Low density lipoprotein (LDL) catabolism occurs by LDL receptor-dependent and LDL receptor-independent pathways. We have shown previously that nonenzymatic glucosylation of LDL in the presence of cyanoborohydride irreversibly blocks the lysine residues of LDL. Glucosylated LDL (GLC-LDL) was not degraded by the LDL receptor of fibroblasts, and its degradation by macrophages was similar to that of native LDL. This suggested that GLC-LDL should be a good tracer of LDL receptor-independent catabolism, and if combined with a tracer of total LDL catabolism, should enable one to calculate the extent of LDL receptor-dependent catabolism.
Y. Antero Kesaniemi, Joseph L. Witztum, Urs P. Steinbrecher
Title and authors | Publication | Year |
---|---|---|
Euphornin L promotes lipid clearance by dual regulation of LDLR and PCSK9
H Li, J Li, X Zhang, J Li, , W Wang, Y Lu, L Xuan |
Experimental and therapeutic medicine | 2021 |
Potential of Lipoprotein-Based Nanoparticulate Formulations for the Treatment of Eye Diseases
R Fukuda, T Murakami |
Biological & Pharmaceutical Bulletin | 2020 |
Relationship between “LDL-C”, estimated true LDL-C, apolipoprotein B-100, and PCSK9 levels following lipoprotein(a) lowering with an antisense oligonucleotide
NJ Viney, C Yeang, X Yang, S Xia, JL Witztum, S Tsimikas |
Journal of Clinical Lipidology | 2018 |
Lipoprotein(a) Mass Levels Increase Significantly According to APOE GenotypeHighlights: An Analysis of 431 239 Patients
PM Moriarty, SA Varvel, PL Gordts, JP McConnell, S Tsimikas |
Arteriosclerosis, thrombosis, and vascular biology | 2017 |
Lipoprotein(a) Mass Levels Increase Significantly According to APOE GenotypeHighlights: An Analysis of 431 239 Patients
PM Moriarty, SA Varvel, PL Gordts, JP McConnell, S Tsimikas |
Arteriosclerosis, thrombosis, and vascular biology | 2017 |
Lipoproteins as Carriers of Pharmacological Agents
J Michael |
2017 | |
The anti-leukemic and lipid lowering effects of imatinib are not hindered by statins in CML: a retrospective clinical study and in vitro assessment of lipid-genes transcription
M Ellis, E Krashin, O Hamburger-Avnery, S Gan, A Elis, O Ashur-Fabian |
Leukemia & Lymphoma | 2016 |
Atherosclerosis: Risks, Mechanisms, and Therapies
HJ Pownall, C Rosales, BK Gillard, AM Gotto |
Atherosclerosis: Risks, Mechanisms, and Therapies | 2015 |
Comprehensive Physiology
SN Cheuvront, RW Kenefick |
Comprehensive Physiology | 2014 |
Alterations in serum lipid profile patterns in oral cancer
S Singh, V Ramesh, B Premalatha, KV Prashad, K Ramadoss |
Journal of Natural Science, Biology, and Medicine | 2013 |
Methods in Enzymology
JD Stone, AS Chervin, DH Aggen, DM Kranz |
Protein Engineering for Therapeutics Part B | 2012 |
Advances in Food and Nutrition Research
N Siriwardhana, NS Kalupahana, N Moustaid-Moussa |
Marine Medicinal Foods - Implications and Applications - Animals and Microbes | 2012 |
Alteration of lipids and the transcription of lipid-related genes in myelodysplastic syndromes via a TP53-related pathway
MH Ellis, L Baraf, A Shaish, A Har-Zahav, D Harats, O Ashur-Fabian |
Experimental Hematology | 2012 |
Chance and Serendipity in Science: Two Examples from My Own Career
D Steinberg |
The Journal of biological chemistry | 2011 |
Advances in Clinical Chemistry
M Mahler |
Advances in Clinical Chemistry Volume 54 | 2011 |
Alterations in serum lipid profile patterns in oral cancer and oral precancerous lesions and conditions—a clinical study
S Gupta, S Gupta |
Indian Journal of Dentistry | 2011 |
Recent insights into factors affecting remnant lipoprotein uptake
KJ Williams, K Chen |
Current Opinion in Lipidology | 2010 |
