Citations to this article

Immunologic studies in asymptomatic hemophilia patients. Relationship to acquired immune deficiency syndrome (AIDS).
A Landay, … , A Lurie, M D Cooper
A Landay, … , A Lurie, M D Cooper
Published May 1, 1983
Citation Information: J Clin Invest. 1983;71(5):1500-1504. https://doi.org/10.1172/JCI110904.
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Immunologic studies in asymptomatic hemophilia patients. Relationship to acquired immune deficiency syndrome (AIDS).

Abstract

Asymptomatic hemophilia patients receiving Factor VIII concentrate were found to have normal natural killer (NK) cells and B cells, and an inverted T helper/suppressor ratio due to an increase in cells of T suppressor phenotype. In contrast, a hemophilia patient with acquired immune deficiency syndrome (AIDS) exhibited nonfunctional NK cells, low B cells, and an inverted T helper/suppressor ratio due to very low numbers of T helper cells. Hemophilia patients on cryoprecipitate therapy exhibited normal immune parameters. A high percentage of hemophilia patients on both treatments had antibody to hepatitis B virus. The isolated finding of elevated levels of T suppressor cells in hemophilia patients receiving Factor VIII concentrate has not been recognized as an early indicator of impending AIDS, and longitudinal studies will be required to determine its clinical significance.

Authors

A Landay, M C Poon, T Abo, S Stagno, A Lurie, M D Cooper

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Year: 2024 2007 1996 1995 1992 1989 1988 1987 1986 1985 1984 1983 Total
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Citations to this article (38)

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