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Gallium nitrate inhibits calcium resorption from bone and is effective treatment for cancer-related hypercalcemia.

R P Warrell Jr, … , M Isaacs, H Staszewski

R P Warrell Jr, … , M Isaacs, H Staszewski

Published May 1, 1984
Citation Information: J Clin Invest. 1984;73(5):1487-1490. https://doi.org/10.1172/JCI111353.

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Title and authors	Publication	Year
3D-printed gallium-infused scaffolds for osteolysis intervention and bone regeneration Xi H, Jiang X, Xiong S, Zhang Y, Zhou J, Liu M, Zhou Z, Zhang C, Liu S, Long Z, Zhou J, Qian G, Xiong L	Materials Today Bio	2025
Survival Outcomes in Malignancy-related Hypercalcemia: A Tertiary Care Single-center Experience Ashfaq S, Shafiq W, Siddiqi AI, Azmat U, Irfan H, Khan SA, Alvi AM, Bakar MA, Hassan M, Farooq A, Sheikh AZ, Siddique K, Asghar K	Journal of Cancer & Allied Specialties	2024
Investigation of Mechanical and Corrosion Properties of New Mg-Zn-Ga Amorphous Alloys for Biomedical Applications Bazhenov VE, Gorobinskiy MV, Bazlov AI, Bautin VA, Koltygin AV, Komissarov AA, Ten DV, Li AV, Drobyshev AY, Kang Y, Jung IH, Shin KS	Journal of Functional Biomaterials	2024
Refractory Hypercalcemia of Malignancy in Squamous Cell Carcinoma of the Buccal Mucosa With Skeletal Muscle Metastasis Reddy Bana SK, Dhadwad JS, Modi K, Roushan K, Kulkarni P, Dash C	Cureus	2024
Efficacy and possible mechanism(s) of action of gallium tetraphenylporphyrin nanoparticles against HIV-TB coinfection in an in vitro granuloma structure model Choi SR, Kulkarni S, Arnett E, Schlesinger LS, Britigan BE, Narayanasamy P	ACS infectious diseases	2024
An In Vivo Rat Study of Bioresorbable Mg-2Zn-2Ga Alloy Implants. Drobyshev A, Gurganchova Z, Redko N, Komissarov A, Bazhenov V, Statnik ES, Sadykova IA, Sviridov E, Salimon AI, Korsunsky AM, Zayratyants O, Ushmarov D, Yanushevich O		2023
Cancer-related hypercalcemia and potential treatments Almuradova E, Cicin I	Frontiers in Endocrinology	2023
Microstructure and Mechanical Properties of Hot-Extruded Mg-Zn-Ga-(Y) Biodegradable Alloys. Bazhenov V, Li A, Tavolzhanskii S, Bazlov A, Tabachkova N, Koltygin A, Komissarov A, Shin KS		2022
Corrosion Behavior and Biocompatibility of Hot-Extruded Mg-Zn-Ga-(Y) Biodegradable Alloys. Bazhenov V, Li A, Iliasov A, Bautin V, Plegunova S, Koltygin A, Komissarov A, Abakumov M, Redko N, Shin KS	Journal of Functional Biomaterials	2022
Intra-tracheal administration increases gallium availability in lung: implications for antibacterial chemotherapy E Mitidieri, D Visaggio, E Frangipani, C Turnaturi, D Vanacore, R Provenzano, G Costabile, R Sorrentino, F Ungaro, P Visca, R dEmmanuele di Villa Bianca	Pharmacological research : the official journal of the Italian Pharmacological Society	2021
A Gallium-doped cement for the treatment of bone cancers. The effect of ZnO ↔ Ga 2 O 3 substitution of an ionomeric glass series on the rheological, mechanical, pH and ion-eluting properties of their corresponding glass polyalkenoate cements S Phull, AR Yazdi, MR Towler	Materials Research Express	2021
Photoluminescence and decay characteristics of cerium, gallium and vanadium - containing borate-based bioactive glass powders for bioimaging applications AM Deliormanlı, S Oguzlar, K Ertekin	Ceramics International	2021
