Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Concurrent sickle cell anemia and alpha-thalassemia. Effect on pathological properties of sickle erythrocytes.
S H Embury, … , G Monroy, N Mohandas
S H Embury, … , G Monroy, N Mohandas
Published January 1, 1984
Citation Information: J Clin Invest. 1984;73(1):116-123. https://doi.org/10.1172/JCI111181.
View: Text | PDF
Research Article Article has an altmetric score of 1

Concurrent sickle cell anemia and alpha-thalassemia. Effect on pathological properties of sickle erythrocytes.

  • Text
  • PDF
Abstract

The concurrence of sickle cell anemia and alpha-thalassemia results in less severe hemolytic anemia apparently as a result of reduced intraerythrocytic concentration of hemoglobin S and its retarded polymerization. We have evaluated the effect of alpha-globin gene number on several interrelated properties of sickle erythrocytes (RBC) that are expected to correlate with the hemolytic and rheologic consequences of sickle cell disease. The irreversibly sickled cell number, proportion of very dense sickle RBC, and diminished deformability of sickle RBC each varied directly with alpha-globin gene number. Sickle RBC density was a direct function of the mean corpuscular hemoglobin concentration (MCHC). Even in nonsickle RBC, alpha-globin gene number varied directly with RBC density. Despite differences in alpha-globin gene number, sickle RBC of the same density had the same degree of deformability and dehydration. These data indicate that the fundamental effect of alpha-thalassemia is to inhibit the generation of sickle RBC having high density and MCHC, and that the other beneficial effects of sickle RBC are secondary to this process. The less consistent effect on overall clinical severity reported for subjects with this concurrence may reflect an undefined detrimental effect of alpha-thalassemia, possibly on the whole blood viscosity or on sickle RBC membrane-mediated adherence phenomena.

Authors

S H Embury, M R Clark, G Monroy, N Mohandas

×

Total citations by year

Year: 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2005 2003 2002 2001 1999 1997 1996 1994 1991 1990 1989 1988 1987 1986 1985 1984 1978 1949 Total
Citations: 3 1 5 3 1 5 7 7 2 6 6 3 2 1 3 2 3 3 2 2 2 2 2 1 1 4 1 2 4 3 2 4 1 1 1 98
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (98)

Title and authors Publication Year
Viscoelastic phenotyping of red blood cells
Gironella-Torrent M, Bergamaschi G, Sorkin R, Wuite GJ, Ritort F
Biophysical Journal 2024
Interplay between α‐thalassemia and β‐hemoglobinopathies: Translating genotype–phenotype relationships into therapies
Vadolas J, Nualkaew T, Voon HP, Vilcassim S, Grigoriadis G
HemaSphere 2024
Relationships Between Markers of Iron Status and Hematological Parameters in Patients With Sickle Cell Disease
Parrow NL, Doherty JM, Conrey A, Thein SL, Fleming RE
Advances in Hematology 2024
Genetic Variation and Sickle Cell Disease Severity: A Systematic Review and Meta-Analysis
Kirkham JK, Estepp JH, Weiss MJ, Rashkin SR
2023
Dynamics of Individual Red Blood Cells Under Shear Flow: A Way to Discriminate Deformability Alterations.
Atwell S, Badens C, Charrier A, Helfer E, Viallat A
Frontiers in physiology 2022
Shear-Stress-Gradient and Oxygen-Gradient Ektacytometry in Sickle Cell Patients at Steady State and during Vaso-Occlusive Crises.
Boisson C, Nader E, Renoux C, Gauthier A, Poutrel S, Bertrand Y, Stauffer E, Virot E, Hot A, Fort R, Cannas G, Joly P, Connes P
Cells 2022
Size and density measurements of single sickle red blood cells using microfluidic magnetic levitation.
Goreke U, Bode A, Yaman S, Gurkan UA, Durmus NG
Lab on a Chip 2022
The pleiotropic effects of α-thalassemia on HbSS and HbSC sickle cell disease: Reduced erythrocyte cation co-transport activity, serum erythropoietin, and transfusion burden, do not translate into increased survival.
