Citations to this article

Human squamous cell lung cancers express increased epidermal growth factor receptors.
F J Hendler, B W Ozanne
F J Hendler, B W Ozanne
Published August 1, 1984
Citation Information: J Clin Invest. 1984;74(2):647-651. https://doi.org/10.1172/JCI111463.
View: Text | PDF
Research Article Article has an altmetric score of 9

Human squamous cell lung cancers express increased epidermal growth factor receptors.

Abstract

Epidermal growth factor (EGF) promotes the growth of cultured benign and malignant cells. Recent studies have demonstrated that the amount of EGF receptor is elevated in squamous cell carcinoma cells in tissue culture when compared with normal epidermal cells. This study demonstrates that elevated levels of EGF receptor are detected in biopsy specimens of human squamous cell carcinomas of the lung with a murine monoclonal antibody, EGF-R1, which binds specifically to the receptor. The increased receptor ranged from 2.5- to 5-fold that of normal skin. These findings have been observed in 11 of 11 squamous carcinomas and two of two epidermoid head and neck cancers. Seven of eight adenocarcinomas, two of two small cell, and four of eight undifferentiated lung cancers had negligible amounts of EGF receptor. The EGF receptor antibody did not bind significantly to normal lung tissues and 35 nonepidermoid tumors. Therefore, EGF receptor may be an excellent marker for epidermoid malignancies.

Authors

F J Hendler, B W Ozanne

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2018 2017 2016 2015 2014 2013 2012 2011 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 1985 1975 Total
Citations: 2 2 2 1 4 5 2 3 2 1 4 1 4 2 4 4 2 4 3 7 2 5 3 1 5 13 13 8 9 14 20 17 14 25 19 13 14 11 8 1 274
Citation information

Citations to this article (274)

Title and authors Publication Year
Free Energy, Rates, and Mechanism of Transmembrane Dimerization in Lipid Bilayers from Dynamically Unbiased Molecular Dynamics Simulations
Jackel E, Lazzeri G, Covino R 		The Journal of Physical Chemistry. B 2025
Advancing Head and Neck Cancer Therapies: From Conventional Treatments to Emerging Strategies
Mordzińska-Rak A, Telejko I, Adamczuk G, Trombik T, Stepulak A, Błaszczak E 		Biomedicines 2025
A Multifunctionalized Potyvirus-Derived Nanoparticle That Targets and Internalizes into Cancer Cells.
Truchado DA, Juárez-Molina M, Rincón S, Zurita L, Tomé-Amat J, Lorz C, Ponz F 		International journal of molecular sciences 2024
Index finger acrometastasis: A unique lung cancer case report
Jaber SK, Hashem GN, Mouawad JA, Kalaji JG, Akl JK 		International Journal of Surgery Case Reports 2024
Targeted therapy for head and neck cancer: signaling pathways and clinical studies
Li Q, Tie Y, Alu A, Ma X, Shi H 		Signal Transduction and Targeted Therapy 2023
Deacetylated Sialic Acid Sensitizes Lung and Colon Cancers to Novel Cucurbitacin-Inspired Estrone Epidermal Growth Factor Receptor (EGFR) Inhibitor Analogs.
Anim MT, Tuffour I, Willis R, Schell M, Ostlund T, Mahnashi MH, Halaweish F, Willand-Charnley R 		Molecules (Basel, Switzerland) 2023
Bispecific Antibody-Based Immune-Cell Engagers and Their Emerging Therapeutic Targets in Cancer Immunotherapy.
Shin HG, Yang HR, Yoon A, Lee S 		International journal of molecular sciences 2022
Targeting of HER/ErbB family proteins using broad spectrum Sec61 inhibitors coibamide A and apratoxin A
S Kazemi, S Kawaguchi, CE Badr, DR Mattos, A Ruiz-Saenz, JD Serrill, MM Moasser, BP Dolan, VO Paavilainen, S Oishi, KL McPhail, JE Ishmael 		Biochemical Pharmacology 2021
Immunoexpression of ttf1 and p63 differentiates lung adenocarcinomas in sputum samples
VS Veena, VN Saritha, PS George, K Rajan, K Jayasree, K Sujathan 		Journal of Cytology / Indian Academy of Cytologists 2021
Anti‑HER3 monoclonal antibody exerts antitumor activity in a mouse model of colorectal adenocarcinoma
T Asano, T Ohishi, J Takei, T Nakamura, R Nanamiya, H Hosono, T Tanaka, M Sano, H Harada, M Kawada, M Kaneko, Y Kato 		Oncology reports 2021
PET and SPECT Imaging of the EGFR Family (RTK Class I) in Oncology
SS Rinne, A Orlova, V Tolmachev 		International journal of molecular sciences 2021
iRhom2: An Emerging Adaptor Regulating Immunity and Disease
MA Al-Salihi, PA Lang 		International journal of molecular sciences 2020
Single-molecule functional anatomy of endogenous HER2-HER3 heterodimers
B Choi, M Cha, GS Eun, DH Lee, S Lee, M Ehsan, PS Chae, WD Heo, YK Park, TY Yoon 		eLife 2020
NIR Photodynamic Destruction of PDAC and HNSCC Nodules Using Triple-Receptor-Targeted Photoimmuno-Nanoconjugates: Targeting Heterogeneity in Cancer
S Bano, G Obaid, JW Swain, M Yamada, BW Pogue, K Wang, T Hasan 		Journal of Clinical Medicine 2020
Metastatic Lung Cancer to the Distal Finger Presenting as Osteomyelitis
LG Diramerian, E Griffin, K Pendergrast, E Arsura, M Roberts 		Cureus 2020
Generation of a soluble and stable apoptin-EGF fusion protein, a targeted viral protein applicable for tumor therapy
N Niesler, J Arndt, K Silberreis, H Fuchs 		Protein Expression and Purification 2020
Established, emerging and elusive molecular targets in the treatment of lung cancer: Clinically relevant molecular subsets of lung cancer
JN Gallant, CM Lovly 		The Journal of Pathology 2018
EGFR overexpression is not common in patients with head and neck cancer. Cell lines are not representative for the clinical situation in this indication
SS Khaznadar, M Khan, E Schmid, S Gebhart, ET Becker, T Krahn, O von Ahsen 		Oncotarget 2018
STAT3 signaling mediates tumour resistance to EGFR targeted therapeutics
AA Zulkifli, FH Tan, TL Putoczki, SS Stylli, RB Luwor 		Molecular and Cellular Endocrinology 2017
A Neuro-oncologist’s Perspective on Management of Brain Metastases in Patients with EGFR Mutant Non-small Cell Lung Cancer
T McGranahan, S Nagpal 		Current Treatment Options in Oncology 2017
A novel recombinant anti-epidermal growth factor receptor peptide vaccine capable of active immunization and reduction of tumor volume in a mouse model: A novel recombinant EGFR peptide vaccine
M Asadi-Ghalehni, MJ Rasaee, M RajabiBazl, M Khosravani, M Motaghinejad, M Javanmardi, S Khalili, H Modjtahedi, E Sadroddiny 		Microbiology and Immunology 2017
Balancing potency, metabolic stability and permeability in pyrrolopyrimidine-based EGFR inhibitors
J Han, S Henriksen, KG Nørsett, E Sundby, BH Hoff 		European Journal of Medicinal Chemistry 2016
