Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Insulin within islets is a physiologic glucagon release inhibitor.
H Maruyama, … , G M Grodsky, R H Unger
H Maruyama, … , G M Grodsky, R H Unger
Published December 1, 1984
Citation Information: J Clin Invest. 1984;74(6):2296-2299. https://doi.org/10.1172/JCI111658.
View: Text | PDF
Research Article

Insulin within islets is a physiologic glucagon release inhibitor.

  • Text
  • PDF
Abstract

To determine if glucagon secretion is under physiological control of intra-islet insulin, pancreata from normal rats were perfused at a 100 mg/dl glucose concentration with either guinea pig antiinsulin serum or normal guinea pig serum in a nonrecirculating system. Perfusion of antiserum was followed within 3 min by a significant rise in glucagon that reached peak levels three times the base-line values and assumed a hectic pattern that returned rapidly to base-line levels upon termination of the antiserum perfusion. Nonimmune guinea pig serum had no effect. To gain insight into the probable site of insulin neutralization, 125I-labeled human gamma-globulin was added to antiserum or nonimmune serum and perfused for 3 min. More than 83% of the radioactivity was recovered in the effluent within 3 min after termination of the infusion, and only 0.05 +/- 0.015% of the radioactivity injected was present in the pancreas 10 min after the perfusion. The maximal amount of insulin that could be completely bound to insulin antibody at a dilution and under conditions simulating those of the perfusion experiments was 20 mU/min. It is concluded that insulin maintains an ongoing restraint upon alpha cell secretion and in its absence causes hectic hypersecretion of glucagon. This restraint probably occurs largely in the intravascular compartment. Loss of this release-inhibiting action of insulin may account for initiation of hyperglucagonemia in insulin-deficient states.

Authors

H Maruyama, A Hisatomi, L Orci, G M Grodsky, R H Unger

×

Total citations by year

Year: 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 1985 Total
Citations: 3 4 3 11 9 6 10 11 12 7 11 5 7 117 36 12 8 6 4 5 1 3 3 2 2 4 3 5 4 4 4 3 5 3 6 6 2 8 4 359
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (359)

Title and authors Publication Year
CK2 activity is crucial for proper glucagon expression.
Ampofo E, Pack M, Wrublewsky S, Boewe AS, Spigelman AF, Koch H, MacDonald PE, Laschke MW, Montenarh M, Götz C
Diabetologia 2024
The Importance of Intra-Islet Communication in the Function and Plasticity of the Islets of Langerhans during Health and Diabetes
Hill TG, Hill DJ
International journal of molecular sciences 2024
Abnormal late postprandial glucagon response in type 1 diabetes is a function of differences in stimulated C-peptide concentrations.
Zhang L, Qin Y, Huang Y, Hu Q, Wu Q, Wang X, Zhang M
Frontiers in Endocrinology 2024
Revisiting the role of glucagon in health, diabetes mellitus and other metabolic diseases.
Hædersdal S, Andersen A, Knop FK, Vilsbøll T
Nature reviews. Endocrinology 2023
Usage of Glucagon-Like Peptide-1 for Obesity in Children; Updated Review of Clinicaltrials.gov.
Alorfi NM, Alshehri FS
Journal of multidisciplinary healthcare 2023
The human α cell in health and disease.
Pettway YD, Saunders DC, Brissova M
The Journal of endocrinology 2023
Conflicting Views About Interactions Between Pancreatic α-Cells and β-Cells
Weir GC, Bonner-Weir S
Diabetes 2023
State of Knowledge on Molecular Adaptations to Exercise in Humans: Historical Perspectives and Future Directions
Lavin KM, Coen PM, Baptista LC, Bell MB, Drummer D, Harper SA, Lixandrão ME, McAdam JS, O\u2019Bryan SM, Ramos S, Roberts LM, Vega RB, Goodpaster BH, Bamman MM, Buford TW
Comprehensive Physiology 2022
Regulation of α‐cell glucagon secretion: The role of second messengers
Acreman S, Zhang Q
Chronic Diseases and Translational Medicine 2022
Physiological Systems in Promoting Frailty
Perazza LR, Brown-Borg HM, Thompson LV
Comprehensive Physiology 2022
Pancreatic β-cell heterogeneity in health and diabetes: classes, sources, and subtypes
MA Miranda, JF Macias-Velasco, HA Lawson
American journal of physiology. Endocrinology and metabolism 2021
Mechanisms controlling pancreatic islet cell function in insulin secretion
JE Campbell, CB Newgard
Nature Reviews Molecular Cell Biology 2021
Preproglucagon Products and Their Respective Roles Regulating Insulin Secretion
M Bethea, N Bozadjieva-Kramer, DA Sandoval
Endocrinology 2021
Insulin receptor substrate 1, but not IRS2, plays a dominant role in regulating pancreatic alpha cell function in mice
T Takatani, J Shirakawa, K Shibue, MK Gupta, H Kim, S Lu, J Hu, MF White, RT Kennedy, RN Kulkarni
The Journal of biological chemistry 2021
Glucagon blockade restores functional β-cell mass in type 1 diabetic mice and enhances function of human islets
MY Wang, ED Dean, E Quittner-Strom, Y Zhu, KH Chowdhury, Z Zhang, S Zhao, N Li, R Ye, Y Lee, Y Zhang, S Chen, X Yu, DC Leonard, G Poffenberger, AV Deylen, SK McCorkle, A Schlegel, KW Sloop, AM Efanov, RE Gimeno, PE Scherer, AC Powers, RH Unger, WL Holland
Proceedings of the National Academy of Sciences 2021
Hyperglucagonemia Does Not Explain the β-Cell Hyperresponsiveness and Insulin Resistance in Dysglycemic Youth Compared With Adults: Lessons From the RISE Study
SE Kahn, KJ Mather, SA Arslanian, E Barengolts, TA Buchanan, S Caprio, DA Ehrmann, TS Hannon, S Marcovina, KJ Nadeau, KM Utzschneider, AH Xiang, SL Edelstein
Diabetes care 2021
