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Citations to this article

Iron and copper promote modification of low density lipoprotein by human arterial smooth muscle cells in culture.
J W Heinecke, … , H Rosen, A Chait
J W Heinecke, … , H Rosen, A Chait
Published November 1, 1984
Citation Information: J Clin Invest. 1984;74(5):1890-1894. https://doi.org/10.1172/JCI111609.
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Iron and copper promote modification of low density lipoprotein by human arterial smooth muscle cells in culture.

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Abstract

Modification of low density lipoproteins by human arterial smooth muscle cells was characterized by increased electrophoretic mobility and increased content of malondialdehyde-like oxidation products reactive with thiobarbituric acid. Lipoprotein modification was promoted by micromolar concentrations of iron or copper in the culture medium and was metal ion concentration- and time-dependent. The ability of diverse media to promote smooth muscle cell-mediated low density lipoprotein modification correlated with their iron concentration. Therefore, metal ion concentration of culture media contributes substantially to low density lipoprotein modification in vitro. Human monocyte-derived macrophages took up and esterified the cholesterol from modified low density lipoprotein more extensively than from native low density lipoprotein. Metal ion-mediated modification of low density lipoprotein may be a contributing factor to the pathogenesis of arteriosclerosis.

Authors

J W Heinecke, H Rosen, A Chait

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MD Carvalho, VE Tobias, CM Vendrame, AF Shimabukuro, M Gidlund, EC Quintão
Lipids 2000
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F Parisi, S Kost-Byerly, I Saponara, R Donato, G Liso
Transplant International 2000
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S Arrol, MI Mackness, PN Durrington
Atherosclerosis 2000
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C Ekmekcioglu, MR Mehrabi, HD Glogar, M Jucewicz, I Volf, PG Spieckermann
International Journal of Clinical & Laboratory Research 2000
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In Vitro Cellular & Developmental Biology - Animal 2000
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In Vitro Cellular & Developmental Biology - Animal 2000
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PL Fox, B Mazumder, E Ehrenwald, CK Mukhopadhyay
Free radical biology & medicine 2000
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G Subbanagounder, AD Watson, JA Berliner
Free radical biology & medicine 2000
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GM Chisolm, D Steinberg
Free radical biology & medicine 2000
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GM Chisolm, YC Chai
Free radical biology & medicine 2000
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SL Hazen, JP Gaut, JR Crowley, FF Hsu, JW Heinecke
Biochemical Journal 2000
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A Daugherty, JL Dunn, DL Rateri, JW Heinecke
European Journal of Biochemistry 2000
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JI Heller, JR Crowley, SL Hazen, DM Salvay, P Wagner, S Pennathur, JW Heinecke
The Journal of biological chemistry 2000
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M Janabi, S Yamashita, K Hirano, N Sakai, H Hiraoka, K Matsumoto, Z Zhang, S Nozaki, Y Matsuzawa
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Textbook of Angiology
JB Chang
2000
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2000
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M Kinoshita, S Oikawa, K Hayasaka, A Sekikawa, T Nagashima, T Toyota, T Miyazawa
Clinical chemistry 2000
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MD Kazatchkine, B Bellon, SV Kaveri
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A Khalil, JP Fortin, JG LeHoux, T Fülöp
Journal of lipid research 2000
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B Liang, J C McMaster, E A Kroeger, G M Hatch, D Mymin, T Dembinski, G Arthur, G Shen, R Y Man, P C Choy
Molecular and Cellular Biochemistry 2000
Novel cell culture medium for use in oxidation experiments provides insights into mechanisms of endothelial cell-mediated oxidation of LDL
TR Dugas, DW Morel, EH Harrison
In vitro cellular & developmental biology. Animal 2000
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T Cyrus, JL Witztum, DJ Rader, R Tangirala, S Fazio, MF Linton, CD Funk
Journal of Clinical Investigation 1999
Is lipid peroxidation relevant to atherogenesis?
JW Heinecke
Journal of Clinical Investigation 1999
Low-Density Lipoprotein Oxidation and Its Prevention by Amidothionophosphate Antioxidants
O Tirosh, J Katzhendler, Y Barenholz, R Kohen
Antioxidants & Redox Signaling 1999
Homocysteine, a risk factor for cardiovascular disease
K Prasad
International Journal of Angiology 1999
Biochemical evidence for a link between elevated levels of homocysteine and lipid peroxidation in vivo
JW Heinecke
Current Atherosclerosis Reports 1999
Keishi-bukuryo-gan prevents the progression of atherosclerosis in cholesterol-fed rabbit
N Sekiya, N Tanaka, T Itoh, Y Shimada, H Goto, K Terasawa
Phytotherapy Research 1999
Essential involvement of 12-lipoxygenase in regiospecific andstereospecific oxidation of low density lipoprotein by macrophages
T Sakashita, Y Takahashi, T Kinoshita, T Yoshimoto
European Journal of Biochemistry 1999
Molecular biology and gene transfer in atherosclerosis in the stenting era
NM Caplice, RD Simari, DR Holmes
Acute Cardiac Care 1999
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T Nguyen-Khoa, ZA Massy, V Witko-Sarsat, S Canteloup, M Kebede, B Lacour, T Drüeke, B Descamps-Latscha
Biochemical and Biophysical Research Communications 1999
Different apolipoprotein B breakdown patterns in models of oxidized low density lipoprotein
H Viita, O Närvänen, S Ylä-Herttuala
Life Sciences 1999
Regulation of Ferritin Light Chain Gene Expression by Oxidized Low-Density Lipoproteins in Human Monocytic THP-1 Cells
MK Jang, MS Choi, YB Park
Biochemical and Biophysical Research Communications 1999
Antioxidant Food Supplements in Human Health
A Gozin, H Sellak, E Franzini, C Pasquier
Antioxidant Food Supplements in Human Health 1999
Nitrogen dioxide radical generated by the myeloperoxidase-hydrogen peroxide-nitrite system promotes lipid peroxidation of low density lipoprotein
J Byun, DM Mueller, JS Fabjan, JW Heinecke
FEBS Letters 1999
Does serum ferritin correlate with coronary angiography findings?
