Human skin fibroblasts synthesize and accumulate glycosaminoglycans (GAG). Recently, we reported that fibroblasts incubated in thyroid hormone-deficient media accumulate more GAG than do cultures incubated in the same media enriched with 0.1 μM triiodothyronine (T3) (1981. Endocrinology. 108: 2397). The current study characterizes that enhanced accumulation. Confluent cultures were maintained in thyroid hormone-deficient media without or with added T3, labeled with [3H]acetate and analyzed for total [3H]GAG and [3H]hyaluronic acid content.
Terry J. Smith, Yoshiharu Murata, Allen L. Horwitz, Louis Philipson, Samuel Refetoff
Title and authors | Publication | Year |
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Vision degrading myodesopsia assessed with optos ultra-widefield scanning laser ophthalmoscope
Lin T, Shi C, Wu B, Pazo EE, Shen L |
BMC ophthalmology | 2023 |
Long-term efficacy and safety of YAG laser vitreolysis for vision degrading myodesopsia
Lin TZ, Shi C, Yang X, Eric Pazo E, Hui YN, Shen LJ |
International Journal of Ophthalmology | 2023 |
Spontaneous remission of vision degrading myodesopsia of posterior vitreous detachment type.
Yang X, Shi C, Liu Q, Pazo EE, Lin T |
2022 | |
Clinical Cases in Pruritus
SC Trotter, A Cusick |
2021 | |
A comparative analysis of the relationship between stature and ultrasound dimensions of internal organs in adolescents
VO Yerkudov, AP Pugovkin, AJ Volkov, OI Musaeva, DJ Volkov, SS Rogozin, MV Chistjakova, AV Kochubeev, MA Pakhomova, TV Brus, MM Zabezhinsky |
2021 | |
Thyroid Function Modulates Lung Fluid and Alveolar Viscoelasticity in Mechanically Ventilated Rat
MS Owji, M Varedi, F Naghibalhossaini, N Pajouhi |
The Journal of surgical research | 2020 |
Slit2 Regulates Hyaluronan & Cytokine Synthesis in Fibrocytes: Potential Relevance to Thyroid-Associated Ophthalmopathy
R Fernando, TJ Smith |
The Journal of clinical endocrinology and metabolism | 2020 |
Association of risk factors with the severity of primary open angle glaucoma
A Tadwalkar, S Karandikar, P Mehta, S Arora |
2020 | |
Physiological and Pathological Role of Circadian Hormones in Osteoarthritis: Dose-Dependent or Time-Dependent?
FarhadHossain, Y Hong, Y Jin, J Choi, Y Hong |
Journal of Clinical Medicine | 2019 |
HYPOTHYROIDISM COULD BE A POTENTIAL FACTOR TO PROLONG SUBCUTANEOUS NODULES OF EXENATIDE ONCE WEEKLY: A CASE REPORT
A Ito, A Kamata, A Nozaki, T Ando, A Kawakami |
AACE Clinical Case Reports | 2019 |
Constitutional diversity in the dimensions of internal organs of teenagers
VO Erkudov, AP Pugovkin, AJ Volkov, OI Musaeva, PA Zhivtsova |
2019 | |
Radionuclide Esophageal Transit Scintigraphy in Primary Hypothyroidism
SH Khan, MV P, TA Rather, BA Laway |
Journal of Neurogastroenterology and Motility | 2017 |
Cardiac actions of thyroid hormone metabolites
G Rutigliano, R Zucchi |
Molecular and Cellular Endocrinology | 2017 |
Case report of hypothyroidism presenting with myxedema ascites
M Atzenhoefer, JH Man, ER Saad |
Journal of Clinical and Translational Endocrinology: Case Reports | 2017 |
Endocrinology
C Napier, SH Pearce |
Endocrinology | 2016 |
Investigation of the choroidal thickness in patients with hypothyroidism
F Ulas, Dogan, O Dikbas, A Keles, S Çelebi |
