F1 hybrid offspring of New Zealand Black mothers and New Zealand White fathers [(NZB X NZW)F1] female mice develop antibodies to single-stranded (ss) and native DNA, immune complex glomerulonephritis, massive proteinuria, and premature death with renal failure. By a series of matings, congenic (NZB X NZW)F1 . xid/xid mice were prepared. These mice were different from (NZB X NZW)F1 mice in having the X chromosome-linked immune deficiency gene, xid, in homozygous form. Such congenic (NZB X NZW)F1 . xid/xid females failed to develop antibodies to single-stranded or native DNA. They also failed to develop fatal renal disease as measured by proteinuria, glomerular histology, glomerular immunofluorescence, and survival. To control for unknown genetic factors, studies were performed with littermates that were derived by mating NZB . xid/+ females with NZW . xid/Y males such that the resulting offspring were either (NZB X NZW)F1 . xid/xid (and therefore "defective") or (NZB X NZW)F1 . xid/+ [phenotypically like (NZB X NZW)F1]. In these and in additional studies, mice were housed in the same cages and identified by ear tagging so as to avoid possible environmental variations from cage to cage. In these studies, xid/xid mice failed to develop the characteristic signs of autoimmunity, whereas the controls did. Similar results were also obtained with (NZW X NZB)F1 xid/xid mice compared with (NZW X NZB)F1 xid/+ mice. The effect of xid/xid upon (NZB X NZW)F1 mice was further investigated by assessing responses to immunization and polyclonal B cell activation in vivo. The xid/xid mice failed to produce anti-ssDNA following immunization with ssDNA complexed to a protein carrier in fluid form or even emulsified in adjuvant. Finally, the xid/xid mice failed to produce antiDNA in response to multiple injections of the polyclonal activator, bacterial lipopolysaccharide (LPS), or the polyclonal activator, polyribose inosinic acid . polyribose cytidylic acid. However, the xid/xid mice were neither generally hyporesponsive nor unable to recognize LPS because they made normal antibody responses following immunization with LPS to which multiple trinitrophenyl groups were chemically attached. We conclude from these studies that xid/xid, which is known to cause the deletion of a B cell subset, has a profound affect upon (NZB X NZW)F1 mice, rendering them insusceptible to the naturally occurring autoimmune disease characteristic of (NZB X NZW)F1 mice, and preventing them from producing antibodies to DNA despite purposeful immunization and polyclonal B cell activation. These results force a reevaluation of previous concepts regarding the mechanisms by which xid/xid might interfere with the development of autoimmunity, and a consideration of therapeutic implications.
B J Steinberg, P A Smathers, K Frederiksen, A D Steinberg
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Aberrant B Cell Signaling in Autoimmune Diseases
Corneth OB, Neys SF, Hendriks RW |
Cells | 2022 |
Bruton’s Tyrosine Kinase Inhibition as an Emerging Therapy in Systemic Autoimmune Disease
SF Neys, J Rip, RW Hendriks, OB Corneth |
Drugs | 2021 |
Bruton Tyrosine Kinase Inhibition and Its Role as an Emerging Treatment in Pemphigus
A Patsatsi, DF Murrell |
Frontiers in Medicine | 2021 |
Systemic lupus erythematosus (SLE): emerging therapeutic targets
LM Mathias, W Stohl |
