Citations to this article

Role of Insulin in the Regulation of Leucine Kinetics in the Conscious Dog
Naji N. Abumrad, … , A. D. Cherrington, W. W. Lacy
Naji N. Abumrad, … , A. D. Cherrington, W. W. Lacy
Published November 1, 1982
Citation Information: J Clin Invest. 1982;70(5):1031-1041. https://doi.org/10.1172/JCI110690.
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Research Article

Role of Insulin in the Regulation of Leucine Kinetics in the Conscious Dog

Abstract

To study the effect of insulin on leucine kinetics, three groups of conscious dogs were studied after an overnight fast (16-18 h). One, saline-infused group (n = 5), served as control. The other two groups were infused with somatostatin and constant replacement amount of glucagon; one group (n = 6) received no insulin replacement, to produce acute insulin deficiency, and the other (n = 6) was constantly replaced with 600 μU/kg per min insulin, to produce twice basal hyperinsulinemia. Hepatic and extrahepatic splanchnic (gut) balance of leucine and α-ketoisocaproate (KIC) were calculated using the arteriovenous difference technique. l,4,5,[3H]Leucine was used to measure the rates (micromoles per kilogram per minute) of appearance (Ra) and disappearance (Rd), and clearance (Cl) of plasma leucine (milliliters per kilogram per minute).

Authors

Naji N. Abumrad, L. S. Jefferson, S. R. Rannels, P. E. Williams, A. D. Cherrington, W. W. Lacy

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