Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Effects of cyclooxygenase inhibitors on the alterations in lung mechanics caused by endotoxemia in the unanesthetized sheep.
J R Snapper, … , M L Ogletree, K L Brigham
J R Snapper, … , M L Ogletree, K L Brigham
Published July 1, 1983
Citation Information: J Clin Invest. 1983;72(1):63-76. https://doi.org/10.1172/JCI110985.
View: Text | PDF
Research Article Article has an altmetric score of 3

Effects of cyclooxygenase inhibitors on the alterations in lung mechanics caused by endotoxemia in the unanesthetized sheep.

  • Text
  • PDF
Abstract

The effects of Escherichia coli endotoxin on lung mechanics, hemodynamics, gas exchange, and lung fluid and solute exchange were studied in 12 chronically instrumented unanesthetized sheep. A possible role for cyclooxygenase products of arachidonate metabolism as mediators of the endotoxin-induced alterations in lung mechanics was investigated by studying sheep before and after cyclooxygenase inhibition with sodium meclofenamate and ibuprofen. Sheep were studied three times in random order: (a) sodium meclofenamate (or ibuprofen) infusion alone; (b) E. coli endotoxin alone; and (c) meclofenamate (or ibuprofen) and endotoxin. Meclofenamate alone had no effect on any of the variables measured. Endotoxin alone caused early marked changes in lung mechanics: resistance to airflow across the lungs (RL) increased 10-fold, dynamic lung compliance (Cdyn) decreased 80% and functional residual capacity (FRC) decreased by greater than 30%. The alveolar-to-arterial oxygen difference (delta AaPO2) increased markedly following endotoxemia. In the presence of sufficient meclofenamate to inhibit accumulation of thromboxane-B2 and 6-keto-prostaglandin F1 alpha in lung lymph, endotoxin caused no increase in RL, Cdyn decreased by less than 40%, and FRC decreased by only 6%. Meclofenamate significantly attenuated the hypoxemia and early pulmonary hypertension caused by endotoxemia but had no effect on the late increases in lung fluid and solute exchange. Ibuprofen had similar effects to those observed with meclofenamate. We conclude that both the pulmonary hypertension and changes in lung mechanics observed after endotoxemia may be mediated, at least in part, by constrictor prostaglandins or thromboxanes and that gas exchange may be improved by preventing endogenous synthesis of these mediators.

Authors

J R Snapper, A A Hutchison, M L Ogletree, K L Brigham

×

Total citations by year

Year: 2019 2018 2015 2014 2008 2007 2006 2005 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 1985 1984 1983 1973 Total
Citations: 1 1 1 1 2 1 3 1 1 3 1 2 2 4 4 8 3 8 12 8 10 10 12 7 12 12 9 2 1 142
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (142)

Title and authors Publication Year
Risk factors for the development of acute respiratory distress syndrome in mechanically ventilated adults in Peru: a multicenter observational study
E Gupta, S Hossen, MR Grigsby, P Herrera, R Roldan, E Paz, AA Jaymez, EE Chirinos, J Portugal, R Quispe, RG Brower, W Checkley
Critical Care 2019
Annual Update in Intensive Care and Emergency Medicine 2018
JL Vincent
2018
Ibuprofen: Discovery, Development and Therapeutics
KD Rainsford
Ibuprofen: Discovery, Development and Therapeutics 2015
Comprehensive Physiology
SN Cheuvront, RW Kenefick
Comprehensive Physiology 2014
Yearbook of Intensive Care and Emergency Medicine
JL Vincent
2008
Analysis of Plasma Serotonin Levels and Hemodynamic Responses Following Chronic Serotonin Infusion in Broilers Challenged with Bacterial Lipopolysaccharide and Microparticles
ME Chapman, RL Taylor, RF Wideman
Poultry science 2008
Sepsis
JM O’Brien, NA Ali, SK Aberegg, E Abraham
The American Journal of Medicine 2007
INFUSION OF INCREASING DOSES OF ENDOTOXIN INDUCES PROGRESSIVE ACUTE LUNG INJURY BUT PREVENTS EARLY PULMONARY HYPERTENSION IN PIGS
R Schmidhammer, E Wassermann, P Germann, H Redl, R Ullrich
Shock 2006
