The effects of Escherichia coli endotoxin on lung mechanics, hemodynamics, gas exchange, and lung fluid and solute exchange were studied in 12 chronically instrumented unanesthetized sheep. A possible role for cyclooxygenase products of arachidonate metabolism as mediators of the endotoxin-induced alterations in lung mechanics was investigated by studying sheep before and after cyclooxygenase inhibition with sodium meclofenamate and ibuprofen. Sheep were studied three times in random order: (a) sodium meclofenamate (or ibuprofen) infusion alone; (b) E. coli endotoxin alone; and (c) meclofenamate (or ibuprofen) and endotoxin. Meclofenamate alone had no effect on any of the variables measured. Endotoxin alone caused early marked changes in lung mechanics: resistance to airflow across the lungs (RL) increased 10-fold, dynamic lung compliance (Cdyn) decreased 80% and functional residual capacity (FRC) decreased by greater than 30%. The alveolar-to-arterial oxygen difference (delta AaPO2) increased markedly following endotoxemia. In the presence of sufficient meclofenamate to inhibit accumulation of thromboxane-B2 and 6-keto-prostaglandin F1 alpha in lung lymph, endotoxin caused no increase in RL, Cdyn decreased by less than 40%, and FRC decreased by only 6%. Meclofenamate significantly attenuated the hypoxemia and early pulmonary hypertension caused by endotoxemia but had no effect on the late increases in lung fluid and solute exchange. Ibuprofen had similar effects to those observed with meclofenamate. We conclude that both the pulmonary hypertension and changes in lung mechanics observed after endotoxemia may be mediated, at least in part, by constrictor prostaglandins or thromboxanes and that gas exchange may be improved by preventing endogenous synthesis of these mediators.
J R Snapper, A A Hutchison, M L Ogletree, K L Brigham
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Risk factors for the development of acute respiratory distress syndrome in mechanically ventilated adults in Peru: a multicenter observational study
E Gupta, S Hossen, MR Grigsby, P Herrera, R Roldan, E Paz, AA Jaymez, EE Chirinos, J Portugal, R Quispe, RG Brower, W Checkley |
Critical Care | 2019 |
Annual Update in Intensive Care and Emergency Medicine 2018
JL Vincent |
2018 | |
Ibuprofen: Discovery, Development and Therapeutics
KD Rainsford |
Ibuprofen: Discovery, Development and Therapeutics | 2015 |
Comprehensive Physiology
SN Cheuvront, RW Kenefick |
Comprehensive Physiology | 2014 |
Yearbook of Intensive Care and Emergency Medicine
JL Vincent |
2008 | |
Analysis of Plasma Serotonin Levels and Hemodynamic Responses Following Chronic Serotonin Infusion in Broilers Challenged with Bacterial Lipopolysaccharide and Microparticles
ME Chapman, RL Taylor, RF Wideman |
Poultry science | 2008 |
Sepsis
JM O’Brien, NA Ali, SK Aberegg, E Abraham |
The American Journal of Medicine | 2007 |
INFUSION OF INCREASING DOSES OF ENDOTOXIN INDUCES PROGRESSIVE ACUTE LUNG INJURY BUT PREVENTS EARLY PULMONARY HYPERTENSION IN PIGS
R Schmidhammer, E Wassermann, P Germann, H Redl, R Ullrich |
Shock | 2006 |
INFUSION OF INCREASING DOSES OF ENDOTOXIN INDUCES PROGRESSIVE ACUTE LUNG INJURY BUT PREVENTS EARLY PULMONARY HYPERTENSION IN PIGS:
R Schmidhammer, E Wassermann, P Germann, H Redl, R Ullrich |
Shock | 2006 |
Evaluation of the Serotonin Receptor Blocker Methiothepin in Broilers Injected Intravenously with Lipopolysaccharide and Microparticles
ME Chapman, RF Wideman |
Poultry science | 2006 |
Endotoxin-induced acute lung injury requires interaction with the liver