Brewin JN, Nardo-Marino A, Stuart-Smith S, El Hoss S, Hanneman A, Strouboulis J, Menzel S, Gibson JS, Rees DC
American Journal of Hematology 2022
Sickle Cell Disease in Children and Adolescents: A Review of the Historical, Clinical, and Public Health Perspective of Sub-Saharan Africa and Beyond.
Egesa WI, Nakalema G, Waibi WM, Turyasiima M, Amuje E, Kiconco G, Odoch S, Kumbakulu PK, Abdirashid S, Asiimwe D
International journal of pediatrics 2022
Sickle cell vaso-occlusion: The dialectic between red cells and white cells
N Conran, SH Embury
Experimental biology and medicine (Maywood, N.J.) 2021
Comparisons of oxygen gradient ektacytometry parameters between sickle cell patients with or without α‐thalassaemia
C Boisson, C Renoux, E Nader, A Gauthier, S Poutrel, M Rab, R Fort, Y Bertrand, E Stauffer, G Cannas, K Kebaili, E Virot, A Hot, V Sheehan, E Beers, R Wijk, P Joly, P Connes
British Journal of Haematology 2021
Oxygen gradient ektacytometry does not predict pain in children with sickle cell anaemia.
Nardo-Marino A, Petersen J, Brewin JN, Birgens H, Williams TN, Kurtzhals JAL, Rees DC, Glenthøj A
British Journal of Haematology 2021
Loss of alpha‐globin genes in human subjects is associated with improved nitric oxide‐mediated vascular perfusion
CC Denton, P Shah, S Suriany, H Liu, W Thuptimdang, J Sunwoo, P Chalacheva, S Veluswamy, R Kato, JC Wood, JA Detterich, MC Khoo, TD Coates
American Journal of Hematology 2020
Genetic modulators of fetal hemoglobin expression and ischemic stroke occurrence in African descendant children with sickle cell anemia
M Nicolau, S Vargas, M Silva, A Coelho, E Ferreira, J Mendonça, L Vieira, P Kjöllerström, R Maia, R Silva, A Dias, T Ferreira, A Morais, IM Soares, J Lavinha, P Faustino
Annals of Hematology 2019
TNFSF/TNFRSF cytokine gene expression in sickle cell anemia: Up-regulated TNF-like cytokine 1A (TL1A) and its decoy receptor (DcR3) in peripheral blood mononuclear cells and plasma
S Safaya, M Alfarhan, A Sulaiman, A Alsulaiman, A Al-Ali
Cytokine 2019
Combined and differential effects of alpha‐thalassemia and HbF‐quantitative trait loci in Senegalese hydroxyurea‐free children with sickle cell anemia
FG Tall, C Martin, EH Ndour, C Renoux, ID Ly, P Connes, PM Gueye, RN Diallo, I Diagne, PA Diop, A Cissé, PL Sall, P Joly
Pediatric Blood & Cancer 2019
Considering the spleen in sickle cell disease
SE Hoss, V Brousse
Expert Review of Hematology 2019
Haemorheology in dilute, semi-dilute and dense suspensions of red blood cells
N Takeishi, ME Rosti, Y Imai, S Wada, L Brandt
Journal of Fluid Mechanics 2019
Association between Oxidative Stress, Genetic Factors, and Clinical Severity in Children with Sickle Cell Anemia
C Renoux, P Joly, C Faes, P Mury, B Eglenen, M Turkay, G Yavas, O Yalcin, Y Bertrand, N Garnier, D Cuzzubbo, A Gauthier, M Romana, B Möckesch, G Cannas, S Antoine-Jonville, V Pialoux, P Connes
The Journal of Pediatrics 2018
Genetic, laboratory and clinical risk factors in the development of overt ischemic stroke in children with sickle cell disease
AR Belisário, CM Silva, C Velloso-Rodrigues, MB Viana
2018
Decreased Hepcidin Levels Are Associated with Low Steady-state Hemoglobin in Children With Sickle Cell Disease in Tanzania
N Lee, J Makani, F Tluway, A Makubi, AE Armitage, SR Pasricha, H Drakesmith, AM Prentice, SE Cox
EBioMedicine 2018
Realizing effectiveness across continents with hydroxyurea: Enrollment and baseline characteristics of the multicenter REACH study in Sub-Saharan Africa