WC Manfroi, AJ Zago, PR Caramori, R Cruz, J Oliveira, LS Kirschnick, K Ordovás, RH Candiago, J Souza, LW Ribeiro, C Leitão, ML Brizolara
International Journal of Cardiology 1999
Effects of atrial and brain natriuretic peptides on lysophosphatidylcholine-mediated endothelial dysfunction
T Murohara, K Kugiyama, Y Ota, H Doi, N Ogata, M Ohgushi, H Yasue
Journal of Cardiovascular Pharmacology 1999
Reactions of · NO, · NO 2 and peroxynitrite in membranes: Physiological implications
SP Goss, RJ Singh, N Hogg, B Kalyanaraman
Free Radical Research 1999
The Oxidation of Lipoproteins by Monocytes-Macrophages: BIOCHEMICAL AND BIOLOGICAL MECHANISMS
GM Chisolm, SL Hazen, PL Fox, MK Cathcart
The Journal of biological chemistry 1999
Lack of a relationship between serum ferritin levels and coronary atherosclerosis evaluated by coronary arteriography
WC Manfroi, AJ Zago, R Cruz, J Oliveira, LS Kirschnick, K Ordovás, RH Candiago, J Souza, LW Ribeiro, C Leitão, ML Brizolara
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] 1999
Mass spectrometric quantification of amino acid oxidation products in proteins: insights into pathways that promote LDL oxidation in the human artery wall
JW Heinecke
The FASEB Journal 1999
Dietary β-Carotene and α-Tocopherol Combination Does Not Inhibit Atherogenesis in an ApoE–Deficient Mouse Model
A Shaish, J George, B Gilburd, P Keren, H Levkovitz, D Harats
Arteriosclerosis, thrombosis, and vascular biology 1999
Iron-Deficient Diet Reduces Atherosclerotic Lesions in ApoE-Deficient Mice
TS Lee, MS Shiao, CC Pan, LY Chau
Circulation 1999
CD36, a Novel Receptor for Oxidized Low-Density Lipoproteins, Is Highly Expressed on Lipid-Laden Macrophages in Human Atherosclerotic Aorta
A Nakata, Y Nakagawa, M Nishida, S Nozaki, J Miyagawa, T Nakagawa, R Tamura, K Matsumoto, K Kameda-Takemura, S Yamashita, Y Matsuzawa
Arteriosclerosis, thrombosis, and vascular biology 1999
Leukocytes Utilize Myeloperoxidase-Generated Nitrating Intermediates as Physiological Catalysts for the Generation of Biologically Active Oxidized Lipids and Sterols in Serum
D Schmitt, Z Shen, R Zhang, SM Colles, W Wu, RG Salomon, Y Chen, GM Chisolm, SL Hazen
Biochemistry 1999
Lipolysis-induced iron release from diferric transferrin: possible role of lipoprotein lipase in LDL oxidation
C Balagopalakrishna, L Paka, S Pillarisetti, IJ Goldberg
Journal of lipid research 1999
Iron and LDL-oxidation in atherogenesis
XM Yuan, UT Brunk
APMIS 1998
Vitamin E Protects Human Aortic Endothelial Cells from Cytotoxic Injury Induced by Oxidized LDL In Vitro 11This project has been funded at least in part with Federal funds from the U.S. Department of Agriculture, Agricultural Research Service under contract number 53-K06-01. The contents of this publication do not necessarily reflect the views or policies of the U.S. Department of Agriculture, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. government
A Martin, D Wu, SN Meydani, JB Blumberg, M Meydani
The Journal of Nutritional Biochemistry 1998
Antioxidant protection of LDL by physiologic concentrations of estrogens is specific for 17-beta-estradiol
GT Shwaery, JA Vita, JF Keaney
Atherosclerosis 1998
Oxidation resistance of LDL is correlated with vitamin E status in β-thalassemia intermedia
L Tesoriere, D D'Arpa, A Maggio, V Giaccone, E Pedone, MA Livrea
Atherosclerosis 1998
Inhibitory Effects of Lipid Oxidation on the Activity of Plasma Lecithin-Cholesterol Acyltransferase
S KAMIYAMA, T YAMATO, Y FURUKAWA
Bioscience, Biotechnology, and Biochemistry 1998
Strong increase in hydroxy fatty acids derived from linoleic acid in human low density lipoproteins of atherosclerotic patients
W Jira
Chemistry and Physics of Lipids 1998
Oxidized Low-Density Lipoprotein, a Two-Faced Janus in Coronary Artery Disease?
S Parthasarathy
Biochemical Pharmacology 1998
Novel 21-aminosteroid U-74389G inhibits low-density lipoprotein peroxidation induced by .OH and O2−. free radicals
A Khalil, A Fortun, S Hébert, JP Jay-Gerin, AE Abbouyi, J Wallach, T Fülöp
Life Sciences 1998
Oxidized Lipids as Inflammatory Agonists
AM Fogelman
Journal of Vascular and Interventional Radiology 1998
Involvement of endotoxins or tumor necrosis factor-α in macrophage-mediated oxidation of low density lipoprotein
K Fujiwara, H Sato, S Bannai
FEBS Letters 1998
Oxidants and antioxidants in the pathogenesis of atherosclerosis: implications for the oxidized low density lipoprotein hypothesis
JW Heinecke
Atherosclerosis 1998
Aggressive medical therapy for the prevention and treatment of coronary artery disease
MJ Malloy, JP Kane
Disease-a-Month 1998
Copper-dependent Inflammation and Nuclear Factor- κ B Activation by Particulate Air Pollution
T Kennedy, AJ Ghio, W Reed, J Samet, J Zagorski, J Quay, J Carter, L Dailey, JR Hoidal, RB Devlin
American journal of respiratory cell and molecular biology 1998
Ceruloplasmin Copper Induces Oxidant Damage by a Redox Process Utilizing Cell-Derived Superoxide as Reductant †
CK Mukhopadhyay, PL Fox
Biochemistry 1998
Strong synergistic anti-peroxidative effects of HDL3 and ascorbic acid against copper-catalyzed LDL peroxidation
M Yoshikawa, N Sakuma, T Hibino, N Tamai, K Sasai, T Yoshimata, Y Jin-no, Y Kamiya
Biochimica et Biophysica Acta 1998
Cell-mediated oxidation of LDL: Comparison of different cell types of the atherosclerotic lesion
K Müller, KL Carpenter, MJ Mitchinson
Free Radical Research 1998
A Simple Method for Assessing Copper-Mediated Oxidation of Very-Low-Density Lipoprotein Isolated by Rapid Ultracentrifugation
J McEneny, ER Trimble, IS Young
Annals of Clinical Biochemistry 1998
Synthesis, Isolation, and Characterization of the Adduct Formed in the Reaction of p -Hydroxyphenyl- acetaldehyde with the Amino Headgroup of Phosphatidylethanolamine and Phosphatidylserine
SL Hazen, J Heller, FF Hsu, A d'Avignon, JW Heinecke
Chemical Research in Toxicology 1998
LDL oxidation by activated monocytes: characterization of the oxidized LDL and requirement for transition metal ions
X Xing, J Baffic, CP Sparrow
Journal of lipid research 1998
Cholesterol and oxygenated cholesterol concentrations are markedly elevated in peripheral tissue but not in brain from mice with the Niemann-Pick type C phenotype
GS Tint, P Pentchev, G Xu, AK Batta, S Shefer, G Salen, A Honda
Journal of Inherited Metabolic Disease 1998
Radical-induced lipoprotein and plasma lipid oxidation in normal and apolipoprotein E gene knockout (apoE–/–) mice: apoE–/– mouse as a model for testing the role of tocopherol-mediated peroxidation in atherogenesis
J Neužil, JK Christison, E Iheanacho, JC Fragonas, V Zammit, NH Hunt, R Stocker
Journal of lipid research 1998
Subendothelial retention of lipoprotein (a). Evidence that reduced heparan sulfate promotes lipoprotein binding to subendothelial matrix
S Pillarisetti, L Paka, JC Obunike, L Berglund, IJ Goldberg
Journal of Clinical Investigation 1997
Localization of distinct F2-isoprostanes in human atherosclerotic lesions
D Praticò, L Iuliano, A Mauriello, L Spagnoli, JA Lawson, J Rokach, J Maclouf, F Violi, GA FitzGerald
Journal of Clinical Investigation 1997
The possible role of copper ions in atherogenesis: the Blue Janus
GA Ferns, DJ Lamb, A Taylor
Atherosclerosis 1997
Oxidized low density lipoproteins stimulate eicosanoid synthesis in mesangial cells
K Matoba, M Ozaki, Y Yamada, M Mune, S Yukawa
Clinical and Experimental Nephrology 1997
The Role of Oxidized LDL in Atherogenesis: Immunological Response and Anti-phospholipid Antibodies
JL Witztum, S Hörkkö
Annals of the New York Academy of Sciences 1997
Oxidized LDLs But Not Native LDLs Augment Ba2+ Currents Through L-Type Ca2+ Channels of the A7r5 Smooth Muscle-Derived Cell Line
Y Mio, S Suga, T Osanai, T Kanazawa, K Onodera, J Wada, N Kamimura, M Wakui
Cellular Signalling 1997
Dynamics of oxidation of LDL and its inhibition by antioxidants
E Niki, N Noguchi
BioFactors 1997
ESTROGENS AND ATHEROSCLEROSIS
LN and, G Chaudhuri
Annual Review of Pharmacology and Toxicology 1997
Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties
SM Sendobry, JA Cornicelli, K Welch, T Bocan, B Tait, BK Trivedi, N Colbry, RD Dyer, SJ Feinmark, A Daugherty
British Journal of Pharmacology 1997
Increased Uptake of LDL by Oxidized Macrophages is the Result of an Initial Enhanced LDL Receptor Activity and of a Further Progressive Oxidation of LDL
B Fuhrman, O Judith, S Keidar, L Ben-Yaish, M Kaplan, M Aviram
Free radical biology & medicine 1997
The Role of Copper Reduction by α-Tocopherol in Low-Density Lipoprotein Oxidation
JM Proudfoot, KD Croft, IB Puddey, LJ Beilin
Free radical biology & medicine 1997
Antioxidant Constituents from Licorice Roots: Isolation, Structure Elucidation and Antioxidative Capacity Toward LDL Oxidation
J Vaya, PA Belinky, M Aviram
Free radical biology & medicine 1997
Effect of lipoproteins on cultured human mesangial cells
Y Nishida, N Yorioka, H Oda, M Yamakido
American Journal of Kidney Diseases 1997
Mass Spectrometric Quantification of Markers for Protein Oxidation by Tyrosyl Radical, Copper, and Hydroxyl Radical in Low Density Lipoprotein Isolated from Human Atherosclerotic Plaques
C Leeuwenburgh, JE Rasmussen, FF Hsu, DM Mueller, S Pennathur, JW Heinecke
The Journal of biological chemistry 1997
Does an acidic pH explain why low density lipoprotein is oxidised in atherosclerotic lesions?