Functional evaluation of fluorescein-labeled derivatives of a peptide inhibitor of the EGF receptor dimerization
K Toyama, T Mizuguchi, W Nomura, H Tamamura 		Bioorganic & Medicinal Chemistry 2016
Receptor Tyrosine Kinases: Family and Subfamilies
DL Wheeler, Y Yarden 		2015
ABC Transporters in Multi-Drug Resistance and ADME-Tox of Small Molecule Tyrosine Kinase Inhibitors
J Deng, J Shao, JS Markowitz, G An 		Pharmaceutical Research 2014
Enzyme- and Transporter-Mediated Drug Interactions with Small Molecule Tyrosine Kinase Inhibitors
J Shao, JS Markowitz, D Bei, G An 		Journal of Pharmaceutical Sciences 2014
Pattern recognition of HER-1 in biological fluids using stochastic sensing
RI Staden, I Moldoveanu, CS Gavan 		Journal of Enzyme Inhibition and Medicinal Chemistry 2014
MicroRNA in Development and in the Progression of Cancer
SR Singh, P Rameshwar 		2014
A view on EGFR-targeted therapies from the oncogene-addiction perspective
R Perez, T Crombet, J Leon, E Moreno 		Frontiers in pharmacology 2013
The ERBB network: at last, cancer therapy meets systems biology
Y Yarden, G Pines 		Nature Reviews Cancer 2012
Lentiviral vector followed by protein immunisation breaks tolerance against the self-antigen Her1 and results in lung cancer immunotherapy : Lentiviral vector immunotherapy for lung cancer
YA Alpizar, K Karwacz, F Arce, AY Rivera, LE Fernández, MK Collins, BS Ramírez 		The Journal of Gene Medicine 2012
Evaluation of dimerization–inhibitory activities of cyclic peptides containing a β-hairpin loop sequence of the EGF receptor
T Mizuguchi, N Ohara, M Iida, R Ninomiya, S Wada, Y Kiso, K Saito, K Akaji 		Bioorganic & Medicinal Chemistry 2012
Effects of an epidermal growth factor receptor-based cancer vaccine on wound healing and inflammation processes in murine experimental models
D Fuentes, L Chacón, A Casacó, N Ledón, N Fernández, A Iglesias, DR Hernández, B Sánchez, R Pérez 		International Wound Journal 2012
An overview of the molecular pathology of head and neck cancer, and its clinical implications
K Hunter, EK Parkinson, N Thakker 		Periodontology 2000 2011
Cetuximab induces mitochondrial translocalization of EGFRvIII, but not EGFR: involvement of mitochondria in tumor drug resistance?
A Dreier, S Barth, A Goswami, J Weis 		Tumor Biology 2011
Reconstitution of Amphiregulin–Epidermal Growth Factor Receptor Signaling in Lung Squamous Cell Carcinomas Activates PTHrP Gene Expression and Contributes to Cancer-Mediated Diseases of the Bone
JL Gilmore, RM Gonterman, K Menon, G Lorch, DJ Riese, A Robling, J Foley 		Molecular cancer research : MCR 2009
The epidermal growth factor system of ligands and receptors in cancer
WJ Gullick 		European Journal of Cancer 2009
Inhibitory effect of a dimerization-arm-mimetic peptide on EGF receptor activation
T Mizuguchi, H Uchimura, T Kakizawa, T Kimura, S Yokoyama, Y Kiso, K Saito 		Bioorganic & Medicinal Chemistry Letters 2009
Allergy Frontiers: Classification and Pathomechanisms
R Pawankar, ST Holgate, LJ Rosenwasser 		2009
Anti-EGFR activation, anti-proliferative and pro-apoptotic effects of polyclonal antibodies induced by EGFR-based cancer vaccine
BS Ramírez, YA Alpízar, DR Fernández, GG Hidalgo, AR Capote, RP Rodríguez, LE Fernández 		Vaccine 2008
Enhanced phosphorylation of the epidermal growth factor receptor at the site of tyrosine 992 in esophageal carcinomas 
M Miyawaki, N Hijiya, Y Tsukamoto, C Nakada, K Kawahara, M Moriyama 		APMIS 2008
Lung Cancer
RS Herbst, JV Heymach, SM Lippman 		New England Journal of Medicine 2008
Multiple TLRs activate EGFR via a signaling cascade to produce innate immune responses in airway epithelium
JL Koff, MX Shao, IF Ueki, JA Nadel 		American journal of physiology. Lung cellular and molecular physiology 2008
HER Receptor Family: Novel Candidate for Targeted Therapy for Gallbladder and Extrahepatic Bile Duct Cancer
T Kawamoto, S Krishnamurthy, E Tarco, S Trivedi, II Wistuba, D Li, I Roa, JC Roa, MB Thomas 		Gastrointestinal cancer research : GCR 2007
Epidermal growth factor receptor is not amplified in schwannomas
RA Prayson, BJ Yoder, GH Barnett 		Annals of Diagnostic Pathology 2007
Modern Nutrition Science
C Cooper, E Tredget, C Watters 		Nutrition and Wound Healing 2006
Regulation of mucin expression: Mechanistic aspects and implications for cancer and inflammatory diseases
M Andrianifahanana, N Moniaux, SK Batra 		Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 2006
Active antimetastatic immunotherapy in Lewis lung carcinoma with self EGFR extracellular domain protein in VSSP adjuvant
BS Ramírez, ES Pestana, GG Hidalgo, TH García, RP Rodríguez, A Ullrich, LE Férnandez 		International Journal of Cancer 2006
Treatment of non-small cell lung cancer with intensity-modulated radiation therapy in combination with cetuximab: the NEAR protocol (NCT00115518)
AD Jensen, MW Münter, H Bischoff, R Haselmann, C Timke, R Krempien, F Sterzing, S Nill, S Heeger, A Hoess, U Haberkorn, PE Huber, M Steins, M Thomas, J Debus, KK Herfarth 		BMC Cancer 2006
Engineering and characterisation of chimeric monoclonal antibody 806 (ch806) for targeted immunotherapy of tumours expressing de2-7 EGFR or amplified EGFR
C Panousis, VM Rayzman, TG Johns, C Renner, Z Liu, G Cartwright, FT Lee, D Wang, H Gan, D Cao, A Kypridis, FE Smyth, MW Brechbiel, AW Burgess, LJ Old, AM Scott 		British Journal of Cancer 2005
Cyclooxygenase-2 protein levels are independent of epidermal growth factor receptor expression or activation in operable non-small cell lung cancer
CM Richardson, D Richardson, DE Swinson, WA Swain, G Cox, KJ O’Byrne 		Lung Cancer 2005
Tumor Cavitation in Stage I Non–Small Cell Lung Cancer: Epidermal Growth Factor Receptor Expression and Prediction of Poor Outcome1
A Onn, DH Choe, RS Herbst, AM Correa, RF Munden, MT Truong, AA Vaporciyan, T Isobe, MZ Gilcrease, EM Marom 		Radiology 2005
Epidermal Growth Factor Receptor (EGFR) Expression in Operable Non-small Cell Lung Carcinoma
JH Ahn, SW Kim, SM Hong, C Suh, WK Kim, IC Lee, JS Lee 		Journal of Korean Medical Science 2004
Expression of Epidermal Growth Factor Receptor in Cervical Tissue and Serum in Patients with Cervical Neoplasia
SC Kim, HM Park, SN Lee, WS Han 		Journal of Lower Genital Tract Disease 2004
Potential role for epidermal growth factor receptor inhibitors in combined-modality therapy for non–small-cell lung cancer