PT McGann, TN Williams, P Olupot-Olupot, GA Tomlinson, A Lane, JL da Fonseca, R Kitenge, G Mochamah, H Wabwire, S Stuber, TA Howard, K McElhinney, B Aygun, T Latham, B Santos, L Tshilolo, RE Ware
American Journal of Hematology 2018
Biological impact of α genes, β haplotypes, and G6PD activity in sickle cell anemia at baseline and with hydroxyurea
F Bernaudin, C Arnaud, A Kamdem, I Hau, F Lelong, R Epaud, C Pondarré, S Pissard
Blood Advances 2018
Rheological properties of sickle erythrocytes in patients with sickle-cell anemia: The effect of hydroxyurea, fetal hemoglobin, and α-thalassemia
SK Ballas, P Connes
European Journal of Haematology 2018
Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry
NL Parrow, PC Violet, H Tu, J Nichols, CA Pittman, C Fitzhugh, RE Fleming, N Mohandas, JF Tisdale, M Levine
Journal of visualized experiments : JoVE 2018
Hemolysis and the Pathophysiology of Sickle Cell Disease
Gregory Kato, Martin H. Steinberg, Mark Gladwin
Journal of Clinical Investigation 2017
Sickle cell disease in the older adult
MS Thein, NE Igbineweka, SL Thein
Pathology 2017
Dielectrophoretic force measurement of red blood cells exposed to oxidative stress using optical tweezers and a microfluidic chip
HJ Jeon, H Lee, DS Yoon, BM Kim
Biomedical Engineering Letters 2017
Variants in the non-coding region of the TLR2 gene associated with infectious subphenotypes in pediatric sickle cell anemia
S David, P Aguiar, L Antunes, A Dias, A Morais, A Sakuntabhai, J Lavinha
Immunogenetics 2017
Measurements of red cell deformability and hydration reflect HbF and HbA 2 in blood from patients with sickle cell anemia
NL Parrow, H Tu, J Nichols, PC Violet, CA Pittman, C Fitzhugh, RE Fleming, N Mohandas, JF Tisdale, M Levine
Blood cells, molecules & diseases 2017
Variability of homozygous sickle cell disease: The role of alpha and beta globin chain variation and other factors
GR Serjeant, E Vichinsky
Blood cells, molecules & diseases 2017
Alpha-thalassaemia promotes frequent vaso-occlusive crises in children with sickle cell anaemia through haemorheological changes: Renoux et al
C Renoux, P Connes, E Nader, S Skinner, C Faes, M Petras, Y Bertrand, N Garnier, D Cuzzubbo, L Divialle-Doumdo, K Kebaïli, C Renard, A Gauthier, M Etienne-Julan, G Cannas, C Martin, MD Hardy-Dessources, V Pialoux, M Romana, P Joly
Pediatric Blood & Cancer 2017
Association of adenylyl cyclase 6 rs3730070 polymorphism and hemolytic level in patients with sickle cell anemia
KC Cita, S Ferdinand, P Connes, L Brudey, B Tressières, M Etienne-Julan, N Lemonne, V Tarer, J Elion, M Romana
Blood Cells, Molecules, and Diseases 2016
Knowledge insufficient: the management of haemoglobin SC disease
LH Pecker, BA Schaefer, L Luchtman-Jones
British Journal of Haematology 2016
Malaria Induces Anemia through CD8 + T Cell-Dependent Parasite Clearance and Erythrocyte Removal in the Spleen
I Safeukui, ND Gomez, AA Adelani, F Burte, NK Afolabi, R Akondy, P Velazquez, A Holder, R Tewari, P Buffet, BJ Brown, WA Shokunbi, D Olaleye, O Sodeinde, J Kazura, R Ahmed, N Mohandas, D Fernandez-Reyes, K Haldar
mBio 2015
From the Bench to the Field in Low-Cost Diagnostics: Two Case Studies
AA Kumar, JW Hennek, BS Smith, S Kumar, P Beattie, S Jain, JP Rolland, TP Stossel, C Chunda-Liyoka, GM Whitesides
Angewandte Chemie (International ed. in English) 2015
The role of blood rheology in sickle cell disease
P Connes, T Alexy, J Detterich, M Romana, MD Hardy-Dessources, SK Ballas
Blood Reviews 2015
Alpha thalassemia among sickle cell anaemia patients in Kampala, Uganda