Research Progress of Bioactive Glass and Its Application in Orthopedics C Huang, M Yu, H Li, X Wan, Z Ding, W Zeng, Z Zhou	Advanced Materials Interfaces	2021
Effect of Heat Treatment on the Mechanical and Corrosion Properties of Mg-Zn-Ga Biodegradable Mg Alloys. Bazhenov V, Lyskovich A, Li A, Bautin V, Komissarov A, Koltygin A, Bazlov A, Tokar A, Ten D, Mukhametshina A		2021
In Vitro Interaction of 5-Aminoorotic Acid and Its Gallium(III) Complex with Superoxide Radical, Generated by Two Model Systems L Todorov, M Traykova, L Saso, I Kostova	International journal of molecular sciences	2020
Gallium-containing magnesium alloy for potential use as temporary implants in osteosynthesis V Bazhenov, A Koltygin, A Komissarov, A Li, V Bautin, R Khasenova, A Anishchenko, A Seferyan, J Komissarova, Y Estrin		2020
Gallium ions promote osteoinduction of human and mouse osteoblasts via the TRPM7/Akt signaling pathway M Yu, Y Wang, Y Zhang, D Cui, G Gu, D Zhao	Molecular medicine reports	2020
Treatment of Virulent Mycobacterium tuberculosis and HIV Coinfected Macrophages with Gallium Nanoparticles Inhibits Pathogen Growth and Modulates Macrophage Cytokine Production S Choi, BE Britigan, P Narayanasamy, MD Zabel	mSphere	2019
In Vitro Efficacy of Free and Nanoparticle Formulations of Gallium(III) meso -Tetraphenylporphyrine against Mycobacterium avium and Mycobacterium abscessus and Gallium Biodistribution in Mice S Choi, BE Britigan, B Switzer, T Hoke, D Moran, P Narayanasamy	Molecular Pharmaceutics	2018
Textbook of Palliative Care RD MacLeod, L van den Block		2018
Ga(III) Nanoparticles Inhibit Growth of both Mycobacterium tuberculosis and HIV and Release of Interleukin-6 (IL-6) and IL-8 in Coinfected Macrophages S Choi, BE Britigan, P Narayanasamy	Antimicrobial agents and chemotherapy	2017
Mesoporous silica-based bioactive glasses for antibiotic-free antibacterial applications S Kaya, M Cresswell, AR Boccaccini	Materials Science and Engineering: C	2017
Gallium and silicon synergistically promote osseointegration of dental implant in patients with osteoporosis J Liu, Z Wu, H He, K Cai, H Zhang, L Xu	Medical Hypotheses	2017
Gallium enhances reconstructive properties of a calcium phosphate bone biomaterial: Gallium stimulates bone reconstruction IS Geljic, N Melis, F Boukhechba, S Schaub, C Mellier, P Janvier, JP Laugier, JM Bouler, E Verron, JC Scimeca	Journal of Tissue Engineering and Regenerative Medicine	2017
The effect of the addition of gallium on the structure of zinc borate glass with controlled gallium ion release AR Yazdi, M Towler	Materials & Design	2016
In vivo evaluation of cerium, gallium and vanadium-doped borate-based bioactive glass scaffolds using rat subcutaneous implantation model AM Deliormanlı, HS Vatansever, H Yesil, F Özdal-Kurt	Ceramics International	2016
Complex formation reactions of gallium(III) and iron(III/II) with l-proline-thiosemicarbazone hybrids: A comparative study F Bacher, O Dömötör, ÉA Enyedy, L Filipović, S Radulović, GS Smith, VB Arion	Inorganica Chimica Acta	2016
Hypercalcemia of malignancy: An update on pathogenesis and management AE Mirrakhimov	North American Journal of Medical Sciences	2015
Design and properties of novel gallium-doped injectable apatitic cements C Mellier, F Fayon, F Boukhechba, E Verron, M LeFerrec, G Montavon, J Lesoeur, V Schnitzler, D Massiot, P Janvier, O Gauthier, JM Bouler, B Bujoli	Acta Biomaterialia	2015
