Protective Role of Superoxide Dismutase against Diabetogenic Drugs

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Abstract

Copper-zinc superoxide dismutase (SOD) is present in relatively high concentrations in the β-cells of human islets. The activity of the extracted enzyme is partially inhibited upon incubation with the diabetogenic drugs alloxan, streptozotocin, or Vacor. The role of this enzyme in protecting β-cells against chemically induced diabetes was further investigated.

Authors

Samuel E. Gandy, Maria G. Buse, Rosalie K. Crouch