Previous studies from our laboratory have demonstrated that dietary intake affects the sympathetic nervous system (SNS); carbohydrate intake, in particular, has been shown to stimulate sympathetic activity. The present studies were undertaken to characterize the effect of dietary fat on SNS activity in the rat. Sympathetic activity was assessed by measurement of norepinephrine (NE) turnover in heart, interscapular brown adipose tissue (IBAT), and pancreas and by excretion of NE in the urine. When fed a fat-enriched diet (50% chow, 50% lard), fractional NE turnover in heart (k) increased from 6.3 +/- 0.6% h in ad lib. fed controls to 14.7 +/- 1.3% h in the high-fat group (P less than 0.001); calculated NE turnover rate increased from 24.5 +/- 2.4 ng/heart per h to 36.8 +/- 3.5 (P less than 0.05). Urinary NE excretion more than doubled after 6 d of the same high fat diet (P less than 0.001). Ganglionic blockade produced a greater effect on NE turnover in fat-fed, as compared with chow-fed animals, consistent with increased sympathetic activity in the fat-fed group. When fat absorption was blocked with a bile acid binding resin (cholestyramine), the same high-fat diet did not increase cardiac NE turnover, indicating that fat absorption is required for the stimulatory effect on sympathetic activity. In another series of experiments, in which chow (and hence protein) intake was held constant, the effect of fat and isocaloric sucrose supplements on NE turnover was assessed in heart, IBAT, and pancreas. The caloric value of the supplements was 50, 100, and 335% of the chow in the different experiments. An effect of fat on NE turnover in heart and IBAT was demonstrable at the lowest level of fat supplement. Fat increased pancreatic NE turnover when added in amounts sufficient to double the caloric intake. The stimulatory effect of sucrose and fat on NE turnover in heart and IBAT was similar. These experiments demonstrate that fat increases SNS activity in the rat and that the magnitude of the effect is similar to that of sucrose. The results imply that fat may contribute to dietary thermogenesis in this species.
J H Schwartz, J B Young, L Landsberg
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Cannabinoid CB1 Receptor Deletion from Catecholaminergic Neurons Protects from Diet-Induced Obesity.
Srivastava RK, Ruiz de Azua I, Conrad A, Purrio M, Lutz B |
International journal of molecular sciences | 2022 |
Effects of short-term hypercaloric nutrition on orthostatic tolerance in healthy individuals: a randomized controlled crossover study.
De Gioannis R, Ewald AC, Gerlach DA, Heusser K, Hoffmann F, Frings-Meuthen P, Heer M, Tank J, Jordan J |
Clinical autonomic research : official journal of the Clinical Autonomic Research Society | 2022 |
Deletion of Rptor in Preosteoblasts Reveals a Role for the Mammalian Target of Rapamycin Complex 1 ( mTORC1) Complex in Dietary‐Induced Changes to Bone Mass and Glucose Homeostasis in Female Mice
P Tangseefa, SK Martin, A Arthur, V Panagopoulos, AJ Page, GA Wittert, CG Proud, S Fitter, AC Zannettino |
JBMR Plus | 2021 |
Deficiency of ataxia-telangiectasia mutated kinase modulates functional and biochemical parameters of the heart in response to Western-type diet.