Synthesis and characterization of cerium- and gallium-containing borate bioactive glass scaffolds for bone tissue engineering AM Deliormanlı	Journal of Materials Science: Materials in Medicine	2015
Current and Recent Advanced Strategies for Combating Biofilms: Strategies for combating biofilm… M Sadekuzzaman, S Yang, MF Mizan, SD Ha	Comprehensive Reviews in Food Science and Food Safety	2015
Electrospun Cerium and Gallium-containing Silicate based 13–93 Bioactive Glass Fibers for Biomedical Applications AM Deliormanlı	Ceramics International	2015
Effect of gallium nitrate on the expression of osteoprotegerin and receptor activator of nuclear factor‑κB ligand in osteoblasts in vivo and in vitro J Li, GB Wang, X Feng, J Zhang, Q Fu	Molecular medicine reports	2015
Repurposing of gallium-based drugs for antibacterial therapy: Gallium-Based Antibacterials C Bonchi, F Imperi, F Minandri, P Visca, E Frangipani	BioFactors	2014
Approach to Diagnosis and Treatment of Hypercalcemia in a Patient With Malignancy P Reagan, A Pani, MH Rosner	American Journal of Kidney Diseases	2014
Promises and failures of gallium as an antibacterial agent F Minandri, C Bonchi, E Frangipani, F Imperi, P Visca	Future Microbiology	2014
In vitro assessment of degradation and mineralisation of V 2 O 5 substituted borate bioactive glass scaffolds AM Deliormanli	MATER TECHNOL	2014
Seldin and Giebisch's The Kidney CJ Cooper, LD Dworkin, WL Henrich	Seldin and Giebisch's The Kidney	2013
Yeast-Incorporated Gallium Attenuates Glucocorticoid-Induced Bone Loss in Rats by Inhibition of Bone Resorption Z Ren, L Yang, F Xue, Q Meng, K Wang, X Wu, C Ji, T Jiang, D Liu, L Zhou, J Zhang, Q Fu	Biological Trace Element Research	2013
Malignitáshoz társuló hypercalcaemia korai felismerésének jelentősége I Radványi, Á Csikós, S Balogh	Orvosi Hetilap	2013
A Novel Glass Polyalkenoate Cement for Fixation and Stabilisation of the Ribcage, Post Sternotomy Surgery: An ex-Vivo Study AM Alhalawani, DJ Curran, B Pingguan-Murphy, D Boyd, MR Towler	Journal of Functional Biomaterials	2013
Iron-Targeting Antitumor Activity of Gallium Compounds and Novel Insights Into Triapine®-Metal Complexes CR Chitambar, WE Antholine	Antioxidants & Redox Signaling	2013
Characterization and Properties of Novel Gallium-Doped Calcium Phosphate Ceramics C Mellier, F Fayon, V Schnitzler, P Deniard, M Allix, S Quillard, D Massiot, JM Bouler, B Bujoli, P Janvier	Inorganic Chemistry	2011
Metallic ions as therapeutic agents in tissue engineering scaffolds: an overview of their biological applications and strategies for new developments V Mouriño, JP Cattalini, AR Boccaccini	Journal of The Royal Society Interface	2011
Annual Reports in Medicinal Chemistry JJ Liu, TW Lee	Annual Reports in Medicinal Chemistry Volume 46	2011
Molecular effects of gallium on osteoclastic differentiation of mouse and human monocytes E Verron, A Loubat, GF Carle, C Vignes-Colombeix, I Strazic, J Guicheux, N Rochet, JM Bouler, JC Scimeca	Biochemical Pharmacology	2011
Medical applications and toxicities of gallium compounds CR Chitambar	International journal of environmental research and public health	2010
Anti-Biofilm Strategies and the Need for Innovations in Wound Care M Ammons	Recent Patents on Anti-Infective Drug Discovery	2010
Gallium modulates osteoclastic bone resorption in vitro without affecting osteoblasts E Verron, M Masson, S Khoshniat, L Duplomb, Y Wittrant, M Baud'huin, Z Badran, B Bujoli, P Janvier, JC Scimeca, JM Bouler, J Guicheux	British Journal of Pharmacology	2010