Multi-omic Approaches to Identify Genetic Factors in Metabolic Syndrome
Clark KC, Kwitek AE
Comprehensive Physiology 2021
Effect of Medical and Surgical Interventions on α-Cell Function in Dysglycemic Youth and Adults in the RISE Study
SE Kahn, SL Edelstein, SA Arslanian, E Barengolts, S Caprio, DA Ehrmann, TS Hannon, S Marcovina, KJ Mather, KJ Nadeau, KM Utzschneider, AH Xiang, TA Buchanan
Diabetes care 2021
Effects of xenin-25 on insulin and glucagon secretions in healthy conscious sheep
T Onaga, H Hayashi, Y Yasui
Domestic Animal Endocrinology 2021
Genetic activation of α-cell glucokinase in mice causes enhanced glucose-suppression of glucagon secretion during normal and diabetic states
V Bahl, CL May, A Perez, B Glaser, KH Kaestner
Molecular Metabolism 2021
Peptides in the regulation of glucagon secretion
DB Andersen, JJ Holst
Peptides 2021
Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes
M Omar-Hmeadi, PE Lund, NR Gandasi, A Tengholm, S Barg
Nature Communications 2020
Paracrine signaling in islet function and survival
SM Hartig, AR Cox
Journal of Molecular Medicine 2020
Ca v 2.3 channel function and Zn 2+ -induced modulation: potential mechanisms and (patho)physiological relevance
F Neumaier, T Schneider, W Albanna
Channels (Austin, Tex.) 2020
Paracrine regulation of somatostatin secretion by insulin and glucagon in mouse pancreatic islets
B Svendsen, JJ Holst
Diabetologia 2020
Glucagon-like Peptide-1: Actions and Influence on Pancreatic Hormone Function
Davis EM, Sandoval DA
Comprehensive Physiology 2020
In the rat pancreas, somatostatin tonically inhibits glucagon secretion and is required for glucose‐induced inhibition of glucagon secretion
SF Xu, DB Andersen, JM Izarzugaza, RE Kuhre, JJ Holst
Acta physiologica (Oxford, England) 2020
Association of British Clinical Diabetologists (ABCD) and Diabetes UK joint position statement and recommendations on the use of sodium–glucose cotransporter inhibitors with insulin for treatment of type 1 diabetes (Updated October 2020)
U Dashora, DC Patel, R Gregory, P Winocour, K Dhatariya, S Rowles, A Macklin, G Rayman, D Nagi
Diabetic Medicine 2020
Pancreatic α-cells – The unsung heroes in islet function
A Wendt, L Eliasson
Seminars in Cell & Developmental Biology 2020
The Role of α-Cells in Islet Function and Glucose Homeostasis in Health and Type 2 Diabetes
P Gilon
Journal of Molecular Biology 2020
The Local Paracrine Actions of the Pancreatic α-Cell
R Rodriguez-Diaz, A Tamayo, M Hara, A Caicedo
Diabetes 2019
Tripartite cell networks for glucose homeostasis
T Song, J Jo
Physical Biology 2019
Novel Preparations of Glucagon for the Prevention and Treatment of Hypoglycemia
CP Hawkes, DD Leon, MR Rickels
Current Diabetes Reports 2019
Pharmacokinetics and Pharmacodynamics of Insulin Tregopil in Relation to Premeal Dosing Time, Between Meal Interval, and Meal Composition in Patients With Type 2 Diabetes Mellitus
A Khedkar, H Lebovitz, A Fleming, A Cherrington, V Jose, SN Athalye, A Vishweswaramurthy
Clinical Pharmacology in Drug Development 2019
Lelio Orci, the modern master of morphology
D Ribatti
Cell Biology International 2019
Obesity dysregulates fasting-induced changes in glucagon secretion
JH Stern, GI Smith, S Chen, RH Unger, S Klein, PE Scherer
Journal of Endocrinology 2019
Chronic Fractalkine Administration Improves Glucose Tolerance and Pancreatic Endocrine Function
Matthew Riopel, Jong Bae Seo, Gautam Bandyopadhyay, Pingping Li, Joshua Wollam, Heekyung Chung, Seung Ryoung Jung, Anne Murphy, Maria Wilson, Ron De Jong, Sanjay Patel, Deepika Balakrishna, James Bilakovics, Andrea Fanjul, Artur Plonowski, Duk-Su Koh, Christopher J. Larson, Jerrold M. Olefsky, Yun Sok Lee
Journal of Clinical Investigation 2018
Mechanisms of Insulin Action and Insulin Resistance
MC Petersen, GI Shulman
Physiological reviews 2018
Design principles of the paradoxical feedback between pancreatic alpha and beta cells
I Garzilli, S Itzkovitz
Scientific Reports 2018
Pancreatic Islet Transplantation in Humans: Recent Progress and Future Directions
MR Rickels, RP Robertson
Endocrine reviews 2018
Sexually dimorphic metabolic responses mediated by CRF2 receptor during nutritional stress in mice
S Paruthiyil, S Hagiwara, K Kundassery, A Bhargava
Biology of sex differences 2018
A novel series of 4-methyl substituted pyrazole derivatives as potent glucagon receptor antagonists: Design, synthesis and evaluation of biological activities
S Shu, A Dai, J Wang, B Wang, Y Feng, J Li, X Cai, D Yang, D Ma, MW Wang, H Liu
Bioorganic & Medicinal Chemistry 2018
Metabolic profiling of umbilical cord blood in macrosomia
H Sun, YC Wang, CC Wang, XX Xu, YH Wang, HT Yan, XJ Yang
International Journal of Obesity 2018
The α-cell in diabetes mellitus
J Gromada, P Chabosseau, GA Rutter
Nature Reviews Endocrinology 2018
Insulin Secretion Depends on Intra-islet Glucagon Signaling
B Svendsen, O Larsen, MB Gabe, CB Christiansen, MM Rosenkilde, DJ Drucker, JJ Holst
Cell Reports 2018
DIABETIC KETOACIDOSIS IN A PATIENT WITH TYPE 1 DIABETES MELLITUS TREATED WITH LOW INSULIN IN COMBINATION WITH EMPAGLIFLOZIN
JG Jiménez-Montero, CJ Mora-Aguilar, CH Chen-Ku
AACE Clinical Case Reports 2018
Exploring the molecular mechanisms underlying α- and β-cell dysfunction in diabetes
D Kawamori
Diabetology International 2017
SGLT2 Inhibition by Empagliflozin Promotes Fat Utilization and Browning and Attenuates Inflammation and Insulin Resistance by Polarizing M2 Macrophages in Diet-induced Obese Mice
L Xu, N Nagata, M Nagashimada, F Zhuge, Y Ni, G Chen, E Mayoux, S Kaneko, T Ota
EBioMedicine 2017