Wingard MC, Dalal S, Shook PL, Myers R, Connelly BA, Thewke DP, Singh M, Singh K |
American journal of physiology. Heart and circulatory physiology | 2021 |
Effects of Virgin Olive Oil on Blood Pressure and Renal Aminopeptidase Activities in Male Wistar Rats
G Domínguez-Vías, AB Segarra, M Ramírez-Sánchez, I Prieto |
International journal of molecular sciences | 2021 |
Restoring Perivascular Adipose Tissue Function in Obesity Using Exercise
SN Saxton, LK Toms, RG Aldous, SB Withers, J Ohanian, AM Heagerty |
Cardiovascular Drugs and Therapy | 2021 |
Castanea sativa Mill. bark extract cardiovascular effects in a rat model of high‐fat diet
M Micucci, R Budriesi, R Aldini, R Fato, C Bergamini, F Vivarelli, D Canistro, C Bolchi, A Chiarini, N Rizzardi, M Pallavicini, M Frosini, A Angeletti |
Phytotherapy research : PTR | 2020 |
Brain-Sparing Sympathofacilitators Mitigate Obesity without Adverse Cardiovascular Effects
I Mahú, A Barateiro, E Rial-Pensado, N Martinéz-Sánchez, SH Vaz, PM Cal, B Jenkins, T Rodrigues, C Cordeiro, MF Costa, R Mendes, E Seixas, MM Pereira, N Kubasova, V Gres, I Morris, C Temporão, M Olivares, Y Sanz, A Koulman, F Corzana, AM Sebastião, M López, GJ Bernardes, AI Domingos |
Cell Metabolism | 2020 |
Differential Effects of Acute Treatment With Antipsychotic Drugs on Peripheral Catecholamines
HN Boyda, AA Ho, L Tse, RM Procyshyn, JW Yuen, DD Kim, WG Honer, AM Barr |
Frontiers in Psychiatry | 2020 |
Reduced Diet-induced Thermogenesis in Apolipoprotein A-IV Deficient Mice
S Pence, Q Zhu, E Binne, M Liu, H Shi, CC Lo |
International journal of molecular sciences | 2019 |
Effect of different intensities of physical activity on cardiometabolic markers and vascular and cardiac function in adult rats fed with a high-fat high-carbohydrate diet
RB Batacan, MJ Duncan, VJ Dalbo, GL Buitrago, AS Fenning |
Journal of Sport and Health Science | 2018 |
Deletion of UCP1 enhances ex vivo aortic vasomotor function in female but not male mice despite similar susceptibility to metabolic dysfunction
NC Winn, ZI Grunewald, ML Gastecki, ML Woodford, RJ Welly, SL Clookey, JR Ball, TK Gaines, NG Karasseva, JA Kanaley, HS Sacks, VJ Vieira-Potter, J Padilla |
American journal of physiology. Endocrinology and metabolism | 2017 |
A nutritional perspective on UCP1-dependent thermogenesis
ML Bonet, J Mercader, A Palou |
Biochimie | 2017 |
Adipose tissue dysfunction as a central mechanism leading to dysmetabolic obesity triggered by chronic exposure to p,p’-DDE
D Pestana, D Teixeira, M Meireles, C Marques, S Norberto, C Sá, VC Fernandes, L Correia-Sá, A Faria, L Guardão, JT Guimarães, WN Cooper, I Sandovici, VF Domingues, C Delerue-Matos, R Monteiro, M Constância, C Calhau |
Scientific Reports | 2017 |
Physiological regulation and metabolic role of browning in white adipose tissue
A Jankovic, V Otasevic, A Stancic, B Buzadzic, A Korac, B Korac |
Hormone Molecular Biology and Clinical Investigation | 2017 |
Differential sympathetic outflow to adipose depots is required for visceral fat loss in response to calorie restriction
LM Sipe, C Yang, J Ephrem, E Garren, J Hirsh, CD Deppmann |
Nutrition and Diabetes | 2017 |
Inverse Association of Serum Docosahexaenoic Acid With Newly Diagnosed Hypertension: A Community-based Case-control Study
B Yang, F Ding, FL Wang, W Yu, D Li |
Medicine | 2016 |
The Consistency in Macronutrient Oxidation and The Role for Epinephrine in the Response to Fasting and Overfeeding
KL Vinales, M Schlögl, P Piaggi, M Hohenadel, A Graham, S Bonfiglio, J Krakoff, MS Thearle |
The Journal of clinical endocrinology and metabolism | 2016 |
The Consistency in Macronutrient Oxidation and The Role for Epinephrine in the Response to Fasting and Overfeeding
