To determine if glucagon secretion is under physiological control of intra-islet insulin, pancreata from normal rats were perfused at a 100 mg/dl glucose concentration with either guinea pig antiinsulin serum or normal guinea pig serum in a nonrecirculating system. Perfusion of antiserum was followed within 3 min by a significant rise in glucagon that reached peak levels three times the base-line values and assumed a hectic pattern that returned rapidly to base-line levels upon termination of the antiserum perfusion. Nonimmune guinea pig serum had no effect. To gain insight into the probable site of insulin neutralization, 125I-labeled human gamma-globulin was added to antiserum or nonimmune serum and perfused for 3 min. More than 83% of the radioactivity was recovered in the effluent within 3 min after termination of the infusion, and only 0.05 +/- 0.015% of the radioactivity injected was present in the pancreas 10 min after the perfusion. The maximal amount of insulin that could be completely bound to insulin antibody at a dilution and under conditions simulating those of the perfusion experiments was 20 mU/min. It is concluded that insulin maintains an ongoing restraint upon alpha cell secretion and in its absence causes hectic hypersecretion of glucagon. This restraint probably occurs largely in the intravascular compartment. Loss of this release-inhibiting action of insulin may account for initiation of hyperglucagonemia in insulin-deficient states.
H Maruyama, A Hisatomi, L Orci, G M Grodsky, R H Unger
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Title and authors | Publication | Year |
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CK2 activity is crucial for proper glucagon expression.
Ampofo E, Pack M, Wrublewsky S, Boewe AS, Spigelman AF, Koch H, MacDonald PE, Laschke MW, Montenarh M, Götz C |
Diabetologia | 2024 |
The Importance of Intra-Islet Communication in the Function and Plasticity of the Islets of Langerhans during Health and Diabetes
Hill TG, Hill DJ |
International journal of molecular sciences | 2024 |
Abnormal late postprandial glucagon response in type 1 diabetes is a function of differences in stimulated C-peptide concentrations.
Zhang L, Qin Y, Huang Y, Hu Q, Wu Q, Wang X, Zhang M |
Frontiers in Endocrinology | 2024 |
Revisiting the role of glucagon in health, diabetes mellitus and other metabolic diseases.
Hædersdal S, Andersen A, Knop FK, Vilsbøll T |
Nature reviews. Endocrinology | 2023 |
Usage of Glucagon-Like Peptide-1 for Obesity in Children; Updated Review of Clinicaltrials.gov.
Alorfi NM, Alshehri FS |
Journal of multidisciplinary healthcare | 2023 |
The human α cell in health and disease.
Pettway YD, Saunders DC, Brissova M |
The Journal of endocrinology | 2023 |
Conflicting Views About Interactions Between Pancreatic α-Cells and β-Cells
Weir GC, Bonner-Weir S |
Diabetes | 2023 |
State of Knowledge on Molecular Adaptations to Exercise in Humans: Historical Perspectives and Future Directions
Lavin KM, Coen PM, Baptista LC, Bell MB, Drummer D, Harper SA, Lixandrão ME, McAdam JS, O\u2019Bryan SM, Ramos S, Roberts LM, Vega RB, Goodpaster BH, Bamman MM, Buford TW |
Comprehensive Physiology | 2022 |
Regulation of α‐cell glucagon secretion: The role of second messengers
Acreman S, Zhang Q |
Chronic Diseases and Translational Medicine | 2022 |
Physiological Systems in Promoting Frailty
Perazza LR, Brown-Borg HM, Thompson LV |
Comprehensive Physiology | 2022 |
Pancreatic β-cell heterogeneity in health and diabetes: classes, sources, and subtypes
MA Miranda, JF Macias-Velasco, HA Lawson |
American journal of physiology. Endocrinology and metabolism | 2021 |
Mechanisms controlling pancreatic islet cell function in insulin secretion
JE Campbell, CB Newgard |
Nature Reviews Molecular Cell Biology | 2021 |
Preproglucagon Products and Their Respective Roles Regulating Insulin Secretion
M Bethea, N Bozadjieva-Kramer, DA Sandoval |
Endocrinology | 2021 |
Insulin receptor substrate 1, but not IRS2, plays a dominant role in regulating pancreatic alpha cell function in mice
T Takatani, J Shirakawa, K Shibue, MK Gupta, H Kim, S Lu, J Hu, MF White, RT Kennedy, RN Kulkarni |
The Journal of biological chemistry | 2021 |
Glucagon blockade restores functional β-cell mass in type 1 diabetic mice and enhances function of human islets
MY Wang, ED Dean, E Quittner-Strom, Y Zhu, KH Chowdhury, Z Zhang, S Zhao, N Li, R Ye, Y Lee, Y Zhang, S Chen, X Yu, DC Leonard, G Poffenberger, AV Deylen, SK McCorkle, A Schlegel, KW Sloop, AM Efanov, RE Gimeno, PE Scherer, AC Powers, RH Unger, WL Holland |
Proceedings of the National Academy of Sciences | 2021 |
Hyperglucagonemia Does Not Explain the β-Cell Hyperresponsiveness and Insulin Resistance in Dysglycemic Youth Compared With Adults: Lessons From the RISE Study
SE Kahn, KJ Mather, SA Arslanian, E Barengolts, TA Buchanan, S Caprio, DA Ehrmann, TS Hannon, S Marcovina, KJ Nadeau, KM Utzschneider, AH Xiang, SL Edelstein |
Diabetes care | 2021 |
Multi-omic Approaches to Identify Genetic Factors in Metabolic Syndrome
Clark KC, Kwitek AE |
Comprehensive Physiology | 2021 |
Effect of Medical and Surgical Interventions on α-Cell Function in Dysglycemic Youth and Adults in the RISE Study
SE Kahn, SL Edelstein, SA Arslanian, E Barengolts, S Caprio, DA Ehrmann, TS Hannon, S Marcovina, KJ Mather, KJ Nadeau, KM Utzschneider, AH Xiang, TA Buchanan |
Diabetes care | 2021 |
Effects of xenin-25 on insulin and glucagon secretions in healthy conscious sheep