INFUSION OF INCREASING DOSES OF ENDOTOXIN INDUCES PROGRESSIVE ACUTE LUNG INJURY BUT PREVENTS EARLY PULMONARY HYPERTENSION IN PIGS:
R Schmidhammer, E Wassermann, P Germann, H Redl, R Ullrich
Shock 2006
Evaluation of the Serotonin Receptor Blocker Methiothepin in Broilers Injected Intravenously with Lipopolysaccharide and Microparticles
ME Chapman, RF Wideman
Poultry science 2006
Endotoxin-induced acute lung injury requires interaction with the liver
AM Siore, RE Parker, AA Stecenko, C Cuppels, M McKean, BW Christman, R Cruz-Gervis, KL Brigham
American journal of physiology. Lung cellular and molecular physiology 2005
Enhanced release of thromboxane A2 after exposure of human airway epithelial cells to meconium
AM Khan, KP Lally, GL Larsen, GN Colasurdo
Pediatric Pulmonology 2002
Ibuprofen attenuates early lung injury in endotoxemic, neutropenic rats
KM Daphtary, SM Heidemann, M Glibetic
Prostaglandins, Leukotrienes and Essential Fatty Acids 2001
Correlation between Increased Airway Responsiveness and Severity of Pulmonary Edema
YS Hwang, PL Lefferts, JR Snapper
Pulmonary Pharmacology & Therapeutics 2001
Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E
A Gullo
2001
Correlation between ventilation and perfusion determinesV˙ a /Q˙ heterogeneity in endotoxemia
AJ Gerbino, S McKinney, RW Glenny
Journal of applied physiology 2000
Effects of ibuprofen on the physiology and survival of hypothermic sepsis:
MM Arons, AP Wheeler, GR Bernard, BW Christman, JA Russell, R Schein, WR Summer, KP Steinberg, W Fulkerson, P Wright, WD Dupont, BB Swindell
Critical Care Medicine 1999
Intravascular macrophage depletion attenuates endotoxin lung injury in anesthetized sheep
Y Sone, VB Serikov, NC Staub
Journal of applied physiology 1999
Role of Endothelin in Endotoxin-induced Sustained Pulmonary Hypertension in Sheep
JR Snapper, JS Thabes, PL Lefferts, W Lu
American journal of respiratory and critical care medicine 1998
Effect of platelet-activating factor-receptor antagonism on endotoxin-induced lung dysfunction in sheep
JR Snapper, W Lu, PL Lefferts, JS Thabes
Journal of applied physiology 1998
Meconium aspiration induces ARDS-like pulmonary response in lungs of ten-week-old pigs
H Soukka, M Rautanen, L Halkola, P Kero, P Kääpä
Pediatric Pulmonology 1997
The Effects of Ibuprofen on the Physiology and Survival of Patients with Sepsis
GR Bernard, AP Wheeler, JA Russell, R Schein, WR Summer, KP Steinberg, WJ Fulkerson, PE Wright, BW Christman, WD Dupont, SB Higgins, BB Swindell
New England Journal of Medicine 1997
Intratracheal Aerosolization of Endotoxin (LPS) in the Rat: A Comprehensive Animal Model to Study Adult (Acute) Respiratory Distress Syndrome
HP van Helden, WC Kuijpers, D Steenvoorden, C Go, PL Bruijnzeel, M Eijk, HP Haagsman
Experimental Lung Research 1997
Experimental fat embolism induces urine 2,3-dinor-6-ketoprostaglandin F sub 1 alpha and 11-dehydrothromboxane B sub 2 excretion in pigs:
M Rautanen, E Gullichsen, A Riutta, K Kuttila, I Mucha, O Nelimarkka, J Niinikoski
Critical Care Medicine 1997
PHARMACOTHERAPY OF SEPSIS
LF Weikert, GR Bernard
Clinics in Chest Medicine 1996
Effects of Anti-inflammatory Agents on Hydrochloric Acid-Induced Pulmonary Injury
CL Westervelt, EU Choe, J Arya, HL Lippton, LM Flint, JJ Ferrara
Journal of Investigative Surgery 1996
Gamma -Linolenic Acid: Metabolism and Its Roles in Nutrition and Medicine
R Zurier, P DeLuca, D Rothman
Gamma -Linolenic Acid: Metabolism and Its Roles in Nutrition and Medicine 1996
Surfactant replacement in the treatment of sepsis-induced adult respiratory distress syndrome in pigs:
GF Nieman, LA Gatto, AM Paskanik, B Yang, R Fluck, A Picone
Critical Care Medicine 1996
Effect of cyclooxygenase inhibition in a canine model of unilateral pulmonary occlusion and reperfusion
W Segiet, H Krieter, C Stieber, DM Albrecht, K Ackern
Intensive Care Medicine 1995
Does Early Posttreatment with Lidocaine Attenuate Endotoxin-induced Acute Lung Injury in Rabbits?
