The past five years have witnessed an explosion of information on the many and varied roles of H+ transport in cell function. H+ transport is involved in three broad areas of cell function: (a) maintenance and alteration of intracellular pH for initiation of specific cellular events, (b) generation of pH gradients in localized regions of the cell, including gradients involved in energy transduction, and (c) transepithelial ion transport. These processes each involve one or more of several H+ translocating mechanisms. The first section of this review will discuss these H+ translocating mechanisms and the second part will deal with the cellular functions controlled by H+ transport.
H E Ives, F C Rector Jr
Title and authors | Publication | Year |
---|---|---|
Carbon-based Nanomaterials and Hybrids: Synthesis, Properties, and Commercial Applications
A Sommer, HJ Fecht |
Carbon-based Nanomaterials and Hybrids: Synthesis, Properties, and Commercial Applications | 2014 |
Methods in Enzymology
JD Stone, AS Chervin, DH Aggen, DM Kranz |
Protein Engineering for Therapeutics Part B | 2012 |
Physiological role and regulation of the Na+/H+exchanger
ME Malo, L Fliegel |
Canadian Journal of Physiology and Pharmacology | 2006 |
The role of pH dynamics and the Na+/H+ antiporter in the etiopathogenesis and treatment of cancer. Two faces of the same coin—one single nature
S Harguindey, G Orive, JL Pedraz, A Paradiso, SJ Reshkin |
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer | 2005 |
Bioelectromagnetics in morphogenesis
M Levin |
Bioelectromagnetics | 2003 |
Encyclopedia of Molecular Biology
B Mannervik |
Encyclopedia of Molecular Biology | 2002 |
Principles of Medical Biology
JO Jørgensen |
Principles of Medical Biology | 1998 |
Secretin causes H+/HCO3− secretion from pig pancreatic ductules by vacuolar-type H+-adenosine triphosphatase
O Villanger, T Veel, MG Ræder |
Gastroenterology | 1995 |
Hsc70/uncoating ATPase activation — Proposal of a new model
ZS Stantchev |
Medical Hypotheses | 1994 |
Diseased cells and pH
K Carlin, S Carlin |
Medical Hypotheses | 1994 |
The antiporter in oncology in the light of the Spontaneous Regression of cancer and cell metabolism
S Harguindey, EJ Cragoe |
Medical Hypotheses | 1992 |
The origin of and subcellular mechanisms causing pancreatic bicarbonate secretion
MG Ræder |
Gastroenterology | 1992 |
International Review of Cytology
RA Miller |
International Review of Cytology | 1991 |
Cascading morphoregulatory energy and the biological form: Theory and reality
VD Deshmukh |
Medical Hypotheses | 1991 |
Sphingosine differentially inhibits activation of the Na+/H+ exchanger by phorbol esters and growth factors
JH Lowe, CL Huang, HE Ives |
The Journal of biological chemistry | 1990 |
Ion transport defects and hypertension. Where is the link?
HE Ives |
Hypertension | 1989 |
Acute cisplatin nephrotoxicity in the rat: Evidence for impaired entry of sodium into proximal tubule cells
MJ Field, TE Bostrom, F Seow, AZ Gyry, DJ Cockayne |
Pflügers Archiv - European Journal of Physiology | 1989 |
Na+/H+ exchange: What, where and why?
RW van Dyke, HE Ives |
Hepatology | 1988 |
Recombinant murine interferon-gamma-induced differentiation of pre-B lymphocytes is associated with Na+/H+ exchange-dependent and -independent cytoplasmic alkalinization
LL Smith, TH Stanton, MB Calalb, K Bomsztyk |
The Journal of biological chemistry | 1988 |
H+ stimulation of cell-mediated bone resorption in tissue culture
P Goldhaber, L Rabadjija |
American journal of physiology. Endocrinology and metabolism | 1987 |
Intracellular pH regulation and proton transport by rabbit renal medullary collecting duct cells. Role of plasma membrane proton adenosine triphosphatase
ML Zeidel, P Silva, JL Seifter |
Journal of Clinical Investigation | 1986 |
Receptor-mediated endocytosis
P Stahl, AL Schwartz |
Journal of Clinical Investigation | 1986 |
Proton secretion by the sodium/hydrogen ion antiporter in the human neutrophil
J Wright, JH Schwartz, R Olson, JM Kosowsky, AI Tauber |
Journal of Clinical Investigation | 1986 |
Properties and physiologic roles of the plasma membrane sodium-hydrogen exchanger
JL Seifter, PS Aronson |
Journal of Clinical Investigation | 1986 |
Distribution and function of classes of ATPases along the nephron
AI Katz |
Kidney International | 1986 |
NN′-dicyclohexylcarbodiimide (DCCD) reduces pancreatic NaHCO3secretion without changing pancreatic tissue ATP levels
T Grotmol, T Buanes, MG Raeder |
Acta Physiologica Scandinavica | 1986 |
Effect of side-chain shortening on the physiologic properties of bile acids: Hepatic transport and effect on biliary secretion of 23-nor-ursodeoxycholate in rodents
YB Yoon, LR Hagey, AF Hofmann, D Gurantz, EL Michelotti, JH Steinbagh |
Gastroenterology | 1986 |
Characterization of N-ethylmaleimide-sensitive proton pump in the rat kidney. Localization along the nephron
AK Ait-Mohamed, S Marsy, C Barlet, C Khadouri, A Doucet |
The Journal of biological chemistry | 1986 |
Evidence for carrier-mediated chloride/bicarbonate exchange in canalicular rat liver plasma membrane vesicles
PJ Meier, R Knickelbein, RH Moseley, JW Dobbins, JL Boyer |
Journal of Clinical Investigation | 1985 |
Immunoelectron microscopic localization of acidic intracellular compartments in hepatoma cells
AL Schwartz, GJ Strous, JW Slot, HJ Geuze |
The EMBO Journal | 1985 |
The amiloride sensitive Na+/H+ antiport in guinea pig pancreatic acini
M Dufresne, MJ Bastie, N Vaysse, Y Creach, E Hollande, A Ribet |
FEBS Letters | 1985 |
Transplasma-membrane redox systems in growth and development
FL Crane, IL Sun, MG Clark, C Grebing, H Löw |
Biochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics | 1985 |
Current Topics in Membranes and Transport
J Gliemann, WD Rees |
Current Topics in Membranes and Transport | 1983 |