Citations to this article

Tubular Mechanism for the Spontaneous Hypercalciuria in Laboratory Rat
Kai Lau, Bonnie K. Eby
Kai Lau, Bonnie K. Eby
Published October 1, 1982
Citation Information: J Clin Invest. 1982;70(4):835-844. https://doi.org/10.1172/JCI110680.
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Research Article

Tubular Mechanism for the Spontaneous Hypercalciuria in Laboratory Rat

Abstract

Recently it has been observed that Ca excretion in laboratory rats does not follow a Gaussian distribution, with ∼10% of them excreting Ca at a rate of 2 SD above the group mean. This phenomenon has been described as spontaneous hypercalciuria (SH). Our studies were designed to define its mechanism. 48 Wistar rats were subjected to metabolic studies to identify SH, prospectively defined as Ca excretion 2 SD above the group mean during 7 d of dietary Ca deprivation (≤0.03% by analysis), in the absence of hypercalcemia, PO4 depletion, or exaggerated natriuresis.

Authors

Kai Lau, Bonnie K. Eby

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Citations to this article (17)

Title and authors Publication Year
Normotensive metabolic syndrome in Transient Receptor Potential Canonical Channel type 1 Trpc1-/- mice.
Atkins RM, Pantalia M, Skaggs C, Lau AK, Mahmood MB, Anwar MM, Barron L, Eby B, Khan U, Tsiokas L, Lau K 		Biology Open 2024
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D Magen, I Zelikovic 		Pediatric Bone 2012
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ZC Chroneos, Z Sever-Chroneos, VL Shepherd 		Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
Hereditary tubular transport disorders: implications for renal handling of Ca2+and Mg2+
H Dimke, JG Hoenderop, RJ Bindels 		Clinical Science 2009
Ca2+Mg2+-ATPase activity in erythrocyte membranes in hypercalciuric nephrolithiasic patients
RM Heguilen, MI Gimenez, N Imperiali, AR Bernasconi, SL Algranati, ED Farias 		Nephrology 2002
Alendronate decreases urine calcium and supersaturation in genetic hypercalciuric rats
DA Bushinsky, KJ Neumann, J Asplin, NS Krieger 		Kidney International 1999
Defective renal calcium reabsorption in genetic hypercalciuric rats
S Tsuruoka, DA Bushinsky, GJ Schwartz 		Kidney International 1997
Response of genetic hypercalciuric rats to a low calcium diet
M Kim, NE Sessler, V Tembe, MJ Favus, DA Bushinsky 		Kidney International 1993
Familial Forms of Hypercalciuria
MJ Favus 		The Journal of Urology 1989
Inheritance of Kidney and Urinary Tract Diseases
A Spitzer, ED Avner 		1989
Mechanism of hypercalciuria in genetic hypercalciuric rats. Inherited defect in intestinal calcium transport
DA Bushinsky, MJ Favus 		Journal of Clinical Investigation 1988
Pathogenese und Klinik der Harnsteine XII
W Vahlensieck, G Gasser 		1987
Bone resorption and hypercalciuria in calcium stoneformers
RA Sutton, VR Walker 		Metabolism 1986
Pathophysiology of spontaneous hypercalciuria in laboratory rats. Role of deranged vitamin D metabolism
K Lau, D Thomas, C Langman, B Eby 		Journal of Clinical Investigation 1985
Evidence for an intestinal mechanism in hypercalciuria of spontaneously hypertensive rats
K Lau, D Zikos, J Spirnak, B Eby 		American journal of physiology. Endocrinology and metabolism 1984
Contemporary Nephrology
S Klahr, SG Massry 		1981

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