DW Kim, H Choy 		International journal of radiation oncology, biology, physics 2004
Radioimmunotherapy as a novel treatment regimen: 125I-labeled monoclonal antibody 425 in the treatment of high-grade brain gliomas
TS Quang, LW Brady 		International journal of radiation oncology, biology, physics 2004
Epidermal Growth Factor Receptor as a Target to Improve Treatment of Lung Cancer
NH Andratschke, KH Dittmann, KA Mason, Z Fan, Z Liao, R Komaki, KK Ang, L Milas 		Clinical Lung Cancer 2004
Epidermal growth factor receptor overexpression correlates with a poor prognosis in completely resected non-small-cell lung cancer
G Selvaggi, S Novello, V Torri, E Leonardo, PD Giuli, P Borasio, C Mossetti, F Ardissone, P Lausi, GV Scagliotti 		Annals of Oncology 2004
Synchronous Overexpression of Epidermal Growth Factor Receptor and HER2- neu Protein Is a Predictor of Poor Outcome in Patients with Stage I Non-Small Cell Lung Cancer
A Onn, AM Correa, M Gilcrease, T Isobe, E Massarelli, CD Bucana, MS OReilly, WK Hong, IJ Fidler, JB Putnam, RS Herbst 		Clinical cancer research 2004
Epidermal growth factor receptors and cyclooxygenase-2 in the pathogenesis of non-small cell lung cancer: potential targets for chemoprevention and systemic therapy
CM Richardson, RA Sharma, G Cox, KJ O'Byrne 		Lung Cancer 2003
EXPRESSION OF FIBROBLAST GROWTH FACTOR RECEPTOR GENES IN HUMAN HEPATOMA-DERIVED CELL LINES
N Asada, Y Tanaka, Y Hayashido, S Toratani, M Kan, M Kitamoto, T Nakanishi, G Kajiyama, K Chayama, T Okamoto 		In vitro cellular & developmental biology. Animal 2003
Epidermal growth factor receptor family in lung cancer and premalignancy
WA Franklin, R Veve, FR Hirsch, BA Helfrich, PA Bunn 		Seminars in Oncology 2002
Applied Immunohistochemistry
M Wu, T Putti, T Bhuiya 		Applied Immunohistochemistry 2002
Lung cancer. 1: prevention of lung cancer
GE Goodman 		Thorax 2002
Comparative Study in the Expression of p53, EGFR, TGF-α, and Cyclin D1 in Verrucous Carcinoma, Verrucous Hyperplasia, and Squamous Cell Carcinoma of Head and Neck Region:
M Wu, TC Putti, TA Bhuiya 		Applied Immunohistochemistry & Molecular Morphology 2002
Radioimmunohistochemistry of Epidermal Growth Factor Receptor in Breast Cancer
KW Robertson, JR Reeves, AK Lannigan, JJ Going, TG Cooke, PD Stanton 		Archives of pathology & laboratory medicine 2002
Evaluating HER2 amplification and overexpression in breast cancer
JM Bartlett, JJ Going, EA Mallon, AD Watters, JR Reeves, P Stanton, J Richmond, B Donald, R Ferrier, TG Cooke 		The Journal of Pathology 2001
Update on HER-2 as a target for cancer therapy: Alternative strategies for targeting the epidermal growth factor system in cancer
WJ Gullick 		Breast Cancer Research 2001
Thoracic Oncology
DS Ettinger 		2001
Induction of apoptosis and activation of the caspase cascade by anti-EGF receptor monoclonal antibodies in DiFi human colon cancer cells do not involve the c-jun N-terminal kinase activity
B Liu, M Fang, M Schmidt, Y Lu, J Mendelsohn, Z Fan 		British Journal of Cancer 2000
Human mammary epithelial cells rapidly exchange empty EGFR between surface and intracellular pools
PM Burke, HS Wiley 		Journal of Cellular Physiology 1999
Epidermal growth factor system regulates mucin production in airways
K Takeyama, K Dabbagh, HM Lee, C Agustí, JA Lausier, IF Ueki, KM Grattan, JA Nadel 		Proceedings of the National Academy of Sciences 1999
Reverse transcriptase polymerase chain reaction as a reliable method to detect epidermal growth factor receptor exon 2–7 gene deletion in human glioblastomas
K Worm, P Dabbagh, K Schwechheimer 		Human Pathology 1999
Epstein-Barr virus-encoded latent membrane protein 1 co-expresses with epidermal growth factor receptor in nasopharyngeal carcinoma
T S Sheen, Y T Huang, Y L Chang, J Y Ko, C S Wu, Y C Yu, C H Tsai, M M Hsu 		Japanese journal of cancer research : Gann 1999
Epstein‐Barr Virus‐encoded Latent Membrane Protein 1 Co‐expresses with Epidermal Growth Factor Receptor in Nasopharyngeal Carcinoma
Sheen T, Huang Y, Chang Y, Ko J, Wu C, Yu Y, Tsai C, Hsu M 		Japanese journal of cancer research : Gann 1999
Recombinant toxins in haematologic malignancies and solid tumours
RJ Kreitman 		Expert Opinion on Investigational Drugs 1998
Characterization of human epidermal growth factor receptor and c-Src interactions in human breast tumor cells
JS Biscardi, AP Belsches, SJ Parsons 		Molecular Carcinogenesis 1998
Bispecific antibodies for treatment of cancer in experimental animal models and man
BJ Kroesen, W Helfrich, G Molema, L Leij 		Advanced Drug Delivery Reviews 1998
The erbB/HER type 1 tyrosine kinase receptor family
RA Walker 		The Journal of Pathology 1998
Prognostic implications of epidermal growth factor receptor immunoreactivity in squamous cell carcinoma of the oral mucosa
E Maiorano, G Favia, P Maisonneuve, G Viale 		The Journal of Pathology 1998
Immunotoxins for targeted cancer therapy
RJ Kreitman, I Pastan 		Advanced Drug Delivery Reviews 1998
The type 1 growth factor receptor family: new ligands and receptors and their role in breast cancer
WJ Gullick, R Srinivasan 		Breast Cancer Research and Treatment 1998
The transcription factor AP-1 is required for EGF-induced activation of rho-like GTPases, cytoskeletal rearrangements, motility, and in vitro invasion of A431 cells
A Malliri, M Symons, RF Hennigan, AF Hurlstone, RF Lamb, T Wheeler, BW Ozanne 		The Journal of Cell Biology 1998
Hormones and Signaling
CK Tang, ME Lippman 		Hormones and Signaling 1998
EGF-Receptor Phosphorylation and Signaling Are Targeted by H 2 O 2 Redox Stress
T Goldkorn, N Balaban, K Matsukuma, V Chea, R Gould, J Last, C Chan, C Chavez 		American journal of respiratory cell and molecular biology 1998
Peroxynitrite Induces Covalent Dimerization of Epidermal Growth Factor Receptors in A431 Epidermoid Carcinoma Cells
A der Vliet, M Hristova, CE Cross, JP Eiserich, T Goldkorn 		The Journal of biological chemistry 1998
Prognostic variables in node-negative and node-positive breast cancer
G Gasparini 		1998
An antisense EGFR oligodeoxynucleotide enveloped in Lipofectin induces growth inhibition in human malignant gliomas in vitro
N Sugawa, S Ueda, Y Nakagawa, H Nishino, K Nosaka, A Iwashima, M Kurimoto 		Journal of Neuro-Oncology 1998
Expression of epidermal growth factor receptor in gestational trophoblastic diseases