Expert Opinion on Therapeutic Targets | 2020 |
Driving Potency with Rotationally Stable Atropisomers: Discovery of Pyridopyrimidinedione-Carbazole Inhibitors of BTK
AS Srivastava, S Ko, SH Watterson, MA Pattoli, S Skala, L Cheng, MT Obermeier, R Vickery, LN Discenza, CJ DArienzo, KM Gillooly, TL Taylor, C Pulicicchio, KW McIntyre, S Yip, P Li, D Sun, DR Wu, J Dai, C Wang, Y Zhang, B Wang, J Pawluczyk, J Kempson, R Zhao, X Hou, R Rampulla, A Mathur, MA Galella, L Salter-Cid, JC Barrish, PH Carter, A Fura, JR Burke, JA Tino |
ACS Medicinal Chemistry Letters | 2020 |
Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase
D Angst, F Gessier, P Janser, A Vulpetti, R Wälchli, C Beerli, A Littlewood-Evans, J Dawson, B Nuesslein-Hildesheim, G Wieczorek, S Gutmann, C Scheufler, A Hinniger, AG Zimmerlin, EG Funhoff, R Pulz, B Cenni |
Journal of Medicinal Chemistry | 2020 |
Efficacy and Pharmacodynamic Modeling of the BTK Inhibitor Evobrutinib in Autoimmune Disease Models
P Haselmayer, M Camps, L Liu-Bujalski, N Nguyen, F Morandi, J Head, A OMahony, SC Zimmerli, L Bruns, AT Bender, P Schroeder, R Grenningloh |
Journal of immunology (Baltimore, Md. : 1950) | 2019 |
Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid In Vivo Inactivation of Bruton's Tyrosine Kinase (BTK)
SH Watterson, Q Liu, MB Bertrand, DG Batt, L Li, MA Pattoli, S Skala, L Chen, MT Obermeier, R Moore, Z Yang, R Vickery, PA Elzinga, LN Discenza, C D'Arienzo, KM Gillooly, TL Taylor, C Pulicicchio, Y Zhang, E Heimrich, KW McIntyre, Q Ruan, RA Westhouse, IM Catlett, N Zheng, C Chaudhry, J Dai, MA Galella, AJ Tebben, M Pokross, J Li, R Zhao, D Smith, RA Rampulla, A Allentoff, MA Wallace, A Mathur, L Salter-Cid, JE Macor, PH Carter, A Fura, JR Burke, JA Tino |
Journal of Medicinal Chemistry | 2019 |
Bruton’s Tyrosine Kinase, a Component of B Cell Signaling Pathways, Has Multiple Roles in the Pathogenesis of Lupus
AB Satterthwaite |
Frontiers in immunology | 2018 |
Btk-specific inhibition blocks pathogenic plasma cell signatures and myeloid cell-associated damage in IFNα-driven lupus nephritis
Arna Katewa, Yugang Wang, Jason Hackney, Tao Huang, Eric Suto, Nandhini Ramamoorthi, Cary D. Austin, Meire Bremer, Jacob Zhi Chen, James J. Crawford, Kevin Currie, Peter Blomgren, Jason DeVoss, Julie DiPaolo, Jonathan Hau, Adam Johnson, Justin Lesch, Laura DeForge, Zhonghua Lin, Marya Liimatta, Joseph Lubach, Sami McVay, Zora Modrusan, Allen Nguyen, Chungkee Poon, Jianyong Wang, Lichuan Liu, Wyne P. Lee, Harvey Wong, Wendy B. Young, Michael Townsend, Karin Reif |
JCI Insight | 2017 |
Reply: LETTERS
LE Nyhoff, LJ Crofford, PL Kendall |
Arthritis & Rheumatology | 2017 |
Increased expression of Bruton’s tyrosine kinase in peripheral blood is associated with lupus nephritis
W Kong, W Deng, Y Sun, S Huang, Z Zhang, B Shi, W Chen, X Tang, G Yao, X Feng, L Sun |
Clinical Rheumatology | 2017 |
Small Molecule Reversible Inhibitors of Bruton’s Tyrosine Kinase (BTK): Structure–Activity Relationships Leading to the Identification of 7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9 H -carbazole-1-carboxamide (BMS-935177)
GV de Lucca, Q Shi, Q Liu, DG Batt, MB Bertrand, R Rampulla, A Mathur, L Discenza, C DArienzo, J Dai, M Obermeier, R Vickery, Y Zhang, Z Yang, P Marathe, AJ Tebben, JK Muckelbauer, CY Chang, H Zhang, K Gillooly, T Taylor, MA Pattoli, S Skala, DW Kukral, KW McIntyre, L Salter-Cid, A Fura, JR Burke, JC Barrish, PH Carter, JA Tino |