Abeloff's Clinical Oncology ER Fearon, GT Bommer	Abeloff's Clinical Oncology	2008
Pamidronate Treatment of Hypercalcemia Caused by Vitamin D Toxicity M Chatterjee, PW Speiser	Journal of Pediatric Endocrinology and Metabolism	2007
Emergencies in Urology M Hohenfellner, RA Santucci		2007
Oncologic Emergencies Jacobsen NE, Beck SD, Foster RS		2007
Randomized, Double-Blind, Phase II Trial of Gallium Nitrate Compared with Pamidronate for Acute Control of Cancer-Related Hypercalcemia F Cvitkovic, JP Armand, M Tubiana-Hulin, JF Rossi, RP Warrell	The Cancer Journal	2006
Activity of Gallium Nitrate in Patients with Refractory Lymphoma GK Reddy, CR Chitambar, VK Jain	Clinical Lymphoma & Myeloma	2004
Bone tissue incorporates in vitro gallium with a local structure similar to gallium-doped brushite M Korbas, E Rokita, W Meyer-Klaucke, J Ryczek	JBIC Journal of Biological Inorganic Chemistry	2003
Treatment of malignant hypercalcaemia P Esbrit, J Hurtado	Expert Opinion on Pharmacotherapy	2002
Extended Survival in Advanced-Stage Multiple Myeloma Patients Treated with Gallium Nitrate R Niesvizky, CG Choy, D Siegel, L Lyons, J Michaeli	Leukemia & Lymphoma	2002
Gallium Nitrate Accelerates Partial Thickness Wound Repair and Alters Keratinocyte Integrin Expression to Favor a Motile Phenotype J Goncalves, N Wasif, D Esposito, JM Coico, B Schwartz, PJ Higgins, RS Bockman, L Staiano-Coico	Journal of Surgical Research	2002
The Parathyroids SJ Marx	The Parathyroids	2001
Complexes of gallium(III) and other metal ions and their potential in the treatment of neoplasia DB Lovejoy, DR Richardson	Expert Opinion on Investigational Drugs	2000
Parathyroid hormone-related protein in metastatic breast cancer induced hypercalcemia: A case report R Graffeo, O Pagani, M Crivelli, F Zappa, P Borella, M Reiner, A Goldhirsch	Annals of Oncology	2000
Gallium nitrate suppresses the production of nitric oxide and liver damage in a murine model of LPS-induced septic shock ME Krecic-Shepard, DR Shepard, D Mullet, G Apseloff, SE Weisbrode, N Gerber	Life Sciences	1999
Bisphosphonates in Clinical Oncology B Thürlimann		1999
Metallopharmaceuticals I MJ Clarke, PJ Sadler		1999
Metabolic Bone Disease and Clinically Related Disorders FR Singer, SM Krane	Metabolic Bone Disease and Clinically Related Disorders	1998
Hypercalcemia and Hypermagnesemia LG Martin	Veterinary Clinics of North America Small Animal Practice	1998
Cancer and Bone* TA Guise, GR Mundy	Endocrine reviews	1998
Osteoporosis DL Glaser, FS Kaplan	Spine	1997
Effect of Gallium Nitrate Therapy on Ga-67 Scintigraphic Detection of Lymphoma: G Akansel, Y Liu, CR Chitambar, MT Kitapci, S Akansel, AZ Krasnow, AT Isitman, BD Collier	Clinical Nuclear Medicine	1997
Gallium nitrate for the treatment of bone metastases RP Warrell	Cancer	1997
Dose-response study of ibandronate in the treatment of cancer-associated hypercalcaemia SH Ralston, D Thiébaud, Z Herrmann, EU Steinhauer, B Thürlimann, J Walls, MR Lichinitser, R Rizzoll, H Hagberg, HJ Huss, M Tubiana-Hulin, JJ Body	British Journal of Cancer	1997
Hypercalcemia of Malignancy GR MD, TA MD	The American Journal of Medicine	1997
PROLONGED MURINE CARDIAC ALLOGRAFT ACCEPTANCE: Characteristics of Persistent Active Alloimmunity after Treatment with Gallium Nitrate Versus Anti-CD4 Monoclonal Antibody1,2 CG Orosz, E Wakely, DD Sedmak, SD Bergese, AM VanBuskirk	Transplantation	1997