P Balaram, M John, TN Rajalekshmy, B Nair, G Schultz, K Nair 		Journal of Cancer Research and Clinical Oncology 1997
Analysis of the Ability of 12-O-Tetradecanoylphorbol-13-Acetate to Induce Epidermal Hyperplasia, Transforming Growth Factor-alpha, and Skin Tumor Promotion in wa-1 Mice
K Kiguchi, L Beltran, A Dubowski, J DiGiovanni 		Journal of Investigative Dermatology 1997
Schannoma cells induce a tumor-cell-specific cytotoxic- T-cell response upon transplantation into syngeneic rats but escape elimination through the secretion of immunosuppressive factors
U Altenschmidt, R Kahl, E Klundt, E Stöcklin, M Mihatsch, K Weindel, B Groner 		International Journal of Cancer 1997
Combined chromosome microdissection and comparative genomic hybridization detect multiple sites of amplified DNA in a human lung carcinoma cell line
T Taguchi, GZ Cheng, DW Bell, B Balsara, Z Liu, JM Siegfried, JR Testa 		Genes, Chromosomes and Cancer 1997
Expression and activation of epidermal growth factor receptors in meningiomas
RS Carroll, PM Black, J Zhang, M Kirsch, I Percec, N Lau, A Guha 		Journal of Neurosurgery 1997
Expression of ER-DS and EGFr in Laryngeal Carcinoma and Pre-malignant Epithelium
E Maiorano, MA Botticella, A Marzullo, L Resta 		Acta Oto-laryngologica 1997
Genetic factors in lung disease Part II: Lung cancer and angiotensin converting enzyme gene
Y KAWAKAMI, E YAMAGUCHI, M MUNAKATA, H DOSAKA-AKITA, K FURUYA 		Respirology 1997
Identification of Epidermal Growth Factor Receptor and c-erbB2 Pathway Inhibitors by Correlation With Gene Expression Patterns
K Wosikowski, D Schuurhuis, K Johnson, SE Bates, KD Paull, TG Myers, JN Weinstein 		JNCI Journal of the National Cancer Institute 1997
Growth Factors and Cytokines in Health and Disease
P Martin, J McCluskey, P Mallucci, S Nodder 		Growth Factors and Cytokines in Health and Disease 1997
Epidermal growth factor receptor immunoreactivity in human laryngeal squamous cell carcinoma
CS Lee, A Redshaw, G Boag 		Pathology 1997
Overexpression of Cellular Src in Fibroblasts Enhances Endocytic Internalization of Epidermal Growth Factor Receptor
MF Ware, DA Tice, SJ Parsons, DA Lauffenburger 		The Journal of biological chemistry 1997
EGF Receptor in Tumor Growth and Progression
RB Lichtner, RN Harkins 		1997
Cancer Therapeutics
BA Teicher 		1997
Ligand Activation of Overexpressed Epidermal Growth Factor Receptor Results in Loss of Epithelial Phenotype and Impaired RGD-Sensitive Integrin Function in HSC-1 Cells
K Fujii 		Journal of Investigative Dermatology 1996
Adenocarcinoma of duodenum and ampulla of Vater: Clinicopathology study and expression of p53, c-neu, TGF-α, CEA, and EMA
L Zhu, K Kim, DR Domenico, HE Appert, JM Howard 		Journal of Surgical Oncology 1996
Multifactor regulation of prostaglandin H synthase-2 in murine keratinocytes
RE Maldve, SM Fischer 		Molecular Carcinogenesis 1996
An enhanced and sensitive autocrine stimulation by transforming growth factor-alpha is acquired in the brain metastatic variant of a human non-small-cell lung cancer cell line
K Fang 		British Journal of Cancer 1996
Lack of prognostic significance of epidermal growth factor receptor and the oncoprotein p185HER-2 in patients with systemically untreated non-small-cell lung cancer: an immunohistochemical study on cryosections
P Pfeiffer, PP Clausen, K Andersen, C Rose 		British Journal of Cancer 1996
Peptides and growth factors in non-small cell lung cancer
TW Moody 		Peptides 1996
Keratinocytes and Cytokine/Growth Factors
C Feliciani, AK Gupta, DN Saucier 		Critical Reviews in Oral Biology & Medicine 1996
Pancreatic cancer: the potential clinical relevance of alterations in growth factors and their receptors
H Friess, P Berberat, M Schilling, J Kunz, MW Büchler, M Korc 		Journal of Molecular Medicine 1996
Molecular alterations in head and neck squamous cell carcinoma
L Bron, P Monnier 		Clinical Otolaryngology 1995
Epidermal growth factor receptor (EGFr) expression in non-small cell lung carcinomas correlates with metastatic involvement of hilar and mediastinal lymph nodes in the squamous subtype
G Fontanini 		European Journal of Cancer 1995
Epidermal Growth Factor Receptor Immunoreactivity in Gallbladder and Extrahepatic Biliary Tract Tumours
CS Lee, A Pirdas 		Pathology - Research and Practice 1995
Immunotoxin Therapy of Cancer: Rationale For Development and Future Potential
CR Bachier, CF LeMaistre 		Clinical immunotherapeutics 1995
Large-scale production and purification of clinical grade pseudomonas aeruginosa exotoxin A from E. coli
A Tsai, M Gallo, T Petterson, J Shiloach 		Bioprocess Engineering 1995
Immunohistochemical localization of epidermal growth factor receptor and epithelial antigen in tumors of the human conjunctiva, eyelid, lacrimal gland, and orbit
T Kodama, S Hayasaka, T Setogawa 		Graefe's Archive for Clinical and Experimental Ophthalmology 1995
Effects of vinorelbine on epidermal growth factor-receptor binding of human breast cancer cell linesin vitro
H Depenbrock, A Shirvani, J Rastetter, 		Investigational New Drugs 1995
Molekularbiologische Grundlagen der Gastroenterologie
HG Beger, MP Manns, H Greten 		1995
Cellular Cancer Markers
CT Garrett, S Sell 		1995
Receptor blockade with monoclomal antibodies as anti-cancer therapy
J Baselga, J Mendelsohn 		Pharmacology & Therapeutics 1994
Immunocytochemical localization of fibroblast growth factor-1 (FGF-1) and FGF-2 in oral squamous cell carcinoma (SCC)
Y Myoken, Y Myoken, T Okamoto, JD Sato, K Takada 		Journal of Oral Pathology and Medicine 1994
EPIDERMAL GROWTH FACTOR BINDING BY MEMBRANES OF HUMAN RENAL CELL CARCINOMAS: ESTABLISHMENT OF AN EPIDERMAL GROWTH FACTOR RECEPTOR ASSAY FOR CLINICAL USE
K Yoshida, A Tosaka 		International Journal of Urology 1994
Altered expression of the epidermal growth factor receptor and transforming growth factor-α during multistage skin carcinogenesis in SENCAR mice
O Rho, LM Beltrán, IB Gimenez-Conti, J Digiovanni 		Molecular Carcinogenesis 1994
Epidermal Growth Factor Receptor Expression and Endometrial Cancer Histotypes
VM Jasonni, D Santini, A Amadori, C Ceccarelli, S Naldi 		Annals of the New York Academy of Sciences 1994
Epidermal growth factor receptor expression by human squamous cell carcinomas of the head and neck, cell lines and xenografts
P Stanton, S Richards, J Reeves, M Nikolic, K Edington, L Clark, G Robertson, D Souter, R Mitchell, FJ Hendler 		British Journal of Cancer 1994
