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Citations to this article

Acceleration of thrombin-antithrombin complex formation in rat hindquarters via heparinlike molecules bound to the endothelium.
J A Marcum, … , J B McKenney, R D Rosenberg
J A Marcum, … , J B McKenney, R D Rosenberg
Published August 1, 1984
Citation Information: J Clin Invest. 1984;74(2):341-350. https://doi.org/10.1172/JCI111429.
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Acceleration of thrombin-antithrombin complex formation in rat hindquarters via heparinlike molecules bound to the endothelium.

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Abstract

We have examined the role of heparinlike molecules in the regulation of coagulation by perfusing rat hindquarters with purified human thrombin and with its plasma inhibitor, antithrombin. Our data indicate that contact of the hemostatic components with the endothelium enhances the rate of thrombin-antithrombin complex formation by as much as 19-fold over the uncatalyzed rate of enzyme-inhibitor interaction. Heparinlike molecules are responsible for the antithrombin accelerating activity. The amount of thrombin-antithrombin complex generated within the hindlimb preparation after pretreatment of the vasculature with purified Flavobacterium heparinase or with addition of platelet Factor IV to the hemostatic components, was equal to the uncatalyzed levels. These heparinlike molecules appear to be tightly bound to the luminal surface of the endothelium, since they could not be detected within the physiologic buffer that was perfused through the animal. The above mucopolysaccharides function in a manner similar to commercial heparin, since modification of antithrombin at a site critical for heparin-dependent acceleration of the protease inhibitor resulted in a level of interaction product identical to the uncatalyzed amount. Finally, addition of diisofluorophosphate-thrombin to the enzyme perfusion stream reduced the amount of thrombin-antithrombin complex formed in the animal by 30-40%, which suggested that thrombin bound to the endothelium as well as enzyme free in solution are accessible to antithrombin that has interacted with heparinlike molecules present on the endothelium.

Authors

J A Marcum, J B McKenney, R D Rosenberg

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Monocyte-derived neutrophil chemotactic factor (MDNCF/IL-8) resides in a gene cluster along with several other members of the platelet factor 4 gene superfamily
WS Modi, M Dean, HN Seuanez, N Mukaida, K Matsushima, SJ O'Brien
Human Genetics 1990
Vitronectin (S protein) is associated with platelets
CJ Parker, OL Stone, VF White, NJ Bernshaw
British Journal of Haematology 1989
Role of Endothelial Cell Surface Heparin-like Polysaccharides
JA Marcum, RD Rosenberg
Annals of the New York Academy of Sciences 1989
The role of vitronectin as multifunctional regulator in the hemostatic and immune systems
KT Preissner
Blut 1989
Activity and transport of antithrombin during acute limb ischemia
PE Burke, CF Harvey, CL Phythian, CA Gervin, LJ Greenfield
Journal of Vascular Surgery 1989
Correlation between antigenic and functional expression of tissue factor on the surface of cultured human endothelial cells following stimulation by lipopolysaccharide endotoxin
M Noguchi, T Sakai, W Kisiel
Thrombosis Research 1989
Improved method for purification of human platelet factor 4 by affinity and ion-exchange chromatography
I Medici, AD Martino, G Cella, L Callegaro, M Prosdocimi
Thrombosis Research 1989
Effect of rabbit thrombomodulin on thrombin inhibition by antithrombin in the presence of heparin
B Marie-Claude
Thrombosis Research 1989
Serpin receptor 1: A hepatic receptor that mediates the clearance of antithrombin III-proteinase complexes
