Citations to this article

Leukotriene biosynthesis by polymorphonuclear leukocytes from two patients with chronic granulomatous disease.
S J Feinmark, … , J Palmblad, C Malmsten
S J Feinmark, … , J Palmblad, C Malmsten
Published November 1, 1983
Citation Information: J Clin Invest. 1983;72(5):1839-1843. https://doi.org/10.1172/JCI111144.
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Research Article

Leukotriene biosynthesis by polymorphonuclear leukocytes from two patients with chronic granulomatous disease.

Abstract

Polymorphonuclear leukocytes (PMNL) isolated from two patients with chronic granulomatous disease (CGD) were tested for their ability to metabolize arachidonic acid to lipoxygenase products including 5(S),12(R)-dihydroxy-6,14-cis-8,10-trans-eicosatetraenoic acid (LTB4). Analyses of incubations of these PMNL with arachidonic acid and the calcium ionophore A23187 did not differ from simultaneous controls in the production of LTB4, other 5,12-dihydroxy-eicosatetraenoic acids, or monohydroxy-eicosatetraenoic acids. The clinical diagnosis of CGD was confirmed in both cases by determination of PMNL chemiluminescence. Leukocytes from both patients failed to generate active oxygen species in response to either LTB4 or formyl-methionyl-leucyl-phenylalanine. The observation of arachidonic acid oxidation in the absence of superoxide anion precludes a role for the active oxygen species in this metabolic process. These studies clearly dissociate the ionophore-induced leukocyte respiratory burst from the oxidation of arachidonate to the leukotrienes. In addition, the defect of CGD appears to be unrelated to the ability of PMNL to carry out arachidonate oxygenation.

Authors

S J Feinmark, A M Udén, J Palmblad, C Malmsten

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Citations to this article (14)

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In Vivo Effect of Lipopolysaccharide on Alveolar and Peritoneal Macrophages of Rats: Superoxide Anion Generation and 5-Lipoxygenase Metabolism of Arachidonic Acid
H Takahashi, M Abe, S Hashimoto, K Takayama, M Miyazaki 		American journal of respiratory cell and molecular biology 1993
Enhanced superoxide anion generation but reduced leukotriene B4 productivity in thioglycollate-elicited peritoneal macrophages
M Abe, H Takahashi, T Gouya, N Nagata, N Shigematsu 		Prostaglandins, Leukotrienes and Essential Fatty Acids 1990
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Endothelial cell leukotriene C4 synthesis results from intercellular transfer of leukotriene A4 synthesized by polymorphonuclear leukocytes
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Release of arachidonate and reduction of oxygen. Independent metabolic bursts of the mouse peritoneal macrophage
S Tsunawaki, CF Nathan 		The Journal of biological chemistry 1986
Free Oxygen Radicals Are Not Detectable by Chemiluminescence during Human Natural Killer Cell Cytotoxicity
U Ramstedt, P Rossi, C Kullman, E Warren, J Palmblad, M Jondal 		Scandinavian Journal of Immunology 1984
Oxygen uptake associated with Sendai-virus-stimulated chemiluminescence in rat thymocytes contains a significant non-mitochondrial component
ME Kolbuch-Braddon, E Peterhans, R Stocker, MJ Weidemann 		Biochemical Journal 1984
Studies on the mechanism of superoxide release from human neutrophils stimulated with arachidonate
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