Glucotoxicity induces abnormal glucagon secretion through impaired insulin signaling in InR1G cells
T Katsura, D Kawamori, E Aida, T Matsuoka, I Shimomura, W Nishimura
PloS one 2017
Oral Insulin Delivery in a Physiologic Context: Review
E Arbit, M Kidron
Journal of diabetes science and technology 2017
Differential Effects of Linagliptin on the Function of Human Islets Isolated from Non-diabetic and Diabetic Donors
Y Zhang, M Wu, W Htun, EW Dong, F Mauvais-Jarvis, VA Fonseca, H Wu
Scientific Reports 2017
Sodium-Glucose Co-transporters and Their Inhibition: Clinical Physiology
E Ferrannini
Cell Metabolism 2017
Artemisinins Target GABA A Receptor Signaling and Impair α Cell Identity
J Li, T Casteels, T Frogne, C Ingvorsen, C Honoré, M Courtney, KV Huber, N Schmitner, RA Kimmel, RA Romanov, C Sturtzel, CH Lardeau, J Klughammer, M Farlik, S Sdelci, A Vieira, F Avolio, F Briand, I Baburin, P Májek, FM Pauler, T Penz, A Stukalov, M Gridling, K Parapatics, C Barbieux, E Berishvili, A Spittler, J Colinge, KL Bennett, S Hering, T Sulpice, C Bock, M Distel, T Harkany, D Meyer, G Superti-Furga, P Collombat, J Hecksher-Sørensen, S Kubicek
Cell 2017
Impaired Insulin Action Is Associated With Increased Glucagon Concentrations in Nondiabetic Humans
A Sharma, RT Varghese, M Shah, CD Man, C Cobelli, RA Rizza, KR Bailey, A Vella
The Journal of clinical endocrinology and metabolism 2017
DIABETIC KETOACIDOSIS IN PATIENTS WITH TYPE 2 DIABETES RECENTLY COMMENCED ON SGLT-2 INHIBITORS: AN ONGOING CONCERN
M Ahmed, MJ McKenna, RK Crowley
Endocrine Practice 2017
Insulin-like growth factor-1 is a negative modulator of glucagon secretion
E Mancuso, GC Mannino, CD Fatta, A Fuoco, R Spiga, F Andreozzi, G Sesti
Oncotarget 2017
Decrease of γ-aminobutyric acid and zinc ions in the islet periportal circulation stimulates glucagon secretion during hypoglycemia
T Yu, Z Jiang, L Liu, Z Fan
Experimental and therapeutic medicine 2017
Hyperglucagonemia in an animal model of insulin- deficient diabetes: what therapy can improve it?
F Barbetti, C Colombo, L Haataja, C Cras-Méneur, S Bernardini, P Arvan
Clinical Diabetes and Endocrinology 2016
Functional and Molecular Adaptations of Enteroendocrine L-Cells in Male Obese Mice Are Associated With Preservation of Pancreatic α-Cell Function and Prevention of Hyperglycemia
R Dusaulcy, S Handgraaf, S Skarupelova, F Visentin, C Vesin, M Heddad-Masson, F Reimann, F Gribble, J Philippe, Y Gosmain
Endocrinology 2016
Impact of islet architecture on β-cell heterogeneity, plasticity and function
SS Roscioni, A Migliorini, M Gegg, H Lickert
Nature Reviews Endocrinology 2016
Clinical Trials, Triumphs, and Tribulations of Glucagon Receptor Antagonists
MJ Pearson, RH Unger, WL Holland
Diabetes care 2016
Dapagliflozin stimulates glucagon secretion at high glucose: experiments and mathematical simulations of human A-cells
MG Pedersen, I Ahlstedt, MF el Hachmane, SO Göpel
Scientific Reports 2016
Pharmacological aspects of the safety of gliflozins
JL Faillie
Pharmacological Research 2016
Shift to Fatty Substrate Utilization in Response to Sodium–Glucose Cotransporter 2 Inhibition in Subjects Without Diabetes and Patients With Type 2 Diabetes
E Ferrannini, S Baldi, S Frascerra, B Astiarraga, T Heise, R Bizzotto, A Mari, TR Pieber, E Muscelli
Diabetes 2016
Nutritional modulation of endogenous glucagon-like peptide-1 secretion: a review
AM Bodnaruc, D Prudhomme, R Blanchet, I Giroux
Nutrition & Metabolism 2016
Endocrinology: Adult and Pediatric
M Gurnell, TJ Visser, P Beck-Peccoz, VK Chatterjee
Endocrinology: Adult and Pediatric 2016
Paracrine Regulation of Glucagon Secretion: The β-α-δ Model
M Watts, J Ha, O Kimchi, A Sherman
American journal of physiology. Endocrinology and metabolism 2016
Glucagon therapeutics: Dawn of a new era for diabetes care: New Era for Diabetes Care
JA Davidson, WL Holland, MG Roth, M Wang, Y Lee, X Yu, SK McCorkle, PE Scherer, RH Unger
Diabetes/Metabolism Research and Reviews 2016
Endocrinology
C Napier, SH Pearce
Endocrinology 2016
A New Biology of Diabetes Revealed by Leptin
RH Unger, MG Roth
Cell Metabolism 2015
Loss of fibroblast growth factor 21 action induces insulin resistance, pancreatic islet hyperplasia and dysfunction in mice
WY So, Q Cheng, A Xu, KS Lam, PS Leung
Cell Death and Disease 2015
Glucagon receptor antibody completely suppresses type 1 diabetes phenotype without insulin by disrupting a novel diabetogenic pathway
MY Wang, H Yan, Z Shi, MR Evans, X Yu, Y Lee, S Chen, A Williams, J Philippe, MG Roth, RH Unger
Proceedings of the National Academy of Sciences 2015
miR-375 gene dosage in pancreatic β-cells: implications for regulation of β-cell mass and biomarker development
M Latreille, K Herrmanns, N Renwick, T Tuschl, MT Malecki, MI McCarthy, KR Owen, T Rülicke, M Stoffel
Journal of Molecular Medicine 2015
Conjoint regulation of glucagon concentrations via plasma insulin and glucose in dairy cows
M Zarrin, O Wellnitz, RM Bruckmaier
Domestic Animal Endocrinology 2015
Euglycemic Diabetic Ketoacidosis: A Predictable, Detectable, and Preventable Safety Concern With SGLT2 Inhibitors
J Rosenstock, E Ferrannini
Diabetes care 2015
Physiological aspects of the combination of insulin and GLP-1 in the regulation of blood glucose control
B Ahrén
Diabetes & Metabolism 2015
Metabolic response to sodium-glucose co-transporter-2 inhibition in type 2 diabetic patients
Ele Ferrannini, Elza Muscelli, Silvia Frascerra, Simona Baldi, Andrea Mari, Tim Heise, Uli Broedl, Hans Woerle
Journal of Clinical Investigation 2014