Indian journal of ophthalmology | 2015 |
Hyaluronan and its function as an unspecific regulator of cell-bound receptors
R Ebid |
Medical Hypotheses | 2015 |
Metabolic Syndrome: A Comprehensive Textbook
RS Ahima |
Metabolic Syndrome | 2014 |
Thyroid Hormone and Wound Healing
JD Safer |
Journal of Thyroid Research | 2013 |
Triiodothyronine (T3) inhibits hyaluronate synthesis in a human dermal equivalent by downregulation of HAS2
T Pouyani, BH Sadaka, S Papp, L Schaffer |
In vitro cellular & developmental biology. Animal | 2013 |
Textbook of Natural Medicine
JA Bralley, RS Lord |
Textbook of Natural Medicine | 2013 |
Diseases of the Vitreo-Macular Interface
A Girach, MD de Smet |
2013 | |
Thyroid hormone action on skin:
JD Safer |
Current opinion in endocrinology, diabetes, and obesity | 2012 |
Metabolic Syndrome
M Wang |
Metabolic Syndrome | 2011 |
Thyroid hormone action on skin
JD Safer |
Dermato-endocrinology | 2011 |
Metabolic Basis of Obesity
RS Ahima |
2010 | |
Thyrotropin Receptor Activation Increases Hyaluronan Production in Preadipocyte Fibroblasts: CONTRIBUTORY ROLE IN HYALURONAN ACCUMULATION IN THYROID DYSFUNCTION
L Zhang, T Bowen, F Grennan-Jones, C Paddon, P Giles, J Webber, R Steadman, M Ludgate |
The Journal of biological chemistry | 2009 |
Anatomie et physiologie du vitré et de l'interface vitréorétinienne
J Sebag |
EMC - Ophtalmologie | 2008 |
The role of thyroid hormones during the development of eye pigmentation in the Pacific bluefin tuna (Thunnus orientalis)
Y Kawakami, K Yokoi, H Kumai, H Ohta |
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology | 2008 |
Risk Factors For Posterior Vitreous Detachment: A Case-Control Study
JY Chuo, TY Lee, H Hollands, AH Morris, RC Reyes, JD Rossiter, SP Meredith, DA Maberley |
American Journal of Ophthalmology | 2006 |
T Helper Type 1 and Type 2 Cytokines Exert Divergent Influence on the Induction of Prostaglandin E2 and Hyaluronan Synthesis by Interleukin-1β in Orbital Fibroblasts: Implications for the Pathogenesis of Thyroid-Associated Ophthalmopathy
R Han, TJ Smith |
Endocrinology | 2006 |
Evaluation of alveolo-capillary permeability in thyrotoxicosis using Tc-99m DTPA aerosol scintigraphy
A Gültekin, M Yüksel, S Mert, Ş Berkarda |
Annals of Nuclear Medicine | 2005 |
Elastic Properties of the Ascending Aorta and Left Ventricular Function in Patients with Hypothyroidism
H Özhan, M Yazici, S Albayrak, E Erbilen, S Bulur, R Akdemir, C Uyan |
Echocardiography | 2005 |
Hypothyroidism impairs long-term potentiation in sympathetic ganglia: Electrophysiologic and molecular studies
KH Alzoubi, AS Bedawi, AM Aleisa, KA Alkadhi |
Journal of Neuroscience Research | 2004 |
A novel splice variant involving the 5’ untranslated region of thyroid hormone receptor β1 (TRβ1)
D Mannavola, LC Moeller, P Beck-Peccoz, L Persani, RE Weiss, S Refetoff |
Journal of Endocrinological Investigation | 2004 |
Current Perspective on the Pathogenesis of Graves’ Disease and Ophthalmopathy
BS Prabhakar, RS Bahn, TJ Smith |
Endocrine reviews | 2003 |
Thyroid Hormone Enhances Aggrecanase-2/ADAM-TS5 Expression and Proteoglycan Degradation in Growth Plate Cartilage
S Makihira, W Yan, H Murakami, M Furukawa, T Kawai, H Nikawa, E Yoshida, T Hamada, Y Okada, Y Kato |