T Onaga, H Hayashi, Y Yasui |
Domestic Animal Endocrinology | 2021 |
Genetic activation of α-cell glucokinase in mice causes enhanced glucose-suppression of glucagon secretion during normal and diabetic states
V Bahl, CL May, A Perez, B Glaser, KH Kaestner |
Molecular Metabolism | 2021 |
Peptides in the regulation of glucagon secretion
DB Andersen, JJ Holst |
Peptides | 2021 |
Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes
M Omar-Hmeadi, PE Lund, NR Gandasi, A Tengholm, S Barg |
Nature Communications | 2020 |
Paracrine signaling in islet function and survival
SM Hartig, AR Cox |
Journal of Molecular Medicine | 2020 |
Ca v 2.3 channel function and Zn 2+ -induced modulation: potential mechanisms and (patho)physiological relevance
F Neumaier, T Schneider, W Albanna |
Channels (Austin, Tex.) | 2020 |
Paracrine regulation of somatostatin secretion by insulin and glucagon in mouse pancreatic islets
B Svendsen, JJ Holst |
Diabetologia | 2020 |
Glucagon-like Peptide-1: Actions and Influence on Pancreatic Hormone Function
Davis EM, Sandoval DA |
Comprehensive Physiology | 2020 |
In the rat pancreas, somatostatin tonically inhibits glucagon secretion and is required for glucose‐induced inhibition of glucagon secretion
SF Xu, DB Andersen, JM Izarzugaza, RE Kuhre, JJ Holst |
Acta physiologica (Oxford, England) | 2020 |
Association of British Clinical Diabetologists (ABCD) and Diabetes UK joint position statement and recommendations on the use of sodium–glucose cotransporter inhibitors with insulin for treatment of type 1 diabetes (Updated October 2020)
U Dashora, DC Patel, R Gregory, P Winocour, K Dhatariya, S Rowles, A Macklin, G Rayman, D Nagi |
Diabetic Medicine | 2020 |
Pancreatic α-cells – The unsung heroes in islet function
A Wendt, L Eliasson |
Seminars in Cell & Developmental Biology | 2020 |
The Role of α-Cells in Islet Function and Glucose Homeostasis in Health and Type 2 Diabetes
P Gilon |
Journal of Molecular Biology | 2020 |
The Local Paracrine Actions of the Pancreatic α-Cell
R Rodriguez-Diaz, A Tamayo, M Hara, A Caicedo |
Diabetes | 2019 |
Tripartite cell networks for glucose homeostasis
T Song, J Jo |
Physical Biology | 2019 |
Novel Preparations of Glucagon for the Prevention and Treatment of Hypoglycemia
CP Hawkes, DD Leon, MR Rickels |
Current Diabetes Reports | 2019 |
Pharmacokinetics and Pharmacodynamics of Insulin Tregopil in Relation to Premeal Dosing Time, Between Meal Interval, and Meal Composition in Patients With Type 2 Diabetes Mellitus
A Khedkar, H Lebovitz, A Fleming, A Cherrington, V Jose, SN Athalye, A Vishweswaramurthy |
Clinical Pharmacology in Drug Development | 2019 |
Lelio Orci, the modern master of morphology
D Ribatti |
Cell Biology International | 2019 |
Obesity dysregulates fasting-induced changes in glucagon secretion
JH Stern, GI Smith, S Chen, RH Unger, S Klein, PE Scherer |
Journal of Endocrinology | 2019 |
Chronic Fractalkine Administration Improves Glucose Tolerance and Pancreatic Endocrine Function
Matthew Riopel, Jong Bae Seo, Gautam Bandyopadhyay, Pingping Li, Joshua Wollam, Heekyung Chung, Seung Ryoung Jung, Anne Murphy, Maria Wilson, Ron De Jong, Sanjay Patel, Deepika Balakrishna, James Bilakovics, Andrea Fanjul, Artur Plonowski, Duk-Su Koh, Christopher J. Larson, Jerrold M. Olefsky, Yun Sok Lee |
Journal of Clinical Investigation | 2018 |
Mechanisms of Insulin Action and Insulin Resistance
MC Petersen, GI Shulman |
Physiological reviews | 2018 |
Design principles of the paradoxical feedback between pancreatic alpha and beta cells
I Garzilli, S Itzkovitz |
Scientific Reports | 2018 |
Pancreatic Islet Transplantation in Humans: Recent Progress and Future Directions
MR Rickels, RP Robertson |
Endocrine reviews | 2018 |
Sexually dimorphic metabolic responses mediated by CRF2 receptor during nutritional stress in mice
S Paruthiyil, S Hagiwara, K Kundassery, A Bhargava |
Biology of sex differences | 2018 |
A novel series of 4-methyl substituted pyrazole derivatives as potent glucagon receptor antagonists: Design, synthesis and evaluation of biological activities
S Shu, A Dai, J Wang, B Wang, Y Feng, J Li, X Cai, D Yang, D Ma, MW Wang, H Liu |
Bioorganic & Medicinal Chemistry | 2018 |
Metabolic profiling of umbilical cord blood in macrosomia
H Sun, YC Wang, CC Wang, XX Xu, YH Wang, HT Yan, XJ Yang |
International Journal of Obesity | 2018 |
The α-cell in diabetes mellitus
J Gromada, P Chabosseau, GA Rutter |
Nature Reviews Endocrinology | 2018 |
Insulin Secretion Depends on Intra-islet Glucagon Signaling
B Svendsen, O Larsen, MB Gabe, CB Christiansen, MM Rosenkilde, DJ Drucker, JJ Holst |
Cell Reports | 2018 |
DIABETIC KETOACIDOSIS IN A PATIENT WITH TYPE 1 DIABETES MELLITUS TREATED WITH LOW INSULIN IN COMBINATION WITH EMPAGLIFLOZIN
JG Jiménez-Montero, CJ Mora-Aguilar, CH Chen-Ku |
AACE Clinical Case Reports | 2018 |
Exploring the molecular mechanisms underlying α- and β-cell dysfunction in diabetes
D Kawamori |
Diabetology International | 2017 |
SGLT2 Inhibition by Empagliflozin Promotes Fat Utilization and Browning and Attenuates Inflammation and Insulin Resistance by Polarizing M2 Macrophages in Diet-induced Obese Mice
L Xu, N Nagata, M Nagashimada, F Zhuge, Y Ni, G Chen, E Mayoux, S Kaneko, T Ota |
EBioMedicine | 2017 |
Glucotoxicity induces abnormal glucagon secretion through impaired insulin signaling in InR1G cells
T Katsura, D Kawamori, E Aida, T Matsuoka, I Shimomura, W Nishimura |
PloS one | 2017 |
Oral Insulin Delivery in a Physiologic Context: Review
E Arbit, M Kidron |