Recent insights into factors affecting remnant lipoprotein uptake:
KJ Williams, K Chen |
Current Opinion in Lipidology | 2010 |
Scavenger Receptors of Endothelial Cells Mediate the Uptake and Cellular Proatherogenic Effects of Carbamylated LDL
EO Apostolov, SV Shah, D Ray, AG Basnakian |
Arteriosclerosis, thrombosis, and vascular biology | 2009 |
Lipoprotein glycation in atherogenesis
NN Younis, H Soran, R Sharma, V Charlton-Menys, PN Durrington |
Clinical Lipidology | 2009 |
Lipid profile in oral submucous fibrosis
R Mehrotra, S Pandya, AK Chaudhary, HP Singh, RK Jaiswal, M Singh, SC Gupta, M Singh |
Lipids in Health and Disease | 2009 |
Glycation as an atherogenic modification of LDL
N Younis, R Sharma, H Soran, V Charlton-Menys, M Elseweidy, PN Durrington |
Current Opinion in Lipidology | 2008 |
Tissue-specific effects of atorvastatin on 3-hydroxy-3-methylglutaryl-coenzyme A reductase expression and activity in spontaneously hypertensive rats1
G CHEN, L YAO, X LU, L LI, S HU |
Acta Pharmacologica Sinica | 2008 |
Glycation as an atherogenic modification of LDL:
N Younis, R Sharma, H Soran, V Charlton-Menys, M Elseweidy, PN Durrington |
Current Opinion in Lipidology | 2008 |
Significance of Alterations in Plasma Lipid Profile Levels in Breast Cancer
FD Shah, SN Shukla, PM Shah, HR Patel, PS Patel |
Integrative Cancer Therapies | 2008 |
Activation of ERK signaling upon alternative protease nexin-1 internalization mediated by syndecan-1
X Li, J Herz, D Monard |
Journal of Cellular Biochemistry | 2006 |
Cellular Drug Delivery
DR Lu, S Øie |
2004 | |
Cardiovascular Disease
AE Guttmacher, FS Collins, EG Nabel |
New England Journal of Medicine | 2003 |
Lipoproteins modify the macrophage uptake of triacylglycerol emulsion and of zymosan particles by similar mechanisms
MD Carvalho, VE Tobias, CM Vendrame, AF Shimabukuro, M Gidlund, EC Quintão |
Lipids | 2000 |
Analysis of low-density lipoprotein catabolism by primary cultures of hepatic cells from normal and low-density lipoprotein receptor knockout mice
TQ Truong, A Auger, F Denizeau, L Brissette |
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2000 |
Epitopes close to the apolipoprotein B low density lipoprotein receptor-binding site are modified by advanced glycation end products
X Wang, R Bucala, R Milne |
Proceedings of the National Academy of Sciences | 1998 |
The syndecan family of proteoglycans. Novel receptors mediating internalization of atherogenic lipoproteins in vitro
IV Fuki, KM Kuhn, IR Lomazov, VL Rothman, GP Tuszynski, RV Iozzo, TL Swenson, EA Fisher, KJ Williams |
Journal of Clinical Investigation | 1997 |
Scintigraphic evaluation of Tc-99m-low-density lipoprotein (LDL) distribution in patients with Gaucher disease
M Lorberboym, S Vallabhajosula, H Lipszyc, G Pastores |
Clinical Genetics | 1997 |
The impact of coexistent diabetes on the prevalence of coronary heart disease
ML Morici, AD Marco, D Sestito, R Candore, C Cangemi, F Accardo, M Donatelli, MG Cataldo, A Lombardo |
Journal of Diabetes and its Complications | 1997 |
Reducing saturated fat intake is associated with increased levels of LDL receptors on mononuclear cells in healthy men and women
VA Mustad, TD Etherton, AD Cooper, AM Mastro, TA Pearson, SS Jonnalagadda, PM Kris-Etherton |
Journal of lipid research | 1997 |
Effect of testosterone replacement therapy on lipids and lipoproteins in hypogonadal and elderly men
S Zgliczynski, M Ossowski, J Slowinska-Srzednicka, A Brzezinska, W Zgliczynski, P Soszynski, E Chotkowska, M Srzednicki, Z Sadowski |
Atherosclerosis | 1996 |
Modification of Lipoproteins in Diabetes
MF Lopes-Virella, RL Klein, G Virella |