DS Leake
Atherosclerosis 1997
Both Intracellular and Extracellular Vitamin C Inhibit Atherogenic Modification of LDL by Human Vascular Endothelial Cells
A Martin, B Frei
Arteriosclerosis, thrombosis, and vascular biology 1997
Plasma LDL Oxidation Leads to Its Aggregation in the Atherosclerotic Apolipoprotein E-Deficient Mice
I Maor, T Hayek, R Coleman, M Aviram
Arteriosclerosis, thrombosis, and vascular biology 1997
Exogenous Oxidized Low-Density Lipoprotein Injures and Alters the Barrier Function of Endothelium in Rats In Vivo
S Rangaswamy, MS Penn, GM Saidel, GM Chisolm
Circulation research 1997
Copper Ions Promote Peroxidation of Low Density Lipoprotein Lipid by Binding to Histidine Residues of Apolipoprotein B100, But They Are Reduced at Other Sites on LDL
P Wagner, JW Heinecke
Arteriosclerosis, thrombosis, and vascular biology 1997
Antioxidant Protection of LDL by Physiological Concentrations of 17β-Estradiol: Requirement for Estradiol Modification
GT Shwaery, JA Vita, JF Keaney
Circulation 1997
Genistein, the Dietary-Derived Angiogenesis Inhibitor, Prevents LDL Oxidation and Protects Endothelial Cells From Damage by Atherogenic LDL
S Kapiotis, M Hermann, I Held, C Seelos, H Ehringer, BM Gmeiner
Arteriosclerosis, thrombosis, and vascular biology 1997
Effect of Iron Overload and Iron Deficiency on Atherosclerosis in the Hypercholesterolemic Rabbit
AJ Dabbagh, GT Shwaery, JF Keaney, B Frei
Arteriosclerosis, thrombosis, and vascular biology 1997
Body Iron Stores and the Risk of Carotid Atherosclerosis: Prospective Results From the Bruneck Study
S Kiechl, J Willeit, G Egger, W Poewe, F Oberhollenzer
Circulation 1997
Oxidative modification of low density lipoprotein in normal and hyperlipidemic patients: effect of lysophosphatidylcholine composition on vascular relaxation
L Chen, B Liang, DE Froese, S Liu, JT Wong, K Tran, GM Hatch, D Mymin, EA Kroeger, RY Man, PC Choy
Journal of lipid research 1997
Mechanisms of enhanced macrophage apoE secretion by oxidized LDL
AA Cader, FM Steinberg, T Mazzone, A Chait
Journal of lipid research 1997
Oxidative modifications of low-density lipoproteins (LDL) by the human endothelial cell line EA.hy 926
MA Pech-Amsellem, I Myara, I Pico, C Mazière, JC Mazière, N Moatti
Experientia 1996
Oxidation of Low-Density Lipoprotein by Human Monocyte-Macrophages Results in Toxicity to the Oxidising Culture
CE Marchant, CV der Wen, NS Law, SJ Hardwick, KL Carpenter, MJ Mitchinson
Free Radical Research 1996
Iron in human atheroma and LDL oxidation by macrophages following erythrophagocytosis
XM Yuan, W Li, AG Olsson, UT Brunk
Atherosclerosis 1996
Catechol based inhibitors of 15-lipoxygenase
BD Tait, RD Dyer, BJ Auerbach, D Bornemeier, L Guilds-Zamarka, M Oxender, BD Roth, BK Trivedi, JA Cornicelli
Bioorganic & Medicinal Chemistry Letters 1996
The role of oxidized lipoproteins in atherogenesis
JA Berliner, JW Heinecke
Free radical biology & medicine 1996
In vitro antioxidant effects of estrogens with a hindered 3-OH function on the copper-induced oxidation of low density lipoprotein
CP Miller, I Jirkovsky, DA Hayhurst, SJ Adelman
Steroids 1996
Advances in Lipobiology
PJ Trotter, DR Voelker
Advances in Lipobiology 1996
Bilirubin sensitized photooxidation of human plasma low density lipoprotein
SA Hulea, TL Smith, E Wasowicz, K Fred
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1996
Ascorbate promotes low density lipoprotein oxidation in the presence of ferritin
L Dai, PG Winyard, Z Zhang, DR Blake, CJ Morris
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1996
Autoantibody titers to oxidized low-density lipoprotein in patients with coronary atherosclerosis
MN Bui, MN Sack, G Moutsatsos, DY Lu, P Katz, R McCown, JA Breall, CE Rackley
American Heart Journal 1996
Lipid and lipoprotein oxidation: basic mechanisms and unresolved questions in vivo
R Bucala
Redox Report 1996
Macrophage erythrophagocytosis and iron exocytosis
XM Yuan, AG Olsson, UT Brunk
Redox Report 1996
Erratum: Human (THP-1) Macrophages Oxidize LDL by a Thiol-dependent Mechanism
A Graham, JL Wood, VJ O'leary, D Stone
Free Radical Research 1996
Ceruloplasmin Enhances Smooth Muscle Cell- and Endothelial Cell-mediated Low Density Lipoprotein Oxidation by a Superoxide-dependent Mechanism
CK Mukhopadhyay, E Ehrenwald, PL Fox
The Journal of biological chemistry 1996
The Yin and Yang of Oxidation in the Development of the Fatty Streak: A Review Based on the 1994 George Lyman Duff Memorial Lecture
M Navab, JA Berliner, AD Watson, SY Hama, MC Territo, AJ Lusis, DM Shih, BJ Lenten, JS Frank, LL Demer, PA Edwards, AM Fogelman
Arteriosclerosis, thrombosis, and vascular biology 1996
Cosupplementation With Coenzyme Q Prevents the Prooxidant Effect of α-Tocopherol and Increases the Resistance of LDL to Transition Metal–Dependent Oxidation Initiation
SR Thomas, J Neužil, R Stocker
Arteriosclerosis, thrombosis, and vascular biology 1996
Drugs Affecting Lipid Metabolism
AM Gotto, R Paoletti, LC Smith, AL Catapano, AS Jackson
1996
Effect of alpha-tocopherol on restenosis after angioplasty in a model of experimental atherosclerosis
AM Lafont, YC Chai, JF Cornhill, PL Whitlow, PH Howe, GM Chisolm
Journal of Clinical Investigation 1995
Dietary probucol preserves endothelial function in cholesterol-fed rabbits by limiting vascular oxidative stress and superoxide generation
JF Keaney, A Xu, D Cunningham, T Jackson, B Frei, JA Vita
Journal of Clinical Investigation 1995
Glutathione peroxidase potentiates the inhibition of platelet function by S-nitrosothiols
JE Freedman, B Frei, GN Welch, J Loscalzo
Journal of Clinical Investigation 1995
Human suction blister interstitial fluid prevents metal ion-dependent oxidation of low density lipoprotein by macrophages and in cell-free systems
AJ Dabbagh, B Frei
Journal of Clinical Investigation 1995
Beta-carotene inhibits atherosclerosis in hypercholesterolemic rabbits
A Shaish, A Daugherty, F O'Sullivan, G Schonfeld, JW Heinecke
Journal of Clinical Investigation 1995
Lipids and atherosclerosis
MJ Halpern
Molecular Aspects of Medicine 1995
Homocysteine and vascular disease
CS Berwanger, JY Jeremy, G Stansby
British Journal of Surgery 1995
Susceptibility of plasma low density lipoprotein to cupric ion—induced peroxidation in patients with variant angina
K Miwa, Y Miyagi, M Fujita
Journal of the American College of Cardiology 1995
Edta Differentially and Incompletely Inhibits Components of Prolonged Cell-Mediated Oxidation of Low-Density Lipoprotein
L Kritharides, W Jessup, RT Dean