SV Pizzo
The American Journal of Medicine 1989
Biochemistry of heparin antithrombin interactions, and the physiologic role of this natural anticoagulant mechanism
RD Rosenberg
The American Journal of Medicine 1989
Congenital antithrombin III deficiency: insights into the pathogenesis of the hypercoagulable state and its management using markers of hemostatic system activation
KA Bauer, RD Rosenberg
The American Journal of Medicine 1989
9 Antithrombin: Structure, genomic organization, function and inherited deficiency
DA Lane, R Caso
Baillière's Clinical Haematology 1989
The mechanism of precartilage mesenchymal condensation: A major role for interaction of the cell surface with the amino-terminal heparin-binding domain of fibronectin
DA Frenz, NS Jaikaria, SA Newman
Developmental Biology 1989
Human platelet factor 4 monomer-dimer-tetramer equilibria investigated by proton NMR spectroscopy
KH Mayo, MJ Chen
Biochemistry 1989
Synthesis and expression of C1 inhibitor by human umbilical vein endothelial cells
AH Schmaier, SC Murray, GD Heda, A Farber, A Kuo, K McCrae, DB Cines
The Journal of biological chemistry 1989
Thrombin and Histamine Stimulate the Phosphorylation of Elongation Factor 2 in Human Umbilical Vein Endothelial Cells
KP Mackie, AC Nairn, G Hampel, G Lam, EA Jaffe
The Journal of biological chemistry 1989
Albuminuria reflects widespread vascular damage: The Steno hypothesis
T Deckert, B Feldt-Rasmussen, K Borch-Johnsen, T Jensen, A Kofoed-Enevoldsen
Diabetologia 1989
The role of vitronectin as multifunctional regulator in the hemostatic and immune systems
KT Preissner
Blut Zeitschrift für die Gesamte Blutforschung 1989
Proposed heparin binding site in antithrombin based on arginine 47. A new variant Rouen-II, 47 Arg to Ser
JY Borg, MC Owen, C Soria, J Soria, J Caen, RW Carrell
Journal of Clinical Investigation 1988
Influence of blood flow and the effect of protamine on the thromboresistant properties of a covalently bonded heparin surface
C Arnander, P Olsson, O Larm
Journal of Biomedical Materials Research 1988
Inherited factors in thrombosis
PM Mannucci, A Tripodi
Blood Reviews 1988
Effects of fibroblasts and endothelial cells on inactivation of target proteases by protease nexin-1, heparin cofactor II, and C1-inhibitor
SA Hiramoto, DD Cunningham
Journal of Cellular Biochemistry 1988
Isolation of heparan sulfates with antithrombin III affinity and anticoagulant potency from 3T3, B16.F10 melanoma, and cutaneous fibrosarcoma cell lines
M Piepkorn, P Hovingh, WM Hentschel
Biochemical and Biophysical Research Communications 1988
Binding, internalization and degradation of heparin and heparin fragments by cultured endothelial cells
S Vannucchi, F Pasquali, F Porciatti, V Chiarugi, L Magnelli, P Bianchini
Thrombosis Research 1988
Neutralization of thrombin by antithrombin III in the presence of cultured human fibroblasts
JT Brandt, RE Stephens, GH Hinkle
Thrombosis Research 1988
Preparation and characterization of monolconal antibodies against the human thrombin-antithrombin III complex
S Asakura, N Yoshida, M Matsuda, H Murayama, G Soe
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 1988
International Review of Experimental Pathology
P Hoedemaeker
International Review of Experimental Pathology 1988
The Molecular and Cellular Biology of Wound Repair
RA Clark, PM Henson
1988
Endothelial Cell Biology in Health and Disease
N Simionescu, M Simionescu
1988
Sulfated N-linked oligosaccharides in mammalian cells. II. Identification of glycosaminoglycan-like chains attached to complex-type glycans
G Sundblad, S Holojda, L Roux, A Varki, HH Freeze
The Journal of biological chemistry 1988
Endotoxin enhances tissue factor and suppresses thrombomodulin expression of human vascular endothelium in vitro