Detection of epidermal growth factor receptor mRNA in tissue sections from biopsy specimens using in situ polymerase chain reaction
VG Patel, A Shum-Siu, BW Heniford, TJ Wieman, FJ Hendler 		The American Journal of Pathology 1994
Differentiation of thyroid neoplasms by evaluating epithelial membrane antigen, Leu-7 antigen, epidermal growth factor receptor, and DNA content
RE Cheifetz, NL Davis, BW Robinson, KW Berean, JC LeRiche 		The American Journal of Surgery 1994
Co-expression of epidermal growth factor-receptor and c-erb B-2 proto-oncogene product in human salivary-gland adenocarcinoma cell line HSG and the implications for HSG cell autocrine growth
S Kyakumoto, R Kurokawa, M Hoshino, M Ota 		Archives of Oral Biology 1994
Advances in Pharmacology
B Drenger, Y Ginosar, Y Gozal 		Advances in Pharmacology 1994
Effects of the microtubule-disturbing agents docetaxel (taxotere®), vinblastine and vincristine on epidermal growth factor-receptor binding of human breast cancer cell lines in vitro
AR Hanauske, H Depenbrock, D Shirvani, J Rastetter 		European Journal of Cancer 1994
Receptor para el factor de crecimiento epidérmico en el cáncer de pulmón no microcítico
M Díez, ML Maestro, A Torres, F Hernando, MD Ortega, JA García-Asenjo, A Picardo, JM Mugüerza, A Sánchez-Pernaute, JL Balibrea 		Archivos de Bronconeumología 1994
Amplification and differential expression of members of theerbB-gene family in human glioblastoma
J Schlegel, G Stumm, K Brndle, A Merdes, G Mechtersheimer, NE Hynes, M Kiessling 		Journal of Neuro-Oncology 1994
Elevated serum levels of a c-erbB-2 oncogene product in ovarian cancer patients and in pregnancy
H Meden, D Marx, A Fattahi, W Rath, M Kron, W Wuttke, A Schauer, W Kuhn 		Journal of Cancer Research and Clinical Oncology 1994
Cell-signaling targets for antitumour drug development
VG Brunton, P Workman 		Cancer Chemotherapy and Pharmacology 1993
Prognostic significance of transforming growth factor-α in human esophageal carcinoma implication for the autocrine proliferation
K Iihara, H Shiozaki, H Tahara, K Kobayashi, M Inoue, S Tamura, M Miyata, H Oka, Y Doki, T Mori 		Cancer 1993
Epidermal growth factor receptor expression in three different human endometrial cancer cell lines
RJ Lelle, F Talavera, H Gretz, JA Roberts, KM Menon 		Cancer 1993
Anti-epidermal growth factor receptor monoclonal antibodies affecting signal transduction
HA Reins, G Steinhilber, B Freiberg, FA Anderer 		Journal of Cellular Biochemistry 1993
Genetic changes in lung cancer
U Pastorino, G Sozzi, M Miozzo, E Tagliabue, S Pilotti, MA Pierotti 		Journal of Cellular Biochemistry 1993
Proliferative state of the urothelium with benign and atypical changes. Correlation with transferrin and epidermal growth factor receptors and blood group antigens
C Limas 		The Journal of Pathology 1993
The role of the pathologist in the clinical management of lung cancer in the 90's
FR Hirsch, K Rygaard 		Lung Cancer 1993
Consumption of EGF by A431 cells: evidence for receptor recycling
H Masui, L Castro, J Mendelsohn 		The Journal of Cell Biology 1993
The human EGF receptor as a target for cancer therapy: six new rat mAbs against the receptor on the breast carcinoma MDA-MB 468
H Modjtahedi, JM Styles, CJ Dean 		British Journal of Cancer 1993
Variation in cellular EGF receptor mRNA expression demonstrated by in situ reverse transcriptase polymerase chain reaction
BW Heniford, A Shum-Siu, M Leonberger, FJ Hendler 		Nucleic Acids Research 1993
Bronchial epithelial changes associated with small cell carcinoma of the lung
K Yoneda, LD Boucher 		Human Pathology 1993
Oncogenes and onco-suppressor genes in lung cancer
ML Anderson, DA Spandidos 		Respiratory Medicine 1993
Photodynamic therapy of squamous cell carcinoma. An evaluation of a new photosensitizing agent, benzoporphyrin derivative and new photoimmunoconjugate
AW Hemming, NL Davis, B Dubois, NF Quenville, RJ Finley 		Surgical Oncology 1993
Epidermal growth factor receptor and lipid membrane components in human lung cancers
AD Carlo, A Mariano, PE Macchia, C Cecere, G Ferrante, V Macchia 		Journal of Endocrinological Investigation 1993
Initiators and Promoters of Lung Cancer
JL Mulshine, AM Treston, PH Brown, MJ Birrer, GL Shaw 		Chest 1993
The neu-oncogene product in serum and tissue of patients with breast carcinoma
R Kath, K Höftken, K Metz, F Hülskamp, C Otte, ME Scheulen, S Seeber 		Annals of Oncology 1993
Expression of epidermal growth factor receptors by odontogenic jaw cysts
TJ Li, RM Browne, JB Matthews 		Virchows Archiv A Pathological Anatomy and Histopathology 1993
Transgenic Animals as Model Systems for Human Diseases
EF Wagner, F Theuring 		1993
ONCOGENES AND GROWTH FACTORS IN HUMAN LUNG CANCER
JA Kern, AE Filderman 		Clinics in Chest Medicine 1993
Increased binding capacity of receptors for the epidermal growth factor in benign thyroid nodules and thyroid malignancies
B Saller, G Stapfer, B Bein, R Hoermann, F Spelsberg, K Mann 		The Clinical Investigator 1993
Molecular markers for the diagnosis and prognosis of lung cancer
AF Gazdar 		Cancer 1992
Transforming growth factors and related peptides in gastrointestinal neoplasia
RJ Coffey, CM McCutchen, R Graves-Deal, WH Polk 		Journal of Cellular Biochemistry 1992
Prognostic markers of colorectal cancer: An evaluation of DNA content, epidermal growth factor receptor, and Ki-67
AW Hemming, NL Davis, A Kluftinger, B Robinson, NF Quenville, B Liseman, J Lcriche 		Journal of Surgical Oncology 1992
Overexpression of the c-erbB-2/neu–encoded p185 protein in primary lung cancer
D Shi, G He, S Cao, W Pan, HZ Zhang, D Yu, MC Hung 		Molecular Carcinogenesis 1992
Expression of epidermal growth factor receptor and transforming growth factor α in human larynx carcinoma
ED Marco, E Albanese, S Benso, F Beatrice, R Cancedda, S Toma 		Cancer Letters 1992
Immunohistochemical demonstration of elevated expression of epidermal growth factor receptor in the neoplastic changes of cervical squamous epithelium
T Maruo, M Yamasaki, CA Ladines-Llave, M Mochizuki 		Cancer 1992
Variation in EGF-induced EGF receptor downregulation in human hepatoma-derived cell lines expressing different amounts of EGF receptor
A Gilligan, S Bushmeyer, BB Knowles 		Experimental Cell Research 1992
Growth control by epidermal growth factor and transforming growth factor-alpha in human lung squamous carcinoma cells