Free Radical Research 1995
Systemic activation of 15-lipoxygenase in heart, lung, and vascular tissues by hypercholesterolemia: relationship to lipoprotein oxidation and atherogenesis
JM Bailey, AN Makheja, R Lee, TH Simon
Atherosclerosis 1995
Metabolism of modified LDL by cultured human placental cells
B Bonet
Atherosclerosis 1995
Oxidation of low-density lipoproteins: effect of antioxidant content, fatty acid composition and intrinsic phospholipase activity on susceptibility to metal ion-induced oxidation
KD Croft, P Williams, S Dimmitt, R Abu-Amsha, LJ Beilin
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1995
Iron Overload: Prevalence and Impact on Health
SR Lynch
Nutrition Reviews 1995
Copper-induced lipid peroxidation in liposomes, micelles, and LDL: Which is the role of vitamin E?
M Maiorino, A Zamburlini, A Roveri, F Ursini
Free radical biology & medicine 1995
Lowering of body iron stores by blood letting and oxidation resistance of serum lipoproteins: a randomized cross-over trial in male smokers
JT Salonen, H Korpela, K Nyyssönen, E Porkkala, TP Tuomainen, JD Belcher, DR JACOBS, R Salonen
Journal of Internal Medicine 1995
Body iron stores, dietary iron intake and coronary heart disease mortality
A Reunanen, H Takkunen, P Knekt, R Seppänen, A Aromaa
Journal of Internal Medicine 1995
Structure, oxidant activity, and cardiovascular mechanisms of human ceruloplasmin
PL Fox, C Mukhopadhyay, E Ehrenwald
Life Sciences 1995
The role of free radicals and antioxidants: How do we know that they are working?
MJ Thomas
Critical Reviews in Food Science and Nutrition 1995
Insights Into the Pathogenesis and Prevention of Coronary Artery Disease
JH O'Keefe, CJ Lavie, BD Mccallister
Mayo Clinic Proceedings 1995
Immunopharmacology of Free Radical Species
C Rice-Evans
Immunopharmacology of Free Radical Species 1995
Effect of in-vivo supplementation with low-dose vitamin E on susceptibility of low-density lipoprotein and high-density lipoprotein to oxidative modification
M Suzukawa, T Ishikawa, H Yoshida, H Nakamura
Journal of the American College of Nutrition 1995
Thyronines and probucol inhibition of human capillary endothelial cell-induced low density lipoprotein oxidation
AN Hanna, LC Titterington, LE Lantry, RE Stephens, HA Newman
Biochemical Pharmacology 1995
Diphenylhexatriene as a Fluorescent Probe for Monitoring Low Density Lipoprotein Peroxidation
JD Routier, C Mazière, FR Robert, M Auclair, R Santus, JC Mazière
Free Radical Research 1995
Prevention of atherosclerosis: The potential role of antioxidants
MR Mehra, CJ Lavie, HO Ventura, RV Milani
Postgraduate Medicine 1995
Atherosclerosis: Basic Mechanisms: Oxidation, Inflammation, and Genetics
JA Berliner, M Navab, AM Fogelman, JS Frank, LL Demer, PA Edwards, AD Watson, AJ Lusis
Circulation 1995
Iron Overload Augments the Development of Atherosclerotic Lesions in Rabbits
JA Araujo, EL Romano, BE Brito, V Parthé, M Romano, M Bracho, RF Montaño, J Cardier
Arteriosclerosis, thrombosis, and vascular biology 1995
Mast Cell Granule Remnants Carry LDL Into Smooth Muscle Cells of the Synthetic Phenotype and Induce Their Conversion Into Foam Cells
Y Wang, KA Lindstedt, PT Kovanen
Arteriosclerosis, thrombosis, and vascular biology 1995
Tissue Factor Pathway Inhibitor Activity Associated With LDL Is Inactivated by Cell- and Copper-Mediated Oxidation
P Lesnik, C Dentan, A Vonica, M Moreau, MJ Chapman
Arteriosclerosis, thrombosis, and vascular biology 1995
Active Oxygen in Biochemistry
JS Valentine, CS Foote, A Greenberg, JF Liebman
1995
Analysis of Free Radicals in Biological Systems
AE Favier, J Cadet, B Kalyanaraman, M Fontecave, JL Pierre
1995
Oxidative Stress and Antioxidant Defenses in Biology
S Ahmad
1995
Exchange of oxidized cholesteryl linoleate between LDL and HDL mediated by cholesteryl ester transfer protein
JK Christison, KA Rye, R Stocker
Journal of lipid research 1995
Oxidation of low density lipoprotein by iron or copper at acidic pH
J Morgan, DS Leake
Journal of lipid research 1995
Role of apolipoprotein B-derived radical and alpha-tocopheroxyl radical in peroxidase-dependent oxidation of low density lipoprotein
B Kalyanaraman, V Darley-Usmar, A Struck, N Hogg, S Parthasarathy
Journal of lipid research 1995
Formation of non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in plasma and low density lipoprotein exposed to oxidative stress in vitro
SM Lynch, JD Morrow, LJ 2nd, B Frei
Journal of Clinical Investigation 1994
Inhibition by interferon-gamma of human mononuclear cell-mediated low density lipoprotein oxidation. Participation of tryptophan metabolism along the kynurenine pathway
S Christen, SR Thomas, B Garner, R Stocker
Journal of Clinical Investigation 1994
Pathophysiological concentrations of glucose promote oxidative modification of low density lipoprotein by a superoxide-dependent pathway
M Kawamura, JW Heinecke, A Chait
Journal of Clinical Investigation 1994
Low density lipoproteins bind more to type I and III collagens by negative charge-dependent mechanisms than to type IV and V collagens
S Jimi, N Sakata, A Matunaga, S Takebayashi
Atherosclerosis 1994
Stimulation of low-density lipoprotein oxidation by insulin and insulin like growth factor I
VA Rifici, SH Schneider, AK Khachadurian
Atherosclerosis 1994
Calcium Channel Antagonists as Antioxidants
N Rojstaczer, DJ Triggle
Cardiovascular Drug Reviews 1994
LDL modification by activated polymorphonuclear leukocytes: A cellular model of mild oxidative stress
C Scaccini, I Jialal
Free radical biology & medicine 1994
Effects of supplementing with vitamin E on the uptake of low density lipoprotein and the stimulation of cholesteryl ester formation in macrophages
M Suzukawa, M Abbey, P Clifton, PJ Nestel
Atherosclerosis 1994
Lysophosphatidylcholine upregulates the level of heparin-binding epidermal growth factor-like growth factor mRNA in human monocytes
T Nakano, EW Raines, JA Abraham, M Klagsbrun, R Ross
Proceedings of the National Academy of Sciences 1994
The effect of iron overload on rat plasma and liver oxidant status in vivo
AJ Dabbagh, T Mannion, SM Lynch, B Frei
Biochemical Journal 1994
Generation of reactive oxygen species and activity of platelet-activating factor acetylhydrolase in human monocyte-derived macrophages
S Ruβwurm, S Krause, L Finkelberg, K Rühling, U Schauer, W Lösche
Thrombosis Research 1994
Photosensitizer targeting in photodynamic therapy II. Conjugates of haematoporphyrin with serum lipoproteins
MR Hamblin, EL Newman