K Nishina, K Mikawa, N Maekawa, Y Takao, H Obara
Anesthesiology 1995
Effect of combined nitric oxide inhalation and N sup G-nitro-L-arginine infusion in porcine endotoxin shock
E Weitzberg, A Rudehill, A Modin, JM Lundberg
Critical Care Medicine 1995
Pulmonary Ventilation, Mechanics, Gas Exchange and Haemodynamics in Calves Following Intratracheal Inoculation of Pasteurella haemolytica
A Linden, D Desmecht, H Amory, G Daube, S Lecomte, P Lekeux
Journal of Veterinary Medicine Series A 1995
Does Early Posttreatment with Lidocaine Attenuate Endotoxin-induced Acute Lung Injury in Rabbits?:
K Nishina, K Mikawa, N Maekawa, Y Takao, H Obara
Anesthesiology 1995
Comparison of the Pulmonary Dysfunction Caused by Cardiogenic and Noncardiogenic Pulmonary Edema
GR Bernard, NA Pou, JW Coggeshall, FE Carroll, JR Snapper
Chest 1995
Clinical Trials for the Treatment of Sepsis
JL Vincent, WJ Sibbald
1995
Effect of cyclooxygenase inhibition in a canine model of unilateral pulmonary occlusion and reperfusion
W Segiet, H Krieter, C Stieber, DM Albrecht, K van Ackern
Intensive Care Medicine 1995
Vascular Endothelium
MA Gimbrone, MI Cybulsky, N Kume, T Collins, N Resnick
Annals of the New York Academy of Sciences 1994
Effect of Bronchodilators on Lung Mechanics in the Acute Respiratory Distress Syndrome (ARDS)
PE Wright, LC Carmichael, GR Bernard
Chest 1994
Adult Respiratory Distress Syndrome—An Update
MJ Chapman
ANAESTH INTENS CARE 1994
Effects of continuous infusion of nitroglycerin on pulmonary hemodynamics, lung lymph balance, and prostanoid products in the response to endotoxin in awake sheep
T Koizumi, K Kubo, K Hirai, S Shinozaki, T Kobayashi, M Sekiguchi, A Sakai
Lung 1993
Nitric oxide inhalation attenuates pulmonary hypertension and improves gas exchange in endotoxin shock
E Weitzberg, A Rudehill, JM Lundberg
European Journal of Pharmacology 1993
Cecal ligation and puncture is associated with pulmonary injury in the rat: Role of cyclooxygenase pathway products
MJ Schneidkraut, RW Carlson
Prostaglandins 1993
Neutrophil Elastase Inhibitors, SC-37698 and SC-39026, Reduce Endotoxin-induced Lung Dysfunction in Awake Sheep
JR Gossage, Y Kuratomi, JM Davidson, PL Lefferts, JR Snapper
American journal of respiratory and critical care medicine 1993
Pharmacologic Reduction in Tumor Necrosis Factor Activity of Pulmonary Alveolar Macrophages
SK Leeper-Woodford, BJ Fisher, HJ Sugerman, AA Fowler
American journal of respiratory cell and molecular biology 1993
Secondary Organ Dysfunction: From Clinical Perspectives to Molecular Mediators
MD Cipolle, MD Pasquale, FB Cerra
Critical Care Clinics 1993
Pathophysiology of Shock, Sepsis, and Organ Failure
G Schlag, H Redl
1993
Blood Transfusion Related Adult Respiratory Distress Syndrome
M Malouf, AR Glanville
ANAESTH INTENS CARE 1993
Pasteurella haemolytica A1 and Bovine Respiratory Disease: Pathogenesis
LO Whiteley, SK Maheswaran, DJ Weiss, TR Ames, MS Kannan
Journal of Veterinary Internal Medicine 1992
Respiratory Distress Resulting from Acute Lung Injury in the Veterinary Patient
CW Frevert, AE Warner
Journal of Veterinary Internal Medicine 1992
Staphylococcal alpha toxin: a study with chronically instrumented awake sheep