PTEN Deletion in Pancreatic α-Cells Protects Against High-Fat Diet–Induced Hyperglucagonemia and Insulin Resistance
L Wang, CT Luk, EP Cai, SA Schroer, EM Allister, SY Shi, MB Wheeler, HY Gaisano, M Woo
Diabetes 2014
Absence of Glucagon and Insulin Action Reveals a Role for the GLP-1 Receptor in Endogenous Glucose Production
LS Jun, RL Millican, ED Hawkins, DL Konkol, AD Showalter, ME Christe, MD Michael, KW Sloop
Diabetes 2014
Hyperglycemia in rodent models of type 2 diabetes requires insulin-resistant alpha cells
Y Lee, ED Berglund, X Yu, MY Wang, MR Evans, PE Scherer, WL Holland, MJ Charron, MG Roth, RH Unger
Proceedings of the National Academy of Sciences 2014
Modeling the Pancreatic α-Cell: Dual Mechanisms of Glucose Suppression of Glucagon Secretion
M Watts, A Sherman
Biophysical Journal 2014
Water sensor ppk28 modulates Drosophila lifespan and physiology through AKH signaling
MJ Waterson, BY Chung, ZM Harvanek, I Ostojic, J Alcedo, SD Pletcher
Proceedings of the National Academy of Sciences 2014
Additive Effects of Miglitol and Anagliptin on Insulin-Treated Type 2 Diabetes Mellitus: A Case Study
M Kishimoto, M Noda
Clinical Drug Investigation 2014
The influence of glucagon on postprandial hyperglycaemia in children 5 years after onset of type 1 diabetes
S Fredheim, ML Andersen, S Pörksen, LB Nielsen, C Pipper, L Hansen, JJ Holst, J Thomsen, J Johannesen, HB Mortensen, J Svensson
Diabetologia 2014
A novel GPR40 agonist, CNX-011-67, suppresses glucagon secretion in pancreatic islets under chronic glucolipotoxic conditions in vitro
M Verma, S Biswas, B Chandravanshi, K Neelima, AM Oommen, MR Jagannath, BP Somesh
BMC Research Notes 2014
Islets of Langerhans, 2. ed
MS Islam
Islets of Langerhans, 2. ed. 2014
Islets of Langerhans
S Islam
2014
Intra-islet glucagon secretion and action in the regulation of glucose homeostasis
Q Wang, X Liang, S Wang
Frontiers in physiology 2013
Long-Term Effects of Bariatric Surgery on Meal Disposal and  -Cell Function in Diabetic and Nondiabetic Patients
S Camastra, E Muscelli, A Gastaldelli, JJ Holst, B Astiarraga, S Baldi, M Nannipieri, D Ciociaro, M Anselmino, A Mari, E Ferrannini
2013
Upregulated insulin secretion in insulin-resistant mice: evidence of increased islet GLP1 receptor levels and GPR119-activated GLP1 secretion
L Ahlkvist, K Brown, B Ahrén
Endocrine Connections 2013
Role of glucagon in treating diabetes: Evidence and concepts (胰高血糖素在糖尿病治疗中的作用:证据与概念): Editorial
Z Bloomgarden
Journal of Diabetes 2013
Increased fetal insulin concentrations for one week fail to improve insulin secretion or β-cell mass in fetal sheep with chronically reduced glucose supply
JR Lavezzi, SR Thorn, MC O'Meara, D LoTurco, LD Brown, WW Hay, PJ Rozance
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2013
Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover
Robert H. Unger, Alan Cherrington
Journal of Clinical Investigation 2012
Minireview: Glucagon in the Pathogenesis of Hypoglycemia and Hyperglycemia in Diabetes
PE Cryer
Endocrinology 2012
NF-κB–inducing kinase (NIK) promotes hyperglycemia and glucose intolerance in obesity by augmenting glucagon action
L Sheng, Y Zhou, Z Chen, D Ren, KW Cho, L Jiang, H Shen, Y Sasaki, L Rui
Nature Medicine 2012
Oestrogens improve human pancreatic islet transplantation in a mouse model of insulin deficient diabetes
S Liu, G Kilic, MS Meyers, G Navarro, Y Wang, J Oberholzer, F Mauvais-Jarvis
Diabetologia 2012
Targeting the glucagon receptor family for diabetes and obesity therapy
YM Cho, CE Merchant, TJ Kieffer
Pharmacology & Therapeutics 2012
Zinc transporters and their role in the pancreatic β‐cell
K Lemaire, F Chimienti, F Schuit
Journal of Diabetes Investigation 2012
Regeneration of Pancreatic Non-β Endocrine Cells in Adult Mice following a Single Diabetes-Inducing Dose of Streptozotocin
Y Zhang, Y Zhang, RN Bone, W Cui, JB Peng, GP Siegal, H Wang, H Wu, K Maedler
PloS one 2012
Gastric Bypass Surgery Enhances Glucagon-Like Peptide 1–Stimulated Postprandial Insulin Secretion in Humans
M Salehi, RL Prigeon, DA D'Alessio
Diabetes 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Glucagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice
Y Lee, MY Wang, XQ Du, MJ Charron, RH Unger
Diabetes 2011
A pilot study of the efficacy of miglitol and sitagliptin for type 2diabetes with a continuous glucose monitoring system and incretin-related markers
M Kishimoto, M Noda
Cardiovascular Diabetology 2011
The role of dysregulated glucagon secretion in type 2 diabetes
D D'Alessio
Diabetes, Obesity and Metabolism 2011
Growth factor signalling in the regulation of α-cell fate
D Kawamori, M Akiyama, J Hu, B Hambro, RN Kulkarni
Diabetes, Obesity and Metabolism 2011
Glucagon Responses of Isolated Alpha Cells to Glucose Insulin, Somatostatin and Leptin
L Chen, J Philippe, RH Unger
Endocrine Practice 2011
Glucotoxicity and α Cell Dysfunction: Involvement of the PI3K/Akt Pathway in Glucose-Induced Insulin Resistance in Rat Islets and Clonal αTC1-6 Cells
X Shen, H Li, L Pan, J Hong, J Xiao, K Hermansen, PB Jeppesen, GW Li
Endocrine Research 2011
A role for zinc in pancreatic islet β-cell cross-talk with the α-cell during hypoglycaemia
RP Robertson, H Zhou, M Slucca
Diabetes Obesity and Metabolism 2011
Partial Inhibition of Insulin Secretion Results in Glucose Intolerance but Not Hyperglucagonemia
RP Ramanathan, AM Arbelaez, PE Cryer
Diabetes 2011
The Gq/G11-mediated signaling pathway is critical for autocrine potentiation of insulin secretion
Antonia Sassmann, Belinda Gier, Hermann-Josef Gröne, Gisela Drews, Stefan Offermanns, Nina Wettschureck