I Lubega, CM Ndugwa, EA Mworozi, JK Tumwine
African health sciences 2015
Vom Labortisch zur Feldforschung: zwei Fallstudien kostengünstiger Diagnostik
AA Kumar, JW Hennek, BS Smith, S Kumar, P Beattie, S Jain, JP Rolland, TP Stossel, C Chunda-Liyoka, GM Whitesides
Angewandte Chemie 2015
Medical and Surgical Complications of Sickle Cell Anemia
A Al-Salem
2015
Haptoglobin, alpha-thalassaemia and glucose-6-phosphate dehydrogenase polymorphisms and risk of abnormal transcranial Doppler among patients with sickle cell anaemia in Tanzania
SE Cox, J Makani, D Soka, VS L'Esperence, E Kija, P Dominguez-Salas, CR Newton, AA Birch, AM Prentice, FJ Kirkham
British Journal of Haematology 2014
Differences in the clinical and genotypic presentation of sickle cell disease around the world
SL Saraf, RE Molokie, M Nouraie, CA Sable, L Luchtman-Jones, GJ Ensing, AD Campbell, SR Rana, XM Niu, RF Machado, MT Gladwin, VR Gordeuk
Paediatric Respiratory Reviews 2014
Blood Thixotropy in Patients with Sickle Cell Anaemia: Role of Haematocrit and Red Blood Cell Rheological Properties
J Vent-Schmidt, X Waltz, M Romana, MD Hardy-Dessources, N Lemonne, M Billaud, M Etienne-Julan, P Connes, W Lam
PloS one 2014
Density-based separation in multiphase systems provides a simple method to identify sickle cell disease
AA Kumar, MR Patton, JW Hennek, SY Lee, G D'Alesio-Spina, X Yang, J Kanter, SS Shevkoplyas, C Brugnara, GM Whitesides
Proceedings of the National Academy of Sciences 2014
Prospective study of sickle cell trait and venous thromboembolism incidence
AR Folsom, W Tang, NS Roetker, AV Kshirsagar, VK Derebail, PL Lutsey, R Naik, JS Pankow, ML Grove, S Basu, NS Key, M Cushman
Journal of Thrombosis and Haemostasis 2014
Evaluation of a Density-Based Rapid Diagnostic Test for Sickle Cell Disease in a Clinical Setting in Zambia
AA Kumar, C Chunda-Liyoka, JW Hennek, H Mantina, SY Lee, MR Patton, P Sambo, S Sinyangwe, C Kankasa, C Chintu, C Brugnara, TP Stossel, GM Whitesides, W Lam
PloS one 2014
Advances in understanding the pathogenesis of cerebrovascular vasculopathy in sickle cell anaemia
P Connes, S Verlhac, F Bernaudin
British Journal of Haematology 2013
Analysis of hemoglobin electrophoresis results and physicians investigative practices in Saudi Arabia
SR Mehdi, BA Dahmash
Indian journal of human genetics 2013
Hematological and Genetic Predictors of Daytime Hemoglobin Saturation in Tanzanian Children with and without Sickle Cell Anemia
SE Cox, J Makani, CR Newton, AM Prentice, FJ Kirkham
ISRN Hematology 2013
Age-dependent changes in the membrane surface area: sickle red blood cell volume may account for differential clinical effects of coinherited α thalassemia on sickle cell anemia : Letter to the Editor
SH Embury
European Journal of Haematology 2012
Erythrocyte density in sickle cell syndromes is associated with specific clinical manifestations and hemolysis
P Bartolucci, C Brugnara, A Teixeira-Pinto, S Pissard, K Moradkhani, H Jouault, F Galacteros
Blood 2012
Encyclopedia of Life Sciences
B Dahlbäck
Encyclopedia of Life Sciences 2011
Modifier genes in Mendelian disorders: the example of hemoglobin disorders
VG Sankaran, G Lettre, SH Orkin, JN Hirschhorn
Annals of the New York Academy of Sciences 2010
Alpha-thalassemia is associated with a decreased occurrence and a delayed age-at-onset of albuminuria in sickle cell anemia patients
D Nebor, C Broquere, K Brudey, D Mougenel, V Tarer, P Connes, J Elion, M Romana
Blood Cells, Molecules, and Diseases 2010