Endocrinology | 2003 |
Fibroblast biology in thyroid diseases
TJ Smith |
Current Opinion in Endocrinology & Diabetes | 2002 |
Cultured Human Fibroblasts Express Constitutive IL-16 mRNA: Cytokine Induction of Active IL-16 Protein Synthesis Through a Caspase-3-Dependent Mechanism
D Sciaky, W Brazer, DM Center, WW Cruikshank, TJ Smith |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
Resistance to Thyroid Hormone Caused by a New Mutation (V336M) in the Thyroid Hormone Receptor β Gene
J Pohlenz, W Schönberger, T Koffler, S Refetoff |
Thyroid | 1999 |
A Novel Point Mutation in Cluster 3 of the Thyroid Hormone Receptor β Gene (P247L) Causing Mild Resistance to Thyroid Hormone
J Pohlenz, L Manders, PM Sadow, PC Kansal, S Refetoff, RE Weiss |
Thyroid | 1999 |
HMC-1 Mast Cells Activate Human Orbital Fibroblasts in Coculture: Evidence for Up-Regulation of Prostaglandin E2 and Hyaluronan Synthesis*
TJ Smith, SJ Parikh |
Endocrinology | 1999 |
Expression of Hyaluronan Synthase Messenger Ribonucleic Acids and Their Induction by Interleukin-1β in Human Orbital Fibroblasts: Potential Insight into the Molecular Pathogenesis of Thyroid-Associated Ophthalmopathy1
LA Kaback, TJ Smith |
The Journal of clinical endocrinology and metabolism | 1999 |
Activation of Human Orbital Fibroblasts through CD40 Engagement Results in a Dramatic Induction of Hyaluronan Synthesis and Prostaglandin Endoperoxide H Synthase-2 Expression: INSIGHTS INTO POTENTIAL PATHOGENIC MECHANISMS OF THYROID-ASSOCIATED OPHTHALMOPATHY
HJ Cao, HS Wang, Y Zhang, HY Lin, RP Phipps, TJ Smith |
The Journal of biological chemistry | 1998 |
The putative role of cytokine-orbital fibroblast interactions in the pathogenesis of thyroid-associated ophthalmopathy
TJ Smith |
Orbit | 1996 |
Molecular Cloning of a Novel Thyroid Hormone-responsive Gene, ZAKI-4 , in Human Skin Fibroblasts
T Miyazaki, Y Kanou, Y Murata, S Ohmori, T Niwa, K Maeda, H Yamamura, H Seo |
The Journal of biological chemistry | 1996 |
Bone and joint manifestations of hypothyroidism
RM McLean, DN Podell |
Seminars in Arthritis and Rheumatism | 1995 |
Effects of Thyro-Parathyroidectomy and Parathyroidectomy upon Dentinogenesis: Part I: Light Microscopy
H Chardin, AC Acevedo, D Septier, JF Staub, M Goldberg |
Connective Tissue Research | 1995 |
Leukoregulin induces plasminogen activator inhibitor type 1 in human orbital fibroblasts
MG Hogg, CH Evans, TJ Smith |
American journal of physiology. Cell physiology | 1995 |
Mutations of CpG dinucleotides located in the triiodothyronine (T3)-binding domain of the thyroid hormone receptor (TR) beta gene that appears to be devoid of natural mutations may not be detected because they are unlikely to produce the clinical phenotyp
Y Hayashi, T Sunthornthepvarakul, S Refetoff |
Journal of Clinical Investigation | 1994 |
Prostaglandin E2 elicits a morphological change in cultured orbital fibroblasts from patients with Graves ophthalmopathy
TJ Smith, HS Wang, MG Hogg, RC Henrikson, CR Keese, I Giaever |
Proceedings of the National Academy of Sciences | 1994 |
Hyaluronan Metabolism in Skin
R Tammi, UM Ågren, AL Tuhkanen, M Tammi |
Progress in Histochemistry and Cytochemistry | 1994 |
Ultrastructure of cultured human orbital fibroblasts