KL Vinales, M Schlögl, P Piaggi, M Hohenadel, A Graham, S Bonfiglio, J Krakoff, MS Thearle |
The Journal of clinical endocrinology and metabolism | 2016 |
The intake of high-fat diets induces the acquisition of brown adipocyte gene expression features in white adipose tissue
E García-Ruiz, B Reynés, R Díaz-Rúa, E Ceresi, P Oliver, A Palou |
International Journal of Obesity | 2015 |
Increased Feeding Speed Is Associated with Higher Subsequent Sympathetic Activity in Dogs
N Ohtani, Y Okamoto, K Tateishi, H Uchiyama, M Ohta, C Sueur |
PloS one | 2015 |
Thermogenic Capacity Is Antagonistically Regulated in Classical Brown and White Subcutaneous Fat Depots by High Fat Diet and Endurance Training in Rats: IMPACT ON WHOLE-BODY ENERGY EXPENDITURE
MV Wu, G Bikopoulos, S Hung, RB Ceddia |
The Journal of biological chemistry | 2014 |
Short-term moderate exercise provides long-lasting protective effects against metabolic dysfunction in rats fed a high-fat diet
LP Tófolo, TA da Ribeiro, A Malta, RA Miranda, RM Gomes, JC de Oliveira, L Abdennebi-Najar, DL de Almeida, AB Trombini, CC da Franco, A Pavanello, GS Fabricio, W Rinaldi, LF Barella, PC de Mathias, K Palma-Rigo |
European Journal of Nutrition | 2014 |
Relationship between the Acyl Chain Length of Paradol Analogs and their Anti-Obesity Activity following Oral Ingestion
A Haratake, D Watase, S Setoguchi, K Terada, K Matsunaga, J Takata |
Journal of Agricultural and Food Chemistry | 2014 |
Altered adipocyte progenitor population and adipose-related gene profile in adipose tissue by long-term high-fat diet in mice
X Xu, C Liu, Z Xu, K Tzan, A Wang, S Rajagopalan, Q Sun |
Life Sciences | 2012 |
Isoenergetic Feeding of Low Carbohydrate-High Fat Diets Does Not Increase Brown Adipose Tissue Thermogenic Capacity in Rats
MJ Betz, M Bielohuby, B Mauracher, W Abplanalp, HH Müller, K Pieper, J Ramisch, MH Tschöp, F Beuschlein, M Bidlingmaier, M Slawik, MB Aguila |
PloS one | 2012 |
Effect of meal content on heart rate variability and cardiovascular reactivity to mental stress : Effect of a meal on reactivity to mental stress
KA Sauder, ER Johnston, AC Skulas-Ray, TS Campbell, SG West |
Psychophysiology | 2012 |
Pharmacological and nutritional agents promoting browning of white adipose tissue
ML Bonet, P Oliver, A Palou |
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2012 |
Effect of meal content on heart rate variability and cardiovascular reactivity to mental stress
KA Sauder, ER Johnston, AC Skulas-Ray, TS Campbell, SG West |
Psychophysiology | 2012 |
Core temperature: a forgotten variable in energy expenditure and obesity?: Core temperature and energy expenditure
L Landsberg |
Obesity Reviews | 2012 |
The Metabolic Syndrome
S Devaraj, D Siegel, I Jialal |
The Metabolic Syndrome | 2011 |
High-fat diet induces emergence of brown-like adipocytes in white adipose tissue of spontaneously hypertensive rats
S Hojna, MD Jordan, H Kollias, Z Pausova |
Hypertension Research | 2011 |
Uncoupling protein 1 expression and high-fat diets
T Fromme, M Klingenspor |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2011 |
Prdm16 determines the thermogenic program of subcutaneous white adipose tissue
Patrick Seale, Heather Conroe, Jennifer Estall, Shingo Kajimura, Andrea Frontini, Jeff Ishibashi, Paul Cohen, Saverio Cinti, Bruce M. Spiegelman |
Journal of Clinical Investigation | 2010 |
Dietary macronutrient and energy intake and urinary incontinence in women
NN Maserejian, EL Giovannucci, KT McVary, C McGrother, JB McKinlay |
American Journal of Epidemiology | 2010 |
Increased cell proliferation and contractility of prostate in insulin resistant rats: Linking hyperinsulinemia with benign prostate hyperplasia
A Vikram, GB Jena, P Ramarao |
The Prostate | 2010 |
Vitamins & Hormones