S Harshman, PL Lefferts, JR Snapper
Infection and immunity 1992
Pharmacologic agents in the treatment of ischemia, hemorrhagic shock, and sepsis
JM Harkema, G Singh, P Wang, IH Chaudry
Journal of Critical Care 1992
The low-chloride cough response is not inhibited by a single, high dose of aspirin
RA Stone, PJ Barnes, RW Fuller
British Journal of Clinical Pharmacology 1992
Effects of thromboxane synthase and cyclooxygenase inhibition on PAF-induced changes in lung function and arachidonic acid metabolism
DS Trochtenberg, PL Lefferts, GA King, YS Hwang, BW Christman, JR Snapper
Prostaglandins 1992
Dibutyryl Cyclic AMP Attenuates Lung Responses Induced by Endotoxin in Conscious Sheep
S Koyama, T Toyofuku, K Hirai, K Yoshimura, A Sakai, T Kobayashi
American journal of respiratory and critical care medicine 1992
Yearbook of Intensive Care and Emergency Medicine 1992
JL Vincent
1992
Mediators of Sepsis
M Lamy, LG Thijs
1992
The pulmonary physician and critical care. 4. A new look at the pulmonary circulation in acute lung injury
GA Fox, DG McCormack
Thorax 1992
Oxygen Transport to Tissue XIII
TK Goldstick, M McCabe, DJ Maguire
1992
Pulmonary Arterial Hypertension In Sepsis And The Adult Respiratory Distress Syndrome
H Spapen, W Vincken
ACTA CLINICA BELGICA 1992
Acute respiratory distress syndrome--two decades later
AJ Cunningham
The Yale journal of biology and medicine 1991
Influence of SK&F 96148 on thromboxane-mediated responses in the airways of the cat
MC Dyson, PJ Kadowitz
European Journal of Pharmacology 1991
Attenuation of the pulmonary vascular response to endotoxin by a thromboxane synthesis inhibitor (UK-38485) in unanesthetized sheep
CL Henry, ML Ogletree, KL Brigham, JW Hammon
Journal of Surgical Research 1991
Influence of SK&F 96148 on thromboxane-mediated responses in the airways of the cat
MC Dyson, PJ Kadowitz
European Journal of Pharmacology 1991
Effects of ritodrine infusion on hemodynamics and lung lymph in awake sheep
FL Watts, GR Bernard
Pulmonary Pharmacology 1991
Effects of Intravenous Amphotericin B Infusion on Hemodynamics and Airway Mechanics in Awake Sheep
WD Hardie, PE Wright, GR Bernard
Chest 1991
Therapy of Bovine Bacterial Pneumonia
CR Clarke, GE Burrows, TR Ames
Veterinary Clinics of North America Food Animal Practice 1991
Update 1991
JL Vincent
1991
ONO 3708: A New Thromboxane A2Receptor Antagonist
C Taneyama, H Goto
Cardiovascular Drug Reviews 1990
Application of reversed phase high performance liquid chromatography to the analysis of sulphidopeptide leukotrienes in pig bile
P Tagari, D Ethier, A Ford-Hutchinson, M Cirino
Biomedical Chromatography 1990
The prominent role of thromboxane A2 formation on early pulmonary hypertension induced by oleic acid administration in sheep
C Rostagno, GF Gensini, S Boncinelli, M Marsili, S Castellani, P Lorenzi, V Merciai, M Linden, GL Chelucci, F Cresci
Thrombosis Research 1990
ONO 3708: A New Thromboxane A 2 Receptor Antagonist
C Taneyama, H Goto
Cardiovascular Drug Reviews 1990
Modern approaches to the therapy of septic shock
C Putterman
The American Journal of Emergency Medicine 1990
Indomethacin enhances histamine-induced pulmonary hemodynamic changes
