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Citations to this article

Selective inhibition of human diploid fibroblast collagen synthesis by interferons.
S A Jimenez, … , B Freundlich, J Rosenbloom
S A Jimenez, … , B Freundlich, J Rosenbloom
Published September 1, 1984
Citation Information: J Clin Invest. 1984;74(3):1112-1116. https://doi.org/10.1172/JCI111480.
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Research Article Article has an altmetric score of 3

Selective inhibition of human diploid fibroblast collagen synthesis by interferons.

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Abstract

The effects of alpha- and gamma-interferons (IFNs) on collagen production by confluent human diploid fibroblasts in culture were examined. It was found that partially purified alpha-IFNs and affinity purified gamma-IFNs caused greater than 50% inhibition of collagen synthesis by these cells independently of their effect on cell proliferation. Recombinant alpha-IFNs showed a similar effect (38.8% inhibition), indicating that collagen synthesis inhibition was a constitutive property of IFNs. Collagen synthesis inhibition by IFNs was concentration dependent. Gel filtration chromatography of the newly synthesized proteins from the media of fibroblasts incubated with partially purified alpha-IFNs demonstrated a selective depression of molecules eluting in the region of procollagen. No detectable increase in collagen degradation products or underhydroxylation of procollagen was observed. Short-term kinetic studies further demonstrated that the major effect of IFNs was due to a net decrease in fibroblast collagen production rather than to impairment of secretion or increased extracellular degradation of the newly synthesized molecules. These results indicate that alpha- and gamma-IFNs are potent inhibitors of human fibroblast collagen production and suggest that they may play an important role in the regulation of normal and pathologic fibrogenesis.

Authors

S A Jimenez, B Freundlich, J Rosenbloom

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Year: 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 1985 Total
Citations: 1 1 1 2 6 2 1 3 1 2 2 4 6 3 3 6 9 6 11 3 9 11 10 7 8 13 8 7 15 12 14 10 12 9 11 10 7 8 8 6 268
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Citations to this article in year 2012 (6)

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Methods in Enzymology
JD Stone, AS Chervin, DH Aggen, DM Kranz
Protein Engineering for Therapeutics Part B 2012
Potential Immunologic Targets for Treating Fibrosis in Systemic Sclerosis: A Review Focused on Leukocytes and Cytokines
M Hasegawa, K Takehara
Seminars in Arthritis and Rheumatism 2012
Les cytokines dans la sclérodermie systémique
J Baraut, D Farge, F Jean-Louis, H Kesmandt, C Durant, F Verrecchia, L Michel
Pathologie Biologie 2012
Cutaneous manifestations of acute radiation exposure: a review: Cutaneous manifestations of acute radiation exposure
KA Ward, JP Jaimes, NV Coots
International Journal of Dermatology 2012
Handbook of Burns
MG Jeschke, LP Kamolz, F Sjöberg, SE Wolf
2012
Principles and Practice of Modern Radiotherapy Techniques in Breast Cancer
A Haydaroglu, G Ozyigit
2012

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Referenced in 4 patents
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