KJ Hare, FK Knop |
Vitamins & Hormones | 2010 |
Regulation of the nuclear hormone receptor nur77 in muscle: Influence of exercise-activated pathways in vitro and obesity in vivo
T Kanzleiter, D Wilks, E Preston, J Ye, G Frangioudakis, GJ Cooney |
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2009 |
Role of the Central Melanocortin Circuitry in Adaptive Thermogenesis of Brown Adipose Tissue
A Voss-Andreae, JG Murphy, KL Ellacott, RC Stuart, EA Nillni, RD Cone, W Fan |
Endocrinology | 2007 |
Feast or Famine: The Sympathetic Nervous System Response to Nutrient Intake
L Landsberg |
Cellular and Molecular Neurobiology | 2006 |
A TELEOLOGICAL VIEW OF OBESITY, DIABETES AND HYPERTENSION
L Landsberg |
Clinical and Experimental Pharmacology and Physiology | 2006 |
Change in Ucp1 mRNA Expression Following Long-Term Cold Exposure under Normal or High-Fat Diet Regimes in the Cold-Intolerant Mammal, Suncus murinus
D SUZUKI, Y MURATA, S ODA |
Experimental Animals | 2006 |
Influence of nutrients on cardiac autonomic function in nondiabetic overweight subjects
P Valensi, J Pariès, B Lormeau, S Attia, JR Attali |
Metabolism | 2005 |
Sympathetic nervous system activity in rat thyroid: potential role in goitrogenesis
JB Young, ME Bürgi-Saville, U Bürgi, L Landsberg |
American journal of physiology. Endocrinology and metabolism | 2005 |
Unlike mice, dogs exhibit effective glucoregulation during low-dose portal and peripheral glucose infusion
MC Moore, S Cardin, DS Edgerton, B Farmer, DW Neal, M Lautz, AD Cherrington |
American journal of physiology. Endocrinology and metabolism | 2004 |
High linoleic acid safflower seed supplementation for gestating ewes: Effects on ewe performance, lamb survival, and brown fat stores1
HB Encinias, GP Lardy, AM Encinias, ML Bauer |
Journal of animal science | 2004 |
Neurobiology of Food and Fluid Intake
EM Stricker, SC Woods |
2004 | |
Interactive relation of insulin and gender to cardiovascular reactivity in healthy young adults
SR Watdstein, HO Barns |
Annals of Behavioral Medicine | 2003 |
Cardiovascular and sympathetic effects of leptin
K Rahmouni, WG Haynes, AL Mark |
Current Hypertension Reports | 2002 |
Insulin Resistance and Insulin Resistance Syndrome
A Cincotta |
Insulin Resistance and Insulin Resistance Syndrome | 2002 |
A Perinatal Strategy For Preventing Adult Disease: The Role Of Long-Chain Polyunsaturated Fatty Acids
UN Das |
2002 | |
Insulin-mediated sympathetic stimulation: role in the pathogenesis of obesity-related hypertension (or, how insulin affects blood pressure, and why)
L Landsberg |
Journal of Hypertension | 2001 |
Effect of Tea Catechins on the Oxidation of Dietary Lipids in Rats
K ONIZAWA, H WATANABE, T YAMAGUCHI, N OSAKI, U HARADA, I TOKIMITSU, H SHIMASAKI, H ITAKURA |
Journal of Oleo Science | 2001 |
Nutritional factors in the pathobiology of human essential hypertension
UN Das |
Nutrition | 2001 |
Insulin-mediated sympathetic stimulation: role in the pathogenesis of obesity-related hypertension (or, how insulin affects blood pressure, and why):
L Landsberg |
Journal of Hypertension | 2001 |
Role of the Sympathetic Adrenal System in the Pathogenesis of the Insulin Resistance Syndrome
L Landsberg |
Annals of the New York Academy of Sciences | 1999 |
Obesity, hypertension, and sympathetic nervous system activity
DB Corry, ML Tuck |
Current Hypertension Reports | 1999 |
Composition of Dietary Fat Affects Blood Pressure and Insulin Responses to Dietary Obesity in the Dog
AA Truett, AT Borne, MP Monteiro, DB West |
Obesity research | 1998 |
Hypertension and the Insulin Resistance Syndrome of Rats
I Klimeš, E Šeböková |
Annals of the New York Academy of Sciences | 1997 |
Hypertension and the Insulin Resistance Syndrome of Rats.: Are They Related?