KL Moore, SP Andreoli, NL Esmon, CT Esmon, NU Bang
Journal of Clinical Investigation 1987
Aging-associated changes in indices of thrombin generation and protein C activation in humans. Normative Aging Study
KA Bauer, LM Weiss, D Sparrow, PS Vokonas, RD Rosenberg
Journal of Clinical Investigation 1987
Suppression of hemostatic system activation by oral anticoagulants in the blood of patients with thrombotic diatheses
EM Conway, KA Bauer, S Barzegar, RD Rosenberg
Journal of Clinical Investigation 1987
Glomerular deposition of cross–linked fibrin in human kidney diseases
T Takemura, K Yoshioka, N Akano, H Miyamoto, K Matsumoto, S Maki
Kidney International 1987
Current views on the pathophysiology and investigations of thrombotic disorders
HH Salem, CA Mitchell, BG Firkin
American Journal of Hematology 1987
Localization of the binding sites of porcine tissue-type plasminogen activator and plasminogen to heparin
S Soeda, M Kakiki, H Shimeno, A Nagamatsu
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 1987
An abnormal antithrombin III (AT III) with low heparin affinity: AT III Clichy
M Aiach, D Franclois, P Priollet, L Capron, M Roncato, M Alhenc-Gelas, JN Fiessinger
British Journal of Haematology 1987
Presidential address: The microcosm of the arterial wall—A plea for research
AD Callow
Journal of Vascular Surgery 1987
The active roles of cells of the blood vessel wall in health and disease
P Libby
Molecular Aspects of Medicine 1987
Comparative effect of heparin and heparan sulphate on two abnormal antithrombin III type 3 variants
AM Fischer, S Beguin, C Sternberg, MD Dautzenberg
British Journal of Haematology 1987
Antithrombin III Northwick Park: demonstration of an inactive high MW complex with increased affinity for heparin
DA Lane, A Flynn, H Ireland, H Erdjument, D Samson, D Howarth, E Thompson
British Journal of Haematology 1987
Human platelet factor 4 and protamine sulphate interaction with glycosaminoglycans in the rabbit
G Cella, CJ Myers, M Prosdocimi, AA Sasahara
European Journal of Clinical Investigation 1987
Matrix-driven translocation: dependence on interaction of amino-terminal domain of fibronectin with heparin-like surface components of cells or particles
SA Newman, DA Frenz, E Hasegawa, SK Akiyama
Proceedings of the National Academy of Sciences 1987
Formation and regulation of platelet and fibrin hemostatic plug
J Hawiger
Human Pathology 1987
Cell biology of endothelial cells
EA Jaffe
Human Pathology 1987
Thrombosis in inherited deficiencies of antithrombin, protein C, and protein S
RD Rosenberg, KA Bauer
Human Pathology 1987
interaction of antithrombin III and thrombinantithrombin III complex with cultured aortic endothelial cells
K Bartha, T Kovacs, I Lerant, B Papp, E Csonka, K Kolev, R MacHovich
Thrombosis Research 1987
Uptake and inactivation of thrombin on the subendothelium: Comparisons with endothelium
S Frebelius, J Swedenborg
Thrombosis Research 1987
Biology of Proteoglycans
EJ Thonar, KE Kuettner
Biology of Proteoglycans 1987
Immune Endothelial-Cell Injury in Heparin-Associated Thrombocytopenia
DB Cines, A Tomaski, S Tannenbaum
New England Journal of Medicine 1987
Endothélium et thrombose
P Molho-Sabatier
La Revue de Médecine Interne 1987
Conditions for radioiodination of antithrombin III retaining its biological properties
J Caix, AP Minnot, A Beziade, L Vuillemin, F Belloc, C Baquey, D Ducassou
International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes 1987
The Pulmonary Circulation in Health and Disease
J Hughes
The Pulmonary Circulation in Health and Disease 1987
Binding of thrombin to thrombomodulin accelerates inhibition of the enzyme by antithrombin III. Evidence for a heparin-independent mechanism
KT Preissner, U Delvos, G Mueller-Berghaus