Journal of diabetes science and technology | 2017 |
Differential Effects of Linagliptin on the Function of Human Islets Isolated from Non-diabetic and Diabetic Donors
Y Zhang, M Wu, W Htun, EW Dong, F Mauvais-Jarvis, VA Fonseca, H Wu |
Scientific Reports | 2017 |
Sodium-Glucose Co-transporters and Their Inhibition: Clinical Physiology
E Ferrannini |
Cell Metabolism | 2017 |
Artemisinins Target GABA A Receptor Signaling and Impair α Cell Identity
J Li, T Casteels, T Frogne, C Ingvorsen, C Honoré, M Courtney, KV Huber, N Schmitner, RA Kimmel, RA Romanov, C Sturtzel, CH Lardeau, J Klughammer, M Farlik, S Sdelci, A Vieira, F Avolio, F Briand, I Baburin, P Májek, FM Pauler, T Penz, A Stukalov, M Gridling, K Parapatics, C Barbieux, E Berishvili, A Spittler, J Colinge, KL Bennett, S Hering, T Sulpice, C Bock, M Distel, T Harkany, D Meyer, G Superti-Furga, P Collombat, J Hecksher-Sørensen, S Kubicek |
Cell | 2017 |
Impaired Insulin Action Is Associated With Increased Glucagon Concentrations in Nondiabetic Humans
A Sharma, RT Varghese, M Shah, CD Man, C Cobelli, RA Rizza, KR Bailey, A Vella |
The Journal of clinical endocrinology and metabolism | 2017 |
DIABETIC KETOACIDOSIS IN PATIENTS WITH TYPE 2 DIABETES RECENTLY COMMENCED ON SGLT-2 INHIBITORS: AN ONGOING CONCERN
M Ahmed, MJ McKenna, RK Crowley |
Endocrine Practice | 2017 |
Insulin-like growth factor-1 is a negative modulator of glucagon secretion
E Mancuso, GC Mannino, CD Fatta, A Fuoco, R Spiga, F Andreozzi, G Sesti |
Oncotarget | 2017 |
Decrease of γ-aminobutyric acid and zinc ions in the islet periportal circulation stimulates glucagon secretion during hypoglycemia
T Yu, Z Jiang, L Liu, Z Fan |
Experimental and therapeutic medicine | 2017 |
Hyperglucagonemia in an animal model of insulin- deficient diabetes: what therapy can improve it?
F Barbetti, C Colombo, L Haataja, C Cras-Méneur, S Bernardini, P Arvan |
Clinical Diabetes and Endocrinology | 2016 |
Functional and Molecular Adaptations of Enteroendocrine L-Cells in Male Obese Mice Are Associated With Preservation of Pancreatic α-Cell Function and Prevention of Hyperglycemia
R Dusaulcy, S Handgraaf, S Skarupelova, F Visentin, C Vesin, M Heddad-Masson, F Reimann, F Gribble, J Philippe, Y Gosmain |
Endocrinology | 2016 |
Impact of islet architecture on β-cell heterogeneity, plasticity and function
SS Roscioni, A Migliorini, M Gegg, H Lickert |
Nature Reviews Endocrinology | 2016 |
Clinical Trials, Triumphs, and Tribulations of Glucagon Receptor Antagonists
MJ Pearson, RH Unger, WL Holland |
Diabetes care | 2016 |
Dapagliflozin stimulates glucagon secretion at high glucose: experiments and mathematical simulations of human A-cells
MG Pedersen, I Ahlstedt, MF el Hachmane, SO Göpel |
Scientific Reports | 2016 |
Pharmacological aspects of the safety of gliflozins
JL Faillie |
Pharmacological Research | 2016 |
Shift to Fatty Substrate Utilization in Response to Sodium–Glucose Cotransporter 2 Inhibition in Subjects Without Diabetes and Patients With Type 2 Diabetes
E Ferrannini, S Baldi, S Frascerra, B Astiarraga, T Heise, R Bizzotto, A Mari, TR Pieber, E Muscelli |
Diabetes | 2016 |
Nutritional modulation of endogenous glucagon-like peptide-1 secretion: a review
AM Bodnaruc, D Prudhomme, R Blanchet, I Giroux |
Nutrition & Metabolism | 2016 |
Endocrinology: Adult and Pediatric
M Gurnell, TJ Visser, P Beck-Peccoz, VK Chatterjee |
Endocrinology: Adult and Pediatric | 2016 |
Paracrine Regulation of Glucagon Secretion: The β-α-δ Model
M Watts, J Ha, O Kimchi, A Sherman |
American journal of physiology. Endocrinology and metabolism | 2016 |
Glucagon therapeutics: Dawn of a new era for diabetes care: New Era for Diabetes Care
JA Davidson, WL Holland, MG Roth, M Wang, Y Lee, X Yu, SK McCorkle, PE Scherer, RH Unger |
Diabetes/Metabolism Research and Reviews | 2016 |
Endocrinology
C Napier, SH Pearce |
Endocrinology | 2016 |
A New Biology of Diabetes Revealed by Leptin
RH Unger, MG Roth |
Cell Metabolism | 2015 |
Loss of fibroblast growth factor 21 action induces insulin resistance, pancreatic islet hyperplasia and dysfunction in mice
WY So, Q Cheng, A Xu, KS Lam, PS Leung |
Cell Death and Disease | 2015 |
Glucagon receptor antibody completely suppresses type 1 diabetes phenotype without insulin by disrupting a novel diabetogenic pathway
MY Wang, H Yan, Z Shi, MR Evans, X Yu, Y Lee, S Chen, A Williams, J Philippe, MG Roth, RH Unger |
Proceedings of the National Academy of Sciences | 2015 |
miR-375 gene dosage in pancreatic β-cells: implications for regulation of β-cell mass and biomarker development
M Latreille, K Herrmanns, N Renwick, T Tuschl, MT Malecki, MI McCarthy, KR Owen, T Rülicke, M Stoffel |
Journal of Molecular Medicine | 2015 |
Conjoint regulation of glucagon concentrations via plasma insulin and glucose in dairy cows
M Zarrin, O Wellnitz, RM Bruckmaier |
Domestic Animal Endocrinology | 2015 |
Euglycemic Diabetic Ketoacidosis: A Predictable, Detectable, and Preventable Safety Concern With SGLT2 Inhibitors
J Rosenstock, E Ferrannini |
Diabetes care | 2015 |
Physiological aspects of the combination of insulin and GLP-1 in the regulation of blood glucose control
B Ahrén |
Diabetes & Metabolism | 2015 |
Metabolic response to sodium-glucose co-transporter-2 inhibition in type 2 diabetic patients
Ele Ferrannini, Elza Muscelli, Silvia Frascerra, Simona Baldi, Andrea Mari, Tim Heise, Uli Broedl, Hans Woerle |
Journal of Clinical Investigation | 2014 |
PTEN Deletion in Pancreatic α-Cells Protects Against High-Fat Diet–Induced Hyperglucagonemia and Insulin Resistance
