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Citations to this article

Evolution of recurrent herpes simplex lesions. An immunohistologic study.
A L Cunningham, … , M F Para, T C Merigan
A L Cunningham, … , M F Para, T C Merigan
Published January 1, 1985
Citation Information: J Clin Invest. 1985;75(1):226-233. https://doi.org/10.1172/JCI111678.
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Research Article Article has an altmetric score of 9

Evolution of recurrent herpes simplex lesions. An immunohistologic study.

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Abstract

We performed immunoperoxidase stains on skin biopsies taken from nine patients with recurrent peripheral herpes simplex lesions at 12 h to 6 d after onset of signs of symptoms to phenotype the inflammatory infiltrate, to detect cells producing interferons alpha and gamma, and to locate herpes simplex virus antigen-containing cells. Viral glycoprotein antigen was located in the nuclei and cytoplasm of necrotic epidermal cells, often within vesicles, in biopsies taken between the first and third day. Histologically, biopsies of all stages showed intradermal focal perivascular and diffuse mononuclear inflammatory infiltrates. The cells constituting the infiltrates were predominantly T lymphocytes with lesser numbers of histiocytes; Leu 7+ (most natural killer/killer) cells and B cells were rare in the biopsy specimens. Leu 3a+ ("helper") T lymphocytes predominated in both subepidermal and perivascular regions of early lesions (12-24 h). Tissue helper/suppressor ratios ranged from 6.3 to 3.4 compared with 1.9-1.0 in blood. In later lesions (after 2 d), monocytes/macrophages were more prominent in tissue sections and the helper/suppressor ratios (2.3-2.5) more nearly approximated those of blood (1.6-2.7). The negative correlation of tissue ratios with time was significant (P less than or equal to 0.02). A large proportion of the infiltrated T lymphocytes expressed DR antigens. There was also diffuse strong DR expression on epidermal cells in five cases (all of two or more days). In six biopsies, scattered macrophages and small cells, presumably lymphocytes, demonstrated cytoplasmic or membrane staining for a substance which copurifies with interferon gamma. We identified such stained cells within vessels, suggesting that these cells circulate. Gamma interferon might have an important role within the herpetic lesions, possibly inducing macrophage activation and cytotoxic T lymphocytes and increasing DR expression on monocyte and epidermal cells.

