Pearce
Endocrinology 2016
Anti-obesity effects of boiled tuna extract in mice with obesity induced by a high-fat diet
Y Kim, MJ Kwon, JW Choi, MK Lee, C Kim, J Jung, H Aprianita, H Nam, TJ Nam
International journal of molecular medicine 2016
Identifying patterns of associated-conditions through topic models of Electronic Medical Records
M Bhattacharya, C Jurkovitz, H Shatkay
2016 IEEE International Conference on Bioinformatics and Biomedicine (BIBM) 2016

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