AM Siore, RE Parker, AA Stecenko, C Cuppels, M McKean, BW Christman, R Cruz-Gervis, KL Brigham |
American journal of physiology. Lung cellular and molecular physiology | 2005 |
Enhanced release of thromboxane A2 after exposure of human airway epithelial cells to meconium
AM Khan, KP Lally, GL Larsen, GN Colasurdo |
Pediatric Pulmonology | 2002 |
Ibuprofen attenuates early lung injury in endotoxemic, neutropenic rats
KM Daphtary, SM Heidemann, M Glibetic |
Prostaglandins, Leukotrienes and Essential Fatty Acids | 2001 |
Correlation between Increased Airway Responsiveness and Severity of Pulmonary Edema
YS Hwang, PL Lefferts, JR Snapper |
Pulmonary Pharmacology & Therapeutics | 2001 |
Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E
A Gullo |
2001 | |
Correlation between ventilation and perfusion determinesV˙ a /Q˙ heterogeneity in endotoxemia
AJ Gerbino, S McKinney, RW Glenny |
Journal of applied physiology | 2000 |
Effects of ibuprofen on the physiology and survival of hypothermic sepsis:
MM Arons, AP Wheeler, GR Bernard, BW Christman, JA Russell, R Schein, WR Summer, KP Steinberg, W Fulkerson, P Wright, WD Dupont, BB Swindell |
Critical Care Medicine | 1999 |
Intravascular macrophage depletion attenuates endotoxin lung injury in anesthetized sheep
Y Sone, VB Serikov, NC Staub |
Journal of applied physiology | 1999 |
Role of Endothelin in Endotoxin-induced Sustained Pulmonary Hypertension in Sheep
JR Snapper, JS Thabes, PL Lefferts, W Lu |
American journal of respiratory and critical care medicine | 1998 |
Effect of platelet-activating factor-receptor antagonism on endotoxin-induced lung dysfunction in sheep
JR Snapper, W Lu, PL Lefferts, JS Thabes |
Journal of applied physiology | 1998 |
Meconium aspiration induces ARDS-like pulmonary response in lungs of ten-week-old pigs
H Soukka, M Rautanen, L Halkola, P Kero, P Kääpä |
Pediatric Pulmonology | 1997 |
The Effects of Ibuprofen on the Physiology and Survival of Patients with Sepsis
GR Bernard, AP Wheeler, JA Russell, R Schein, WR Summer, KP Steinberg, WJ Fulkerson, PE Wright, BW Christman, WD Dupont, SB Higgins, BB Swindell |
New England Journal of Medicine | 1997 |
Intratracheal Aerosolization of Endotoxin (LPS) in the Rat: A Comprehensive Animal Model to Study Adult (Acute) Respiratory Distress Syndrome
HP van Helden, WC Kuijpers, D Steenvoorden, C Go, PL Bruijnzeel, M Eijk, HP Haagsman |
Experimental Lung Research | 1997 |
Experimental fat embolism induces urine 2,3-dinor-6-ketoprostaglandin F sub 1 alpha and 11-dehydrothromboxane B sub 2 excretion in pigs:
M Rautanen, E Gullichsen, A Riutta, K Kuttila, I Mucha, O Nelimarkka, J Niinikoski |
Critical Care Medicine | 1997 |
PHARMACOTHERAPY OF SEPSIS
LF Weikert, GR Bernard |
Clinics in Chest Medicine | 1996 |
Effects of Anti-inflammatory Agents on Hydrochloric Acid-Induced Pulmonary Injury
CL Westervelt, EU Choe, J Arya, HL Lippton, LM Flint, JJ Ferrara |
Journal of Investigative Surgery | 1996 |
Gamma -Linolenic Acid: Metabolism and Its Roles in Nutrition and Medicine
R Zurier, P DeLuca, D Rothman |
Gamma -Linolenic Acid: Metabolism and Its Roles in Nutrition and Medicine | 1996 |
Surfactant replacement in the treatment of sepsis-induced adult respiratory distress syndrome in pigs:
GF Nieman, LA Gatto, AM Paskanik, B Yang, R Fluck, A Picone |
Critical Care Medicine | 1996 |
Effect of cyclooxygenase inhibition in a canine model of unilateral pulmonary occlusion and reperfusion
W Segiet, H Krieter, C Stieber, DM Albrecht, K Ackern |
Intensive Care Medicine | 1995 |
Does Early Posttreatment with Lidocaine Attenuate Endotoxin-induced Acute Lung Injury in Rabbits?