Journal of Photochemistry and Photobiology B Biology 1994
Partitioning of chemically modified low-density lipoprotein in aqueous polymer two-phase systems
D Wiegel, O Richter, K Arnold
Journal of Chromatography A 1994
Natural Antioxidants in Human Health and Disease
M Levine, KR Dhariwal, Y Wang, JB Park, RW Welch
Natural Antioxidants in Human Health and Disease 1994
Human (THP-1) Macrophages Oxidize LDL by a Thiol-Dependent Mechanism
A Graham, JL Wood, VJ O'leary, D Stone
Free Radical Research 1994
Increased oxidazability of plasma low density lipoprotein from patients with coronary artery disease
HC Chiu, JR Jeng, SM Shieh
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1994
Antiproliferative effect of desferrioxamine on vascular smooth muscle cells in vitro and in vivo
E Porreca, S Ucchino, CD Febbo, ND Bartolomeo, D Angelucci, AM Napolitano, A Mezzetti, F Cuccurullo
Arteriosclerosis Thrombosis and Vascular Biology 1994
PAF-acether-degrading acetylhydrolase in plasma LDL is inactivated by copper- and cell-mediated oxidation
C Dentan, P Lesnik, MJ Chapman, E Ninio
Arteriosclerosis Thrombosis and Vascular Biology 1994
Oxidation of LDL to a biologically active form by derivatives of nitric oxide and nitrite in the absence of superoxide. Dependence on pH and oxygen
GJ Chang, P Woo, HM Honda, LJ Ignarro, L Young, JA Berliner, LL Demer
Arteriosclerosis Thrombosis and Vascular Biology 1994
Free Radicals in Diagnostic Medicine
D Armstrong
1994
Tyrosyl radical generated by myeloperoxidase is a physiological catalyst for the initiation of lipid peroxidation in low density lipoprotein
ML Savenkova, DM Mueller, JW Heinecke
The Journal of biological chemistry 1994
Modified forms of low-density lipoprotein and atherosclerosis
D Steinberg
Journal of Internal Medicine 1993
Probucol as an antioxidant and antiatherogenic drug
M Kuzuya, F Kuzuya
Free radical biology & medicine 1993
Oxidized low-density lipoprotein in experimental focal glomerulosclerosis
AB Magil, JJ Frohlich, SM Innis, UP Steinbrecher
Kidney International 1993
The Gordon Wilson Lecture. Plasma cholesterol: atherogenesis and mortality
WR Fisher
Transactions of the American Clinical and Climatological Association 1993
Oxidation of low-density lipoprotein with hypochlorite causes transformation of the lipoprotein into a high-uptake form for macrophages
LJ Hazell, R Stocker
Biochemical Journal 1993
Role of oxidised low density lipoprotein in atherogenesis
JL Witztum
British heart journal 1993
Physical changes of low-density lipoprotein on oxidation
JN Herak
Chemistry and Physics of Lipids 1993
Influence of culture medium characteristics on the ability to oxidize low-density lipoproteins
MA Pech, I Myara, N Moatti, A Caprani
Bioelectrochemistry and Bioenergetics 1993
Prooxidant role of vitamin E in copper induced lipid peroxidation
M Maiorino, A Zamburlini, A Roveri, F Ursini
FEBS Letters 1993
In vitro formation of oxidatively-modified and reassembled human low-density lipoproteins: Antioxidant effect of albumin
A Dobrian, R Mora, M Simionescu, N Simionescu
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1993
Inhibition of low density lipoprotein oxidation by thyronines and probucol
AN Hanna, DR Feller, DT Witiak, HA Newman
Biochemical Pharmacology 1993
The Early Atherosclerotic Lesion — Morphology and Mechanisms
J Nilsson
1993
Inhibition of copper-mediated oxidation of LDL by rat serosal mast cells. A novel cellular protective mechanism involving proteolysis of the substrate under oxidative stress
KA Lindstedt, JO Kokkonen, PT Kovanen
Arteriosclerosis Thrombosis and Vascular Biology 1993
Macrophages and Related Cells
MA Horton
1993
Free Radicals: from Basic Science to Medicine
G Poli, E Albano, MU Dianzani
1993
Cellular Metabolism of the Arterial Wall and Central Nervous System
G Schettler, H Greten, AJ Habenicht
1993
Mechanisms of copper- and iron-dependent oxidative modification of human low density lipoprotein
SM Lynch, B Frei
Journal of lipid research 1993
The action of oxidized low density lipoprotein on calcium transients in isolated rabbit cardiomyocytes
K Liu, H Massaeli, GN Pierce
The Journal of biological chemistry 1993
Inhibition of macrophage-mediated low density lipoprotein oxidation by stimulated rat serosal mast cells
KA Lindstedt
The Journal of biological chemistry 1993
Cellular oxidation of low density lipoprotein is caused by thiol production in media containing transition metal ions
CP Sparrow, J Olszewski
Journal of lipid research 1993
Oxidation of low density lipoprotein by thiols: superoxide-dependent and -independent mechanisms
JW Heinecke, M Kawamura, L Suzuki, A Chait
Journal of lipid research 1993
Content of antioxidants, preformed lipid hydroperoxides, and cholesterol as predictors of the susceptibility of human LDL to metal ion-dependent and -independent oxidation
B Frei, JM Gaziano
Journal of lipid research 1993
Free radicals, lipoproteins and cardiovascular dysfunction
C Rice-Evans, KR Bruckdorfer
Molecular Aspects of Medicine 1992
Role of oxidized low density lipoprotein in atherogenesis
S Parthasarathy, SM Rankin
Progress in Lipid Research 1992
The role of lipid peroxidation and antioxidants in oxidative modification of LDL
H Esterbauer, J Gebicki, H Puhl, G Jürgens
Free radical biology & medicine 1992
A protective role for nitric oxide in the oxidative modification of low density lipoproteins by mouse macrophages
MT Yates, LE Lambert, JP Whitten, I McDonald, M Mano, G Ku, SJ Mao
FEBS Letters 1992
Macrophage colony-stimulating factor gene expression in vascular cells and in experimental and human atherosclerosis
SK Clinton, R Underwood, L Hayes, ML Sherman, DW Kufe, P Libby
The American Journal of Pathology 1992
Immunohistochemical distribution of lipoprotein epitopes in xanthomata from patients with familial hypercholesterolemia
N Sugiyama, S Marcovina, AM Gown, H Seftel, B Joffe, A Chait
The American Journal of Pathology 1992
Studies on epitopes on low-density lipoprotein modified by 4-hydroxynonenal. Biochemical characterization and determination
Q Chen, H Esterbauer, G Jürgens
Biochemical Journal 1992
Lysolecithin actions on vascular smooth muscle cells
R Locher, B Weisser, T Mengden, C Brunner, W Vetter
Biochemical and Biophysical Research Communications 1992
Inhibition of human low-density lipoprotein oxidation in vitro by Maharishi Ayur-Veda herbal mixtures
HM Sharma, AN Hanna, EM Kauffman, HA Newman
Pharmacology Biochemistry and Behavior 1992
Lipid peroxidation — a common pathogenetic mechanism?