I Klimeš, E Šeböková |
Annals of the New York Academy of Sciences | 1997 |
Early and late stimulation of ob mRNA expression in meal-fed and overfed rats
RB Harris, TG Ramsay, SR Smith, RC Bruch |
Journal of Clinical Investigation | 1996 |
Crude protein and supplemental dietary tryptophan effects on growth and tissue neurotransmitterlevels in the broiler chicken
RW Rosebrough |
British Journal of Nutrition | 1996 |
Glucose Tolerance and Postprandial Glucose and Insulin Kinetics in Rats with Short- and Long-Term α1-Adrenergic Blockade
N Fajardo, Y Deshaies |
Journal of Cardiovascular Pharmacology | 1996 |
Research prospects with benfluorex
D Ravel, N Laudignon |
Journal of Diabetes and its Complications | 1996 |
Glucose Tolerance and Postprandial Glucose and Insulin Kinetics in Rats with Short- and Long-Term α1-Adrenergic Blockade:
N Fajardo, Y Deshaies |
Journal of Cardiovascular Pharmacology | 1996 |
Insulin regulation of muscle glucose metabolism: Role of pre-receptorial mechanisms
B Capaldo, L Saccà |
Diabetes / Metabolism Reviews | 1995 |
Obesity-related hypertension and the insulin resistance syndrome
L Landsberg |
Transactions of the American Clinical and Climatological Association | 1995 |
Increased sympathetic nervous system activity in Chinese hypertensive patients with type II diabetes mellitus
P Chan, CW Wang, TS Lin, CW Tsai, WH Pan |
International Journal of Cardiology | 1995 |
Lipase Inhibition and Hormonal Status, Body Composition and Gastrointestinal Processing of a Liquid High-Fat Mixed Meal in Moderately Obese Subjects
ML Drent, C Popp-Snijders, HJ Adér, JB Jansen, EA Veen |
Obesity research | 1995 |
Renal Denervation Attenuates the Sodium Retention and Hypertension Associated With Obesity
S Kassab, T Kato, FC Wilkins, R Chen, JE Hall, JP Granger |
Hypertension | 1995 |
Stimulatory influence of d(−)3-hydroxybutyrate feeding on sympathetic nervous system activity in the rat
J Kolanowski, JB Young, L Landsberg |
Metabolism | 1994 |
Differential effects of dietary fats on sympathetic nervous system activity in the rat
JB Young, MC Walgren |
Metabolism | 1994 |
Nutritional effects on neurotransmitter metabolism in the broiler chicken
RW Rosebrough |
Comparative Biochemistry and Physiology Part A: Physiology | 1994 |
Extracellular Hypothalamic Monoamines Measured by In Vivo Microdialysis in a Rat Model of Dietary Fat-Induced Obesity
H Shimizu, JS Fisler, GA Bray |
Obesity research | 1994 |
d-Fenfluramine in a rat model of dietary fat-induced obesity
JS Fisler, SJ Underberger, DA York, GA Bray |
Pharmacology Biochemistry and Behavior | 1993 |
In patients with mild hypertension, does exercise and a gradual rather than abrupt increase in fatty acid and salt intake cause less rise in cardiovascular risk factors?
