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Citations to this article

Relationship between obesity and maximal insulin-stimulated glucose uptake in vivo and in vitro in Pima Indians.
C Bogardus, … , A Kashiwagi, J E Foley
C Bogardus, … , A Kashiwagi, J E Foley
Published March 1, 1984
Citation Information: J Clin Invest. 1984;73(3):800-805. https://doi.org/10.1172/JCI111274.
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Research Article

Relationship between obesity and maximal insulin-stimulated glucose uptake in vivo and in vitro in Pima Indians.

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Abstract

Previous studies have left unanswered whether human obesity, independent of glucose intolerance, is associated with a "postreceptor" defect in insulin action. We have studied the relationship between the degree of obesity (as estimated by underwater weighing) and the maximal insulin-stimulated glucose disposal rate (M) in vivo in 52 glucose-tolerant Pima Indian males. The relationship was examined independently of differences in age and maximal oxygen uptake (an estimate of "physical fitness"). The maximal insulin-stimulated glucose transport rate (MTR) was also measured in isolated abdominal adipocytes from the same subjects to determine whether differences in M could be explained by differences in glucose transport. The results showed that there was a large variance in M and MTR among these glucose-tolerant subjects. M was better correlated with glucose storage rates than with oxidation rates, as estimated by indirect calorimetry. The most obese subjects had only a 20% lower mean M and 30% lower MTR than the most lean subjects. The lower M in the obese subjects was due to both lower glucose oxidation and storage rates. There was no significant, independent correlation between age or degree of obesity and M or MTR. The maximal oxygen uptake (VO2 max) appeared to independently account for 20% of the variance observed in M. MTR was only weakly correlated with M (r = 0.36, P less than 0.02). We concluded that differences in M in these glucose-tolerant subjects must be explained by factor(s) other than maximal oxygen uptake, age, maximal insulin-stimulated glucose transport in vitro, or degree of adiposity per se.

Authors

C Bogardus, S Lillioja, D Mott, G R Reaven, A Kashiwagi, J E Foley

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Total citations by year

Year: 2023 2022 2020 2019 2018 2017 2016 2014 2013 2011 2010 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 1985 Total
Citations: 1 2 2 1 1 2 2 1 3 17 4 3 2 2 1 3 4 3 4 1 6 3 1 2 2 2 5 4 3 2 7 5 5 3 109
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Citations to this article in year 2013 (3)

Title and authors Publication Year
Pleiotropic Actions of Insulin Resistance and Inflammation in Metabolic Homeostasis
JI Odegaard, A Chawla
Science 2013
The relationship between insulin sensitivity and maximal oxygen uptake is confounded by method of adjustment for body composition
BA Grice, CC Mason, EJ Weil, WC Knowler, J Pomeroy
Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease 2013
A Systems Biology Approach to Study Metabolic Syndrome
M Orešič, A Vidal-Puig
2013

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