R Dargel
Experimental and Toxicologic Pathology 1992
Malondialdehyde modification and copper-induced autooxidation of high-density lipoprotein decrease cholesterol efflux from human cultured fibroblasts
S Salmon, C Maziére, M Auclair, L Theron, R Santus, JC Maziére
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1992
Role of lipoprotein-copper complex in copper catalyzed-peroxidation of low-density lipoprotein
M Kuzuya, K Yamada, T Hayashi, C Funaki, M Naito, K Asai, F Kuzuya
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1992
The influence of medium components on Cu2+-dependent oxidation of low-density lipoproteins and its sensitivity to superoxide dismutase
CE Thomas
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1992
The Role of Iron in Oxygen-Mediated Toxicities
TP Ryan, SD Aust
Critical Reviews in Toxicology 1992
The participation of nitric oxide in cell free- and its restriction of macrophage-mediated oxidation of low-density lipoprotein
W Jessup, D Mohr, SP Gieseg, RT Dean, R Stocker
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1992
Supplementation with vitamin E but not beta-carotene in vivo protects low density lipoprotein from lipid peroxidation in vitro. Effect of cigarette smoking
HM Princen, G van Poppel, C Vogelezang, R Buytenhek, FJ Kok
Arteriosclerosis Thrombosis and Vascular Biology 1992
Oxidatively modified HDLs are potent inhibitors of cholesterol biosynthesis in human skin fibroblasts
G Ghiselli, L Giorgini, M Gelati, R Musanti
Arteriosclerosis Thrombosis and Vascular Biology 1992
Endothelial Cell Dysfunctions
N Simionescu, M Simionescu
1992
Role of oxidized human plasma low density lipoproteins in atherosclerosis: effects on smooth muscle cell proliferation
S Chatterjee
Molecular and Cellular Biochemistry 1992
Gene expression in macrophage-rich human atherosclerotic lesions. 15-lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts
S Ylä-Herttuala, ME Rosenfeld, S Parthasarathy, E Sigal, T Särkioja, JL Witztum, D Steinberg
Journal of Clinical Investigation 1991
Role of oxidized low density lipoprotein in atherogenesis
JL Witztum, D Steinberg
Journal of Clinical Investigation 1991
Monocyte transmigration induced by modification of low density lipoprotein in cocultures of human aortic wall cells is due to induction of monocyte chemotactic protein 1 synthesis and is abolished by high density lipoprotein
M Navab, SS Imes, SY Hama, GP Hough, LA Ross, RW Bork, AJ Valente, JA Berliner, DC Drinkwater, H Laks
Journal of Clinical Investigation 1991
Enzymic mechanisms of superoxide production
AR Cross, OT Jones
Biochimica et Biophysica Acta (BBA) - Bioenergetics 1991
The spin trap, α-phenyl N-tert-butylnitrone, inhibits the oxidative modification of low density lipoprotein
B Kalyanaraman, J Joseph, S Parthasarathy
FEBS Letters 1991
Effect of Antioxidants on Oxidative Modification of LDL
H Esterbauer, H Puhl, M Dieber-rotheneder, G Waeg, H Rabl
Annals of Medicine 1991
Antioxidants and atherosclerosis: A current assessment
GM Chisolm
Clinical Cardiology 1991
Therapeutic potential of vitamin E in the pathogenesis of spontaneous atherosclerosis
DR Janero
Free radical biology & medicine 1991
Oxidized Low Density Lipoproteins: a Role in the Pathogenesis of Atherosclerosis in Diabetes?
TJ Lyons
Diabetic Medicine 1991
Gas phase oxidants of cigarette smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma. Protective effects of ascorbic acid
B Frei, TM Forte, BN Ames, CE Cross
Biochemical Journal 1991
New trends in photobiology
I Freitas, GF Baronzio
Journal of Photochemistry and Photobiology B Biology 1991
Oxidative Damage & Repair
A Sevanian
Oxidative Damage & Repair 1991
Oxidation of low-density lipoprotein by copper and iron in phosphate buffer
K Masafumi, Y Kazuyoshi, H Toshio, F Chiaki, N Michitaka, A Kanichi, K Fumio
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1991
Enhanced in vitro oxidation of plasma lipoproteins derived from hypercholesterolemic patients
A Lavy, GJ Brook, G Dankner, AB Amotz, M Aviram
Metabolism 1991
Calcium Antagonists Prevent Monocyte and Endothelial Cell-Induced Modification of Low Density Lipoproteins
C Breugnot, C Mazière, M Auclair, L Mora, MF Ronveaux, S Salmon, R Santus, P Morlière, A Lenaers, JC Mazière
Free Radical Research 1991
Epr Evidence for the Oxidation-Induced Formation of Negatively Charged Species on the Low-Density Lipoprotein Surface
J Brnjas-Kraljević, G Pifat, JN Herak, G Jürgens
Free Radical Research 1991
The liver metabolite S-422 of the hypolipidaemic drug benfluorex decreases cholesterol esterification in fibroblasts and monocyte-like cells
JC Mazire, C Mazire, M Auclair, L Mora, O Arnaud
European Journal of Clinical Pharmacology 1991
Lipid peroxide and transition metals are required for the toxicity of oxidized low density lipoprotein to cultured endothelial cells
M Kuzuya, M Naito, C Funaki, T Hayashi, K Asai, F Kuzuya
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1991
Ultraviolet-treated lipoproteins as a model system for the study of the biological effects of lipid peroxides on cultured cells. III. The protective effect of antioxidants (probucol, catechin, vitamin E) against the cytotoxicity of oxidized LDL occurs in two different ways
A Negre-Salvayre, Y Alomar, M Troly, R Salvayre
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1991
Phagocytosis of lipase-aggregated low density lipoprotein promotes macrophage foam cell formation. Sequential morphological and biochemical events
JW Heinecke, AG Suits, M Aviram, A Chait
Arteriosclerosis Thrombosis and Vascular Biology 1991
Attenuation of atherosclerosis in a modified strain of hypercholesterolemic Watanabe rabbits with use of a probucol analogue (MDL 29,311) that does not lower serum cholesterol
SJ Mao, MT Yates, RA Parker, EM Chi, RL Jackson
Arteriosclerosis Thrombosis and Vascular Biology 1991
Enhanced susceptibility to in vitro oxidation of the dense low density lipoprotein subfraction in healthy subjects
J de Graaf, HL Hak-Lemmers, MP Hectors, PN Demacker, JC Hendriks, AF Stalenhoef
Arteriosclerosis Thrombosis and Vascular Biology 1991
Effects of copper and histidine on oxidative modification of low density lipoprotein and its subsequent binding to collagen
N Kalant, S McCormick, MA Parniak
Arteriosclerosis Thrombosis and Vascular Biology 1991
Atherosclerosis: Cellular and Molecular Interactions in the Artery Wall
AI Gotlieb, BL Langille, S Fedoroff
Atherosclerosis 1991
Activated platelets secrete a protein-like factor that stimulates oxidized-LDL receptor activity in macrophages
B Fuhrman, GJ Brook, M Aviram
Journal of lipid research 1991
Fractionation of charge-modified low density lipoproteins by fast protein liquid chromatography
B Vedie, I Myara, MA Pech, JC Maziere, C Maziere, A Caprani, N Moatti
Journal of lipid research 1991
Uptake and degradation of low density lipoproteins in atherosclerotic rabbit aorta: role of local LDL modification
O Wiklund, L Mattsson, T Björnheden, G Camejo, G Bondjers
Journal of lipid research 1991