RC Henrikson, TJ Smith |
Cell and Tissue Research | 1994 |
Regulation of lysosomal sulfate transport by thyroid hormone
HF Chou, M Passage, AJ Jonas |
The Journal of biological chemistry | 1994 |
Effect of therapy for thyroid dysfunction on musculoskeletal symptoms
M Kloppenburg, BA Dijkmans, JJ Rasker |
Clinical Rheumatology | 1993 |
Interferon Gamma Regulation of De Novo Protein Synthesis in Human Dermal Fibroblasts in Culture Is Anatomic Site Dependent
TJ Smith, PJ Higgins |
Journal of Investigative Dermatology | 1993 |
Surgical Endocrinology
M Press |
Surgical Endocrinology | 1993 |
Pleotrophic action of interferon gamma in human orbital fibroblasts
PJ Higgins, TJ Smith |
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 1993 |
Bidimensional gel electrophoretic analysis of protein synthesis and response to interferon-γ in cultured human dermal fibroblasts
TJ Smith, PJ Higgins |
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 1993 |
Thyroid Function & Disease
JH Oppenheimer |
Thyroid Function & Disease | 1990 |
The Vitreous
J Sebag |
1989 | |
Keratinocytes Convert Thyroxine to Triiodothyronine
MM Kaplan, PR Gordon, C Pan, JK Lee, BA Gilchrest |
Annals of the New York Academy of Sciences | 1988 |
Effect of Thyroid Hormone Deficiency on Proteoglycan Synthesis by Human Skin Fibroblast Cultures
Y Shishiba, M Yanagishita, VC Hascall |
Connective Tissue Research | 1988 |
Glucocorticoid regulation of glycosaminoglycan synthesis in cultured human skin fibroblasts: Evidence for a receptor-mediated mechanism involving effects on specific de novo protein synthesis
TJ Smith |
Metabolism | 1988 |
3,3′,5-L-triiodothyronine but not L-thyroxine can block the induction of tyrosinase by imidazole in cultured B16 melanoma cells
TJ Smith, EL Kline |
Biochemical and Biophysical Research Communications | 1988 |
3 Clinical pathophysiology and metabolic effects of hypothyroidism
U Bürgi, MP König |
Baillière's Clinical Endocrinology and Metabolism | 1988 |
n-Butyrate inhibition of hyaluronate synthesis in cultured human fibroblasts
TJ Smith |
Journal of Clinical Investigation | 1987 |
Thyroid and Glucocorticoid Hormone Regulation of specific Protein Abundance in Cultured Human Skin Fibroblasts
RE Davis, TJ Smith |
Endocrine Research | 1987 |
Nuclear thyroid hormone receptors in cultured human fibroblasts: Improved method of isolation, partial characterization, and interaction with chromatin
K Ichikawa, LJ DeGroot, S Refetoff, AL Horwitz, ER Pollak |
Metabolism | 1986 |
Angiotensin-converting enzyme: Characteristics in human skin fibroblasts
RC Smallridge, GT Gamblin, C Eil |
Metabolism | 1986 |
Chemically Induced Renal Papillary Necrosis and Upper Urothelial Carcinoma. Part 2
PH Bach, JW Bridges, GH Mudge |
Critical Reviews in Toxicology | 1985 |
Glucocorticoid Regulation of Glycosaminoglycan Accumulation in Murine Fibroblasts
TJ Smith |
Endocrine Research | 1985 |
Dexamethasone regulation of glycosaminoglycan synthesis in cultured human skin fibroblasts. Similar effects of glucocorticoid and thyroid hormones
TJ Smith |
Journal of Clinical Investigation | 1984 |
Effects of 3,5,3'-triiodothyronine on collagen synthesis by cultured human skin fibroblasts
C Rycker, JL Vandalem, G Hennen |
FEBS Letters | 1984 |