K Nishina, K Mikawa, N Maekawa, Y Takao, H Obara |
Anesthesiology | 1995 |
Effect of combined nitric oxide inhalation and N sup G-nitro-L-arginine infusion in porcine endotoxin shock
E Weitzberg, A Rudehill, A Modin, JM Lundberg |
Critical Care Medicine | 1995 |
Pulmonary Ventilation, Mechanics, Gas Exchange and Haemodynamics in Calves Following Intratracheal Inoculation of Pasteurella haemolytica
A Linden, D Desmecht, H Amory, G Daube, S Lecomte, P Lekeux |
Journal of Veterinary Medicine Series A | 1995 |
Does Early Posttreatment with Lidocaine Attenuate Endotoxin-induced Acute Lung Injury in Rabbits?:
K Nishina, K Mikawa, N Maekawa, Y Takao, H Obara |
Anesthesiology | 1995 |
Comparison of the Pulmonary Dysfunction Caused by Cardiogenic and Noncardiogenic Pulmonary Edema
GR Bernard, NA Pou, JW Coggeshall, FE Carroll, JR Snapper |
Chest | 1995 |
Clinical Trials for the Treatment of Sepsis
JL Vincent, WJ Sibbald |
1995 | |
Effect of cyclooxygenase inhibition in a canine model of unilateral pulmonary occlusion and reperfusion
W Segiet, H Krieter, C Stieber, DM Albrecht, K van Ackern |
Intensive Care Medicine | 1995 |
Vascular Endothelium
MA Gimbrone, MI Cybulsky, N Kume, T Collins, N Resnick |
Annals of the New York Academy of Sciences | 1994 |
Effect of Bronchodilators on Lung Mechanics in the Acute Respiratory Distress Syndrome (ARDS)
PE Wright, LC Carmichael, GR Bernard |
Chest | 1994 |
Adult Respiratory Distress Syndrome—An Update
MJ Chapman |
ANAESTH INTENS CARE | 1994 |
Effects of continuous infusion of nitroglycerin on pulmonary hemodynamics, lung lymph balance, and prostanoid products in the response to endotoxin in awake sheep
T Koizumi, K Kubo, K Hirai, S Shinozaki, T Kobayashi, M Sekiguchi, A Sakai |
Lung | 1993 |
Nitric oxide inhalation attenuates pulmonary hypertension and improves gas exchange in endotoxin shock
E Weitzberg, A Rudehill, JM Lundberg |
European Journal of Pharmacology | 1993 |
Cecal ligation and puncture is associated with pulmonary injury in the rat: Role of cyclooxygenase pathway products
MJ Schneidkraut, RW Carlson |
Prostaglandins | 1993 |
Neutrophil Elastase Inhibitors, SC-37698 and SC-39026, Reduce Endotoxin-induced Lung Dysfunction in Awake Sheep
JR Gossage, Y Kuratomi, JM Davidson, PL Lefferts, JR Snapper |
American journal of respiratory and critical care medicine | 1993 |
Pharmacologic Reduction in Tumor Necrosis Factor Activity of Pulmonary Alveolar Macrophages
SK Leeper-Woodford, BJ Fisher, HJ Sugerman, AA Fowler |
American journal of respiratory cell and molecular biology | 1993 |
Secondary Organ Dysfunction: From Clinical Perspectives to Molecular Mediators
MD Cipolle, MD Pasquale, FB Cerra |
Critical Care Clinics | 1993 |
Pathophysiology of Shock, Sepsis, and Organ Failure
G Schlag, H Redl |
1993 | |
Blood Transfusion Related Adult Respiratory Distress Syndrome
M Malouf, AR Glanville |
ANAESTH INTENS CARE | 1993 |
Pasteurella haemolytica A1 and Bovine Respiratory Disease: Pathogenesis
LO Whiteley, SK Maheswaran, DJ Weiss, TR Ames, MS Kannan |
Journal of Veterinary Internal Medicine | 1992 |
Respiratory Distress Resulting from Acute Lung Injury in the Veterinary Patient
CW Frevert, AE Warner |
Journal of Veterinary Internal Medicine | 1992 |
Staphylococcal alpha toxin: a study with chronically instrumented awake sheep