Oxidation-labile subfraction of human plasma low density lipoprotein isolated by ion-exchange chromatography
H Shimano, N Yamada, S Ishibashi, H Mokuno, N Mori, T Gotoda, K Harada, Y Akanuma, T Murase, Y Yazaki
Journal of lipid research 1991
Evidence for a dominant role of lipoxygenase(s) in the oxidation of LDL by mouse peritoneal macrophages
SM Rankin, S Parthasarathy, D Steinberg
Journal of lipid research 1991
Minimally modified low density lipoprotein stimulates monocyte endothelial interactions
JA Berliner, MC Territo, A Sevanian, S Ramin, JA Kim, B Bamshad, M Esterson, AM Fogelman
Journal of Clinical Investigation 1990
Oxidized low density lipoproteins cause contraction and inhibit endothelium-dependent relaxation in the pig coronary artery
BC Simon, LD Cunningham, RA Cohen
Journal of Clinical Investigation 1990
Role of oxidatively modified LDL in atherosclerosis
UP Steinbrecher, H Zhang, M Lougheed
Free radical biology & medicine 1990
Atherogenic Lipoproteins Resulting from Genetic Defects of Apolipoproteins B and E
KH Weisgraber, TL Innerarity, SC Rall, RW Mahley
Annals of the New York Academy of Sciences 1990
Effect of Eicosapentaenoic Acid on the Binding and Degradation of Oxidized LDL and the Production of LTB4, LTC4, and PGE2in Rat Peritoneal Macrophages
KJ Chang, H Saito, Y Tamura, S Yoshida
Annals of the New York Academy of Sciences 1990
Oxidation of low-density lipoprotein by Cu2+ and lipoxygenase: an electron spin resonance study
B Kalyanaraman, WE Antholine, S Parthasarathy
Biochimica et Biophysica Acta (BBA) - General Subjects 1990
Oxidized low density lipoprotein induces differentiation and adhesion of human monocytes and the monocytic cell line U937
J Frostegård, J Nilsson, A Haegerstrand, A Hamsten, H Wigzell, M Gidlund
Proceedings of the National Academy of Sciences 1990
The oxidative modification of low-density lipoproteins by macrophages
DS Leake, SM Rankin
Biochemical Journal 1990
Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions
S Ylä-Herttuala, ME Rosenfeld, S Parthasarathy, CK Glass, E Sigal, JL Witztum, D Steinberg
Proceedings of the National Academy of Sciences 1990
Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells
SD Cushing, JA Berliner, AJ Valente, MC Territo, M Navab, F Parhami, R Gerrity, CJ Schwartz, AM Fogelman
Proceedings of the National Academy of Sciences 1990
Alpha-tocopherol consumption during low-density-lipoprotein oxidation
W Jessup, SM Rankin, CV de Whalley, JR Hoult, J Scott, DS Leake
Biochemical Journal 1990
Sensitivity of tryptophan and related compounds to oxidation induced by lipid autoperoxidation. Application to human serum low- and high-density lipoproteins
JP Reyftmann, R Santus, JC Mazière, P Morlière, S Salmon, C Candide, C Mazière, J Haigle
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1990
Ultraviolet-treated lipoproteins as a model system for the study of the biological effects of lipid peroxides on cultured cell. I. Chemical modifications of ultraviolet-treated low-density lipoproteins
N Dousset, A Negre-Salvayre, M Lopez, R Salvayre, L Douste-Blazy
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1990
Ultraviolet-treated lipoproteins as a model system for the study of the biological effects of lipid peroxides on cultured cells. II. Uptake and cytotoxicity of ultraviolet-treated LDL on lymphoid cell lines
A Negre-Salvayre, M Lopez, T Levade, MT Pieraggi, N Dousset, L Douste-Blazy, R Salvayre
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1990
Activation of soluble guanylate cyclase by nitrovasodilators is inhibited by oxidized low-density lipoprotein
K Schmidt, WF Graier, GM Kostner, B Mayer, WR Kukovetz
Biochemical and Biophysical Research Communications 1990
Free radical generation by early glycation products: A mechanism for accelerated atherogenesis in diabetes
CJ Mullarkey, D Edelstein, M Brownlee
Biochemical and Biophysical Research Communications 1990
Phenothiazines inhibit copper and endothelial cell-induced peroxidation of low density lipoprotein
C Breugnot, C Mazière, S Salmon, M Auclair, R Santus, P Morlière, A Lenaers, JC Mazière
Biochemical Pharmacology 1990
Flavonoids inhibit the oxidative modification of low density lipoproteins by macrophages
CV de Whalley, SM Rankin, JR Hoult, W Jessup, DS Leake
Biochemical Pharmacology 1990
Free Radicals, Lipoproteins, and Membrane Lipids
AC de Paulet, L Douste-Blazy, R Paoletti
1990
Antisera and monoclonal antibodies specific for epitopes generated during oxidative modification of low density lipoprotein
W Palinski, S Ylä-Herttuala, ME Rosenfeld, SW Butler, SA Socher, S Parthasarathy, LK Curtiss, JL Witztum
Arteriosclerosis (Dallas, Tex.) 1990
Distribution of oxidation specific lipid-protein adducts and apolipoprotein B in atherosclerotic lesions of varying severity from WHHL rabbits
ME Rosenfeld, W Palinski, S Ylä-Herttuala, S Butler, JL Witztum
Arteriosclerosis (Dallas, Tex.) 1990
Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, in Vivo Kinetics
CL Malmendier, P Alaupovic, HB Brewer
1990
Macrophages, Endothelial Cells, and Lipoprotein Oxidation in the Pathogenesis of Atherosclerosis*
ME Rosenfeld, W Palinski, S Ylä-Herttuala, TE Carew
Toxicologic pathology 1990
Lipid hydroperoxy and hydroxy derivatives in copper-catalyzed oxidation of low density lipoprotein
ML Lenz, H Hughes, , DP Via, , AA Taylor, AM Gotto, CV Smith
Journal of lipid research 1990
Vitamin E and other Lipophilic Antioxidants Protect LDL against Oxidation
H Esterbauer, M Rotheneder, G Striegl, G Waeg, A Ashy, W Sattler, G Jürgens
Fett Wissenschaft Technologie/Fat Science Technology 1989
Macrophages modify β-VLDL by proteolysis and enhance subsequent lipid accumulation in arterial smooth muscle cells
JB Davis, DE Bowyer
Atherosclerosis 1989
The action of defined oxygen-centred free radicals on human low-density lipoprotein
S Bedwell, RT Dean, W Jessup
Biochemical Journal 1989
Phagocytosis of aggregated lipoprotein by macrophages: low density lipoprotein receptor-dependent foam-cell formation
AG Suits, A Chait, M Aviram, JW Heinecke
Proceedings of the National Academy of Sciences 1989
Direct evidence for a protein recognized by a monoclonal antibody against oxidatively modified LDL in atherosclerotic lesions from a Watanabe heritable hyperlipidemic rabbit
HC Boyd, AM Gown, G Wolfbauer, A Chait
The American Journal of Pathology 1989
The iron paradigm of ischemic heart disease
JL Sullivan
American Heart Journal 1989
Role of biologically modified low-density lipoprotein in atherosclerosis
TE Carew
The American Journal of Cardiology 1989
Beyond Cholesterol
FH Epstein, D Steinberg, S Parthasarathy, TE Carew, JC Khoo, JL Witztum
New England Journal of Medicine 1989
Effect of probucol on the physical properties of low-density lipoproteins oxidized by copper
LR McLean, KA Hagaman
Biochemistry 1989
Probucol does not affect lipoprotein metabolism in macrophages of Watanabe heritable hyperlipidemic rabbits
Y Nagano, T Kita, M Yokode, K Ishii, N Kume, H Otani, H Arai, C Kawai