JY Tsang, H Ohtaka, M Ohgami, RR Schellenberg
Prostaglandins 1990
Edema pulmonar no cardiogénico
JI Sznajder
Archivos de Bronconeumología 1990
Adult Respiratory Distress Syndrome: A Complication of Shock
P Vaughan, C Brooks
Critical Care Nursing Clinics of North America 1990
Cellular and Humoral Mediators of Sepsis Syndrome
M Stroud, B Swindell, GR Bernard
Critical Care Nursing Clinics of North America 1990
Pharmacologic Treatment of the Adult Respiratory Distress Syndrome
G Goldstein, JM Luce
Clinics in Chest Medicine 1990
Pharmacology of Aprotinin and Efficacy During Cardiopulmonary Bypass
TE Emerson
Cardiovascular Drug Reviews 1989
Protection against pulmonary oxygen toxicity by interleukin-1 and tumor necrosis factor: Role of antioxidant enzymes and effect of cyclooxygenase inhibitors
CW White, P Ghezzi
Biotherapy 1989
The adult respiratory distress syndrome. New insights into diagnosis, pathophysiology, and treatment
MA Matthay
The Western journal of medicine 1989
Role of prostanoids in respiratory failure during circulatory shock of intestinal origin in dogs
T Mózes, E Wieszt
Prostaglandins, Leukotrienes and Essential Fatty Acids 1989
The pathophysiology and treatment of canine kerosene pulmonary injury: Effects of plasmapheresis and positive end-expiratory pressure
AR Zucker, JL Sznajder, CJ Becker, S Berger, LD Wood
Journal of Critical Care 1989
Pharmacologic Modulation of Lung Injury
SI Said, HD Foda
American journal of respiratory and critical care medicine 1989
Acute Lung Injury in Septic Shock
A Bersten, WJ Sibbald
Critical Care Clinics 1989
Prostaglandins, Cyclo-oxygenase Inhibitors, and Thromboxane Synthetase Inhibitors in the Pathogenesis of Multiple Systems Organ Failure
RA Petrak, RA Balk, RC Bone
Critical Care Clinics 1989
Effects of a thromboxane A2 analogue and prostacyclin on lung fluid balance in newborn lambs
K Yoshimura, ML Tod, KG Pier, LJ Rubin
Circulation research 1989
Differential effects of ibuprofen, indomethacin, and meclofenamate on prostaglandin endoperoxide H2 metabolism
PR Mayeux, PJ Kadowitz, DB McNamara
Molecular and Cellular Biochemistry 1989
Biochemical, physiological and clinical aspects of endotoxemia
NC Olson, WL Salzer, CE McCall
Molecular Aspects of Medicine 1988
Continuous air embolization into sheep causes sustained pulmonary hypertension and increased pulmonary vasoreactivity
EA Perkett, KL Brigham, B Meyrick
The American Journal of Pathology 1988
Ventilation-perfusion inequality during endotoxin-induced pulmonary vasoconstriction in conscious sheep: mechanisms of hypoxia
PC Hüttemeier, C Ringsted, K Eliasen, T Mogensen
Clinical Physiology 1988
Anaphylatoxin C3a peptide contracts human pulmonary vasculature
RR Schellenberg, JB Mullen, A Foster, MM Glovsky
Pulmonary Pharmacology 1988
Attenuation of endotoxin-induced cytotoxicity and prostacyclin production in cultured bovine pulmonary artery endothelial cells by phosphodiesterase inhibition
A Hussein, B Meyrick, S Graber, L Berry Jr, K L Brigham
Experimental Lung Research 1988
The Physiology of Stress and Its Relationship to Mechanisms of Disease and Therapeutics
JE Breazile
Veterinary Clinics of North America Food Animal Practice 1988