S Harshman, PL Lefferts, JR Snapper |
Infection and immunity | 1992 |
Pharmacologic agents in the treatment of ischemia, hemorrhagic shock, and sepsis
JM Harkema, G Singh, P Wang, IH Chaudry |
Journal of Critical Care | 1992 |
The low-chloride cough response is not inhibited by a single, high dose of aspirin
RA Stone, PJ Barnes, RW Fuller |
British Journal of Clinical Pharmacology | 1992 |
Effects of thromboxane synthase and cyclooxygenase inhibition on PAF-induced changes in lung function and arachidonic acid metabolism
DS Trochtenberg, PL Lefferts, GA King, YS Hwang, BW Christman, JR Snapper |
Prostaglandins | 1992 |
Dibutyryl Cyclic AMP Attenuates Lung Responses Induced by Endotoxin in Conscious Sheep
S Koyama, T Toyofuku, K Hirai, K Yoshimura, A Sakai, T Kobayashi |
American journal of respiratory and critical care medicine | 1992 |
Yearbook of Intensive Care and Emergency Medicine 1992
JL Vincent |
1992 | |
Mediators of Sepsis
M Lamy, LG Thijs |
1992 | |
The pulmonary physician and critical care. 4. A new look at the pulmonary circulation in acute lung injury
GA Fox, DG McCormack |
Thorax | 1992 |
Oxygen Transport to Tissue XIII
TK Goldstick, M McCabe, DJ Maguire |
1992 | |
Pulmonary Arterial Hypertension In Sepsis And The Adult Respiratory Distress Syndrome
H Spapen, W Vincken |
ACTA CLINICA BELGICA | 1992 |
Acute respiratory distress syndrome--two decades later
AJ Cunningham |
The Yale journal of biology and medicine | 1991 |
Influence of SK&F 96148 on thromboxane-mediated responses in the airways of the cat
MC Dyson, PJ Kadowitz |
European Journal of Pharmacology | 1991 |
Attenuation of the pulmonary vascular response to endotoxin by a thromboxane synthesis inhibitor (UK-38485) in unanesthetized sheep
CL Henry, ML Ogletree, KL Brigham, JW Hammon |
Journal of Surgical Research | 1991 |
Influence of SK&F 96148 on thromboxane-mediated responses in the airways of the cat
MC Dyson, PJ Kadowitz |
European Journal of Pharmacology | 1991 |
Effects of ritodrine infusion on hemodynamics and lung lymph in awake sheep
FL Watts, GR Bernard |
Pulmonary Pharmacology | 1991 |
Effects of Intravenous Amphotericin B Infusion on Hemodynamics and Airway Mechanics in Awake Sheep
WD Hardie, PE Wright, GR Bernard |
Chest | 1991 |
Therapy of Bovine Bacterial Pneumonia
CR Clarke, GE Burrows, TR Ames |
Veterinary Clinics of North America Food Animal Practice | 1991 |
Update 1991
JL Vincent |
1991 | |
ONO 3708: A New Thromboxane A2Receptor Antagonist
C Taneyama, H Goto |
Cardiovascular Drug Reviews | 1990 |
Application of reversed phase high performance liquid chromatography to the analysis of sulphidopeptide leukotrienes in pig bile
P Tagari, D Ethier, A Ford-Hutchinson, M Cirino |
Biomedical Chromatography | 1990 |
The prominent role of thromboxane A2 formation on early pulmonary hypertension induced by oleic acid administration in sheep
C Rostagno, GF Gensini, S Boncinelli, M Marsili, S Castellani, P Lorenzi, V Merciai, M Linden, GL Chelucci, F Cresci |
Thrombosis Research | 1990 |
ONO 3708: A New Thromboxane A 2 Receptor Antagonist
C Taneyama, H Goto |
Cardiovascular Drug Reviews | 1990 |
Modern approaches to the therapy of septic shock
C Putterman |
The American Journal of Emergency Medicine | 1990 |
Indomethacin enhances histamine-induced pulmonary hemodynamic changes