Arteriosclerosis (Dallas, Tex.) 1989
Modification of low density lipoprotein with 4-hydroxynonenal induces uptake by macrophages
HF Hoff, J O'Neil, GM rd, TB Cole, O Quehenberger, H Esterbauer, G Jürgens
Arteriosclerosis (Dallas, Tex.) 1989
Diseases of the Arterial Wall
JP Camilleri, CL Berry, JN Fiessinger, J Bariéty
1989
Differences in the metabolism of oxidatively modified low density lipoprotein and acetylated low density lipoprotein by human endothelial cells: inhibition of cholesterol esterification by oxidatively modified low density lipoprotein
I Jialal, A Chait
Journal of lipid research 1989
Concentration-dependent antioxidant activity of probucol in low density lipoproteins in vitro: probucol degradation precedes lipoprotein oxidation
RL Barnhart, SJ Busch, RL Jackson
Journal of lipid research 1989
Lipid Peroxidation Changes the Expression of Specific Epitopes of Apolipoprotein A-I
YL Marcel, D Jewer, L Leblond, PK Weech, RW Milne
The Journal of biological chemistry 1989
Probucol: A Reappraisal of its Pharmacological Properties and Therapeutic Use in Hypercholesterolaemia
MM Buckley, KL Goa, AH Price, RN Brogden
Drugs 1989
Stimulated arachidonate metabolism during foam cell transformation of mouse peritoneal macrophages with oxidized low density lipoprotein
M Yokode, T Kita, Y Kikawa, T Ogorochi, S Narumiya, C Kawai
Journal of Clinical Investigation 1988
Oxidative modification of low density lipoprotein (LDL) by activated human monocytes and the cell lines U937 and HL60
MK Cathcart, GM Chisolm, AK McNally, DW Morel
In Vitro Cellular & Developmental Biology 1988
Apolipoproteins, Dyslipoproteinaemia and Premature Coronary Heart Disease
A Hamsten
Acta Medica Scandinavica 1988
Extracts of human atherosclerotic lesions can modify low density lipoproteins leading to enhanced uptake by macrophages
HF Hoff, J O'Neil
Atherosclerosis 1988
Lysophosphatidylcholine: a chemotactic factor for human monocytes and its potential role in atherogenesis
MT Quinn, S Parthasarathy, D Steinberg
Proceedings of the National Academy of Sciences 1988
Cholesteryl ester accumulation in macrophages incubated with low density lipoprotein pretreated with cigarette smoke extract
M Yokode, T Kita, H Arai, C Kawai, S Narumiya, M Fujiwara
Proceedings of the National Academy of Sciences 1988
Role of superoxide in endothelial-cell modification of low-density lipoproteins
UP Steinbrecher
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1988
Advances in Genetics
BH Bowman, F Yang, GS Adrian
Advances in genetics 1988
Lipoprotein oxidation and cytotoxicity: Effect of probucol on streptozotocin-treated rats
GM Chisolm, DW Morel
The American Journal of Cardiology 1988
Prevention of atherosclerotic progression in Watanabe rabbits by probucol
T Kita, Y Nagano, M Yokode, K Ishii, N Kume, S Narumiya, C Kawai
The American Journal of Cardiology 1988
Preferential metabolism by macrophages of conditioned rabbit hypercholesterolemic remnant lipoproteins
D Haratz, O Stein, R Shwartz, EM Berry, Y Stein
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1988
Interaction of native and cell-modified low density lipoprotein with collagen gel
GA Hoover, S McCormick, N Kalant
Arteriosclerosis (Dallas, Tex.) 1988
Copper and Zinc in Inflammation
R Milanino, KD Rainsford, GP Velo
1988
Oxidative modification of low density lipoprotein (LDL) by activated human monocytes and the cell lines U937 and HL60
MK Cathcart, GM Chisolm, AK McNally, DW Morel
In Vitro Cellular & Developmental Biology – Animal 1988
Toxicity of oxidized low-density lipoprotein to cultured fibroblasts is selective for S phase of the cell cycle
K Kosugi, DW Morel, PE DiCorleto, GM Chisolm
Journal of Cellular Physiology 1987
MACROPHAGES AND ATHEROGENESIS
MJ Mitchinson, RY Ball
The Lancet 1987
Free radical modification of low-density lipoprotein: Mechanisms and biological consequences
JW Heinecke
Free radical biology & medicine 1987
Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia
T Kita, Y Nagano, M Yokode, K Ishii, N Kume, A Ooshima, H Yoshida, C Kawai
Proceedings of the National Academy of Sciences 1987
Modification of human serum low density lipoprotein by oxidation — Characterization and pathophysiological implications
G Jürgens, HF Hoff, GM Chisolm, H Esterbauer
Chemistry and Physics of Lipids 1987
Immunological detection of low-density lipoproteins modified by malondialdehyde in vitro or in vivo
S Salmon, C Maziere, L Theron, I Beucler, M Ayrault-Jarrier, S Goldstein, J Polonovski
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1987
Decrease in reactive amino groups during oxidation or endothelial cell modification of LDL. Correlation with changes in receptor-mediated catabolism
UP Steinbrecher, JL Witztum, S Parthasarathy, D Steinberg
Arteriosclerosis (Dallas, Tex.) 1987
Lipoprotein-mediated inhibition of endothelial cell production of platelet-derived growth factor-like protein depends on free radical lipid peroxidation
PL Fox, GM Chisolm, PE DiCorleto
The Journal of biological chemistry 1987
The role of sulfur-containing amino acids in superoxide production and modification of low density lipoprotein by arterial smooth muscle cells
JW Heinecke, H Rosen, LA Suzuki, A Chait
The Journal of biological chemistry 1987
Nonenzymatic oxidative cleavage of peptide bonds in apoprotein B-100
LG Fong, S Parthasarathy, JL Witztum, D Steinberg
Journal of lipid research 1987
Oxidation of human low density lipoprotein results in derivatization of lysine residues of apolipoprotein B by lipid peroxide decomposition products
UP Steinbrecher
The Journal of biological chemistry 1987
Superoxide-mediated modification of low density lipoprotein by arterial smooth muscle cells
JW Heinecke, L Baker, H Rosen, A Chait
Journal of Clinical Investigation 1986
Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine
G Starkebaum, JM Harlan
Journal of Clinical Investigation 1986
Effects of reagent and cell-generated hydrogen peroxide on the properties of low density lipoprotein
RR Montgomery, CF Nathan, ZA Cohn
Proceedings of the National Academy of Sciences 1986
Studies on the mechanism of action of probucol
D Steinberg
The American Journal of Cardiology 1986
Role of endothelial cells and their products in the modification of low-density lipoproteins
VW van Hinsbergh, M Scheffer, L Havekes, HJ Kempen
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1986
Essential role of phospholipase A2 activity in endothelial cell-induced modification of low density lipoprotein
S Parthasarathy, UP Steinbrecher, J Barnett, JL Witztum, D Steinberg
Proceedings of the National Academy of Sciences 1985
The behaviour of caeruloplasmin in stored human extracellular fluids in relation to ferroxidase II activity, lipid peroxidation and phenanthroline-detectable copper
JM Gutteridge, PG Winyard, DR Blake, J Lunec, S Brailsford, B Halliwell
Biochemical Journal 1985
New Comprehensive Biochemistry
S Yamamoto
New Comprehensive Biochemistry 1983

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