Neonatal Adaptation to Stress of Parturition and Dystocia
JE Breazile, LA Vollmer, LE Rice
Veterinary Clinics of North America Food Animal Practice 1988
Therapeutic Strategies for Acute Hypoxemic Respiratory Failure
AR Zucker
Critical Care Clinics 1988
ZAK München 1987
K Peter, J Groh
1988
Update 1988
JL Vincent
1988
Eicosanoids in the Cardiovascular and Renal Systems
PV Halushka, DE Mais
1988
Pulmonary Dysfunction in Multisystem Organ Failure
G Ruskin, H Ulrich
Anesthesiology Clinics of North America 1988
Vasodilatory effect of aerosol histamine during pulmonary vasoconstriction in unanesthetized sheep
AA Stecenko, PL Lefferts, JA Mitchell, JR Snapper, KL Brigham
Pediatric Pulmonology 1987
Prevention by granulocyte depletion of endotoxininduced adult respiratory distress syndrome. An experimental study in pigs
J Modig, T Samuelsson
Resuscitation 1987
Prostaglandin and thromboxane levels during endotoxin-induced respiratory failure in pigs
EM Hardie, NC Olson
Prostaglandins, Leukotrienes and Medicine 1987
Effects of Ibuprofen on the Hypoxemia of Established Ethchlorvynol-Induced Unilateral Acute Lung Injury in Anesthetized Dogs
RS Sprague, AH Stephenson, TE Dahms, NG Asner, AJ Lonigro
Chest 1987
Update 1987
JL Vincent
1987
Corticosteroids, nonsteroidal anti-inflammatory drugs, and naloxone in the sepsis syndrome
WM Long, CL Sprung
World Journal of Surgery 1987
Thromboxane and prostacyclin release in adult respiratory distress syndrome
G Deby-Dupont, M Braun, M Lamy, C Deby, J Pincemail, ME Faymonville, P Damas, L Bodson, MP Lecart, R Goutier
Intensive Care Medicine 1987
Prophylactic and delayed treatment with indomethacin in a porcine model of early adult respiratory distress syndrome induced by endotoxaemia
T Borg, B Gerdin, J Modig
Acta Anaesthesiologica Scandinavica 1986
Direct effects of E coli endotoxin on structure and permeability of pulmonary endothelial monolayers and the endothelial layer of intimal explants
BO Meyrick, US Ryan, KL Brigham
The American Journal of Pathology 1986
Effects of ibuprofen on a pig Pseudomonas ARDS model
CC Lee, HJ Sugerman, JL Tatum, TP Wright, PD Hirsh, JI Hirsch
Journal of Surgical Research 1986
Indomethacin, dazoxiben and extravascular lung water after Escherichia coli infusion
S Price, J Harlan, CJ Carrico, J Hildebrandt, R Winn
Journal of Surgical Research 1986
The effect of ibuprofen on endotoxin-induced injury in sheep
RA Balk, AF Tryka, RC Bone, GH Mazurek, LG Holst, JW Townsend
Journal of Critical Care 1986
Effects of Ibuprofen on Endotoxin-Induced Alveolitis: Biphasic Dose Response and Dissociation Between Inflammation and Hypoxemia
JE Rinaldo, B Pennock
The American Journal of the Medical Sciences 1986
Indomethacin and Ketanserin Block Ethchlorvynol-lnduced Hypoxemia in Dogs
JE Millen, FL Glauser
The American Journal of the Medical Sciences 1986
The Cardiopulmonary Effects of Sepsis on the Trauma Patient
RH Demling
Critical Care Clinics 1986
Mechanisms of Acute Lung Injury: What Have We Learned From Experimental Animal Models?
MR Flick
Critical Care Clinics 1986
Pathophysiology of the Adult Respiratory Distress Syndrome: What Have We Learned From Human Studies?
