Citations to this article

Identification of the human T cell lymphoma virus in B cell lines established from patients with adult T cell leukemia.
D L Mann, … , W A Blattner, R C Gallo
D L Mann, … , W A Blattner, R C Gallo
Published July 1, 1984
Citation Information: J Clin Invest. 1984;74(1):56-62. https://doi.org/10.1172/JCI111418.
View: Text | PDF
Research Article

Identification of the human T cell lymphoma virus in B cell lines established from patients with adult T cell leukemia.

Abstract

Cell lines were established from the peripheral blood of two patients with adult T cell leukemia. In contrast to our previous experience, where all such lines expressed T cell markers, these two cell lines expressed B cell antigens and Ig light chains (kappa on CF-2, lambda on HS). Human T cell lymphoma proviral (HTLV) sequences were demonstrated in both cell lines. Since only a portion of the cells in culture expressed Ig light chains, experiments were carried out to exclude the possibility that the cultures were not a mixture of B and T or non-B cells. Cells that expressed kappa- or lambda-light chains were separated by cell sorting from kappa- or lambda-negative cells and replaced in culture. Light chain negative cells reexpressed light chains after time in culture. After 5-azacytidine treatment of the cell lines, all cells expressed Ig light chains. These studies show that the human retrovirus HTLV, which has been demonstrated to be associated with certain T cell malignancies, can infect B cells or B cell precursors.

Authors

D L Mann, J Clark, M Clarke, M Reitz, M Popovic, G Franchini, C D Trainor, D M Strong, W A Blattner, R C Gallo

×

Total citations by year

Year: 2024 2018 2016 2010 2007 2001 1997 1996 1995 1994 1992 1991 1990 1988 1987 1986 1985 1984 Total
Citations: 1 1 1 1 1 1 1 1 1 1 1 3 1 2 4 5 5 1 32
Citation information

Citations to this article (32)