Journal of Medicinal Chemistry | 2016 |
The role of Bruton’s tyrosine kinase in autoimmunity and implications for therapy
LJ Crofford, LE Nyhoff, JH Sheehan, PL Kendall |
Expert Review of Clinical Immunology | 2016 |
Bruton's Tyrosine Kinase Deficiency Inhibits Autoimmune Arthritis in Mice but Fails to Block Immune Complex-Mediated Inflammatory Arthritis: BTK IN AUTOIMMUNE AND INFLAMMATORY ARTHRITIS
LE Nyhoff, BL Barron, EM Johnson, RH Bonami, D Maseda, BA Fensterheim, W Han, TS Blackwell, LJ Crofford, PL Kendall |
Arthritis & Rheumatology | 2016 |
Discovery of 6-Fluoro-5-( R )-(3-( S )-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4 H )-yl)-2-methylphenyl)-2-( S )-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1 H -carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton’s Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers
SH Watterson, GV de Lucca, Q Shi, CM Langevine, Q Liu, DG Batt, MB Bertrand, H Gong, J Dai, S Yip, P Li, D Sun, DR Wu, C Wang, Y Zhang, SC Traeger, MA Pattoli, S Skala, L Cheng, MT Obermeier, R Vickery, LN Discenza, CJ DArienzo, Y Zhang, E Heimrich, KM Gillooly, TL Taylor, C Pulicicchio, KW McIntyre, MA Galella, AJ Tebben, JK Muckelbauer, CY Chang, R Rampulla, A Mathur, L Salter-Cid, JC Barrish, PH Carter, A Fura, JR Burke, JA Tino |
Journal of Medicinal Chemistry | 2016 |
Potent and selective Bruton’s tyrosine kinase inhibitors: Discovery of GDC-0834
WB Young, J Barbosa, P Blomgren, MC Bremer, JJ Crawford, D Dambach, S Gallion, SG Hymowitz, JE Kropf, SH Lee, L Liu, JW Lubach, J Macaluso, P Maciejewski, B Maurer, SA Mitchell, DF Ortwine, JD Paolo, K Reif, H Scheerens, A Schmitt, CG Sowell, X Wang, H Wong, JM Xiong, J Xu, Z Zhao, KS Currie |
Bioorganic & Medicinal Chemistry Letters | 2015 |
Killer B Lymphocytes and Their Fas Ligand Positive Exosomes as Inducers of Immune Tolerance
SK Lundy, MW Klinker, DA Fox |
Frontiers in immunology | 2015 |
Overexpression of Fkbp11 , a feature of lupus B cells, leads to B cell tolerance breakdown and initiates plasma cell differentiation: The role of Fkbp11 in B cells and autoimmunity
J Ruer-Laventie, L Simoni, JN Schickel, A Soley, M Duval, AM Knapp, L Marcellin, D Lamon, AS Korganow, T Martin, JL Pasquali, P Soulas-Sprauel |
Immunity, Inflammation and Disease | 2015 |
B Cell Receptor Signaling
T Kurosaki, J Wienands |
B Cell Receptor Signaling | 2015 |
Molecular abnormalities of the B cell in systemic lupus erythematosus are candidates for functional inhibition treatments
SN Liossis, K Melissaropoulos |
Expert Opinion on Pharmacotherapy | 2014 |
Purine derivatives as potent Bruton’s tyrosine kinase (BTK) inhibitors for autoimmune diseases
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Selective Inhibition of BTK Prevents Murine Lupus and Antibody-Mediated Glomerulonephritis
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Journal of immunology (Baltimore, Md. : 1950) | 2013 |
Dubois' Lupus Erythematosus and Related Syndromes
JC Crispín, GC Tsokos |
Dubois' Lupus Erythematosus and Related Syndromes | 2013 |
Reference Module in Chemistry, Molecular Sciences and Chemical Engineering
AN Hegde |
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Carabin deficiency in B cells increases BCR-TLR9 costimulation-induced autoimmunity
JN Schickel, JL Pasquali, A Soley, AM Knapp, M Decossas, A Kern, JD Fauny, L Marcellin, AS Korganow, T Martin, P Soulas-Sprauel |