Authors

A L Cunningham, R R Turner, A C Miller, M F Para, T C Merigan

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Genital ulcer disease control and HIV prevention
R Steen, G Dallabetta
Journal of Clinical Virology 2004
Skin Immune System: Cutaneous Immunology and Clinical Immunodermatology, Third Edition
E Guigné, J Revuz, JC Roujeau
Skin Immune System: Cutaneous Immunology and Clinical Immunodermatology, Third Edition 2004
Calculating the Contribution of Herpes Simplex Virus Type 2 Epidemics to Increasing HIV Incidence: Treatment Implications
S Blower, L Ma
Clinical Infectious Diseases 2004
Absence of Intercellular Adhesion Molecule 1 Expression in Varicella Zoster Virus–infected Keratinocytes During Herpes Zoster: Another Immune Evasion Strategy?
AF Nikkels, C Sadzot-Delvaux, GE Piérard
The American Journal of Dermatopathology 2004
Recent progress in herpes simplex virus immunobiology and vaccine research
DM Koelle, L Corey
Clinical microbiology reviews 2003
The role of dendritic cells in immune responses against vaginal infection by herpes simplex virus type 2
A Iwasaki
Microbes and Infection 2003
HSV-1 antigens and DNA in the corneal explant buttons of patients with non-herpetic or clinically atypical herpetic stromal keratitis
JG Garweg, CE Russ, M Schellhorn, M Böhnke, M Halberstadt
Graefe's Archive for Clinical and Experimental Ophthalmology 2003
The herpes simplex virus-1 Us3 protein kinase blocks CD8T cell lysis by preventing the cleavage of Bid by granzyme B
A Cartier, E Broberg, T Komai, M Henriksson, MG Masucci
Cell Death and Differentiation 2003
Expression of Cutaneous Lymphocyte-Associated Antigen and Functional E-Selectin Ligand by CD8+ T-cells Specific for a Skin-Tropic Virus
David M. Koelle, Zhi Liu, Christopher M. McClurkan, Max S. Topp, Stanley R. Riddell, Eric G. Pamer, Andrew S. Johnson, Anna Wald, Lawrence Corey
Journal of Clinical Investigation 2002
Home sweet home: How do virus-specific T cells navigate to the skin?
Anthony L. Cunningham
Journal of Clinical Investigation 2002
El chancroide
PZ Diego, MA Martín, BS Colomo
Piel 2002
Vaccines Against Genital Herpes: Progress and Limitations
LA Morrison
Drugs 2002
Herpesviruses and Immunity
PG Medveczky, H Friedman, M Bendinelli
2002
Viral Proteins Counteracting Host Defenses
UH Koszinowski, H Hengel
2002
A candidate phocid herpesvirus vaccine that provides protection against feline herpesvirus infection
BE Martina, MI Airikkala, TC Harder, G Amerongen, AD Osterhaus
Vaccine 2001
Herpes simplex virus-specific immune responses in subjects with frequent and infrequent orofacial recrudescences
DB Mckenna, WA Neill, M Norval
British Journal of Dermatology 2001
Infection of murine keratinocytes with herpes simplex virus type 1 induces the expression of interleukin-10, but not interleukin-1 alpha or tumour necrosis factor-alpha
M Zak-Prelich, KE Halliday, C Walker, CM Yates, M Norval, RC McKenzie
Immunology 2001
Alpha and gamma interferons inhibit herpes simplex virus type 1 infection and spread in epidermal cells after axonal transmission
Z Mikloska, AL Cunningham
Journal of virology 2001
Immature monocyte-derived dendritic cells are productively infected with herpes simplex virus type 1
Z Mikloska, L Bosnjak, AL Cunningham
Journal of virology 2001
CD8 CTL from Genital Herpes Simplex Lesions: Recognition of Viral Tegument and Immediate Early Proteins and Lysis of Infected Cutaneous Cells
DM Koelle, HB Chen, MA Gavin, A Wald, WW Kwok, L Corey
Journal of immunology (Baltimore, Md. : 1950) 2001
Chancroid: From Clinical Practice to Basic Science
DA Lewis
AIDS Patient Care and STDs 2000
Reactivation of Human Herpesviruses after Allogeneic Peripheral Blood Stem Cell Transplantation and Bone Marrow Transplantation
Y Maeda, T Teshima, M Yamada, M Harada
Leukemia & Lymphoma 2000
Sexually Transmitted Diseases
P Vandepapelière
Sexually Transmitted Diseases 2000
An overview of sexually transmitted diseases. Part III. Sexually transmitted diseases in HIV-infected patients
A Czelusta, A Yen-Moore, MV der Straten, D Carrasco, SK Tyring
Journal of the American Academy of Dermatology 2000
Women and Health
R Ramsey-Goldman, S Manzi
Women and Health 2000
Immune Protection against HSV-2 in B-Cell-Deficient Mice
KL Dudley, N Bourne, GN Milligan
Virology 2000
Why do we lack an effective vaccine against herpes simplex virus infections?
SP Deshpande, U Kumaraguru, BT Rouse
Microbes and Infection 2000
Monophosphoryl Lipid A and QS21 Increase CD8 T Lymphocyte Cytotoxicity to Herpes Simplex Virus-2 Infected Cell Proteins 4 and 27 Through IFN-γ and IL-12 Production
Z Mikloska, M Rückholdt, I Ghadiminejad, H Dunckley, M Denis, AL Cunningham
Journal of immunology (Baltimore, Md. : 1950) 2000
Chronic erosive herpes simplex virus infection of the penis, a possible immune reconstitution disease
PA Fox, SE Barton, N Francis, M Youle, DC Henderson, D Pillay, MA Johnson, L Fearfield, BG Gazzard, CB Bunker
HIV Medicine 1999
Recurrent Herpes Simplex Infection from Western and Traditional Chinese Medicine Viewpoints
P Stoyanov, E Iliev
Acupuncture in Medicine 1999
Clearance of HSV-2 from recurrent genital lesions correlates with infiltration of HSV-specific cytotoxic T lymphocytes
DM Koelle, CM Posavad, GR Barnum, ML Johnson, JM Frank, L Corey
Journal of Clinical Investigation 1998
HERPES SIMPLEX VIRUS–2 INFECTION
M Schomogyi, A Wald, L Corey
Infectious Disease Clinics of North America 1998
Differential effect of phototherapy on the activities of human natural killer cells and cytotoxic T cells