L Wang, CT Luk, EP Cai, SA Schroer, EM Allister, SY Shi, MB Wheeler, HY Gaisano, M Woo |
Diabetes | 2014 |
Absence of Glucagon and Insulin Action Reveals a Role for the GLP-1 Receptor in Endogenous Glucose Production
LS Jun, RL Millican, ED Hawkins, DL Konkol, AD Showalter, ME Christe, MD Michael, KW Sloop |
Diabetes | 2014 |
Hyperglycemia in rodent models of type 2 diabetes requires insulin-resistant alpha cells
Y Lee, ED Berglund, X Yu, MY Wang, MR Evans, PE Scherer, WL Holland, MJ Charron, MG Roth, RH Unger |
Proceedings of the National Academy of Sciences | 2014 |
Modeling the Pancreatic α-Cell: Dual Mechanisms of Glucose Suppression of Glucagon Secretion
M Watts, A Sherman |
Biophysical Journal | 2014 |
Water sensor ppk28 modulates Drosophila lifespan and physiology through AKH signaling
MJ Waterson, BY Chung, ZM Harvanek, I Ostojic, J Alcedo, SD Pletcher |
Proceedings of the National Academy of Sciences | 2014 |
Additive Effects of Miglitol and Anagliptin on Insulin-Treated Type 2 Diabetes Mellitus: A Case Study
M Kishimoto, M Noda |
Clinical Drug Investigation | 2014 |
The influence of glucagon on postprandial hyperglycaemia in children 5 years after onset of type 1 diabetes
S Fredheim, ML Andersen, S Pörksen, LB Nielsen, C Pipper, L Hansen, JJ Holst, J Thomsen, J Johannesen, HB Mortensen, J Svensson |
Diabetologia | 2014 |
A novel GPR40 agonist, CNX-011-67, suppresses glucagon secretion in pancreatic islets under chronic glucolipotoxic conditions in vitro
M Verma, S Biswas, B Chandravanshi, K Neelima, AM Oommen, MR Jagannath, BP Somesh |
BMC Research Notes | 2014 |
Islets of Langerhans, 2. ed
MS Islam |
Islets of Langerhans, 2. ed. | 2014 |
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S Islam |
2014 | |
Intra-islet glucagon secretion and action in the regulation of glucose homeostasis
Q Wang, X Liang, S Wang |
Frontiers in physiology | 2013 |
Long-Term Effects of Bariatric Surgery on Meal Disposal and -Cell Function in Diabetic and Nondiabetic Patients
S Camastra, E Muscelli, A Gastaldelli, JJ Holst, B Astiarraga, S Baldi, M Nannipieri, D Ciociaro, M Anselmino, A Mari, E Ferrannini |
2013 | |
Upregulated insulin secretion in insulin-resistant mice: evidence of increased islet GLP1 receptor levels and GPR119-activated GLP1 secretion
L Ahlkvist, K Brown, B Ahrén |
Endocrine Connections | 2013 |
Role of glucagon in treating diabetes: Evidence and concepts (胰高血糖素在糖尿病治疗中的作用:证据与概念): Editorial
Z Bloomgarden |
Journal of Diabetes | 2013 |
Increased fetal insulin concentrations for one week fail to improve insulin secretion or β-cell mass in fetal sheep with chronically reduced glucose supply
JR Lavezzi, SR Thorn, MC O'Meara, D LoTurco, LD Brown, WW Hay, PJ Rozance |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2013 |
Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover
Robert H. Unger, Alan Cherrington |
Journal of Clinical Investigation | 2012 |
Minireview: Glucagon in the Pathogenesis of Hypoglycemia and Hyperglycemia in Diabetes
PE Cryer |
Endocrinology | 2012 |
NF-κB–inducing kinase (NIK) promotes hyperglycemia and glucose intolerance in obesity by augmenting glucagon action
L Sheng, Y Zhou, Z Chen, D Ren, KW Cho, L Jiang, H Shen, Y Sasaki, L Rui |
Nature Medicine | 2012 |
Oestrogens improve human pancreatic islet transplantation in a mouse model of insulin deficient diabetes
S Liu, G Kilic, MS Meyers, G Navarro, Y Wang, J Oberholzer, F Mauvais-Jarvis |
Diabetologia | 2012 |
Targeting the glucagon receptor family for diabetes and obesity therapy
YM Cho, CE Merchant, TJ Kieffer |
Pharmacology & Therapeutics | 2012 |
Zinc transporters and their role in the pancreatic β‐cell
K Lemaire, F Chimienti, F Schuit |
Journal of Diabetes Investigation | 2012 |
Regeneration of Pancreatic Non-β Endocrine Cells in Adult Mice following a Single Diabetes-Inducing Dose of Streptozotocin
Y Zhang, Y Zhang, RN Bone, W Cui, JB Peng, GP Siegal, H Wang, H Wu, K Maedler |
PloS one | 2012 |
Gastric Bypass Surgery Enhances Glucagon-Like Peptide 1–Stimulated Postprandial Insulin Secretion in Humans
M Salehi, RL Prigeon, DA D'Alessio |
Diabetes | 2011 |
Comprehensive Physiology
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Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Glucagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice
Y Lee, MY Wang, XQ Du, MJ Charron, RH Unger |
Diabetes | 2011 |
A pilot study of the efficacy of miglitol and sitagliptin for type 2diabetes with a continuous glucose monitoring system and incretin-related markers
M Kishimoto, M Noda |
Cardiovascular Diabetology | 2011 |
The role of dysregulated glucagon secretion in type 2 diabetes
D D'Alessio |
Diabetes, Obesity and Metabolism | 2011 |
Growth factor signalling in the regulation of α-cell fate
D Kawamori, M Akiyama, J Hu, B Hambro, RN Kulkarni |
Diabetes, Obesity and Metabolism | 2011 |
Glucagon Responses of Isolated Alpha Cells to Glucose Insulin, Somatostatin and Leptin
L Chen, J Philippe, RH Unger |
Endocrine Practice | 2011 |
Glucotoxicity and α Cell Dysfunction: Involvement of the PI3K/Akt Pathway in Glucose-Induced Insulin Resistance in Rat Islets and Clonal αTC1-6 Cells
X Shen, H Li, L Pan, J Hong, J Xiao, K Hermansen, PB Jeppesen, GW Li |
Endocrine Research | 2011 |
A role for zinc in pancreatic islet β-cell cross-talk with the α-cell during hypoglycaemia
RP Robertson, H Zhou, M Slucca |
Diabetes Obesity and Metabolism | 2011 |