Journal of Clinical Investigation 2010
The Islets of Langerhans
S Islam
2010
The Islets of Langerhans
S Islam
2010
The Islets of Langerhans
S Islam
2010
The Islets of Langerhans
S Islam
2010
The Islets of Langerhans
S Islam
2010
The Islets of Langerhans
S Islam
2010
The Islets of Langerhans
S Islam
2010
The Islets of Langerhans
S Islam
2010
The Islets of Langerhans
S Islam
2010
The Islets of Langerhans
S Islam
2010
The Islets of Langerhans
S Islam
2010
The Islets of Langerhans
S Islam
2010
The Islets of Langerhans
S Islam
2010
The Islets of Langerhans
S Islam
2010
The Islets of Langerhans
S Islam
2010
The Islets of Langerhans
S Islam
2010
The Islets of Langerhans
S Islam
2010
The Islets of Langerhans
S Islam
2010
The Islets of Langerhans
S Islam
2010
The Islets of Langerhans
S Islam
2010
The Islets of Langerhans
S Islam
2010
The Islets of Langerhans
S Islam
2010
The Islets of Langerhans
S Islam
2010
The Islets of Langerhans
S Islam
2010
The Islets of Langerhans
S Islam
2010
The Islets of Langerhans
S Islam
2010
The Islets of Langerhans
S Islam
2010
Delayed onset of hyperglycaemia in a mouse model with impaired glucagon secretion demonstrates that dysregulated glucagon secretion promotes hyperglycaemia and type 2 diabetes
N Gustavsson, T Seah, Y Lao, GK Radda, TC Südhof, W Han
Diabetologia 2010
Paracrinology of islets and the paracrinopathy of diabetes
RH Unger, L Orci
Proceedings of the National Academy of Sciences 2010
Identification of Novel Molecules Regulating Differentiation and Hormone Secretion and Clarification of Their Functional Mechanisms in Pancreatic Endocrine Cells
T OKA, M OHTANI, J SUZUKI
YAKUGAKU ZASSHI 2010
Glucagon Secreting Cells Responds to Insulin Secretion In vitro Using Immunocytochemistry
M Aswar, U Aswar, N Subhedar
Journal of young pharmacists : JYP 2010
Vitamins & Hormones
KJ Hare, FK Knop
Vitamins & Hormones 2010
Models of Glucagon Secretion, Their Application to the Analysis of the Defects in Glucagon Counterregulation and Potential Extension to Approximate Glucagon Action
LS Farhy, AL McCall
Journal of diabetes science and technology 2010
Reactive hypoglycaemia following GLP-1 infusion in pancreas transplant recipients
MR Rickels, A Naji
Diabetes, Obesity and Metabolism 2010
Insulin Reciprocally Regulates Glucagon Secretion in Humans
BA Cooperberg, PE Cryer
Diabetes 2010
Novel methods for measuring cardiac autophagy in vivo
CN Perry, S Kyoi, N Hariharan, H Takagi, J Sadoshima, RA Gottlieb
Methods in enzymology 2009
Insulin Signaling in α Cells Modulates Glucagon Secretion In Vivo
D Kawamori, AJ Kurpad, J Hu, CW Liew, JL Shih, EL Ford, PL Herrera, KS Polonsky, OP McGuinness, RN Kulkarni
Cell Metabolism 2009
Hypothalamic AMP-activated protein kinase activation with AICAR amplifies counterregulatory responses to hypoglycemia in a rodent model of type 1 diabetes
X Fan, Y Ding, S Brown, L Zhou, M Shaw, MC Vella, H Cheng, EC McNay, RS Sherwin, RJ McCrimmon
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2009
A paradigm of integrative physiology, the crosstalk between bone and energy metabolisms
CB Confavreux, RL Levine, G Karsenty
Molecular and Cellular Endocrinology 2009
Native pancreatic α-cell adaptation in streptozotocin-induced diabetic primates: importance for pig islet xenotransplantation
D Dufrane, JF Maillart, N Aouassar, RM Goebbels, Y Guiot, P Gianello
Xenotransplantation 2009
Differential expression of glucagon and glucagon-like peptide 1 receptors in mouse pancreatic alpha and beta cells in two models of alpha cell hyperplasia
MH Kedees, M Grigoryan, Y Guz, G Teitelman
Molecular and Cellular Endocrinology 2009
Histological, Immunocytochemical, and Morphometrical Analyses of Pancreatic Islets in the BSB Mouse Model of Obesity
BG Slavin, C Zarow, CH Warden, JS Fisler
The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology 2009
The  -Cell Conundrum: ATP-Sensitive K+ Channels and Glucose Sensing
DA Jacobson, BL Wicksteed, LH Philipson
Diabetes 2009
 -Cell-Mediated Signaling Predominates Over Direct  -Cell Signaling in the Regulation of Glucagon Secretion in Humans
BA Cooperberg, PE Cryer
Diabetes care 2009
Impact of Incretin Therapy on Islet Dysfunction: An Underlying Defect in the Pathophysiology of Type 2 Diabetes
JB McGill
Postgraduate Medicine 2009
Hypothalamic AMP-activated protein kinase activation with AICAR amplifies counterregulatory responses to hypoglycemia in a rodent model of type 1 diabetes
X Fan, Y Ding, S Brown, L Zhou, M Shaw, MC Vella, H Cheng, EC McNay, RS Sherwin, RJ McCrimmon
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2009
Stem Cell Therapy for Diabetes
S Efrat
2009
Motivations and Methods for Analyzing Pulsatile Hormone Secretion
JD Veldhuis, DM Keenan, SM Pincus
Endocrine reviews 2008
Hepatic Insulin Gene Therapy Normalizes Diurnal Fluctuation of Oxidative Metabolism in Diabetic BB/Wor Rats
DE Olson, AG Campbell, MH Porter, KG Freeman, E Kelso, WP Flatt, PM Thulé
Molecular Therapy 2008
The mechanisms that underlie glucose sensing during hypoglycaemia in diabetes
R McCrimmon
Diabetic Medicine 2008
Islet alpha cell number is maintained in microencapsulated islet transplantation
S Bohman, AJ King
Biochemical and Biophysical Research Communications 2008
Amplification of pulsatile glucagon counterregulation by switch-off of α-cell-suppressing signals in streptozotocin-treated rats
LS Farhy, Z Du, Q Zeng, PP Veldhuis, ML Johnson, KL Brayman, AL McCall
American journal of physiology. Endocrinology and metabolism 2008