WA Neill, KE Halliday, M Norval
Journal of Photochemistry and Photobiology B: Biology 1998
Tipping the scales of herpes simplex virus reactivation: the important responses are local
C M Posavad, D M Koelle, L Corey
Nature Medicine 1998
Molecular Aspects of Herpes Simplex Virus I Latency, Reactivation, and Recurrence
CS Miller, RJ Danaher, RJ Jacob
Critical Reviews in Oral Biology & Medicine 1998
Herpes simplex virus seropositivity and reactivation at delivery among pregnant women infected with human immunodeficiency virus-1
J Hitti, DH Watts, SK Burchett, T Schacker, S Selke, ZA Brown, L Corey
American Journal of Obstetrics and Gynecology 1997
Preferential presentation of herpes simplex virus T-cell antigen by HLA DQA1*0501/DQB1*0201 in comparison to HLA DQA1*0201/DQB1*0201
DM Koelle, ML Johnson, AN Ekstrom, P Byers, WW Kwok
Human Immunology 1997
Growth of herpes simplex type 1 on skin explants of atopic eczema
H Goodyear, J Davies, P Mcleish, A Buchan, G Skinner, M Winther, J Harper
Clinical and Experimental Dermatology 1996
Small, freshly arrived histiocytes in cutaneous and mucosal herpetic lesions
JJ Oord, R Vos, C Wolf-Peeters
Archives of Dermatological Research 1996
IMMUNE RESPONSES TO VARICELLA-ZOSTER VIRUS
AM Arvin
Infectious Disease Clinics of North America 1996
Small, freshly arrived histiocytes in cutaneous and mucosal herpetic lesions
JJ van den Oord, RD Vos, CD Wolf-Peeters
Archives of Dermatological Research 1996
Chancroid and Haemophilus ducreyi: an update
DL Trees, SA Morse
Clinical microbiology reviews 1995
The T-lymphocyte response to varicella zoster virus and its relevance to vaccine development
AM Arvin
Reviews in Medical Virology 1994
Antigenic specificities of human CD4+ T-cell clones recovered from recurrent genital herpes simplex virus type 2 lesions
DM Koelle, L Corey, RL Burke, RJ Eisenberg, GH Cohen, R Pichyangkura, SJ Triezenberg
Journal of virology 1994
Cytotoxic T-Lymphocytes in Human Viral and Malaria Infections
MB Oldstone
1994
Herpes simplex virus type 2 infection of heterosexual men attending a sexual health centre
I Bassett, B Donovan, NJ Bodsworth, PR Field, DW Ho, AL Cunningham, S Jeansson
The Medical Journal of Australia 1994
Herpes simplex virus infection of human fibroblasts and keratinocytes inhibits recognition by cloned CD8+ cytotoxic T lymphocytes
DM Koelle, MA Tigges, RL Burke, FW Symington, SR Riddell, H Abbo, L Corey
Journal of Clinical Investigation 1993
Herpes simplex virus infections during the decade since the licensure of acyclovir
L Corey
Journal of Medical Virology 1993
Herpes simplex virus detection from genital lesions: a comparative study using antigen detection (HerpChek) and culture
RW Cone, PD Swenson, AC Hobson, M Remington, L Corey
Journal of clinical microbiology 1993
Recurrent aphthous ulceration: Virological and immunological aspects
A Pedersen
APMIS 1993
4 Herpes simplex virus infection in pregnancy
DE Dwyer, AL Cunningham
Baillière's Clinical Obstetrics and Gynaecology 1993
Mucocutaneous infections with herpes simplex virus and their management
J Vestey, M Norval
Clinical and Experimental Dermatology 1992
Herpes Simplex Virus
BT Rouse
1992
Herpes simplex keratitis: Role of viral infection versus immune response
JS Pepose
Survey of Ophthalmology 1991
Thy 1+ asialo GM 1 + dendritic epidermal cells in skin defense mechanisms of vaccinia virus-infected mice
S Ikeda, T Tominaga, C Nishimura
Archives of Virology 1991
AIDS and Women’s Reproductive Health
LC Chen, JS Amor, SJ Segal, JM Anderson
1991
Antigen presentation in patients with recrudescent orofacial herpes simplex virus infections
J Vestey, M Norval, S Howie, J Maingay, W Neill
British Journal of Dermatology 1990
Histopathology of endocervical infection caused by Chlamydia trachomatis, herpes simplex virus, Trichomonas vaginalis, and Neisseria gonorrhoeae
NB Kiviat, JA Paavonen, P Wølner-Hanssen, CW Critchlow, WE Stamm, J Douglas, DA Eschenbach, LA Corey, KK Holmes
Human Pathology 1990
Role of keratinocytes in human recurrent herpetic lesions. Ability to present herpes simplex virus antigen and act as targets for T lymphocyte cytotoxicity in vitro
AL Cunningham, JR Noble
Journal of Clinical Investigation 1989
Inhibitory Effect of Gamma Interferon on Cultured Human Keratinocyte Thrombospondin Production, Distribution, and Biologic Activities
BJ Nickoloff, BL Riser, RS Mitra, VM Dixit, J Varani
Journal of Investigative Dermatology 1988
Advances in Virus Research
LA Babiuk, MJ Lawman, HB Ohmann
Advances in virus research 1988
Keratinocyte proliferation in wound healing and skin diseases
VB Morhenn
Immunology Today 1988
Is Recombinant Interleukin-2 the Best Way to Deliver Interferon-γ in Human Disease?
TC Merigan
Journal of Interferon Research 1987
The histopathologic identification of CMV infected cells in biopsies of human renal allografts
W Ulrich, MP Schlederer, P Buxbaum, H Stummoll, S Rockenschaub, J Kovarik, I Krisch
Pathology - Research and Practice 1986
Local and Systemic Effects of Intradermal Recombinant Interferon-γ in Patients with Lepromatous Leprosy
CF Nathan, G Kaplan, WR Levis, A Nusrat, MD Witmer, SA Sherwin, CK Job, CR Horowitz, RM Steinman, ZA Cohn
New England Journal of Medicine 1986
Role of Macrophage D-Region Antigens and T-Lymphocyte Differentiation Antigens in Induction of Gamma Interferon
AL Cunningham, TY Basham, MF Para, TC Merigan
Journal of Interferon Research 1985
Infectious Diseases
AM Ramsay, RT Emond
Infectious Diseases 1967

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