Biochemistry 1987
Human placental anticoagulant protein: isolation and characterization
T Funakoshi, RL Heimark, LE Hendrickson, BA McMullen, K Fujikawa
Biochemistry 1987
Modulation of glycosaminoglycan production and antithrombin III binding by cultured aortic endothelial cells treated with 4-methylumbelliferyl-beta-D-xyloside
K Shimada, T Ozawa
Arteriosclerosis (Dallas, Tex.) 1987
In vitro stimulation of megakaryocyte maturation by megakaryocyte stimulatory factor
SM Greenberg, DJ Kuter, RD Rosenberg
The Journal of biological chemistry 1987
Correlation between thrombin-induced prostacyclin production and inositol trisphosphate and cytosolic free calcium levels in cultured human endothelial cells
EA Jaffe, J Grulich, BB Weksler, G Hampel, K Watanabe
The Journal of biological chemistry 1987
Activation of heparin cofactor II by fibroblasts and vascular smooth muscle cells
EA McGuire, DM Tollefsen
The Journal of biological chemistry 1987
Identification of a factor IX/IXa binding protein on the endothelial cell surface
S Rimon, R Melamed, N Savion, T Scott, PP Nawroth, DM Stern
The Journal of biological chemistry 1987
Structural requirements for the neutralization of heparin-like saccharides by complement S protein/vitronectin
DA Lane, AM Flynn, G Pejler, U Lindahl, J Choay, K Preissner
The Journal of biological chemistry 1987
Endothelial cell function in diabetic microangiopathy
M Porta, ML Selva, P Molinatti, GM Molinatti
Diabetologia 1987
Disseminated intravascular coagulation
S Fruchtman, LM Aledort
Journal of the American College of Cardiology 1986
A pathway of coagulation on bovine capillary endothelial cells
PP Nawroth, DM Stern, W Kisiel, M Dietrich
British Journal of Haematology 1986
Clearance of thrombin in vivo: significance of alternative pathways
TH Carlson
Molecular and Cellular Biochemistry 1986
Thrombin-Cellular Interactions
MA Shuman
Annals of the New York Academy of Sciences 1986
Thrombin
JW Fenton
Annals of the New York Academy of Sciences 1986
Anticoagulantly active heparin-like molecules from cultured fibroblasts
JA Marcum, EM Conway, H Youssoufian, RD Rosenberg
Experimental Cell Research 1986
Heparin fractions and analogues: a new therapeutic possibility for thrombosis
D Prost
Trends in Pharmacological Sciences 1986
Choices among the Possible Reaction Routes Catalyzed by Thrombin
R Machovich
Annals of the New York Academy of Sciences 1986
Endothelial binding sites for heparin. Specificity and role in heparin neutralization
T Bârzu, JL van Rijn, M Petitou, P Molho, G Tobelem, JP Caen
Biochemical Journal 1986
Structure and function of heparan sulphate proteoglycans
JT Gallagher, M Lyon, WP Steward
Biochemical Journal 1986
Functional domains of rabbit thrombomodulin
MC Bourin, MC Boffa, I Björk, U Lindahl
Proceedings of the National Academy of Sciences 1986
Higher susceptibility of mast-cell-deficient W/WV mutant mice to brain thromboembolism and mortality caused by intravenous injection of India ink
Y Kitamura, T Taguchi, M Yokoyama, M Inoue, A Yamatodani, H Asano, T Koyama, A Kanamaru, K Hatanaka, BK Wershil
The American Journal of Pathology 1986
A unique heparan sulfate in the nuclei of hepatocytes: structural changes with the growth state of the cells
NS Fedarko, HE Conrad
The Journal of Cell Biology 1986
Specific association of thrombin-antithrombin complexes with a human hepatoma cell line
DS Fair, EF Plow
Thrombosis Research 1986
Anticoagulantly active heparin from clam (Mercenaria mercenaria)
RE Jordan, JA Marcum
Archives of Biochemistry and Biophysics 1986
Measurement of the kinetics of inhibition of activated coagulation factor X in human plasma: The effect of plasma and inhibitor concentration
J Jesty
Analytical Biochemistry 1986
Heparin: Do We Understand Its Antithrombotic Actions?