Investigation of Transport Mechanisms and Regulation of Intracellular Zn 2+ in Pancreatic α-Cells
AV Gyulkhandanyan, H Lu, SC Lee, A Bhattacharjee, N Wijesekara, JE Fox, PE MacDonald, F Chimienti, FF Dai, MB Wheeler
The Journal of biological chemistry 2008
Insulin as a physiological modulator of glucagon secretion
P Bansal, Q Wang
American journal of physiology. Endocrinology and metabolism 2008
Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas
J de Heer, C Rasmussen, DH Coy, JJ Holst
Diabetologia 2008
α-Cells of the Endocrine Pancreas: 35 Years of Research but the Enigma Remains
J Gromada, I Franklin, CB Wollheim
Endocrine reviews 2007
Endocrine Regulation of Energy Metabolism by the Skeleton
NK Lee, H Sowa, E Hinoi, M Ferron, JD Ahn, C Confavreux, R Dacquin, PJ Mee, MD McKee, DY Jung, Z Zhang, JK Kim, F Mauvais-Jarvis, P Ducy, G Karsenty
Cell 2007
A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans
PE MacDonald, YZ de Marinis, R Ramracheya, A Salehi, X Ma, PR Johnson, R Cox, L Eliasson, P Rorsman
PLoS Biology 2007
Genome-Wide Linkage Analysis to Identify Chromosomal Regions Affecting Phenotypic Traits in the Chicken. IV. Metabolic Traits
H Zhou, CM Evock-Clover, JP McMurtry, CM Ashwell, SJ Lamont
Poultry science 2007
Zinc, Not Insulin, Regulates the Rat  -Cell Response to Hypoglycemia In Vivo
H Zhou, T Zhang, JS Harmon, J Bryan, RP Robertson
Diabetes 2007
Glucose-Dependent Regulation of  -Aminobutyric Acid (GABAA) Receptor Expression in Mouse Pancreatic Islet  -Cells
SJ Bailey, MA Ravier, GA Rutter
Diabetes 2007
A Conditional Model Reveals That Induction of Hepatocyte Nuclear Factor-1  in Hnf1 -Null Mutant  -Cells Can Activate Silenced Genes Postnatally, Whereas Overexpression Is Deleterious
RF Luco, MA Maestro, N Pozo, WM Philbrick, PP de la Ossa, J Ferrer
Diabetes 2006
Intra-islet insulin suppresses glucagon release via GABA-GABAA receptor system
E Xu, M Kumar, Y Zhang, W Ju, T Obata, N Zhang, S Liu, A Wendt, S Deng, Y Ebina, MB Wheeler, M Braun, Q Wang
Cell Metabolism 2006
Gamma-aminobutyric acid up- and downregulates insulin secretion from beta cells in concert with changes in glucose concentration
H Dong, M Kumar, Y Zhang, A Gyulkhandanyan, YY Xiang, B Ye, J Perrella, A Hyder, N Zhang, M Wheeler, WY Lu, Q Wang
Diabetologia 2006
The Inhibitory Effects of Insulin on Hepatic Glucose Production Are Both Direct and Indirect
J Girard
Diabetes 2006
Regulation of glucagon secretion at low glucose concentrations: evidence for adenosine triphosphate-sensitive potassium channel involvement
A Muñoz, M Hu, K Hussain, J Bryan, L Aguilar-Bryan, AS Rajan
Endocrinology 2005
Glucagon secretion in relation to insulin sensitivity in healthy subjects
B Ahrén
Diabetologia 2005
Islet cell hormonal responses to hypoglycemia after human islet transplantation for type 1 diabetes
Michael R Rickels, Mark H Schutta, Rebecca Mueller, James F Markmann, Clyde F Barker, Ali Naji, Karen L Teff
Diabetes 2005
Impaired glucagon secretory responses in mice lacking the type 1 sulfonylurea receptor
C Shiota, JV Rocheleau, M Shiota, DW Piston, MA Magnuson
American journal of physiology. Endocrinology and metabolism 2005
Glucose-regulated Glucagon Secretion Requires Insulin Receptor Expression in Pancreatic α-Cells
J Diao, Z Asghar, CB Chan, MB Wheeler
The Journal of biological chemistry 2005
Involvement of ?1 and ?-adrenoceptors in adrenaline stimulation of the glucagon-secreting mouse ?-cell
E Vieira, YJ Liu, E Gylfe
Naunyn-Schmiedeberg's Archives of Pharmacology 2004
Brain-derived neurotrophic factor modulates glucagon secretion from pancreatic alpha cells: its contribution to glucose metabolism
O Hanyu, K Yamatani, T Ikarashi, S Soda, S Maruyama, T Kamimura, S Kaneko, S Hirayama, K Suzuki, O Nakagawa, H Nawa, Y Aizawa
Diabetes, Obesity and Metabolism 2003
Effects of PACAP1–27on the canine endocrine pancreas in vivo: interaction with cholinergic mechanism
N Yamaguchi, TR Minassian, S Yamaguchi
Canadian Journal of Physiology and Pharmacology 2003
A fall in portal vein insulin does not cause the alpha-cell response to mild, non-insulin-induced hypoglycemia in conscious dogs
SM Gustavson, M Nishizawa, B Farmer, D Neal, M Brissova, AC Powers, AD Cherrington
Metabolism 2003
AICAR and phlorizin reverse the hypoglycemia-specific defect in glucagon secretion in the diabetic BB rat
RJ McCrimmon, ML Evans, RJ Jacob, X Fan, Y Zhu, GI Shulman, RS Sherwin
American journal of physiology. Endocrinology and metabolism 2002
Insulin sensitively controls the glucagon response to mild hypoglycemia in the dog
K Igawa, M Mugavero, M Shiota, DW Neal, AD Cherrington
Diabetes 2002
Intraislet hyperinsulinemia prevents the glucagon response to hypoglycemia despite an intact autonomic response
S Banarer, VP McGregor, PE Cryer
Diabetes 2002
Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia
NJ Sund, MZ Vatamaniuk, M Casey, SL Ang, MA Magnuson, DA Stoffers, FM Matschinsky, KH Kaestner
Genes & development 2001
Preptin derived from proinsulin-like growth factor II (proIGF-II) is secreted from pancreatic islet beta-cells and enhances insulin secretion
CM Buchanan, AR Phillips, GJ Cooper
Biochemical Journal 2001
Leptin resistance of adipocytes in obesity: role of suppressors of cytokine signaling
Z Wang, YT Zhou, T Kakuma, Y Lee, SP Kalra, PS Kalra, W Pan, RH Unger
Biochemical and Biophysical Research Communications 2000
Chronic blockade of NO synthase paradoxically increases islet NO production and modulates islet hormone release
R Henningsson, P Alm, E Lindström, I Lundquist