Title and authors Publication Year
Establishment of a novel human T-cell leukemia virus type 1 infection model using cell-free virus
Nagata K, Tezuka K, Kuramitsu M, Fuchi N, Hasegawa Y, Hamaguchi I, Miura K 		Journal of virology 2024
Inhibition of Tunneling Nanotube (TNT) Formation and Human T-cell Leukemia Virus Type 1 (HTLV-1) Transmission by Cytarabine
M Omsland, C Pise-Masison, D Fujikawa, V Galli, C Fenizia, RW Parks, BT Gjertsen, G Franchini, V Andresen 		Scientific Reports 2018
Molecular Mechanisms of HTLV-1 Cell-to-Cell Transmission
C Gross, A Thoma-Kress 		Viruses 2016
Quantitative comparison of HTLV-1 and HIV-1 cell-to-cell infection with new replication dependent vectors
D Mazurov, A Ilinskaya, G Heidecker, P Lloyd, D Derse 		PLoS pathogens 2010
Phenotypic and Genotypic Comparisons of Human T-Cell Leukemia Virus Type 1 Reverse Transcriptases from Infected T-Cell Lines and Patient Samples
MS Mitchell, ET Bodine, S Hill, G Princler, P Lloyd, H Mitsuya, M Matsuoka, D Derse 		Journal of virology 2007
Examining Human T-Lymphotropic Virus Type 1 Infection and Replication by Cell-Free Infection with Recombinant Virus Vectors
D Derse, SA Hill, PA Lloyd, H Chung, BA Morse 		Journal of virology 2001
X-I and X-II Open Reading Frames of HTLV-I Are Not Required for Virus Replication or for Immortalization of Primary T-Cellsin Vitro
D Derse, J Mikovits, F Ruscetti 		Virology 1997
Examining the Molecular Genetics of HTLV-I with an Infectious Molecular Clone of the Virus and Permissive Cell Culture Systems
D Derse, J Mikovits, D Waters, S Brining, F Ruscetti 		Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 1996
Virions released from cells transfected with a molecular clone of human T-cell leukemia virus type I give rise to primary and secondary infections of T cells
D Derse, J Mikovits, M Polianova, BK Felber, F Ruscetti 		Journal of virology 1995
Detection of human T-cell leukaemia virus 1 permissive cells using cell lines producing selectable recombinant virions
KF Copeland, AG Haaksma, D Derse, JL Heeney 		Journal of Virological Methods 1994
Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: novel mRNAs and proteins produced by HTLV type I
V Ciminale, GN Pavlakis, D Derse, CP Cunningham, BK Felber 		Journal of virology 1992
Regulation of lymphocyte blastogenesis and antibody production by soluble factor released by a human B-lymphoblastoid cell line
K Morikawa, S Morikawa, K Imai, F Oseko 		Cytokine 1991
The Human Retroviruses
TA Waldmann 		The Human Retroviruses 1991
Deleted HTLV-I Provirus in Blood and Cutaneous Lesions of Patients with Mycosis Fungoides
WW Hall, CR Liu, O Schneewind, H Takahashi, MH Kaplan, G Röupe, A Vahlne 		Science 1991
Human T cell leukemia virus type I induces DNA synthesis and immunoglobulin secretion in human lymphocyte cultures
V Boyer, MD Dodon, L Gazzolo 		Cellular Immunology 1990
Lymphoma-specific T- and B-cell responses suggest the involvement of HTLV-I in virus-non-productive lymphomas of a married couple
EM Schneider, JG Saal, DL Mann, G Pawelec, J Schneider, W Schlote, P Wernet 		International Journal of Cancer 1988
Molecular epidemiology of HTLV-I-Associated non-Hodgkin's lymphomas in Jamaica
JW Clark, C Gurgo, G Franchini, WN Gibbs, W Lofters, C Neuland, D Mann, C Saxinger, RC Gallo, WA Blattner 		Cancer 1988
In vitro susceptibility of different human T-cell subpopulations and resistance of large granular lymphocytes to HTLV-I infection
B Macchi, M Popovic, P Allavena, J Ortaldo, P Rossi, RC Gallo, E Bonmassar 		International Journal of Cancer 1987
Effects of Human Immunodeficiency Virus (HIV) on the Cytotoxic Response to Epstein Barr Virus (EBV) Transformed B Lymphocytes
RS Blumberg, TJ Paradis, D Crawford, RE Byington, MS Hirsch, RT Schooley 		AIDS Research and Human Retroviruses 1987
HTLV-I-RELATED AGENT AND NON-HODGKIN LYMPHOMAS IN MARRIED COUPLE
JG Saal, EM Schneider, C Muller, HD Waller 		The Lancet 1987
HTLV-I—Associated B-Cell CLL: Indirect Role for Retrovirus in Leukemogenesis
DL Mann, P DeSantis, G Mark, A Pfeifer, M Newman, N Gibbs, M Popovic, MG Sarngadharan, RC Gallo, J Clark, W Blattner 		Science 1987
Configuration and expression of the T cell receptor beta chain gene in human T-lymphotrophic virus I-infected cells
RF Jarrett, H Mitsuya, DL Mann, J Cossman, S Broder, MS Reitz 		Journal of Experimental Medicine 1986
Differential response to the cytopathic effects of human T-cell lymphotropic virus type III (HTLV-III) superinfection in T4+ (helper) and T8+ (suppressor) T-cell clones transformed by HTLV-I
AD Rossi, G Franchini, A Aldovini, AD Mistro, L Chieco-Bianchi, RC Gallo, F Wong-Staal 		Proceedings of the National Academy of Sciences 1986
The Role of Pharmacology in Pediatric Oncology
DG Poplack, L Massimo, P Cornaglia-Ferraris 		1986
Genetics, Development, and Evolution
JP Gustafson, GL Stebbins, FJ Ayala 		1986
Trans -Activator Gene of HTLV-II Induces IL-2 Receptor and IL-2 Cellular Gene Expression
WC Greene, WJ Leonard, Y Wano, PB Svetlik, NJ Peffer, JG Sodroski, CA Rosen, WC Goh, WA Haseltine 		Science 1986
Molecular and immunologic analysis of a chronic lymphocytic leukemia case with antibodies against human T-cell leukemia virus
JW Clark, BH Hahn, DL Mann, F Wong-Staal, M Popovic, E Richardson, DM Strong, WS Lofters, WA Blattner, WN Gibbs, RC Gallo 		Cancer 1985
HTLV-I infection of T and B cells of a patient with adult T-cell leukemia-lymphoma (ATLL) and transmission of HTLV-I from B cells to normal T cells
G Franchini, DL Mann, M Popovic, RR Zicht, RC Gallo, F Wong-staal 		Leukemia Research 1985
Retroviruses and Lymphoproliferative Disease
AR Solomon 		Dermatologic Clinics 1985
Human T-cell leukemia/lymphoma virus I and/or Epstein-Barr virus-infected B-cell lines spontaneously produce acid-labile ?-interferon
DT Boumpas, JJ Hooks, M Popovic, GC Tsokos, DL Mann 		Journal of Clinical Immunology 1985
International Symposium: Retroviruses and Human Pathology
RC Gallo, D Stehelin, OE Varnier 		1985
Methylation of human T-cell leukemia virus proviral DNA and viral RNA expression in short- and long-term cultures of infected cells
MF Clarke, CD Trainor, DL Mann, RC Gallo, MS Reitz 		Virology 1984

Advertisement