Suki and Massry’s THERAPY OF RENAL DISEASES AND RELATED DISORDERS WN Suki, SG Massry		1997
Chemotherapy for invasive bladder cancer SB Malkowicz, DJ Vaughn	Urology	1996
Acute Management of Cancer-Related Hypercalcemia MA Chisholm, AL Mulloy, AT Taylor	The Annals of pharmacotherapy	1996
Effects of the antihypercalcemic drugs gallium nitrate and pamidronate on hormone release of pathologic human parathyroid cells P Ridefelt, E Gylfe, G Akerström, J Rastad	Surgery	1995
Hypercalcemia: How to pinpoint the cause and customize treatment TB Kaye	Postgraduate Medicine	1995
Ultrastructural and Histomorphometric Evaluations of Gallium Nitrate on Bone in Nude Mice Bearing a Canine Adenocarcinoma (CAC-8) Model of Humoral Hypercalcemia of Malignancy H Okada, JI Merryman, CC Capen, TJ Rosol	Veterinary pathology	1995
CYTOTOXICITY OF GALLIUM NITRATE IN VITRO USING BLADDER CANCER CELLS T Aoyagi, NH Bander	International journal of urology : official journal of the Japanese Urological Association	1995
Effects of gallium nitrate in nude mice bearing a canine adenocarcinoma (CAC-8) model of humoral hypercalcemia of malignancy JI Merryman, CC Capen, TJ Rosol	Journal of Bone and Mineral Research	1994
The effects of gallium nitrate on osteopenia induced by ovariectomy and a low-calcium diet in rats LS Stern, V Matkovic, SE Weisbrode, G Apseloff, DR Shepard, DC Mays, N Gerber	Bone and Mineral	1994
Effects of Humoral Hypercalcemia of Malignancy and Gallium Nitrate on Thyroid C Cells in Nude Mice: Immunohistochemical and Ultrastructural Investigations H Okada, JI Merryman, TJ Rosol, CC Capen	Veterinary pathology	1994
Metal Compounds in Cancer Therapy SP Fricker		1994
Gallium nitrate increases type I collagen and fibronectin mRNA and collagen protein levels in bone and fibroblast cells RS Bockman, PT Guidon, LC Pan, R Salvatori, A Kawaguchi	Journal of Cellular Biochemistry	1993
Gallium nitrate regulates rat osteoblast expression of osteocalcin protein and mRNA levels PT Guidon, R Salvatori, RS Bockman	Journal of Bone and Mineral Research	1993
Effect of gallium nitrate in vitro and in normal rats LG Jenis, CE Waud, GS Stein, JB Lian, DT Baran	Journal of Cellular Biochemistry	1993
Gallium nitrate inhibits alkaline phosphatase activity in a differentiating mesenchymal cell culture AL Boskey, W Ziecheck, P Guidon, SB Doty	Bone and Mineral	1993
Surgical Endocrinology M Press	Surgical Endocrinology	1993
Metal Compounds in Therapy and Diagnosis MJ Abrams, BA Murrer	Science	1993
The Effect of Gallium Nitrate on Healing of Vitamin D– and Phosphate–Deficient Rickets in the Immature Rat R Donnelly, R Bockman, E DiCarlo, F Betts, A Boskey	Calcified Tissue International	1993
Developmental toxicity evaluation of gallium nitrate in mice M Gómez, DJ Sánchez, JL Domingo, J Corbella	Archives of Toxicology	1992
Effects of Gallium on Bone in the Rat GK Wakley, J Garand, D Brown, BW Szukalski, NH Bell, RT Turner	Journal of Bone and Mineral Research	1992
Treatment with gallium nitrate: Evidence for interference with iron metabolism in vivo PA Seligman, PL Moran, RB Schleicher, ED Crawford	American Journal of Hematology	1992
Reversible inhibition of osteoclastic activity by bone-bound gallium (III) HC Blair, SL Teitelbaum, HL Tan, PH Schlesinger	Journal of Cellular Biochemistry	1992
Trace Element Nutrition and Bone Metabolism JH Beattie, A Avenell	Nutrition Research Reviews	1992
Medical management of hypercalcaemia SH Ralston	British Journal of Clinical Pharmacology	1992