American journal of physiology. Endocrinology and metabolism 2000
Gastrectomy induces impaired insulin and glucagon secretion: evidence for a gastro-insular axis in mice
A Salehi, D Chen, R Håkanson, G Nordin, I Lundquist
The Journal of Physiology 1999
Biotin enhances glucose-stimulated insulin secretion in the isolated perfused pancreas of the rat
H Sone, M Ito, K Sugiyama, M Ohneda, M Maebashi, Y Furukawa
The Journal of Nutritional Biochemistry 1999
Counterregulatory Response to Hypoglycemia Differs According to the Insulin Delivery Route, But Does Not Affect Glucose Production in Normal Humans1
GF Lewis, A Carpentier, D Bilinski, A Giacca, M Vranic
The Journal of clinical endocrinology and metabolism 1999
Oral Glibenclamide Suppresses Glucagon Secretion during Insulin-Induced Hypoglycemia in Patients with Type 2 Diabetes1
L Landstedt-Hallin, U Adamson, PE Lins
The Journal of clinical endocrinology and metabolism 1999
Insulin, But Not Glucose Lowering Corrects the Hyperglucagonemia and Increased Proglucagon Messenger Ribonucleic Acid Levels Observed in Insulinopenic Diabetes 1
E Dumonteil, C Magnan, B Ritz-Laser, P Meda, P Dussoix, M Gilbert, A Ktorza, J Philippe
Endocrinology 1998
Arginine-induced insulin release is decreased and glucagon increased in parallel with islet NO production
R Henningsson, I Lundquist
American journal of physiology. Endocrinology and metabolism 1998
Hypothalamic Mediated Action of Free Fatty Acid on Growth Hormone Secretion in Sheep
N Briard, M Rico-Gomez, V Guillaume, N Sauze, V Vuaroqueaux, F Dadoun, YL Bouc, C Oliver, A Dutour
Endocrinology 1998
Interaction of the islet nitric oxide system with L-arginine-induced secretion of insulin and glucagon in mice
B Akesson, H Mosén, G Panagiotidis, I Lundquist
British Journal of Pharmacology 1996
Suppression of Ca2+ oscillations in glucagon-producing α2-cells by insulin/glucose and amino acids
A Berts, A Ball, E Gylfe, B Hellman
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1996
Effects of glimepiride on insulin and glucagon release from isolated rat pancreas at different glucose concentrations
F Gregorio, F Ambrosi, S Cristallini, P Filipponi, F Santeusanio
Acta Diabetologica 1996
Acute Catabolic State
A Revhaug
1996
Glucagon III
PJ Lefèbvre
1996
Exogenous insulin dose-dependently suppresses glucopenia-induced glucagon secretion from perfused rat pancreas
K Ito, H Maruyama, H Hirose, K Kido, K Koyama, K Kataoka, T Saruta
Metabolism 1995
Adrenoceptor antagonists, but not guanethidine, reduce glucopenia-induced glucagon secretion from perfused rat pancreas
K Ito, H Hirose, K Kido, K Koyama, H Maruyama, T Saruta
Diabetes Research and Clinical Practice 1995
Salivary Peptide P-C Potentiates Insulin Release and Inhibits Glucagon Release from Isolated Perfused Pancreas of the Diabetic GK Rat
N Nakashima, I Kimura, M Kimura
The Japanese Journal of Pharmacology 1995
Interaction of glucagon-like peptide-I (GLP-I) and galanin in insulin (beta TC-1)- and somatostatin (RIN T3)-secreting cells and evidence that both peptides have no receptors on glucagon (INR1G9)-secreting cells.
Fehmann HC, Janssen M, Göke B
Acta Diabetologica 1995
Effects of diazoxide on α- and β-cell function in isolated perfused rat pancreas
H Hirose, H Maruyama, K Ito, K Kido, K Koyama, T Saruta
Diabetes Research and Clinical Practice 1994
Glucose modulates the amount, but not the kinetics, of insulin released by sulfonylureas
F Gregorio, F Ambrosi, P Filipponi, S Cristallini, F Santeusanio
Journal of Diabetes and its Complications 1994
Advances in Pharmacology
B Drenger, Y Ginosar, Y Gozal
Advances in Pharmacology 1994
Post-GLUT-2 defects in beta-cells of non-insulin-dependent diabetic obese rats
M Ohneda, JH Johnson, YH Lee, Y Nagasawa, RH Unger
American journal of physiology. Endocrinology and metabolism 1994
Improvement in blunted glucagon response to insulin-induced hypoglycemia by strict glycemic control in diabetics
M Katsura, R Kawamori, Y Yamasaki, N Iwama, M Kubota, Y Goriya, Y Kajimoto, M Shichiri, T Kamada
Diabetes Research and Clinical Practice 1993
3 Action of insulin on glucose metabolism in vivo
YJ Hannele
Baillière's Clinical Endocrinology and Metabolism 1993
Effects of α2- and β-adrenergic agonism on glucagon secretion from perfused pancreata of normal and streptozocin-induced diabetic rats
H Hirose, H Maruyama, K Ito, K Kido, K Koyama, T Saruta
Metabolism 1993
The Incretin Notion and its Relevance to Diabetes
JF Habener
Endocrinology and metabolism clinics of North America 1993
Glucagon mediates arginine-induced somatostatin secretion from isolated rat pancreatic islets
B Vonen, J Florholmen, D Malm, P Torjessen, PG Burhol
Scandinavian Journal of Clinical & Laboratory Investigation 1992
Coexistence of glucagon and pancreatic polypeptide in human and rat pancreatic endocrine cells
IS Park, M Bendayan
Endocrine Pathology 1992
Therapeutical concentrations of tolbutamide, glibenclamide, gliclazide and gliquidone at different glucose levels: in vitro effects on pancreatic A- and B-cell function
F Gregorio, F Ambrosi, S Cristallini, M Pedetti, P Filipponi, F Santeusanio
Diabetes Research and Clinical Practice 1992
Intra-islet insulin permits glucose to directly suppress pancreatic A cell function
CJ Greenbaum, PJ Havel, GJ Taborsky, LJ Klaff
Journal of Clinical Investigation 1991
Morphological changes in the human endocrine pancreas induced by chronic excess of endogenous glucagon
D Bani, G Biliotti, TB Sacchi
Virchows Archiv B Cell Pathology Including Molecular Pathology 1991