History and Current Status of Newborn Screening for Hemoglobinopathies
JM Benson, BL Therrell
Seminars in Perinatology 2010
Red blood cell aggregation, aggregate strength and oxygen transport potential of blood are abnormal in both homozygous sickle cell anemia and sickle-hemoglobin C disease
J Tripette, T Alexy, MD Hardy-Dessources, D Mougenel, E Beltan, T Chalabi, R Chout, M Etienne-Julan, O Hue, HJ Meiselman, P Connes
Haematologica 2009
β S -Globin Gene Cluster Haplotypes in the West Bank of Palestine
F Samarah, S Ayesh, M Athanasiou, J Christakis, N Vavatsi
Hemoglobin 2009
Red cell membrane: past, present, and future
N Mohandas, PG Gallagher
Blood 2008
Disorders of red cell membrane
X An, N Mohandas
British Journal of Haematology 2008
G6PD deficiency, absence of alpha-thalassemia, and hemolytic rate at baseline are significant independent risk factors for abnormally high cerebral velocities in patients with sickle cell anemia
Françoise Bernaudin, Suzanne Verlhac, Sylvie Chevret, Martine Torres, Lena Coic, Cécile Arnaud, Annie Kamdem, Isabelle Hau, Maria Grazia Neonato, Christophe Delacourt
Blood 2008
Hemolysis-associated priapism in sickle cell disease
VG Nolan, DF Wyszynski, LA Farrer, MH Steinberg
Blood 2005
Predicting clinical severity in sickle cell anaemia
MH Steinberg
British Journal of Haematology 2005
Sickle Cell Vaso-Occlusion
EY Chiang, PS Frenette
Hematology/Oncology Clinics of North America 2005
Alpha Thalassemia is Associated With Decreased Risk of Abnormal Transcranial Doppler Ultrasonography in Children With Sickle Cell Anemia
LL Hsu, ST Miller, E Wright, A Kutlar, V McKie, W Wang, CH Pegelow, C Driscoll, A Hurlet, G Woods, L Elsas, S Embury, RJ Adams
Journal of Pediatric Hematology/Oncology 2003
Differential gene expression in the kidney of sickle cell transgenic mice: upregulated genes
AC Rybicki, ME Fabry, MD Does, DK Kaul, RL Nagel
Blood Cells, Molecules, and Diseases 2003
Developing treatment for sickle cell disease
C Brugnara, MH Steinberg
Expert Opinion on Investigational Drugs 2002
Sickle Cell Disease: An Overview
HO BB(ASCP)SC
Laboratory Medicine 2002
Pleiotropic and epistatic effects in sickle cell anemia
RL Nagel
Current Opinion in Hematology 2001
Effect of α-Globin Genotype on the Pathophysiology of Sickle Cell Disease
SK Ballas
Pediatric Pathology & Molecular Medicine 2001
Multi-ribozyme Targeting of Human α-Globin Gene Expression
TJ Shen, P Ikonomi, R Smith, CT Noguchi, C Ho
Blood Cells, Molecules, and Diseases 1999
Evidence that Microdeletions in the α Globin Gene Protect Against the Development of Sickle Cell Glomerulopathy in Humans
A Guasch, CF Zayas, JR Eckman, K Muralidharan, W Zhang, LJ Elsas
Journal of the American Society of Nephrology : JASN 1999
Benign clinical course in homozygous sickle cell disease: A search for predictors
PW Thomas, DR Higgs, GR Serjeant
Journal of Clinical Epidemiology 1997
Is Hb A 2 Elevated in Adults with Sickle-A-Thalassemi (β S /β S ; -α/-α)
SK Ballas, RN Gay, FF Chehab
Hemoglobin 1997
Influence of α-thalassemia trait on spleen function in sickle cell anemia patients with high HbF
AD Adekile, M Tuli, MZ Haider, K Al-Zaabi, S Mohannadi, A Owunwanne
American Journal of Hematology 1996
Alpha thalassemia and stroke risk in sickle cell anemia
RJ Adams, A Kutlar, V McKie, E Carl, FT Nichols, JC Liu, K McKie, A Clary
American Journal of Hematology 1994
Effects of alpha-thalassemia and sickle polymerization tendency on the urine-concentrating defect of individuals with sickle cell trait
AK Gupta, KA Kirchner, R Nicholson, JG 3rd, AN Schechter, CT Noguchi, MH Steinberg