GJ Rabiasz, SP Langdon, JM Bartlett, AJ Crew, EP Miller, WN Scott, JF Smyth, WR Miller 		British Journal of Cancer 1992
Evaluation of epidermal growth factor receptor in squamous cell carcinoma of the oral cavity
T Yamada, M Takagi, S Shioda 		Oral Surgery, Oral Medicine, Oral Pathology 1992
Pulmonary Endocrine Pathology
JR Gosney 		Pulmonary Endocrine Pathology 1992
Epidermal growth factor receptor in human brain tumors
AD Carlo, A Mariano, PE Macchia, MC Moroni, L Beguinot, V Macchia 		Journal of Endocrinological Investigation 1992
Targeting growth factor receptors with fusion toxins
RJ Kreitman, D Fitzgerald, I Pastan 		International Journal of Immunopharmacology 1992
Expression of Epidermal Growth Factor Receptor in Plutonium-239-induced Lung Neoplasms in Dogs
NA Gillett, BL Stegelmeier, G Kelly, PJ Haley, FF Hahn 		Veterinary pathology 1992
Rational design of a chimeric toxin: an intramolecular location for the insertion of transforming growth factor .alpha. within Pseudomonas exotoxin as a targeting ligand
RJ Kreitman, VK Chaudhary, CB Siegall, DJ FitzGerald, I Pastan 		Bioconjugate Chemistry 1992
Oncogenes in Ovarian Cancer
A Berchuck, MF Kohler, RC Bast 		Hematology/Oncology Clinics of North America 1992
Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development
FA Valeriote, TH Corbett, LH Baker 		1992
Breast Cancer: Biological and Clinical Progress
L Dogliotti, A Sapino, G Bussolati 		1992
Role of Peptide Growth Factors in Asbestos-Related Human Lung Cancer
B Guillemin, Y Zhang, TC Lee, WN Rom 		Annals of the New York Academy of Sciences 1991
Molecular mechanisms in lung pathogenesis
DL Bucchagen 		Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1991
Immunohistologic detection of the epidermal growth factor receptor in human esophageal squamous cell carcinoma
H Yano, H Shiozaki, K Kobayashi, T Yano, H Tahara, S Tamura, T Mori 		Cancer 1991
Dexamethasone and retinoic acid regulate the expression of epidermal growth factor receptor mRNA by distinct mechanisms
KC Oberg, G Carpenter 		Journal of Cellular Physiology 1991
The EGF Receptor System as a Target for Antitumor Therapy
BW Ennis, ME Lippman, RB Dickson 		Cancer Investigation 1991
Immunoreactivity and receptor expression of insulinlike growth factor I and insulin in human adrenal tumors. An immunohistochemical study of 94 cases
T Kamio, K Shigematsu, K Kawai, H Tsuchiyama 		The American Journal of Pathology 1991
Epidermal growth factor receptor in lung malignancies. Comparison between cancer and normal tissue
R Dittadi, M Gion, V Pagan, A Brazzale, OD Maschio, A Bargossi, A Busetto, G Bruscagnin 		British Journal of Cancer 1991
Measurement of human epidermal growth factor receptor in the endometrium during the menstrual cycle
V Troche, DM O’Connor, RP Schaudies 		American Journal of Obstetrics and Gynecology 1991
Patterns of Epidermal Growth Factor Receptors in Basal and Squamous Cell Carcinoma
EA Springer, JK Robinson 		The Journal of Dermatologic Surgery and Oncology 1991
Influence of Chloroquine and Lidocaine on Retention and Cytotoxic Effects of [ 131 I]EGF: Studies on Cultured Glioma Cells
J Capala, J Carlsson 		International Journal of Radiation Biology 1991
Immunohistochemical Study of Epidermal Growth Factor Receptor in Severe Dysplasia and Carcinoma in situ of the Vocal Cords
M Miyaguchi, J Olofsson, HB Hellquist 		Acta Oto-laryngologica 1991
Immunohistochemical localization of epidermal growth factor (EGF) and EGF receptor in human oral mucosa and its malignancy
K Shirasuna, Y Hayashido, M Sugiyama, H Yoshioka, T Matsuya 		Virchows Archiv A Pathological Anatomy and Histopathology 1991
Recombinant Toxins for Cancer Treatment
I Pastan, D FitzGerald 		Science 1991
Characterization of a monoclonal antibody directed against the epidermal growth factor receptor binding site
R Pellegrini, F Centis, S Martignone, A Mastroianni, E Tagliabue, E Tosi, S Ménard, MI Colnaghi 		Cancer Immunology, Immunotherapy 1991
Monoclonal antibodies to epidermal growth factor receptors in studies of receptor structure and function
T Kawamoto, GH Sato, K Takahashi, M Nishi, S Taniguchi, JD Sato 		Cytotechnology 1990
Lung carcinoid cell lines have Bombesin-like peptides and EGF receptors
TW Moody, M Lee, RM Kris, F Bellot, G Bepler, H Oie, AF Gazdar 		Journal of Cellular Biochemistry 1990
Characterization of epidermal growth factor receptor in normal and neoplastic human endometrium
RK Reynolds, F Talavera, JA Roberts, MP Hopkins, KM Menon 		Cancer 1990
Retroviral Expression of Transforming Growth Factor-Alpha Does Not Transform Fibroblasts or Keratinocytes
E Finzi, T Fleming, JH Pierce 		Journal of Investigative Dermatology 1990
Inhibition of epidermal growth factor receptor activity by retinoic acid in glioma cells
PA Steck, A Hadi, R Lotan, WK Yung 		Journal of Cellular Biochemistry 1990
Structure, function and transforming potential of the epidermal growth factor receptor
TJ Velu 		Molecular and Cellular Endocrinology 1990
Association of EGF receptor expression with proliferating cells and of ras p21 expression with differentiating cells in various skin tumours
A Kikuchi, M Amagai, K Hayakawa, M Ueda, S Hirohashi, N Shimizu, T Nishikawa 		British Journal of Dermatology 1990
Chromosome alterations in 21 non-small cell lung carcinomas
I Miura, JM Siegfried, J Resau, SM Keller, JY Zhou, JR Testa 		Genes, Chromosomes and Cancer 1990
Cytogenetics of non-small cell lung cancer: Analysis of consistent non-random abnormalities
R Lukeis, L Irving, M Garson, S Hasthorpe 		Genes, Chromosomes and Cancer 1990
Epidermal growth factor receptors on ependymomas and other brain tumors
WA Hall, MJ Merrill, S Walbridge, RJ Youle 		Journal of Neurosurgery 1990
An immunohistochemical assessment of cellular proliferation markers in head and neck squamous cell cancers
JH Kearsley, KL Furlong, RA Cooke, MJ Waters 		British Journal of Cancer 1990
A truncated, secreted form of the epidermal growth factor receptor is encoded by an alternatively spliced transcript in normal rat tissue
LA Petch, J Harris, VW Raymond, A Blasband, DC Lee, HS Earp 		Molecular and cellular biology 1990
Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas
N Sugawa, AJ Ekstrand, CD James, VP Collins 		Proceedings of the National Academy of Sciences 1990