Diabetes/Metabolism Reviews | 1996 |
Prevention of diabetic nephropathy in db/db mice with glycated albumin antagonists. A novel treatment strategy
MP Cohen, K Sharma, Y Jin, E Hud, VY Wu, J Tomaszewski, FN Ziyadeh |
Journal of Clinical Investigation | 1995 |
Regulation of apolipoprotein B secretion in hepatocytes from Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia
M Tanaka, H Otani, M Yokode, T Kita |
Atherosclerosis | 1995 |
Apolipoproteins and Gallstone Disease
T Juvonen, MJ Savolainen, YA Kesaniemi |
Annals of Medicine | 1995 |
Accumulation of 99mTc-low-density lipoprotein in human malignant glioma
J Leppälä, M Kallio, T Nikula, P Nikkinen, K Liewendahl, J Jääskeläinen, S Savolainen, H Gylling, J Hiltunen, J Callaway |
British Journal of Cancer | 1995 |
Regulation of hepatic 7 alpha-hydroxylase expression by dietary psyllium in the hamster
JD Horton, JA Cuthbert, DK Spady |
Journal of Clinical Investigation | 1994 |
Amelioration of diabetic nephropathy by treatment with monoclonal antibodies against glycated albumin
MP Cohen, E Hud, VY Wu |
Kidney International | 1994 |
Modification of low density lipoprotein by advanced glycation end products contributes to the dyslipidemia of diabetes and renal insufficiency
R Bucala, Z Makita, G Vega, S Grundy, T Koschinsky, A Cerami, H Vlassara |
Proceedings of the National Academy of Sciences | 1994 |
Lipoprotein disorders in diabetes mellitus
WV Brown |
Medical Clinics of North America | 1994 |
Low-density lipoproteins of the postprandial state induce cellular cholesteryl ester accumulation in macrophages
M Lechleitner, F Hoppichler, B Föger, JR Patsch |
Arteriosclerosis Thrombosis and Vascular Biology | 1994 |
Apolipoprotein B and a second major gene locus contribute to phenotypic variation of spontaneous hypercholesterolemia in pigs
RJ Aiello, DN Nevin, DL Ebert, PJ Uelmen, ME Kaiser, JW MacCluer, J Blangero, TD Dyer, AD Attie |
Arteriosclerosis Thrombosis and Vascular Biology | 1994 |
Effects of doxazosin, an α1-adrenergic inhibitor, on plasma lipid and lipoprotein levels, low density lipoprotein metabolism and cholesterol absorption in cynomolgus monkeys
AF Stucchi, DB Vespa, AH Terpstra, RJ Nicolosi |
Atherosclerosis | 1993 |
Glycated LDL Concentrations in Non-Diabetic and Diabetic Subjects Measured with Monoclonal Antibodies Reactive with Glycated Apolipoprotein B Epitopes
MP Cohen, G Lautenslager, E Shea |
Clinical Chemistry and Laboratory Medicine | 1993 |
Apolipoprotein B gene DNA polymorphisms are associated with macro- and microangiopathy in non-insulin-dependent diabetes mellitus
O Ukkola, MJ Savolainen, PI Salmela, K Dickhoff, YA Kesäniemi |
Clinical Genetics | 1993 |
Metabolism of cholesterol and apolipoprotein B in celiac disease
M Vuoristo, YA Kesäniemi, H Gylling, TA Miettinen |
Metabolism | 1993 |
Cellular Mechanisms of Lipid Injury in the Glomerulus
D Schlondorff |
American Journal of Kidney Diseases | 1993 |
Fenofibrate and LDL metabolic heterogeneity in hypercholesterolemia
MJ Caslake, CJ Packard, A Gaw, E Murray, BA Griffin, BD Vallance, J Shepherd |
Arteriosclerosis Thrombosis and Vascular Biology | 1993 |
Ten-year cardiovascular mortality in relation to risk factors and abnormalities in lipoprotein composition in Type 2 (non-insulin-dependent) diabetic and non-diabetic subjects
MI Uusitupa, LK Niskanen, O Siitonen, E Voutilainen, K Pyrl |
Diabetologia | 1993 |
Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans
JM Dietschy, SD Turley, DK Spady |
Journal of lipid research | 1993 |
Lovastatin enhances hepatic uptake of low density lipoprotein in humans
K Kervinen, MJ Savolainen, JI Heikkilä, YA Kesäniemi |
Journal of lipid research | 1993 |
Down-regulation of mRNA for the low density lipoprotein receptor in transgenic mice containing the gene for human cholesteryl ester transfer protein. Mechanism to explain accumulation of lipoprotein B particles
XC Jiang, L Masucci-Magoulas, J Mar, M Lin, A Walsh, JL Breslow, A Tall |
The Journal of biological chemistry | 1993 |
Technetium-99m labelled LDL as a tracer for quantitative LDL scintigraphy: I. Tracer purification, in vitro and in vivo long-term stability, in vitro validation and biodistribution
T Leitha, M Hermann, M Hüttinger, P Angelberger, R Dudczak |
European Journal of Nuclear Medicine | 1993 |
Plasma triglyceride and low density lipoprotein metabolism
MJ Caslake, CJ Packard, JJ Series, B Yip, MM Dagen, J Shepherd |
European Journal of Clinical Investigation | 1992 |
Apolipoprotein B gene mutations affecting cholesterol levels
RV Farese, MF Linton, SG Young |
Journal of Internal Medicine | 1992 |
Receptor-dependent and -independent catabolism of low-density lipoprotein in a kindred with familial hypobetalipoproteinemia
CL Malmendier, JF Lontie, C Delcroix, C Sérougne, J Férézou, DM Lee |
Metabolism | 1992 |
Carbamylation-induced alterations in low-density lipoprotein metabolism
S Hörkkö, MJ Savolainen, K Kervinen, YA Kesäniemi |
Kidney International | 1992 |
Management of Hyperlipidemia in Diabetes Mellitus
FL Dunn |
Endocrinology and metabolism clinics of North America | 1992 |
Change in LDL particle size is associated with change in plasma triglyceride concentration
JR McNamara, JL Jenner, Z Li, PW Wilson, EJ Schaefer |
Arteriosclerosis Thrombosis and Vascular Biology | 1992 |
Glycated low density lipoprotein catabolism is increased in rabbits with alloxan-induced diabetes mellitus
W Kortlandt, C Benschop, HJ van Rijn, DW Erkelens |
Diabetologia | 1992 |
Diabetes and Atherosclerosis
RW Stout |
1992 | |
Induction of low density lipoprotein receptor and a transcription factor SP-1 by tumor necrosis factor in human microvascular endothelial cells
R Hamanaka, K Kohno, T Seguchi, K Okamura, A Morimoto, M Ono, J Ogata, M Kuwano |
The Journal of biological chemistry | 1992 |
Use of an anti-low density lipoprotein receptor antibody to quantify the role of the LDL receptor in the removal of chylomicron remnants in the mouse in vivo
SY Choi, LG Fong, MJ Kirven, AD Cooper |
Journal of Clinical Investigation | 1991 |
Low Density Lipoprotein Derivatization by Acetaldehyde Affects Lysine Residues and the B/E Receptor Binding Affinity
K Kervinen, MJ Savolainen, MJ Tikkanen, YA Kesälniemi |
Alcoholism, clinical and experimental research | 1991 |
Diabetes and Arterial Disease
FA Gries, T Koschinsky |
Diabetic Medicine | 1991 |
Multiple Changes in Apoprotein B Containing Lipoproteins after Ethanol Withdrawal in Alcoholic Men
K Kervinen, MJ Savolainen, YA Kesäniemi |
Annals of Medicine | 1991 |
Familial defective apo B-100, characterization of an Italian family
A Corsini, BJ McCARTHY, A Granata, LF Soria, SF Bernini, C Romano, L Romano, R Fumagalli, AL Catapano |
European Journal of Clinical Investigation | 1991 |
The relationship between hepatic low-density lipoprotein receptor activity and serum cholesterol level in the human fetus
HJ Cai, CL Xie, Q Chen, XY Chen, YH Chen |
Hepatology | 1991 |
Probing of the expression of the low-density lipoprotein receptor in vivo using an anti-receptor monoclonal antibody
E Gherardi, DE Bowyer, C Fitzsimmons, TL Cras, A Hutchings, G Butcher |
Biochemical Journal | 1991 |
Evidence for sterol-independent regulation of low-density lipoprotein receptor activity in Hep-G2 cells
JL Ellsworth, C Chandrasekaran, AD Cooper |
Biochemical Journal | 1991 |
In vivo regulation of low-density lipoprotein receptor and apolipoprotein B gene expressions by dietary fat and cholesterol in inbred strains of mice
RA Srivastava, S Jiao, J Tang, BA Pfleger, RT Kitchens, G Schonfeld |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1991 |
Abnormal serum immunoglobulin concentrations in patients with diabetes mellitus
S Rodríguez-Segade, MF Camiña, JM Paz, RD Río |
Clinica Chimica Acta | 1991 |
George Lyman Duff Memorial Lecture. Multifactorial etiology of hypercholesterolemia. Implications for prevention of coronary heart disease
SM Grundy |
Arteriosclerosis Thrombosis and Vascular Biology | 1991 |
Hyperlipidemia in diabetes mellitus
FL Dunn |
Diabetes / Metabolism Reviews | 1990 |
Effects of endogenous and exogenous cholesterol on the ultrastructure and steroid secretion of undifferentiated rat adrenocortical cells in primary culture
P Heikkilä |
Cell and Tissue Research | 1990 |
Mechanisms of hypercholesterolaemia in glycogen storage disease type I: defective metabolism of low density lipoprotein in cultured skin fibroblasts
E Levy, L Thibault, CC Roy, J Letarte, M Lambert, EG Seidman |
European Journal of Clinical Investigation | 1990 |
Cholesterol uptake by human glioma cells via receptor-mediated endocytosis of low-density lipoprotein
M Murakami, Y Ushio, Y Mihara, JI Kuratsu, S Horiuchi, Y Morino |
Journal of Neurosurgery | 1990 |
Enhanced Hepatic Uptake of Low Density Lipoprotein by Lovastatin (Mevinolin) in Man
MJ Savolainen, K Kervinen, J Heikkilä, A Kesäniemi |
Drug Investigation | 1990 |
Cholesterol Metabolism, Ldl, and the Ldl Receptor
NB Myant |
Cholesterol Metabolism, Ldl, and the Ldl Receptor | 1990 |
99mTc-low density lipoprotein: Intracellularly trapped radiotracer for noninvasive imaging of low density lipoprotein metabolism in vivo
S Vallabhajosula, SJ Goldsmith |
Seminars in Nuclear Medicine | 1990 |
Hyperlipidemia in Diabetes Mellitus: Pathogenesis, Diagnosis, and Pharmacological Therapy
K Johansen |
Annals of Saudi medicine | 1990 |
Effect of dietary fat saturation and cholesterol on LDL composition and metabolism. In vivo studies of receptor and nonreceptor-mediated catabolism of LDL in cebus monkeys
RJ Nicolosi, AF Stucchi, MC Kowala, LK Hennessy, DM Hegsted, EJ Schaefer |
Arteriosclerosis (Dallas, Tex.) | 1990 |
Recent progress in understanding apolipoprotein B
SG Young |
Circulation | 1990 |
Causes of high blood cholesterol
SM Grundy, GL Vega |
Circulation | 1990 |
In vivo clearance of low density lipoprotein in pigeons occurs by a receptor-like mechanism that is not down-regulated by cholesterol feeding
JW Reagan, LR Miller, RW Clair |
The Journal of biological chemistry | 1990 |
Effects of dietary cholesterol and fatty acids on plasma cholesterol level and hepatic lipoprotein metabolism
H Ohtani, K Hayashi, Y Hirata, S Dojo, K Nakashima, E Nishio, H Kurushima, M Saeki, G Kajiyama |
Journal of lipid research | 1990 |
Rapid intracellular transport of LDL-derived cholesterol to the plasma membrane in cultured fibroblasts
DL Brasaemle, AD Attie |
Journal of lipid research | 1990 |
Kinetics of a heterogeneous population of particles in low density lipoprotein apolipoprotein B
CL Malmendier, C Delcroix, JF Lontie |
Atherosclerosis | 1989 |
The low density lipoprotein receptor: Structure, function and pharmacological modulation
AL Catapano |
Pharmacology & Therapeutics | 1989 |
Identification of glycation at the N-terminus of albumin by gas chromatography-mass spectrometry
DA Robb, OS Olufemi, DA Williams, JM Midgley |
Biochemical Journal | 1989 |
Studies on mechanisms for enhanced clearance of low-density lipoproteins in patients with primary hypertriglyceridaemia
GL Vega, SM Grundy |
Journal of Internal Medicine | 1989 |
Beyond Cholesterol
FH Epstein, D Steinberg, S Parthasarathy, TE Carew, JC Khoo, JL Witztum |
New England Journal of Medicine | 1989 |
Current approaches to drug therapy for the hypercholesterolemic patient
JL Witztum |
Circulation | 1989 |
Human Apolipoprotein Mutants 2
CR Sirtori, G Franceschini, HB Brewer, G Assmann |
1989 | |
Cholesterol Transport Systems and Their Relation to Atherosclerosis
A Steinmetz, H Kaffarnik, J Schneider |
1989 | |
Colestipol-induced changes in LDL composition and metabolism. II. Studies in humans
SG Young, JL Witztum, TE Carew, RW Krauss, FT Lindgren |
Journal of lipid research | 1989 |
Effects of lovastatin therapy on guinea pig low density lipoprotein composition and metabolism
L Berglund, MF Sharkey, RL Elam, JL Witztum |
Journal of lipid research | 1989 |
Receptor-mediated uptake of low density lipoprotein stimulates bile acid synthesis by cultured rat hepatocytes
LH Junker, RA Davis |
Journal of lipid research | 1989 |
Interaction of dietary cholesterol and triglycerides in the regulation of hepatic low density lipoprotein transport in the hamster
DK Spady, JM Dietschy |
Journal of Clinical Investigation | 1988 |
Catabolic rate of low density lipoprotein is influenced by variation in the apolipoprotein B gene
T Demant, RS Houlston, MJ Caslake, JJ Series, J Shepherd, CJ Packard, SE Humphries |
Journal of Clinical Investigation | 1988 |
Hyperglycemia in normotriglyceridemic, hypercholesterolemic insulin-treated diabetic rabbits does not accelerate atherogenesis
BG Nordestgaard, DB Zilversmit |
Atherosclerosis | 1988 |
Lipoprotein alterations in diabetes mellitus
GM Kostner, I Kar�di |
Diabetologia | 1988 |
How bile acids differ: studies of receptor-mediated LDL uptake
RH Palmer, MM Fuh |
Transactions of the American Clinical and Climatological Association | 1988 |
The biochemistry of diabetes
R Taylor, L Agius |
Biochemical Journal | 1988 |
Purification of low density lipoprotein receptor from liver and its quantification by anti-receptor monoclonal antibodies
E Gherardi, N Brugni, DE Bowyer |
Biochemical Journal | 1988 |
Stimulation of receptor-dependent and receptor-independent pathways of low-density lipoprotein degradation in arterial smooth muscle cells by platelet-derived growth factor
A Chait, R Ross, EL Bierman |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1988 |
HMG-CoA Reductase Inhibitors for Treatment of Hypercholesterolemia
JA Oates, AJ Wood, SM Grundy |
New England Journal of Medicine | 1988 |
Der Internist
E Buchborn, M Classen, W Dölle, R Gross, J van de Loo, G Riecker, PC Scriba, W Siegenthaler, P von Wichert |
Der Internist | 1988 |
Transbilayer movement of cholesterol in the human erythrocyte membrane
DL Brasaemle, AD Robertson, AD Attie |
Journal of lipid research | 1988 |
Lipoprotein alterations in diabetes mellitus
GM Kostner, I Kardi |
Diabetologia | 1988 |
Pharmacological treatment of lipid disorders in diabetes mellitus
MF Lopes-Virella, JA Colwell |
Diabetes / Metabolism Reviews | 1987 |
Acetaldehyde modification of low density lipoprotein accelerates its catabolism in man
YA Kesäniemi, K Kervinen, TA Miettinen |
European Journal of Clinical Investigation | 1987 |
Cholesterol absorption efficiency regulates plasma cholesterol level in the Finnish population
YA Kesäniemi, TA Miettinen |
European Journal of Clinical Investigation | 1987 |
Multicentric reticulohistiocytosis, another lipid disorder with normolipidemic xanthomatosis?
YA Kesäniemi, C Ehnholm, TA Miettinen |
Atherosclerosis | 1987 |
The effects of chemically modifying serum apolipoproteins on their ability to activate lipoprotein lipase
PF Dodds, A Lopez-Johnston, VA Welch, MI Gurr |
Biochemical Journal | 1987 |
Integrated study of low density lipoprotein metabolism and very low density lipoprotein metabolism in non-insulin-dependent diabetes
BV Howard, WG Abbott, WF Beltz, IT Harper, RM Fields, SM Grundy, MR Taskinen |
Metabolism | 1987 |
Regulation of low-density lipoprotein apolipoprotein B levels
YA Kesäniemi, M Färkkilä, K Kervinen, P Koivisto, M Vuoristo, TA Miettinen |
American Heart Journal | 1987 |
Mechanisms of primary hypercholesterolemia in humans
GL Vega, SM Grundy |
American Heart Journal | 1987 |
Enhanced cholesterol elimination and synthesis related to low-density lipoprotein metabolism
TA Miettinen, YA Kesäniemi, M Färkkilä, P Koivisto, M Vuoristo |
American Heart Journal | 1987 |
Atherosclerosis and Cardiovascular Diseases
S Lenzi, GC Descovich |
1987 | |
Lipoprotein metabolism in diabetes mellitus
BV Howard |
Journal of lipid research | 1987 |
Kinetic constants for receptor-dependent and receptor-independent low density lipoprotein transport in the tissues of the rat and hamster
DK Spady, JB Meddings, JM Dietschy |
Journal of Clinical Investigation | 1986 |
Bile acids regulate hepatic low density lipoprotein receptor activity in the hamster by altering cholesterol flux across the liver
DK Spady, EF Stange, LE Bilhartz, JM Dietschy |
Proceedings of the National Academy of Sciences | 1986 |
Impaired hepatocyte binding, uptake and degradation of glucosylated low-density lipoproteins
JE Triau, J Arbetter, EJ Schaefer |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1986 |
Metabolism of glycosylated very-low-density lipoproteins in human skin fibroblasts
Y Masaharu, S Ranganathan, BA Kottke |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1986 |
Receptor-Mediated Uptake in the Liver
H Greten, E Windler, U Beisiegel |
1986 | |
Cultured human hepatocytes. Evidence for metabolism of low density lipoproteins by a pathway independent of the classical low density lipoprotein receptor
SB Edge, JM Hoeg, T Triche, PD Schneider, HB Brewer |
The Journal of biological chemistry | 1986 |
Role of receptor-independent low density lipoprotein transport in the maintenance of tissue cholesterol balance in the normal and WHHL rabbit
DK Spady, M Huettinger, DW Bilheimer, JM Dietschy |
Journal of lipid research | 1986 |
Receptor-independent low density lipoprotein transport in the rat in vivo. Quantitation, characterization, and metabolic consequences
DK Spady, SD Turley, JM Dietschy |
Journal of Clinical Investigation | 1985 |
Discrepancies in the catabolic pathways of human and rat high-density lipoprotein apolipoprotein A-I in the rat
FM van Hooft, AV Tol |
European Journal of Clinical Investigation | 1985 |
Abnormalities in Metabolism of Low Density Lipoproteins Associated with Coronary Heart Disease
SM Grundy, GL Vega, YA Kesäniemi |
Acta Medica Scandinavica | 1985 |
HYPOCHOLESTEROLAEMIA IN MALIGNANCY DUE TO ELEVATED LOW-DENSITY-LIPOPROTEIN-RECEPTOR ACTIVITY IN TUMOUR CELLS: EVIDENCE FROM STUDIES IN PATIENTS WITH LEUKAEMIA
S Vitols, M Björkholm, G Gahrton, C Peterson |
The Lancet | 1985 |
Dietary saturated triacylglycerols suppress hepatic low density lipoprotein receptor activity in the hamster
DK Spady, JM Dietschy |
Proceedings of the National Academy of Sciences | 1985 |
Regulation of Hmg-coa Reductase
LC Smith, AM Gotto |
Regulation of Hmg-coa Reductase | 1985 |
Limited nonenzymatic glucosylation of low-density lipoprotein does not alter its catabolism in tissue culture
E Schleicher, B Olgemöller, J Schön, T Dürst, OH Wieland |
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 1985 |
Kinetic mechanisms determining variability in low density lipoprotein levels and rise with age
SM Grundy, GL Vega, DW Bilheimer |
Arteriosclerosis (Dallas, Tex.) | 1985 |
Comparison of Type I and Type II Diabetes
M Vranic, CH Hollenberg, G Steiner |
1985 | |
Rates of low density lipoprotein uptake and cholesterol synthesis are regulated independently in the liver
DK Spady, SD Turley, JM Dietschy |
Journal of lipid research | 1985 |
WHY DOES PLASMA LOW DENSITY LIPOPROTEIN CONCENTRATION IN ADULTS INCREASE WITH AGE?
NE Miller |
The Lancet | 1984 |
Autoantibodies to glucosylated proteins in the plasma of patients with diabetes mellitus
JL Witztum, UP Steinbrecher, YA Kesaniemi, M Fisher |
Proceedings of the National Academy of Sciences | 1984 |
Receptor-independent low-density lipoprotein catabolism
HR Slater, L Mckinney, J Shepherd, CJ Packard |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1984 |
Elevated hemoglobin A1c and low-density lipoprotein cholesterol levels in thiazide-treated diabetic patients
ZT Bloomgarden, F Ginsberg-Fellner, EJ Rayfield, J Bookman, WV Brown |
The American Journal of Medicine | 1984 |
Contribution of the receptor pathway to low density lipoprotein catabolism in humans. New methods for quantitation
HR Slater, L McKinney, CJ Packard, J Shepherd |
Arteriosclerosis (Dallas, Tex.) | 1984 |
Pathophysiology of human lipoprotein receptors: clinical consequences of a cellular defect
J Shepherd, CJ Packard |
Journal of clinical pathology | 1984 |
Cologne Atherosclerosis Conference No. 2: Lipids
MJ Parnham |
1984 | |
Gallstone dissolution and the cholesterol-bile acid-lipoprotein axis. Propitious effects of ursodeoxycholic acid
H Fromm |
Gastroenterology | 1984 |
Pathogenesis of hyperlipoproteinemia
SM Grundy |
Journal of lipid research | 1984 |
Abnormal high density lipoproteins from patients with liver disease regulate cholesterol metabolism in cultured human skin fibroblasts
JS Owen, H Goodall, P Mistry, DS Harry, RC Day, N McIntyre |
Journal of lipid research | 1984 |
Influence of probucol on cholesterol and lipoprotein metabolism in man
YA Kesäniemi, SM Grundy |
Journal of lipid research | 1984 |
Characterization of low density lipoprotein binding to human adipocytes and adipocyte membranes
BS Fong, PO Rodrigues, A Angel |
The Journal of biological chemistry | 1984 |
Comparison of glucosylated low density lipoprotein with methylated or cyclohexanedione-treated low density lipoprotein in the measurement of receptor-independent low density lipoprotein catabolism
UP Steinbrecher, JL Witztum, YA Kesaniemi, RL Elam |
Journal of Clinical Investigation | 1983 |
Lipoprotein receptors in the liver. Control signals for plasma cholesterol traffic
MS Brown, JL Goldstein |
Journal of Clinical Investigation | 1983 |
A novel method for generating region-specific monoclonal antibodies to modified proteins. Application to the identification of human glucosylated low density lipoproteins
LK Curtiss, JL Witztum |
Journal of Clinical Investigation | 1983 |
Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes
DW Bilheimer, SM Grundy, MS Brown, JL Goldstein |
Proceedings of the National Academy of Sciences | 1983 |
New Comprehensive Biochemistry
S Yamamoto |
New Comprehensive Biochemistry | 1983 |
Lipoproteins and atherosclerosis. A look back and a look ahead
D Steinberg |
Arteriosclerosis (Dallas, Tex.) | 1983 |