Partial Inhibition of Insulin Secretion Results in Glucose Intolerance but Not Hyperglucagonemia
RP Ramanathan, AM Arbelaez, PE Cryer |
Diabetes | 2011 |
The Gq/G11-mediated signaling pathway is critical for autocrine potentiation of insulin secretion
Antonia Sassmann, Belinda Gier, Hermann-Josef Gröne, Gisela Drews, Stefan Offermanns, Nina Wettschureck |
Journal of Clinical Investigation | 2010 |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
Delayed onset of hyperglycaemia in a mouse model with impaired glucagon secretion demonstrates that dysregulated glucagon secretion promotes hyperglycaemia and type 2 diabetes
N Gustavsson, T Seah, Y Lao, GK Radda, TC Südhof, W Han |
Diabetologia | 2010 |
Paracrinology of islets and the paracrinopathy of diabetes
RH Unger, L Orci |
Proceedings of the National Academy of Sciences | 2010 |
Identification of Novel Molecules Regulating Differentiation and Hormone Secretion and Clarification of Their Functional Mechanisms in Pancreatic Endocrine Cells
T OKA, M OHTANI, J SUZUKI |
YAKUGAKU ZASSHI | 2010 |
Glucagon Secreting Cells Responds to Insulin Secretion In vitro Using Immunocytochemistry
M Aswar, U Aswar, N Subhedar |
Journal of young pharmacists : JYP | 2010 |
Vitamins & Hormones
KJ Hare, FK Knop |
Vitamins & Hormones | 2010 |
Models of Glucagon Secretion, Their Application to the Analysis of the Defects in Glucagon Counterregulation and Potential Extension to Approximate Glucagon Action
LS Farhy, AL McCall |
Journal of diabetes science and technology | 2010 |
Reactive hypoglycaemia following GLP-1 infusion in pancreas transplant recipients
MR Rickels, A Naji |
Diabetes, Obesity and Metabolism | 2010 |
Insulin Reciprocally Regulates Glucagon Secretion in Humans
BA Cooperberg, PE Cryer |
Diabetes | 2010 |
Novel methods for measuring cardiac autophagy in vivo
CN Perry, S Kyoi, N Hariharan, H Takagi, J Sadoshima, RA Gottlieb |
Methods in enzymology | 2009 |
Insulin Signaling in α Cells Modulates Glucagon Secretion In Vivo
D Kawamori, AJ Kurpad, J Hu, CW Liew, JL Shih, EL Ford, PL Herrera, KS Polonsky, OP McGuinness, RN Kulkarni |
Cell Metabolism | 2009 |
Hypothalamic AMP-activated protein kinase activation with AICAR amplifies counterregulatory responses to hypoglycemia in a rodent model of type 1 diabetes
X Fan, Y Ding, S Brown, L Zhou, M Shaw, MC Vella, H Cheng, EC McNay, RS Sherwin, RJ McCrimmon |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2009 |
A paradigm of integrative physiology, the crosstalk between bone and energy metabolisms
CB Confavreux, RL Levine, G Karsenty |
Molecular and Cellular Endocrinology | 2009 |
Native pancreatic α-cell adaptation in streptozotocin-induced diabetic primates: importance for pig islet xenotransplantation
D Dufrane, JF Maillart, N Aouassar, RM Goebbels, Y Guiot, P Gianello |
Xenotransplantation | 2009 |
Differential expression of glucagon and glucagon-like peptide 1 receptors in mouse pancreatic alpha and beta cells in two models of alpha cell hyperplasia
MH Kedees, M Grigoryan, Y Guz, G Teitelman |
Molecular and Cellular Endocrinology | 2009 |
Histological, Immunocytochemical, and Morphometrical Analyses of Pancreatic Islets in the BSB Mouse Model of Obesity
BG Slavin, C Zarow, CH Warden, JS Fisler |
The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology | 2009 |
The -Cell Conundrum: ATP-Sensitive K+ Channels and Glucose Sensing
DA Jacobson, BL Wicksteed, LH Philipson |
Diabetes | 2009 |
-Cell-Mediated Signaling Predominates Over Direct -Cell Signaling in the Regulation of Glucagon Secretion in Humans
BA Cooperberg, PE Cryer |
Diabetes care | 2009 |
Impact of Incretin Therapy on Islet Dysfunction: An Underlying Defect in the Pathophysiology of Type 2 Diabetes
JB McGill |
Postgraduate Medicine | 2009 |
Hypothalamic AMP-activated protein kinase activation with AICAR amplifies counterregulatory responses to hypoglycemia in a rodent model of type 1 diabetes
X Fan, Y Ding, S Brown, L Zhou, M Shaw, MC Vella, H Cheng, EC McNay, RS Sherwin, RJ McCrimmon |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2009 |
Stem Cell Therapy for Diabetes
S Efrat |
2009 | |
Motivations and Methods for Analyzing Pulsatile Hormone Secretion
JD Veldhuis, DM Keenan, SM Pincus |
Endocrine reviews | 2008 |
Hepatic Insulin Gene Therapy Normalizes Diurnal Fluctuation of Oxidative Metabolism in Diabetic BB/Wor Rats
DE Olson, AG Campbell, MH Porter, KG Freeman, E Kelso, WP Flatt, PM Thulé |
Molecular Therapy | 2008 |
The mechanisms that underlie glucose sensing during hypoglycaemia in diabetes
R McCrimmon |
Diabetic Medicine | 2008 |
Islet alpha cell number is maintained in microencapsulated islet transplantation
S Bohman, AJ King |
Biochemical and Biophysical Research Communications | 2008 |
Amplification of pulsatile glucagon counterregulation by switch-off of α-cell-suppressing signals in streptozotocin-treated rats
LS Farhy, Z Du, Q Zeng, PP Veldhuis, ML Johnson, KL Brayman, AL McCall |
American journal of physiology. Endocrinology and metabolism | 2008 |
Investigation of Transport Mechanisms and Regulation of Intracellular Zn 2+ in Pancreatic α-Cells
AV Gyulkhandanyan, H Lu, SC Lee, A Bhattacharjee, N Wijesekara, JE Fox, PE MacDonald, F Chimienti, FF Dai, MB Wheeler |
The Journal of biological chemistry | 2008 |
Insulin as a physiological modulator of glucagon secretion
P Bansal, Q Wang |
American journal of physiology. Endocrinology and metabolism | 2008 |
Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas
J de Heer, C Rasmussen, DH Coy, JJ Holst |
Diabetologia | 2008 |