A Fein, JP Wiener-Kronish, M Niederman, MA Matthay
Critical Care Clinics 1986
Therapeutic Implications of Acute Lung Injury
ER Jacobs, RC Bone
Critical Care Clinics 1986
Clinical Endocrinology
A Labhart
Clinical Endocrinology 1986
Intrarenal prostaglandin release: Effects of arachidonic acid and hyperchloremia
CS Wilcox, S Roddis, WS Peart, D Gordon, GP Lewis
Kidney International 1985
Cellular basis for injury and repair in the adult respiratory distress syndrome
MA Matthay
The Western journal of medicine 1985
Species variations in the pulmonary responses to arachidonic acid metabolites
NF Voekel
Prostaglandins 1985
Effect of the thromboxane receptor antagonist EP 092 on endotoxin shock in the sheep
RA Armstrong, RL Jones, NH Wilson
Prostaglandins 1985
Administration of Dazoxiben, a Selective Thromboxane Synthetase Inhibitor, in the Adult Respiratory Distress Syndrome
M Leeman, JM Boeynaems, JP Degaute, JL Vincent, RJ Kahn
Chest 1985
Endothelial Function in Clinical Pulmonary Hypertension
RJ Barst, SA Stalcup
Chest 1985
Potential Role of Arachidonic Acid Metabolites in Hypoxic Pulmonary Vasoconstriction
NF Voelkel, M Morganroth, OC Feddersen
Chest 1985
Vasoconstriction and Remodeling in Pulmonary Hypertension
B Meyrick, KL Brigham
Chest 1985
Specific Cardiovascular Drugs Utilized in the Critically Ill
S Teich, B Chernow
Critical Care Clinics 1985
Organfunktion und Stoffwechsel in der perioperativen Phase
K Reinhart, K Eyrich
1985
Lung Mechanics in Pulmonary Edema
JR Snapper
Clinics in Chest Medicine 1985
Sepsis and Pulmonary Edema
JH Newman
Clinics in Chest Medicine 1985
Effect of N-acetylcysteine on the pulmonary response to endotoxin in the awake sheep and upon in vitro granulocyte function
GR Bernard, WD Lucht, ME Niedermeyer, JR Snapper, ML Ogletree, KL Brigham
Journal of Clinical Investigation 1984
Effects of platelet depletion on the unanesthetized sheep's pulmonary response to endotoxemia
JR Snapper, JM Hinson, AA Hutchison, PL Lefferts, ML Ogletree, KL Brigham
Journal of Clinical Investigation 1984
The effect of a single infusion of zymosan-activated plasma on the pulmonary microcirculation of sheep. Structure-function relationships
BO Meyrick, KL Brigham
The American Journal of Pathology 1984
Effects of oleic acid on pulmonary capillary leak and thromboxanes
LS Olanoff, HD Reines, KM Spicer, PV Halushka
Journal of Surgical Research 1984
Inflammation and Airway Reactivity
JR Snapper, KL Brigham
Experimental Lung Research 1984
Arachidonic Acid Metabolites in the Healthy Diseased Lung
JH Newman, JR Sheller
The American Journal of the Medical Sciences 1984
The Effects of Group B Streptococcus and Other Organisms on the Pulmonary Vasculature
J Rojas, M Stahlman
Clinics in Perinatology 1984
Interactions of granulocytes with the lungs
KL Brigham, B Meyrick
Circulation research 1984
Intensive Care and Emergency Medicine
JL Vincent
1984
Septicemia and Lung Injury
KL Brigham, CJ Begley, GR Bernard, AA Hutchison, JE Loyd, WD Lucht, B Meyrick, JH Newman, ME Niedermeyer, ML Ogletree, JR Sheller, JR Snapper
Clinics in Laboratory Medicine 1983
Care of the Critically Ill Patient
J Tinker, M Rapin
1983
Pulmonary Edema
ED Robin, CE Cross, R Zelis
New England Journal of Medicine 1973

← Previous 1 2 3 4 5 6 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Referenced in 1 clinical guideline sources
10 readers on Mendeley
See more details