JY Tsang, H Ohtaka, M Ohgami, RR Schellenberg |
Prostaglandins | 1990 |
Edema pulmonar no cardiogénico
JI Sznajder |
Archivos de Bronconeumología | 1990 |
Adult Respiratory Distress Syndrome: A Complication of Shock
P Vaughan, C Brooks |
Critical Care Nursing Clinics of North America | 1990 |
Cellular and Humoral Mediators of Sepsis Syndrome
M Stroud, B Swindell, GR Bernard |
Critical Care Nursing Clinics of North America | 1990 |
Pharmacologic Treatment of the Adult Respiratory Distress Syndrome
G Goldstein, JM Luce |
Clinics in Chest Medicine | 1990 |
Pharmacology of Aprotinin and Efficacy During Cardiopulmonary Bypass
TE Emerson |
Cardiovascular Drug Reviews | 1989 |
Protection against pulmonary oxygen toxicity by interleukin-1 and tumor necrosis factor: Role of antioxidant enzymes and effect of cyclooxygenase inhibitors
CW White, P Ghezzi |
Biotherapy | 1989 |
The adult respiratory distress syndrome. New insights into diagnosis, pathophysiology, and treatment
MA Matthay |
The Western journal of medicine | 1989 |
Role of prostanoids in respiratory failure during circulatory shock of intestinal origin in dogs
T Mózes, E Wieszt |
Prostaglandins, Leukotrienes and Essential Fatty Acids | 1989 |
The pathophysiology and treatment of canine kerosene pulmonary injury: Effects of plasmapheresis and positive end-expiratory pressure
AR Zucker, JL Sznajder, CJ Becker, S Berger, LD Wood |
Journal of Critical Care | 1989 |
Pharmacologic Modulation of Lung Injury
SI Said, HD Foda |
American journal of respiratory and critical care medicine | 1989 |
Acute Lung Injury in Septic Shock
A Bersten, WJ Sibbald |
Critical Care Clinics | 1989 |
Prostaglandins, Cyclo-oxygenase Inhibitors, and Thromboxane Synthetase Inhibitors in the Pathogenesis of Multiple Systems Organ Failure
RA Petrak, RA Balk, RC Bone |
Critical Care Clinics | 1989 |
Effects of a thromboxane A2 analogue and prostacyclin on lung fluid balance in newborn lambs
K Yoshimura, ML Tod, KG Pier, LJ Rubin |
Circulation research | 1989 |
Differential effects of ibuprofen, indomethacin, and meclofenamate on prostaglandin endoperoxide H2 metabolism
PR Mayeux, PJ Kadowitz, DB McNamara |
Molecular and Cellular Biochemistry | 1989 |
Biochemical, physiological and clinical aspects of endotoxemia
NC Olson, WL Salzer, CE McCall |
Molecular Aspects of Medicine | 1988 |
Continuous air embolization into sheep causes sustained pulmonary hypertension and increased pulmonary vasoreactivity
EA Perkett, KL Brigham, B Meyrick |
The American Journal of Pathology | 1988 |
Ventilation-perfusion inequality during endotoxin-induced pulmonary vasoconstriction in conscious sheep: mechanisms of hypoxia
PC Hüttemeier, C Ringsted, K Eliasen, T Mogensen |
Clinical Physiology | 1988 |
Anaphylatoxin C3a peptide contracts human pulmonary vasculature
RR Schellenberg, JB Mullen, A Foster, MM Glovsky |
Pulmonary Pharmacology | 1988 |
Attenuation of endotoxin-induced cytotoxicity and prostacyclin production in cultured bovine pulmonary artery endothelial cells by phosphodiesterase inhibition
A Hussein, B Meyrick, S Graber, L Berry Jr, K L Brigham |
Experimental Lung Research | 1988 |
The Physiology of Stress and Its Relationship to Mechanisms of Disease and Therapeutics
JE Breazile |
Veterinary Clinics of North America Food Animal Practice | 1988 |