α-Cells of the Endocrine Pancreas: 35 Years of Research but the Enigma Remains
J Gromada, I Franklin, CB Wollheim |
Endocrine reviews | 2007 |
Endocrine Regulation of Energy Metabolism by the Skeleton
NK Lee, H Sowa, E Hinoi, M Ferron, JD Ahn, C Confavreux, R Dacquin, PJ Mee, MD McKee, DY Jung, Z Zhang, JK Kim, F Mauvais-Jarvis, P Ducy, G Karsenty |
Cell | 2007 |
A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans
PE MacDonald, YZ de Marinis, R Ramracheya, A Salehi, X Ma, PR Johnson, R Cox, L Eliasson, P Rorsman |
PLoS Biology | 2007 |
Genome-Wide Linkage Analysis to Identify Chromosomal Regions Affecting Phenotypic Traits in the Chicken. IV. Metabolic Traits
H Zhou, CM Evock-Clover, JP McMurtry, CM Ashwell, SJ Lamont |
Poultry science | 2007 |
Zinc, Not Insulin, Regulates the Rat -Cell Response to Hypoglycemia In Vivo
H Zhou, T Zhang, JS Harmon, J Bryan, RP Robertson |
Diabetes | 2007 |
Glucose-Dependent Regulation of -Aminobutyric Acid (GABAA) Receptor Expression in Mouse Pancreatic Islet -Cells
SJ Bailey, MA Ravier, GA Rutter |
Diabetes | 2007 |
A Conditional Model Reveals That Induction of Hepatocyte Nuclear Factor-1 in Hnf1 -Null Mutant -Cells Can Activate Silenced Genes Postnatally, Whereas Overexpression Is Deleterious
RF Luco, MA Maestro, N Pozo, WM Philbrick, PP de la Ossa, J Ferrer |
Diabetes | 2006 |
Intra-islet insulin suppresses glucagon release via GABA-GABAA receptor system
E Xu, M Kumar, Y Zhang, W Ju, T Obata, N Zhang, S Liu, A Wendt, S Deng, Y Ebina, MB Wheeler, M Braun, Q Wang |
Cell Metabolism | 2006 |
Gamma-aminobutyric acid up- and downregulates insulin secretion from beta cells in concert with changes in glucose concentration
H Dong, M Kumar, Y Zhang, A Gyulkhandanyan, YY Xiang, B Ye, J Perrella, A Hyder, N Zhang, M Wheeler, WY Lu, Q Wang |
Diabetologia | 2006 |
The Inhibitory Effects of Insulin on Hepatic Glucose Production Are Both Direct and Indirect
J Girard |
Diabetes | 2006 |
Regulation of glucagon secretion at low glucose concentrations: evidence for adenosine triphosphate-sensitive potassium channel involvement
A Muñoz, M Hu, K Hussain, J Bryan, L Aguilar-Bryan, AS Rajan |
Endocrinology | 2005 |
Glucagon secretion in relation to insulin sensitivity in healthy subjects
B Ahrén |
Diabetologia | 2005 |
Islet cell hormonal responses to hypoglycemia after human islet transplantation for type 1 diabetes
Michael R Rickels, Mark H Schutta, Rebecca Mueller, James F Markmann, Clyde F Barker, Ali Naji, Karen L Teff |
Diabetes | 2005 |
Impaired glucagon secretory responses in mice lacking the type 1 sulfonylurea receptor
C Shiota, JV Rocheleau, M Shiota, DW Piston, MA Magnuson |
American journal of physiology. Endocrinology and metabolism | 2005 |
Glucose-regulated Glucagon Secretion Requires Insulin Receptor Expression in Pancreatic α-Cells
J Diao, Z Asghar, CB Chan, MB Wheeler |
The Journal of biological chemistry | 2005 |
Involvement of ?1 and ?-adrenoceptors in adrenaline stimulation of the glucagon-secreting mouse ?-cell
E Vieira, YJ Liu, E Gylfe |
Naunyn-Schmiedeberg's Archives of Pharmacology | 2004 |
Brain-derived neurotrophic factor modulates glucagon secretion from pancreatic alpha cells: its contribution to glucose metabolism
O Hanyu, K Yamatani, T Ikarashi, S Soda, S Maruyama, T Kamimura, S Kaneko, S Hirayama, K Suzuki, O Nakagawa, H Nawa, Y Aizawa |
Diabetes, Obesity and Metabolism | 2003 |
Effects of PACAP127on the canine endocrine pancreas in vivo: interaction with cholinergic mechanism
N Yamaguchi, TR Minassian, S Yamaguchi |
Canadian Journal of Physiology and Pharmacology | 2003 |
A fall in portal vein insulin does not cause the alpha-cell response to mild, non-insulin-induced hypoglycemia in conscious dogs
SM Gustavson, M Nishizawa, B Farmer, D Neal, M Brissova, AC Powers, AD Cherrington |
Metabolism | 2003 |
AICAR and phlorizin reverse the hypoglycemia-specific defect in glucagon secretion in the diabetic BB rat
RJ McCrimmon, ML Evans, RJ Jacob, X Fan, Y Zhu, GI Shulman, RS Sherwin |
American journal of physiology. Endocrinology and metabolism | 2002 |
Insulin sensitively controls the glucagon response to mild hypoglycemia in the dog
K Igawa, M Mugavero, M Shiota, DW Neal, AD Cherrington |
Diabetes | 2002 |
Intraislet hyperinsulinemia prevents the glucagon response to hypoglycemia despite an intact autonomic response
S Banarer, VP McGregor, PE Cryer |
Diabetes | 2002 |
Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia
NJ Sund, MZ Vatamaniuk, M Casey, SL Ang, MA Magnuson, DA Stoffers, FM Matschinsky, KH Kaestner |
Genes & development | 2001 |
Preptin derived from proinsulin-like growth factor II (proIGF-II) is secreted from pancreatic islet beta-cells and enhances insulin secretion
CM Buchanan, AR Phillips, GJ Cooper |
Biochemical Journal | 2001 |
Leptin resistance of adipocytes in obesity: role of suppressors of cytokine signaling
Z Wang, YT Zhou, T Kakuma, Y Lee, SP Kalra, PS Kalra, W Pan, RH Unger |
Biochemical and Biophysical Research Communications | 2000 |
Chronic blockade of NO synthase paradoxically increases islet NO production and modulates islet hormone release
R Henningsson, P Alm, E Lindström, I Lundquist |
American journal of physiology. Endocrinology and metabolism | 2000 |
Gastrectomy induces impaired insulin and glucagon secretion: evidence for a gastro-insular axis in mice
A Salehi, D Chen, R Håkanson, G Nordin, I Lundquist |
The Journal of Physiology | 1999 |
Biotin enhances glucose-stimulated insulin secretion in the isolated perfused pancreas of the rat