Inhibition of epidermal growth factor receptor biosynthesis caused by the src oncogene product, pp60v-src
WJ Wasilenko, M Nori, N Testerman, MJ Weber 		Molecular and cellular biology 1990
Immunohistochemical expression of epidermal growth factor receptors in human adrenocortical carcinoma
T Kamio, K Shigematsu, H Sou, K Kawai, H Tsuchiyama 		Human Pathology 1990
Autonomy in tumor cell proliferation
M Chigira, K Noda, H Watanabe 		Medical Hypotheses 1990
Growth factors and oncogenes in pancreatic cancer
NR Lemoine, PA Hall 		Bailliere's Clinical Gastroenterology 1990
Epidermal Growth Factor Receptor mRNA Is Not Increased in Psoriatic Skin
H Kobayashi, H Yasuda, H Matsue, A Ohkawara, Y Ogiso, N Kuzumaki 		The Journal of Dermatology 1990
Expression of Epidermal Growth Factor Receptor in Laryngeal Dysplasia and Carcinoma
M Miyaguchi, J Olofsson, HB Hellquist 		Acta Oto-laryngologica 1990
Keratinocyte Cytokines and Growth Factors: Functions in Skin Immunity and Homeostasis
RC McKenzie, DN Sauder 		Dermatologic Clinics 1990
Biotinylated epidermal growth factor: a useful tool for the histochemical analysis of specific binding sites
K Kayser, G Weisse, HJ Gabius, T Hintze 		The Histochemical Journal 1990
Epidermal growth factor receptor overexpression and trisomy 7 in a case of Barrett's esophagus
H Garewal, P Meltzer, J Trent, R Prabhala, R Sampliner, M Korc 		Digestive Diseases and Sciences 1990
Epidermal growth factor receptors and adenylate cyclase activity in human thyroid tissues
QY Duh, AE Siperstein, RA Miller, JJ Sancho, MJ Demeure, OH Clark 		World Journal of Surgery 1990
Chemical Carcinogenesis and Mutagenesis II
CS Cooper, PL Grover 		1990
Potential role of the epidermal growth factor receptor in human pancreatic cancer
M Korc 		International Journal of Gastrointestinal Cancer 1990
The expression of epidermal growth factor receptors in the oral mucosa of patients with oral cancer
W Bergler, H Bier, U Ganzer 		Archives of Oto-Rhino-Laryngology 1989
Characterization of insulin-like growth factor I and epidermal growth factor receptors in meningioma
M Kurihara, Y Tokunaga, K Tsutsumi, T Kawaguchi, K Shigematsu, M Niwa, K Mori 		Journal of Neurosurgery 1989
Prognostic significance of epidermal growth factor receptor in esophageal squamous cell carcinomas
S Ozawa, M Ueda, N Ando, N Shimizu, O Abe 		Cancer 1989
Absence of a Stratum Corneum Antigen in Disorders of Epidermal Cell Proliferation: Detection with an Anti-Ganglioside GM3 Antibody
AS Paller, JN Siegel, DE Spalding, EG Bremer 		Journal of Investigative Dermatology 1989
Retroviruses expressing different levels of the normal epidermal growth factor receptor: Biological properties and new bioassay
TJ Velu, L Beguinot, WC Vass, K Zhang, I Pastan, DR Lowy 		Journal of Cellular Biochemistry 1989
Epidermal growth factor receptors in spontaneous ovarian granulosa cell tumors of swr-derived mice
BJ Tennent, WG Beamer, LD Shultz, ED Adamson 		International Journal of Cancer 1989
Expression of epidermal growth factor receptors in four histologic cell types of lung cancer
S Kaseda, M Ueda, S Ozawa, T Ishihara, O Abe, N Shimizu 		Journal of Surgical Oncology 1989
Vegulatory mechanisms of the papillomaviruses
P Ward, DV Coleman, AD Malcolm 		Trends in Genetics 1989
Epidermal Growpi Factor: Its Relevance to Dermatology
LE King, CM Stoscheck 		Cutaneous and Ocular Toxicology 1989
Growth factors and growth factor receptors in human malignancies, with special reference to human lung cancer: a review
L Damstrup, M Rørth, HS Poulsen 		Lung Cancer 1989
Anti-EGF receptor monoclonal antibodies: biological studies and potential clinical applications
J Mendelsohn 		Transactions of the American Clinical and Climatological Association 1989
Expression of epidermal growth factor receptor (EGF-R) in non-small cell lung cancer. Use of archival tissue and correlation of EGF-R with histology, tumour size, node status and survival
H Dazzi, PS Hasleton, N Thatcher, DM Barnes, S Wilkes, R Swindell, RA Lawson 		British Journal of Cancer 1989
Epidermal Growth Factor Receptor Gene Expression in Normal Human Kidney and Renal Cell Carcinoma
ER Sargent, LG Gomella, A Belldegrun, WM Linehan, A Kasid 		The Journal of Urology 1989
Advances in Growth Hormone and Growth Factor Research
EE MÜller, D Cocchi, V Locatelli 		1989
Immunohistochemical expression of epidermal growth factor receptor in salivary gland tumours
K Yamada, K Iwai, Y Okada, M Mori 		Virchows Archiv A Pathological Anatomy and Histopathology 1989
Expression of epidermal growth factor receptor in benign and malignant primary tumours of the breast
P Mller, G Mechtersheimer, M Kaufmann, G Moldenhauer, F Momburg, T Mattfeldt, HF Otto 		Virchows Archiv A Pathological Anatomy and Histopathology 1989
Cell to Cell Signals in Mammalian Development
SW de Laat, JG Bluemink, CL Mummery 		1989
Basic and Clinical Concepts of Lung Cancer
HH Hansen 		1989
Protamine enhances epidermal growth factor (EGF)-stimulated mitogenesis by increasing cell surface EGF receptor number
VB Lokeshwar, SS Huang, JS Huang 		The Journal of biological chemistry 1989
Murine monoclonal antibodies in breast cancer: An overview
JJ Tjandra, IF McKenzie 		British Journal of Surgery 1988
Epidermal growth factor receptor in meningiomas is expressed predominantly on endothelial cells
RA Shiurba, LF Eng, H Vogel, YL Lee, DS Horoupian, H Urich 		Cancer 1988
Simultaneous detection of epidermal growth factor receptor (EGF-R), epidermal growth factor (EGF) and ras p21 in cholangiocarcinoma by an immunocytochemical method
A Nonomura, G Ohta, Y Nakanuma, R Izumi, Y Mizukami, F Matsubara, M Hayashi, K Watanabe, N Takayanagi 		Liver 1988
Ligand activation of overexpressed epidermal growth factor receptors transforms NIH 3T3 mouse fibroblasts
H Riedel, S Massoglia, J Schlessinger, A Ullrich 		Proceedings of the National Academy of Sciences 1988
The Role of Epidermal Growth Factor in Skin Diseases
LE King, DL Ellis, RE Gates, WH Inman, CM Stoscheck, RA Fava, LB Nanney 		The American Journal of the Medical Sciences 1988
Effect of Epidermal Growth Factor (EGF) on a Newly Established Head and Neck Squamous Carcinoma Cell Line
RS Weber, S Pathak, R Frankenthaler, GE Gallick, PG Sacks 		Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 1988
The Immunohistochemical Investigation of Epidermal Growth Factor (EGF) Receptors in Various Gynecological Tumors