Neonatal Adaptation to Stress of Parturition and Dystocia
JE Breazile, LA Vollmer, LE Rice |
Veterinary Clinics of North America Food Animal Practice | 1988 |
Therapeutic Strategies for Acute Hypoxemic Respiratory Failure
AR Zucker |
Critical Care Clinics | 1988 |
ZAK München 1987
K Peter, J Groh |
1988 | |
Update 1988
JL Vincent |
1988 | |
Eicosanoids in the Cardiovascular and Renal Systems
PV Halushka, DE Mais |
1988 | |
Pulmonary Dysfunction in Multisystem Organ Failure
G Ruskin, H Ulrich |
Anesthesiology Clinics of North America | 1988 |
Vasodilatory effect of aerosol histamine during pulmonary vasoconstriction in unanesthetized sheep
AA Stecenko, PL Lefferts, JA Mitchell, JR Snapper, KL Brigham |
Pediatric Pulmonology | 1987 |
Prevention by granulocyte depletion of endotoxininduced adult respiratory distress syndrome. An experimental study in pigs
J Modig, T Samuelsson |
Resuscitation | 1987 |
Prostaglandin and thromboxane levels during endotoxin-induced respiratory failure in pigs
EM Hardie, NC Olson |
Prostaglandins, Leukotrienes and Medicine | 1987 |
Effects of Ibuprofen on the Hypoxemia of Established Ethchlorvynol-Induced Unilateral Acute Lung Injury in Anesthetized Dogs
RS Sprague, AH Stephenson, TE Dahms, NG Asner, AJ Lonigro |
Chest | 1987 |
Update 1987
JL Vincent |
1987 | |
Corticosteroids, nonsteroidal anti-inflammatory drugs, and naloxone in the sepsis syndrome
WM Long, CL Sprung |
World Journal of Surgery | 1987 |
Thromboxane and prostacyclin release in adult respiratory distress syndrome
G Deby-Dupont, M Braun, M Lamy, C Deby, J Pincemail, ME Faymonville, P Damas, L Bodson, MP Lecart, R Goutier |
Intensive Care Medicine | 1987 |
Prophylactic and delayed treatment with indomethacin in a porcine model of early adult respiratory distress syndrome induced by endotoxaemia
T Borg, B Gerdin, J Modig |
Acta Anaesthesiologica Scandinavica | 1986 |
Direct effects of E coli endotoxin on structure and permeability of pulmonary endothelial monolayers and the endothelial layer of intimal explants
BO Meyrick, US Ryan, KL Brigham |
The American Journal of Pathology | 1986 |
Effects of ibuprofen on a pig Pseudomonas ARDS model
CC Lee, HJ Sugerman, JL Tatum, TP Wright, PD Hirsh, JI Hirsch |
Journal of Surgical Research | 1986 |
Indomethacin, dazoxiben and extravascular lung water after Escherichia coli infusion
S Price, J Harlan, CJ Carrico, J Hildebrandt, R Winn |
Journal of Surgical Research | 1986 |
The effect of ibuprofen on endotoxin-induced injury in sheep
RA Balk, AF Tryka, RC Bone, GH Mazurek, LG Holst, JW Townsend |
Journal of Critical Care | 1986 |
Effects of Ibuprofen on Endotoxin-Induced Alveolitis: Biphasic Dose Response and Dissociation Between Inflammation and Hypoxemia
JE Rinaldo, B Pennock |
The American Journal of the Medical Sciences | 1986 |
Indomethacin and Ketanserin Block Ethchlorvynol-lnduced Hypoxemia in Dogs
JE Millen, FL Glauser |
The American Journal of the Medical Sciences | 1986 |
The Cardiopulmonary Effects of Sepsis on the Trauma Patient
RH Demling |
Critical Care Clinics | 1986 |
Mechanisms of Acute Lung Injury: What Have We Learned From Experimental Animal Models?
MR Flick |
Critical Care Clinics | 1986 |
Pathophysiology of the Adult Respiratory Distress Syndrome: What Have We Learned From Human Studies?