H Sone, M Ito, K Sugiyama, M Ohneda, M Maebashi, Y Furukawa |
The Journal of Nutritional Biochemistry | 1999 |
Counterregulatory Response to Hypoglycemia Differs According to the Insulin Delivery Route, But Does Not Affect Glucose Production in Normal Humans1
GF Lewis, A Carpentier, D Bilinski, A Giacca, M Vranic |
The Journal of clinical endocrinology and metabolism | 1999 |
Oral Glibenclamide Suppresses Glucagon Secretion during Insulin-Induced Hypoglycemia in Patients with Type 2 Diabetes1
L Landstedt-Hallin, U Adamson, PE Lins |
The Journal of clinical endocrinology and metabolism | 1999 |
Insulin, But Not Glucose Lowering Corrects the Hyperglucagonemia and Increased Proglucagon Messenger Ribonucleic Acid Levels Observed in Insulinopenic Diabetes 1
E Dumonteil, C Magnan, B Ritz-Laser, P Meda, P Dussoix, M Gilbert, A Ktorza, J Philippe |
Endocrinology | 1998 |
Arginine-induced insulin release is decreased and glucagon increased in parallel with islet NO production
R Henningsson, I Lundquist |
American journal of physiology. Endocrinology and metabolism | 1998 |
Hypothalamic Mediated Action of Free Fatty Acid on Growth Hormone Secretion in Sheep
N Briard, M Rico-Gomez, V Guillaume, N Sauze, V Vuaroqueaux, F Dadoun, YL Bouc, C Oliver, A Dutour |
Endocrinology | 1998 |
Interaction of the islet nitric oxide system with L-arginine-induced secretion of insulin and glucagon in mice
B Akesson, H Mosén, G Panagiotidis, I Lundquist |
British Journal of Pharmacology | 1996 |
Suppression of Ca2+ oscillations in glucagon-producing α2-cells by insulin/glucose and amino acids
A Berts, A Ball, E Gylfe, B Hellman |
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 1996 |
Effects of glimepiride on insulin and glucagon release from isolated rat pancreas at different glucose concentrations
F Gregorio, F Ambrosi, S Cristallini, P Filipponi, F Santeusanio |
Acta Diabetologica | 1996 |
Acute Catabolic State
A Revhaug |
1996 | |
Glucagon III
PJ Lefèbvre |
1996 | |
Exogenous insulin dose-dependently suppresses glucopenia-induced glucagon secretion from perfused rat pancreas
K Ito, H Maruyama, H Hirose, K Kido, K Koyama, K Kataoka, T Saruta |
Metabolism | 1995 |
Adrenoceptor antagonists, but not guanethidine, reduce glucopenia-induced glucagon secretion from perfused rat pancreas
K Ito, H Hirose, K Kido, K Koyama, H Maruyama, T Saruta |
Diabetes Research and Clinical Practice | 1995 |
Salivary Peptide P-C Potentiates Insulin Release and Inhibits Glucagon Release from Isolated Perfused Pancreas of the Diabetic GK Rat
N Nakashima, I Kimura, M Kimura |
The Japanese Journal of Pharmacology | 1995 |
Interaction of glucagon-like peptide-I (GLP-I) and galanin in insulin (beta TC-1)- and somatostatin (RIN T3)-secreting cells and evidence that both peptides have no receptors on glucagon (INR1G9)-secreting cells.
Fehmann HC, Janssen M, Göke B |
Acta Diabetologica | 1995 |
Effects of diazoxide on α- and β-cell function in isolated perfused rat pancreas
H Hirose, H Maruyama, K Ito, K Kido, K Koyama, T Saruta |
Diabetes Research and Clinical Practice | 1994 |
Glucose modulates the amount, but not the kinetics, of insulin released by sulfonylureas
F Gregorio, F Ambrosi, P Filipponi, S Cristallini, F Santeusanio |
Journal of Diabetes and its Complications | 1994 |
Advances in Pharmacology
B Drenger, Y Ginosar, Y Gozal |
Advances in Pharmacology | 1994 |
Post-GLUT-2 defects in beta-cells of non-insulin-dependent diabetic obese rats
M Ohneda, JH Johnson, YH Lee, Y Nagasawa, RH Unger |
American journal of physiology. Endocrinology and metabolism | 1994 |
Improvement in blunted glucagon response to insulin-induced hypoglycemia by strict glycemic control in diabetics
M Katsura, R Kawamori, Y Yamasaki, N Iwama, M Kubota, Y Goriya, Y Kajimoto, M Shichiri, T Kamada |
Diabetes Research and Clinical Practice | 1993 |
3 Action of insulin on glucose metabolism in vivo
YJ Hannele |
Baillière's Clinical Endocrinology and Metabolism | 1993 |
Effects of α2- and β-adrenergic agonism on glucagon secretion from perfused pancreata of normal and streptozocin-induced diabetic rats
H Hirose, H Maruyama, K Ito, K Kido, K Koyama, T Saruta |
Metabolism | 1993 |
The Incretin Notion and its Relevance to Diabetes
JF Habener |
Endocrinology and metabolism clinics of North America | 1993 |
Glucagon mediates arginine-induced somatostatin secretion from isolated rat pancreatic islets
B Vonen, J Florholmen, D Malm, P Torjessen, PG Burhol |
Scandinavian Journal of Clinical & Laboratory Investigation | 1992 |
Coexistence of glucagon and pancreatic polypeptide in human and rat pancreatic endocrine cells
IS Park, M Bendayan |
Endocrine Pathology | 1992 |
Therapeutical concentrations of tolbutamide, glibenclamide, gliclazide and gliquidone at different glucose levels: in vitro effects on pancreatic A- and B-cell function
F Gregorio, F Ambrosi, S Cristallini, M Pedetti, P Filipponi, F Santeusanio |
Diabetes Research and Clinical Practice | 1992 |
Intra-islet insulin permits glucose to directly suppress pancreatic A cell function
CJ Greenbaum, PJ Havel, GJ Taborsky, LJ Klaff |
Journal of Clinical Investigation | 1991 |
Morphological changes in the human endocrine pancreas induced by chronic excess of endogenous glucagon
D Bani, G Biliotti, TB Sacchi |
Virchows Archiv B Cell Pathology Including Molecular Pathology | 1991 |
Neuronal influence on hormone release from anglerfish islet cells
SL Milgram, JK McDonald, BD Noe |
American journal of physiology. Endocrinology and metabolism | 1991 |
