Abstract
Rabbit transferrin in vitro is shown to load ferrous iron at random on its specific binding sites. The release of iron to reticulocytes is shown to be an all-or-none phenomenon. The two monoferric transferrins have similar in vivo plasma iron clearance rates and tissue distribution. Diferric transferrin, while giving a similar tissue distribution of radioiron, has a plasma iron clearance rate approximately twice that of the monoferric transferrins at low plasma iron concentrations. This difference diminishes as the plasma iron concentration increases. These results are consistent with a progressively greater in vivo conversion of mono- to diferric transferrin as transferrin saturation increases. The in vivo plasma iron turnover in the rabbit increases progressively as the plasma iron increases, from a mean value of ∼0.8 mg/dl whole blood per d at a plasma iron concentration of 50 μg/dl to 2.0 at a plasma iron concentration of 300.
Authors
Helmut Huebers, David Uvelli, Antonio Celada, Betty Josephson, Clement Finch
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