FM Wittmaack, D Schwörer, HO Wintzer, SV Kleist, A Pfleidere, T Bauknecht 		International journal of immunopathology and pharmacology 1988
Molecular analysis of signal transduction by growth factors
Y Yarden, A Ullrich 		Biochemistry 1988
The epidermal growth factor receptor as a multifunctional allosteric protein
J Schlessinger 		Biochemistry 1988
Epidermal growth factor receptors in cancer tissues of esophagus, lung, pancreas, colorectum, breast and stomach
S Ozawa, M Ueda, N Ando, O Abe, N Shimizu 		Japanese journal of cancer research : Gann 1988
Epidermal growth factor receptor on human thyroid neoplasms
H Masuda, A Sugenoya, S Kobayashi, Y Kasuga, F Iida 		World Journal of Surgery 1988
Malignant Melanoma: Biology, Diagnosis, and Therapy
L Nathanson 		1988
Epidermal Growth Factor Receptors in Cancer Tissues of Esophagus, Lung, Pancreas, Colorectum, Breast and Stomach
Ozawa S, Ueda M, Ando N, Abe O, Shimizu N 		Japanese journal of cancer research : Gann 1988
OVEREXPRESSION OF THE c-erbB-2 ONCOPROTEIN IN HUMAN BREAST CARCINOMAS: IMMUNOHISTOLOGICAL ASSESSMENT CORRELATES WITH GENE AMPLIFICATION
DJ Venter, S Kumar, NL Tuzi, WJ Gullick 		The Lancet 1987
Subversion of growth regulatory pathways in malignant transformation
CH Heldin, C Betsholtz, L Claesson-Welsh, B Westermark 		Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1987
Down-modulation of EGF receptors in cells transformed by thesrc oncogene
WJ Wasilenko, LK Shawver, MJ Weber 		Journal of Cellular Physiology 1987
Epidermal growth factor receptors in lung tumours
MS Berger, WJ Gullick, C Greenfield, S Evans, BJ Addis, MD Waterfield 		The Journal of Pathology 1987
Stimulation by EGF of the growth of EGF receptor-hyperproducing tumor cells in athymic mice
S Ozawa, M Ueda, N Ando, O Abe, M Hirai, N Shimizu 		International Journal of Cancer 1987
High incidence of egf receptor hyperproduction in esophageal squamous-cell carcinomas
S Ozawa, M Ueda, N Ando, O Abe, N Shimizu 		International Journal of Cancer 1987
Proteins phosphorylated on tyrosine as markers of human tumor cell lines
S Giordano, MF di Renzo, D Cirillo, L Naldini, LC Piat, PM Comoglio 		International Journal of Cancer 1987
Expression of thec-erbB-2 protein in normal and transformed cells
WJ Gullick, MS Berger, PL Bennett, JB Rothbard, MD Waterfield 		International Journal of Cancer 1987
Evaluation of epidermal growth factor receptors in bladder tumours
MS Berger, C Greenfield, WJ Gullick, J Haley, J Downward, DE Neal, AL Harris, MD Waterfield 		British Journal of Cancer 1987
Production of transforming growth factor alpha in human pancreatic cancer cells: evidence for a superagonist autocrine cycle
JJ Smith, R Derynck, M Korc 		Proceedings of the National Academy of Sciences 1987
Epidermal growth factor receptors in non-small cell lung cancer
D Veale, T Ashcroft, C Marsh, GJ Gibson, AL Harris 		British Journal of Cancer 1987
Immunology of Malignant Diseases
VS Byers, RW Baldwin 		1987
Development and Recognition of the Transformed Cell
MI Greene, T Hamaoka 		1987
Change in metabolic turnover is an alternate mechanism increasing cell surface epidermal growth factor receptor levels in tumor cells
S Gamou, N Shimizu 		The Journal of biological chemistry 1987
Over-expression of the EGF receptor is a hallmark of squamous cell carcinomas
B Ozanne, CS Richards, F Hendler, D Burns, B Gusterson 		The Journal of Pathology 1986
Basic Science Review: Growth Factors in Cancer and Their Relationship to Oncogenes
DS Salomon, I Perroteau 		Cancer Investigation 1986
Cowden disease: gene marker studies and measurements of epidermal growth factor
HE Carlson, TW Burns, SL Davenport, AM Luger, MA Spence, RS Sparkes, DN Orth 		The American Journal of Human Genetics 1986
Inhibition of tumor growth by a monoclonal antibody reactive with an oncogene-encoded tumor antigen
JA Drebin, VC Link, RA Weinberg, MI Greene 		Proceedings of the National Academy of Sciences 1986
Expression of epidermal growth factor receptor (EGF-R) in human lung tumours
T Cerny, DM Barnes, P Hasleton, PV Barber, K Healy, W Gullick, N Thatcher 		British Journal of Cancer 1986
Enhanced expression of epidermal growth factor receptor correlates with alterations of chromosome 7 in human pancreatic cancer
M Korc, P Meltzer, J Trent 		Proceedings of the National Academy of Sciences 1986
Monoclonal antibody against epidermal growth factor receptor is internalized without stimulating receptor phosphorylation
H Sunada, BE Magun, J Mendelsohn, CL MacLeod 		Proceedings of the National Academy of Sciences 1986
Oncogenes
CT Garrett 		Clinica Chimica Acta 1986
Mechanisms involved in the induction of malignant cell differentiation
AC Sartorelli, K Ishiguro, CL King, MJ Morin, M Reiss 		Advances in Enzyme Regulation 1986
Advances in the Biology of Non-small Cell Lung Cancer
AF Gazdar 		Chest 1986
Human esophageal carcinoma cells have fewer, but higher affinity epidermal growth factor receptors
SP Banks-Schlegel, J Quintero 		The Journal of biological chemistry 1986
Elevated epidermal growth factor receptor gene copy number and expression in a squamous carcinoma cell line
GT Merlino, YH Xu, N Richert, AJ Clark, S Ishii, S Banks-Schlegel, I Pastan 		Journal of Clinical Investigation 1985
Regulation of the epidermal growth factor receptor by phosphorylation
PJ Bertics, W Weber, C Cochet, GN Gill 		Journal of Cellular Biochemistry 1985
Evidence for increased epidermal growth factor receptors in human sarcomas
G Cowley, J McIlhinney, B Gusterson, B Ozanne, C Fisher, B Reeves 		International Journal of Cancer 1985
Amplified, overexpressed and rearranged epidermal growth factor receptor gene in a human astrocytoma cell line
J Filmus, MN Pollak, JG Cairncross, RN Buick 		Biochemical and Biophysical Research Communications 1985
A direct radioimmunoassay for human epidermal growth factor receptor using 32P-autophosphorylated receptor
H Sunada, C MacLeod, J Mendelsohn 		Analytical Biochemistry 1985
Expression of the receptor for epidermal growth factor correlates with increased dosage of chromosome 7 in malignant melanoma
H Koprowski, M Herlyn, G Balaban, A Parmiter, A Ross, P Nowell 		Somatic Cell and Molecular Genetics 1985
Monoclonal Antibody Therapy of Human Cancer
KA Foon, AC Morgan 		1985
Monoclonal Antibodies and Breast Cancer
RL Ceriani 		1985
Pancreatic Disease
EC Kafka, MH Kalser 		Postgraduate Medicine 1975

Advertisement