RB Singh, VK Sharma, SS Rastogi, NK Singh |
Clinical Nutrition | 1992 |
Obesity, blood pressure, and the sympathetic nervous system
L Landsberg, R Troisi, D Parker, JB Young, ST Weiss |
Annals of Epidemiology | 1991 |
Hypertension in obesity may reflect a homeostatic thermogenic response
MG Clark, S Rattigan, EQ Colquhoun |
Life Sciences | 1991 |
How dietary fat intake affects cold tolerance and energy balance in the rat
MJ Mazier, J LeBlanc |
Nutrition Research | 1991 |
Hypertension and sympathetic hyperactivity induced in rats by high-fat or glucose diets
LN Kaufman, MM Peterson, SM Smith |
American journal of physiology. Endocrinology and metabolism | 1991 |
Effect of energy-restricted diet on sympathetic muscle nerve activity in obese women
B Andersson, M Elam, BG Wallin, P Björntorp, OK Andersson |
Hypertension | 1991 |
Insulin Resistance, Energy Balance and Sympathetic Nervous System Activity
L Landsberg |
Clinical and Experimental Hypertension | 1990 |
Diet and coronary heart disease risk factors in a population with varied intake
M Trevisan, V Krogh, JL Freudenheim, A Blake, P Muti, S Panico, E Farinaro, M Mancini, A Menotti, G Ricci |
Preventive Medicine | 1990 |
Effects of energy restriction on norepinephrine turnover and serum glucose and fatty acids in lean mice
JE Davis-Street, JL Johnston |
Pharmacology Biochemistry and Behavior | 1990 |
The sympathoadrenal system, obesity and hypertension: An overview
L Landsberg |
Journal of Neuroscience Methods | 1990 |
Brown adipose tissue thermogenesis and obesity
J Himms-Hagen |
Progress in Lipid Research | 1989 |
Obesity, metabolism, and hypertension
L Landsberg |
The Yale journal of biology and medicine | 1989 |
Differential catecholamine responses to dietary intake: Effects of macronutrients on dopamine and epinephrine excretion in the rat
LN Kaufman, JB Young, L Landsberg |
Metabolism | 1989 |
Effect of a high-fat diet on firing rate of sympathetic nerves innervating brown adipose tissue in anesthetized rats
T Sakaguchi, K Arase, JS Fisler, GA Bray |
Physiology & Behavior | 1989 |
Pathogenesis of weight-related changes in blood pressure in dogs
AP Rocchini, CP Moorehead, S DeRemer, D Bondie |
Hypertension | 1989 |
Refeeding hypertension in dietary obesity
P Ernsberger, DO Nelson |
The American journal of physiology | 1988 |
Nutritional Modulation of Neural Function
WH Karasov |
Nutritional Modulation of Neural Function | 1988 |
The effects of various carbohydrates on sympathetic activity in heart and interscapular brown adipose tissue of the rat
MC Walgren, JB Young, LN Kaufman, L Landsberg |
Metabolism | 1987 |
Effect of protein on sympathetic nervous system activity in the rat. Evidence for nutrient-specific responses
LN Kaufman, JB Young, L Landsberg |
Journal of Clinical Investigation | 1986 |
Comparative studies on the hypercholesterolaemia induced by excess dietary tyrosine or polychlorinated biphenyls in rats
S Nagaoka, M Kato, Y Aoyama, A Yoshida† |
British Journal of Nutrition | 1986 |
Thermogenesis and sympathetic activity in BAT of overfed rats after adrenalectomy
D Marchington, NJ Rothwell, MJ Stock, DA York |
American journal of physiology. Endocrinology and metabolism | 1986 |
Increased brown adipose tissue thermogenesis in obese (ob/ob) mice fed a palatable diet
J Himms-Hagen, S Hogan, G Zaror-Behrens |
American journal of physiology. Endocrinology and metabolism | 1986 |
Effect of glucose and fat feeding on norepinephrine turnover in rats
S Welle, J Feldman |
Journal of Neural Transmission | 1986 |
Photoperiodic control of seasonal body weight cycles in hamsters☆
T Bartness, G Wade |
Neuroscience & Biobehavioral Reviews | 1985 |
The effect of non-esterified long-chain fatty acids on blood flow and thermogenesis in brown adipose tissue in the young dog
A Astrup, J Bülow, NJ Christensen |
Acta Physiologica Scandinavica | 1985 |
Photoperiodic control of seasonal body weight cycles in hamsters
TJ Bartness, GN Wade |
Neuroscience & Biobehavioral Reviews | 1985 |
The role of the sympathoadrenal system in modulating energy expenditure
L Landsberg, JB Young |
Clinics in Endocrinology and Metabolism | 1984 |
Guanethidine sympathectomy does not prevent meal-induced increases in the weight or oxygen consumption of brown fat
MG Tordoff, Z Glick, LL Butcher, D Novin |
Physiology & Behavior | 1984 |