Management of Acute Hypercalcemia AJ Wood, JP Bilezikian	New England Journal of Medicine	1992
Ga3+ inhibits parathyroid hormone release without interacting with the Ca2+ receptor of the parathyroid cell P Ridefelt, P Hellman, O Ljunggren, S Ljunghall, G Åkerström, J Rastad, E Gylfe	Biochemical and Biophysical Research Communications	1992
Gallium Nitrate TE Hughes, LA Hansen	The Annals of pharmacotherapy	1992
Hypercalcemia of malignancy: pathophysiology, diagnosis and treatment L Mosekilde, EF Eriksen, P Charles	Critical Reviews in Oncology/Hematology	1991
Effects of Metal Ions on Apatite Formation and Bone Mineralization NC Blumenthal, V Cosma	MRS Proceedings	1991
Gallium nitrate inhibits bone resorption and collagen synthesis in neonatal mouse calvariae P Lakatos, S Mong, PH Stern	Journal of Bone and Mineral Research	1991
International Review of Cytology RA Miller	International Review of Cytology	1991
Cardiovascular and Musculoskeletal Systems TC Jones, U Mohr, RD Hunt		1991
Gallium Nitrate: A Review of its Pharmacological Properties and Therapeutic Potential in Cancer-Related Hypercalcaemia PA Todd, A Fitton	Drugs	1991
Distribution of trace levels of therapeutic gallium in bone as mapped by synchrotron x-ray microscopy RS Bockman, MA Repo, RP Warrell, JG Pounds, G Schidlovsky, BM Gordon, KW Jones	Proceedings of the National Academy of Sciences	1990
Gallium inhibits bone resorption by a direct effect on osteoclasts TJ Hall, TJ Chambers	Bone and Mineral	1990
In Vivo Body Composition Studies S Yasumura, JE Harrison, KG McNeill, AD Woodhead, FA Dilmanian		1990
Effect of gallium on thein vitro formation, growth, and solubility of hydroxyapatite NC Blumenthal, V Cosma, S Levine	Calcified Tissue International	1989
Recent Advances in Pathophysiology and Treatment of Hypercalcemia of Malignancy GR Mundy, AJ Yates	American Journal of Kidney Diseases	1989
Hypercalcaemia of malignancy PJ Kelly, JA Eisman	Cancer and Metastasis Reviews	1989
Phase II evaluation of gallium nitrate by continuous infusion in breast cancer K Jabboury, D Frye, FA Holmes, G Fraschini, G Hortobagyi	Investigational New Drugs	1989
Effect of gallium on bone mineral properties MA Repo, RS Bockman, F Betts, AL Boskey, NW Alcock, RP Warrell	Calcified Tissue International	1988
Hypercalcemia JP Bilezikian	Disease-a-Month	1988
X-Ray Microscopy II D Sayre, J Kirz, M Howells, H Rarback		1988
Bone modeling in gallium nitrate-treated rats G Cournot-Witmer, A Bourdeau, M Lieberherr, CL Thil, JJ Plachot, G Enault, R Bourdon, S Balsan	Calcified Tissue International	1987
Bone metastases: Pathogenesis, treatment, and rationale for use of resorption inhibitors HI Scher, A Yagoda	The American Journal of Medicine	1987
Cancer Chemotherapy by Infusion JJ Lokich		1987
Clinical Science Review: Ectopic Hormone Syndromes PC Kohler, DL Trump	Cancer Investigation	1986
Gallium increases bone calcium and crystallite perfection of hydroxyapatite RS Bockman, AL Boskey, NC Blumenthal, NW Alcock, RP Warrell	Calcified Tissue International	1986
The effects of immobilization on bone histomorphometry in rats RT Turner, NH Bell	Journal of Bone and Mineral Research	1986
Hypercalcemia in the Critically Ill Patient C Reasner, GR Mundy	Journal of Intensive Care Medicine	1986
Treatment of Hypercalcemia RS Goldsmith	Medical Clinics of North America	1972

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