Neuronal influence on hormone release from anglerfish islet cells
SL Milgram, JK McDonald, BD Noe
American journal of physiology. Endocrinology and metabolism 1991
Abnormal glucagon response to arginine and its normalization in obese hyperinsulinaemic patients with glucose intolerance: importance of insulin action on pancreatic Alpha cells
T Hamaguchi, H Fukushima, M Uehara, S Wada, T Shirotani, H Kishikawa, K Ichinose, K Yamaguchi, M Shichiri
Diabetologia 1991
Diabetic Hyperglycemia: Link to Impaired Glucose Transport in Pancreatic β Cells
RH Unger
Science 1991
Plasma concentrations of glucagon during hyperglycemic clamp with or without somatostatin infusion in obese subjects
E Bonora, P Moghetti, V Cacciatori, M Zenere, F Tosi, D Travia, G Zoppini, L Perobelli, M Muggeo
Acta Diabetologica Latina 1990
Glucagon and Insulin Secretion in Low Birthweight Preterm Infants The Effect of Glucose Infusion
S Grasso, F Fallucca, MG Romeo, G Distefano, E Sciullo, G Reitano
Acta Paediatrica 1990
Islet somatostatin-microvascular, paracrine, and pulsatile regulation
E Samols, JI Stagner
Metabolism 1990
Binding and internalization of somatostatin, insulin, and glucagon by cultured rat islet cells
M Amherdt, YC Patel, L Orci
Journal of Clinical Investigation 1989
Glucagon gene transcription is negatively regulated by insulin in a hamster islet cell line
J Philippe
Journal of Clinical Investigation 1989
Fasting for 72 h decreases the responses of counterregulatory hormones to insulin-induced hypoglycaemia in normal man
U Adamson, PE Lins, V Grill
Scandinavian Journal of Clinical & Laboratory Investigation 1989
Responses of the pancreatic A cell during hypoglycemia and hyperglycemia are dependent on the B cell
DK McCulloch, PK Raghu, DJ Koerker, JP Palmer, LJ Klaff
Metabolism 1989
The anterograde and retrograde infusion of glucagon antibodies suggests that A cells are vascularly perfused before D cells within the rat islet
JI Stagner, E Samols, V Marks
Diabetologia 1989
Effects of starvation and refeeding a high carbohydrate diet on the intra-acinar distribution pattern of phosphoenolpyruvate carboxykinase activity in the liver of male and female rats
M Wimmer
Histochemistry 1989
The order of islet microvascular cellular perfusion is B----A----D in the perfused rat pancreas
E Samols, JI Stagner, RB Ewart, V Marks
Journal of Clinical Investigation 1988
Isolated cells in suspension for biological research — Part II. Structure and functional properties of cells from pancreatic islets and acini
K Hartmann, A Lenz, G Letko, HU Schulz, A Sokolowski, H Spormann, H Zühlke
Experimental Pathology 1988
Intra-islet regulation
E Samols, JI Stagner
The American Journal of Medicine 1988
Heterogeneities of the islets in the rabbit pancreas and the problem of ?paracrine? regulation of islet cells
A Jrns, E Barklage, D Grube
Anatomy and Embryology 1988
The Pathology of the Endocrine Pancreas in Diabetes
PJ Lefèbvre, DG Pipeleers
1988
Exogenous hyperglucagonaemia in insulin controlled diabetic rats increases urea excretion and nitrogen loss from organs
TP Almdal, H Vilstrup
Diabetologia 1988
Somatostatin
SR Bloom, JM Polak
British medical journal (Clinical research ed.) 1987
Pulsatility of insulin and glucagon release: physiological significance and pharmacological implications
PJ Lefbvre, G Paolisso, AJ Scheen, JC Henquin
Diabetologia 1987
Retrograde perfusion as a model for testing the relative effects of glucose versus insulin on the A cell
JI Stagner, E Samols
Journal of Clinical Investigation 1986
Experimental reduction of B-cell mass: Implications for the pathogenesis of diabetes
GC Weir, JL Leahy, S Bonner-Weir
Diabetes / Metabolism Reviews 1986
Loss of insulin response to glucose but not arginine during the development of autoimmune diabetes in BB/W rats: relationships to islet volume and glucose transport rate
M Tominaga, I Komiya, JH Johnson, L Inman, T Alam, J Moltz, B Crider, Y Stefan, D Baetens, K McCorkle
Proceedings of the National Academy of Sciences 1986
Decreased insulin binding to pancreatic islets of genetically obese (fa/fa) rats
EJ Verspohl, MC Melien, HP Ammon
Diabetes Research and Clinical Practice 1986
2 Intra-islet insulin—glucagon—somatostatin relationships
E Samols, S Bonner-Weir, GC Weir
Clinics in Endocrinology and Metabolism 1986
Morphological Considerations
NB Clark, K Kaul, SI Roth
Morphological Considerations 1986
Somatostatin potentiation of insulin-induced glucose uptake in normal individuals
MS Wu, LT Ho, JJ Chen, YD Chen, GM Reaven
American journal of physiology. Endocrinology and metabolism 1986
Neuropeptidergic versus cholinergic and adrenergic regulation of islet hormone secretion
B Ahrén, GJ Taborsky, D Porte
Diabetologia 1986
Effect of metabolic clearance rate and hepatic extraction of insulin on hepatic and peripheral contributions to hypoglycemia
Z Chap, T Ishida, J Chou, CJ Hartley, RM Lewis, M Entman, JB Field
Journal of Clinical Investigation 1985
Correction of hyperglycemia with phloridzin restores the glucagon response to glucose in insulin-deficient dogs: implications for human diabetes
A Starke, S Grundy, JD McGarry, RH Unger
Proceedings of the National Academy of Sciences 1985
Glucagon physiology and pathophysiology in the light of new advances
RH Unger
Diabetologia 1985
The alpha cell response to glucose change during perfusion of anti-insulin serum in pancreas isolated from normal rats
H Maruyama, M Tominaga, G Bolli, L Orci, RH Unger
Diabetologia 1985

← Previous 1 2 3 … 14 15 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts