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Citations to this article

Receptor-mediated Catabolism of Low Density Lipoprotein in Man. QUANTITATION USING GLUCOSYLATED LOW DENSITY LIPOPROTEIN
Y. Antero Kesaniemi, … , Joseph L. Witztum, Urs P. Steinbrecher
Y. Antero Kesaniemi, … , Joseph L. Witztum, Urs P. Steinbrecher
Published April 1, 1983
Citation Information: J Clin Invest. 1983;71(4):950-959. https://doi.org/10.1172/JCI110849.
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Research Article

Receptor-mediated Catabolism of Low Density Lipoprotein in Man. QUANTITATION USING GLUCOSYLATED LOW DENSITY LIPOPROTEIN

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Abstract

Low density lipoprotein (LDL) catabolism occurs by LDL receptor-dependent and LDL receptor-independent pathways. We have shown previously that nonenzymatic glucosylation of LDL in the presence of cyanoborohydride irreversibly blocks the lysine residues of LDL. Glucosylated LDL (GLC-LDL) was not degraded by the LDL receptor of fibroblasts, and its degradation by macrophages was similar to that of native LDL. This suggested that GLC-LDL should be a good tracer of LDL receptor-independent catabolism, and if combined with a tracer of total LDL catabolism, should enable one to calculate the extent of LDL receptor-dependent catabolism.

Authors

Y. Antero Kesaniemi, Joseph L. Witztum, Urs P. Steinbrecher

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Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1984
Elevated hemoglobin A1c and low-density lipoprotein cholesterol levels in thiazide-treated diabetic patients
ZT Bloomgarden, F Ginsberg-Fellner, EJ Rayfield, J Bookman, WV Brown
The American Journal of Medicine 1984
Contribution of the receptor pathway to low density lipoprotein catabolism in humans. New methods for quantitation
HR Slater, L McKinney, CJ Packard, J Shepherd
Arteriosclerosis (Dallas, Tex.) 1984
Pathophysiology of human lipoprotein receptors: clinical consequences of a cellular defect
J Shepherd, CJ Packard
Journal of clinical pathology 1984
Cologne Atherosclerosis Conference No. 2: Lipids
MJ Parnham
1984
Gallstone dissolution and the cholesterol-bile acid-lipoprotein axis. Propitious effects of ursodeoxycholic acid
H Fromm
Gastroenterology 1984
Pathogenesis of hyperlipoproteinemia
SM Grundy
Journal of lipid research 1984
Abnormal high density lipoproteins from patients with liver disease regulate cholesterol metabolism in cultured human skin fibroblasts
JS Owen, H Goodall, P Mistry, DS Harry, RC Day, N McIntyre
Journal of lipid research 1984
Influence of probucol on cholesterol and lipoprotein metabolism in man
YA Kesäniemi, SM Grundy
Journal of lipid research 1984
Characterization of low density lipoprotein binding to human adipocytes and adipocyte membranes
BS Fong, PO Rodrigues, A Angel
The Journal of biological chemistry 1984
Comparison of glucosylated low density lipoprotein with methylated or cyclohexanedione-treated low density lipoprotein in the measurement of receptor-independent low density lipoprotein catabolism
UP Steinbrecher, JL Witztum, YA Kesaniemi, RL Elam
Journal of Clinical Investigation 1983
Lipoprotein receptors in the liver. Control signals for plasma cholesterol traffic
MS Brown, JL Goldstein
Journal of Clinical Investigation 1983
A novel method for generating region-specific monoclonal antibodies to modified proteins. Application to the identification of human glucosylated low density lipoproteins
LK Curtiss, JL Witztum
Journal of Clinical Investigation 1983
Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes
DW Bilheimer, SM Grundy, MS Brown, JL Goldstein
Proceedings of the National Academy of Sciences 1983
New Comprehensive Biochemistry
S Yamamoto
New Comprehensive Biochemistry 1983
Lipoproteins and atherosclerosis. A look back and a look ahead
D Steinberg
Arteriosclerosis (Dallas, Tex.) 1983

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