A Fein, JP Wiener-Kronish, M Niederman, MA Matthay |
Critical Care Clinics | 1986 |
Therapeutic Implications of Acute Lung Injury
ER Jacobs, RC Bone |
Critical Care Clinics | 1986 |
Clinical Endocrinology
A Labhart |
Clinical Endocrinology | 1986 |
Intrarenal prostaglandin release: Effects of arachidonic acid and hyperchloremia
CS Wilcox, S Roddis, WS Peart, D Gordon, GP Lewis |
Kidney International | 1985 |
Cellular basis for injury and repair in the adult respiratory distress syndrome
MA Matthay |
The Western journal of medicine | 1985 |
Species variations in the pulmonary responses to arachidonic acid metabolites
NF Voekel |
Prostaglandins | 1985 |
Effect of the thromboxane receptor antagonist EP 092 on endotoxin shock in the sheep
RA Armstrong, RL Jones, NH Wilson |
Prostaglandins | 1985 |
Administration of Dazoxiben, a Selective Thromboxane Synthetase Inhibitor, in the Adult Respiratory Distress Syndrome
M Leeman, JM Boeynaems, JP Degaute, JL Vincent, RJ Kahn |
Chest | 1985 |
Endothelial Function in Clinical Pulmonary Hypertension
RJ Barst, SA Stalcup |
Chest | 1985 |
Potential Role of Arachidonic Acid Metabolites in Hypoxic Pulmonary Vasoconstriction
NF Voelkel, M Morganroth, OC Feddersen |
Chest | 1985 |
Vasoconstriction and Remodeling in Pulmonary Hypertension
B Meyrick, KL Brigham |
Chest | 1985 |
Specific Cardiovascular Drugs Utilized in the Critically Ill
S Teich, B Chernow |
Critical Care Clinics | 1985 |
Organfunktion und Stoffwechsel in der perioperativen Phase
K Reinhart, K Eyrich |
1985 | |
Lung Mechanics in Pulmonary Edema
JR Snapper |
Clinics in Chest Medicine | 1985 |
Sepsis and Pulmonary Edema
JH Newman |
Clinics in Chest Medicine | 1985 |
Effect of N-acetylcysteine on the pulmonary response to endotoxin in the awake sheep and upon in vitro granulocyte function
GR Bernard, WD Lucht, ME Niedermeyer, JR Snapper, ML Ogletree, KL Brigham |
Journal of Clinical Investigation | 1984 |
Effects of platelet depletion on the unanesthetized sheep's pulmonary response to endotoxemia
JR Snapper, JM Hinson, AA Hutchison, PL Lefferts, ML Ogletree, KL Brigham |
Journal of Clinical Investigation | 1984 |
The effect of a single infusion of zymosan-activated plasma on the pulmonary microcirculation of sheep. Structure-function relationships
BO Meyrick, KL Brigham |
The American Journal of Pathology | 1984 |
Effects of oleic acid on pulmonary capillary leak and thromboxanes
LS Olanoff, HD Reines, KM Spicer, PV Halushka |
Journal of Surgical Research | 1984 |
Inflammation and Airway Reactivity
JR Snapper, KL Brigham |
Experimental Lung Research | 1984 |
Arachidonic Acid Metabolites in the Healthy Diseased Lung
JH Newman, JR Sheller |
The American Journal of the Medical Sciences | 1984 |
The Effects of Group B Streptococcus and Other Organisms on the Pulmonary Vasculature
J Rojas, M Stahlman |
Clinics in Perinatology | 1984 |
Interactions of granulocytes with the lungs
KL Brigham, B Meyrick |
Circulation research | 1984 |
Intensive Care and Emergency Medicine
JL Vincent |
1984 | |
Septicemia and Lung Injury
KL Brigham, CJ Begley, GR Bernard, AA Hutchison, JE Loyd, WD Lucht, B Meyrick, JH Newman, ME Niedermeyer, ML Ogletree, JR Sheller, JR Snapper |
Clinics in Laboratory Medicine | 1983 |
Care of the Critically Ill Patient
J Tinker, M Rapin |
1983 | |
Pulmonary Edema
ED Robin, CE Cross, R Zelis |
New England Journal of Medicine | 1973 |