DB Cines
Chest 1986
New Insights into Hypercoagulable States
RD Rosenberg, KA Bauer
Hospital Practice 1986
The mechanism of fibrin-induced disorganization of cultured human endothelial cell monolayers
B Weimar, U Delvos
Arteriosclerosis (Dallas, Tex.) 1986
Hemostatic regulation and Whitehead's philosophy of organism
JA Marcum, GM Verschuuren
Acta Biotheoretica 1986
The anticoagulant properties of thrombomodulin
H Salem, I Maruyama, H Ishii, CE Bell, CA Mitchell, EA Thompson, PW Majerus
The Medical Journal of Australia 1986
2 The Multiple Levels of Endothelial Cell-Coagulation Factor Interactions
PP Nawroth, D Handley, DM Stern
Clinics in Haematology 1986
5 The Natural Anticoagulants
HH Salem
Clinics in Haematology 1986
Cloned bovine aortic endothelial cells synthesize anticoagulantly active heparan sulfate proteoglycan
JA Marcum, DH Atha, LM Fritze, P Nawroth, D Stern, RD Rosenberg
The Journal of biological chemistry 1986
Cultured bovine aortic endothelial cells promote activated protein C-protein S-mediated inactivation of factor Va
DM Stern, PP Nawroth, K Harris, CT Esmon
The Journal of biological chemistry 1986
Neutralization of heparin-related saccharides by histidine-rich glycoprotein and platelet factor 4
DA Lane, G Pejler, AM Flynn, EA Thompson, U Lindahl
The Journal of biological chemistry 1986
The kinetics of inhibition of alpha-thrombin in human plasma
J Jesty
The Journal of biological chemistry 1986
Current Issues in Thrombosis Prevention with Antiplatelet Drugs:
G de Gaetano, C Cerletti, E Dejana, J Vermylen
Drugs 1986
Interaction of antithrombin III with bovine aortic segments. Role of heparin in binding and enhanced anticoagulant activity
D Stern, P Nawroth, J Marcum, D Handley, W Kisiel, R Rosenberg, K Stern
Journal of Clinical Investigation 1985
Evidence that cell surface heparan sulfate is involved in the high affinity thrombin binding to cultured porcine aortic endothelial cells
K Shimada, T Ozawa
Journal of Clinical Investigation 1985
Elevated factor Xa activity in the blood of asymptomatic patients with congenital antithrombin deficiency
KA Bauer, TL Goodman, BL Kass, RD Rosenberg
Journal of Clinical Investigation 1985
Die Bedeutung des Endothels der Gefäßwand für die Aufrechterhaltung der Hämostase
U Delvos, G Müller-Berghaus
Klinische Wochenschrift 1985
A pathway of coagulation on endothelial cells
PP Nawroth, DM Stern
Journal of Cellular Biochemistry 1985
Self-regulation of procoagulant events on the endothelial cell surface
DM Stern, I Bank, PP Nawroth, J Cassimeris, W Kisiel, JW 2nd, C Dinarello, L Chess, EA Jaffe
Journal of Experimental Medicine 1985
An endothelial cell-dependent pathway of coagulation
D Stern, P Nawroth, D Handley, W Kisiel
Proceedings of the National Academy of Sciences 1985
Comparison of the behaviour in vivo of two molecular forms of antithrombin III
TH Carlson, AC Atencio, TL Simon
Biochemical Journal 1985
An antiproliferative heparan sulfate species produced by postconfluent smooth muscle cells
LM Fritze, CF Reilly, RD Rosenberg
The Journal of Cell Biology 1985
Heparinlike molecules with anticoagulant activity are synthesized by cultured endothelial cells
JA Marcum, RD Rosenberg
Biochemical and Biophysical Research Communications 1985
Interaction of complement S-protein with thrombin-antithrombin complexes: A role for the S-protein in haemostasis
D Jenne, F Hugo, S Bhakdi
Thrombosis Research 1985
Mechanisms of Stimulus—Response Coupling in Platelets
J Westwick, MF Scully, DE MacIntyre, VV Kakkar
1985
Formation of the Fibrin Clot: the Balance of Procoagulant and Inhibitory Factors
B Lämmle, JH Griffin
Clinics in Haematology 1985
The Role of Endothelium in the Homeostatic Balance of Haemostasis
P Nawroth, W Kisiel, D Stern
Clinics in Haematology 1985
Verhandlungen der Deutschen Gesellschaft für Innere Medizin
B Schlegel
1962

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