Journal of Clinical Investigation 1991
Laboratory diagnosis of hemoglobinopathies
B Lubin, H Witkowska, K Kleman
Clinical Biochemistry 1991
The Interactions of α -Thalassemia with Hemoglobinopathies
MH Steinberg
Hematology/Oncology Clinics of North America 1991
ß s -Gene-Cluster Haplotypes in Sickle Cell Anemia: Clinical and Hematologic Features
DR Powars
Hematology/Oncology Clinics of North America 1991
The Challenge of Sickle Cell Disease in Saudi Arabia
GR Serjeant
Annals of Saudi medicine 1990
Alpha Thalassemia
SH Embury
Annals of the New York Academy of Sciences 1989
Rheological and Adherence Properties of Sickle Cells
N Mohandas, E Evans
Annals of the New York Academy of Sciences 1989
Effect of human beta (s)-globin chains on cellular properties of red cells from beta-thalassemic mice
EM Rubin, YW Kan, N Mohandas
Journal of Clinical Investigation 1988
Evolution of Laboratory Parameters During Sickle Cell Painful Crisis: Evidence Compatible with Dense Red Cell Sequestration Without Thrombosis
HH Billett, RL Nagel, ME Fabry
The American Journal of the Medical Sciences 1988
The Interaction of α-Thalassemia with Sickle Cell Anemia
SH Embury
Hemoglobin 1988
Analysis of crossover type in the ?-3�7 haplotype among sickle cell anemia patients from various parts of Africa
C Dod, A Berth, J Rochette, R Girot, D Labie
Human Genetics 1988
The haematology of steady state homozygous sickle cell disease: interrelationships between haematological indices
GH Maude, RJ Hayes, GR Serjeant
British Journal of Haematology 1987
Effects of α-thalassemia-2 on the developmental changes of hematological values in children with sickle cell disease from georgia
AE Felice, KM McKie, MP Cleek, EM Marino, A Kutlar, VC McKie
American Journal of Hematology 1987
6 Rheology of the sickle cell disorders
J Stuart, CS Johnson
Baillière's Clinical Haematology 1987
The effect of Hb F and α-thalassemia on the red cell indices in sickle cell anemia
PF Milner, GJ Garbutt, LV Nolan-Davis, F Jonah, LB Wilson, JT Wilson
American Journal of Hematology 1986
Hemoglobin SC disease and alpha-thalassemia. Prolonged survival and mild clinical course
GP Rodgers, EA Sahovic, LE Pierce, NP Anagnou, CT Noguchi, AN Schechter
The American Journal of Medicine 1986
Alpha thalassemia changes erythrocyte heterogeneity in sickle cell disease
CT Noguchi, GJ Dover, GP Rodgers, GR Serjeant, SE Antonarakis, NP Anagnou, DR Higgs, DJ Weatherall, AN Schechter
Journal of Clinical Investigation 1985
The Interaction of Coexistent ?-Thalassemia and Sickle Cell Anemia: A Model for the Clinical and Cellular Results of Diminished Polymerization?
SH Embury
Annals of the New York Academy of Sciences 1985
The many pathophysiologies of sickle cell anemia
RL Nagel, ME Fabry
American Journal of Hematology 1985
Hematologically and Genetically Distinct Forms of Sickle Cell Anemia in Africa: The Senegal Type and the Benin Type
RL Nagel, ME Fabry, J Pagnier, I Zohoun, H Wajcman, V Baudin, D Labie
New England Journal of Medicine 1985
?-Thalassemia among sickle cell anemia patients in various African populations
J Pagnier, O Dunda-Belkhodja, I Zohoun, J Teyssier, H Baya, G Jaeger, RL Nagel, D Labie
Human Genetics 1984
Prenatal Diagnosis of Hemoglobinopathies
CO Leonard, HH Kazazian
Pediatric Clinics of North America 1978
Hematology
JJ Shea, JJ Shea
The Laryngoscope 1949

← Previous 1 2 3 4 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Pinned by 1 on Pinterest
53 readers on Mendeley
See more details