Abnormal glucagon response to arginine and its normalization in obese hyperinsulinaemic patients with glucose intolerance: importance of insulin action on pancreatic Alpha cells
T Hamaguchi, H Fukushima, M Uehara, S Wada, T Shirotani, H Kishikawa, K Ichinose, K Yamaguchi, M Shichiri |
Diabetologia | 1991 |
Diabetic Hyperglycemia: Link to Impaired Glucose Transport in Pancreatic β Cells
RH Unger |
Science | 1991 |
Plasma concentrations of glucagon during hyperglycemic clamp with or without somatostatin infusion in obese subjects
E Bonora, P Moghetti, V Cacciatori, M Zenere, F Tosi, D Travia, G Zoppini, L Perobelli, M Muggeo |
Acta Diabetologica Latina | 1990 |
Glucagon and Insulin Secretion in Low Birthweight Preterm Infants The Effect of Glucose Infusion
S Grasso, F Fallucca, MG Romeo, G Distefano, E Sciullo, G Reitano |
Acta Paediatrica | 1990 |
Islet somatostatin-microvascular, paracrine, and pulsatile regulation
E Samols, JI Stagner |
Metabolism | 1990 |
Binding and internalization of somatostatin, insulin, and glucagon by cultured rat islet cells
M Amherdt, YC Patel, L Orci |
Journal of Clinical Investigation | 1989 |
Glucagon gene transcription is negatively regulated by insulin in a hamster islet cell line
J Philippe |
Journal of Clinical Investigation | 1989 |
Fasting for 72 h decreases the responses of counterregulatory hormones to insulin-induced hypoglycaemia in normal man
U Adamson, PE Lins, V Grill |
Scandinavian Journal of Clinical & Laboratory Investigation | 1989 |
Responses of the pancreatic A cell during hypoglycemia and hyperglycemia are dependent on the B cell
DK McCulloch, PK Raghu, DJ Koerker, JP Palmer, LJ Klaff |
Metabolism | 1989 |
The anterograde and retrograde infusion of glucagon antibodies suggests that A cells are vascularly perfused before D cells within the rat islet
JI Stagner, E Samols, V Marks |
Diabetologia | 1989 |
Effects of starvation and refeeding a high carbohydrate diet on the intra-acinar distribution pattern of phosphoenolpyruvate carboxykinase activity in the liver of male and female rats
M Wimmer |
Histochemistry | 1989 |
The order of islet microvascular cellular perfusion is B----A----D in the perfused rat pancreas
E Samols, JI Stagner, RB Ewart, V Marks |
Journal of Clinical Investigation | 1988 |
Isolated cells in suspension for biological research — Part II. Structure and functional properties of cells from pancreatic islets and acini
K Hartmann, A Lenz, G Letko, HU Schulz, A Sokolowski, H Spormann, H Zühlke |
Experimental Pathology | 1988 |
Intra-islet regulation
E Samols, JI Stagner |
The American Journal of Medicine | 1988 |
Heterogeneities of the islets in the rabbit pancreas and the problem of ?paracrine? regulation of islet cells
A Jrns, E Barklage, D Grube |
Anatomy and Embryology | 1988 |
The Pathology of the Endocrine Pancreas in Diabetes
PJ Lefèbvre, DG Pipeleers |
1988 | |
Exogenous hyperglucagonaemia in insulin controlled diabetic rats increases urea excretion and nitrogen loss from organs
TP Almdal, H Vilstrup |
Diabetologia | 1988 |
Somatostatin
SR Bloom, JM Polak |
British medical journal (Clinical research ed.) | 1987 |
Pulsatility of insulin and glucagon release: physiological significance and pharmacological implications
PJ Lefbvre, G Paolisso, AJ Scheen, JC Henquin |
Diabetologia | 1987 |
Retrograde perfusion as a model for testing the relative effects of glucose versus insulin on the A cell
JI Stagner, E Samols |
Journal of Clinical Investigation | 1986 |
Experimental reduction of B-cell mass: Implications for the pathogenesis of diabetes
GC Weir, JL Leahy, S Bonner-Weir |
Diabetes / Metabolism Reviews | 1986 |
Loss of insulin response to glucose but not arginine during the development of autoimmune diabetes in BB/W rats: relationships to islet volume and glucose transport rate
M Tominaga, I Komiya, JH Johnson, L Inman, T Alam, J Moltz, B Crider, Y Stefan, D Baetens, K McCorkle |
Proceedings of the National Academy of Sciences | 1986 |
Decreased insulin binding to pancreatic islets of genetically obese (fa/fa) rats
EJ Verspohl, MC Melien, HP Ammon |
Diabetes Research and Clinical Practice | 1986 |
2 Intra-islet insulin—glucagon—somatostatin relationships
E Samols, S Bonner-Weir, GC Weir |
Clinics in Endocrinology and Metabolism | 1986 |
Morphological Considerations
NB Clark, K Kaul, SI Roth |
Morphological Considerations | 1986 |
Somatostatin potentiation of insulin-induced glucose uptake in normal individuals
MS Wu, LT Ho, JJ Chen, YD Chen, GM Reaven |
American journal of physiology. Endocrinology and metabolism | 1986 |
Neuropeptidergic versus cholinergic and adrenergic regulation of islet hormone secretion
B Ahrén, GJ Taborsky, D Porte |
Diabetologia | 1986 |
Effect of metabolic clearance rate and hepatic extraction of insulin on hepatic and peripheral contributions to hypoglycemia
Z Chap, T Ishida, J Chou, CJ Hartley, RM Lewis, M Entman, JB Field |
Journal of Clinical Investigation | 1985 |
Correction of hyperglycemia with phloridzin restores the glucagon response to glucose in insulin-deficient dogs: implications for human diabetes
A Starke, S Grundy, JD McGarry, RH Unger |
Proceedings of the National Academy of Sciences | 1985 |
Glucagon physiology and pathophysiology in the light of new advances
RH Unger |
Diabetologia | 1985 |
The alpha cell response to glucose change during perfusion of anti-insulin serum in pancreas isolated from normal rats
H Maruyama, M Tominaga, G Bolli, L Orci, RH Unger |
Diabetologia | 1985 |