EMBO Molecular Medicine | 2012 |
Modulating proximal cell signaling by targeting Btk ameliorates humoral autoimmunity and end-organ disease in murine lupus
J Hutcheson, K Vanarsa, A Bashmakov, S Grewal, D Sajitharan, BY Chang, JJ Buggy, XJ Zhou, Y Du, AB Satterthwaite, C Mohan |
Arthritis Research & Therapy | 2012 |
Epistatic Suppression of Fatal Autoimmunity in New Zealand Black Bicongenic Mice
C Loh, E Pau, G Lajoie, TT Li, Y Baglaenko, YH Cheung, NH Chang, JE Wither |
Journal of immunology (Baltimore, Md. : 1950) | 2011 |
Advances in Immunology
E Pinaud, M Marquet, R Fiancette, S Péron, C Vincent-Fabert, Y Denizot, M Cogné |
Advances in Immunology Volume 110 | 2011 |
Lupus Nephritis: Role of Antinucleosome Autoantibodies
J der Vlag, JH Berden |
Seminars in Nephrology | 2011 |
Class switching and consecutive loss of dsDNA-reactive B1a B cells from the peritoneal cavity during murine lupus development
P Enghard, JY Humrich, VT Chu, E Grussie, F Hiepe, GR Burmester, A Radbruch, C Berek, G Riemekasten |
European Journal of Immunology | 2010 |
Reduced Diabetes in btk -Deficient Nonobese Diabetic Mice and Restoration of Diabetes with Provision of an Anti-Insulin IgH Chain Transgene
PL Kendall, DJ Moore, C Hulbert, KL Hoek, WN Khan, JW Thomas |
Journal of immunology (Baltimore, Md. : 1950) | 2009 |
CD22 and Siglec-G: B-cell inhibitory receptors with distinct functions
L Nitschke |
Immunological Reviews | 2009 |
Btk regulates localization, in vivo activation, and class switching of anti-DNA B cells
KE Halcomb, S Musuka, T Gutierrez, HL Wright, AB Satterthwaite |
Molecular Immunology | 2008 |
Natural killer T cells and innate immune B cells from lupus-prone NZB/W mice interact to generate IgM and IgG autoantibodies
T Takahashi, S Strober |
European Journal of Immunology | 2007 |
Siglec-G is a B1 cell–inhibitory receptor that controls expansion and calcium signaling of the B1 cell population
A Hoffmann, S Kerr, J Jellusova, J Zhang, F Weisel, U Wellmann, TH Winkler, B Kneitz, PR Crocker, L Nitschke |
Nature Immunology | 2007 |
Chemical Genetic Transcriptional Fingerprinting for Selectivity Profiling of Kinase Inhibitors
S Jiang, J DiPaolo, K Currie, S Alderucci, A Ramamurthy, J Peppers, X Qian, D Qian, T Awad, M Velleca, JA Whitney |
ASSAY and Drug Development Technologies | 2007 |
Glomerular expression of large polyomavirus T antigen in binary tet-off regulated transgenic mice induces apoptosis, release of chromatin and initiates a lupus-like nephritis
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Molecular Immunology | 2007 |
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D Savitsky, K Calame |
Journal of Experimental Medicine | 2006 |
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M Petri |
JCR: Journal of Clinical Rheumatology | 2006 |
B-lymphocytes, innate immunity, and autoimmunity
M Viau, M Zouali |
Clinical Immunology | 2005 |
Effect of the B cell superantigen protein A from S. aureus on the early lupus disease of (NZB×NZW) F1 mice
M Viau, M Zouali |
Molecular Immunology | 2005 |
Separation of the New Zealand Black Genetic Contribution to Lupus from New Zealand Black Determined Expansions of Marginal Zone B and B1a Cells
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Journal of immunology (Baltimore, Md. : 1950) | 2004 |
Role of the chemokine stromal cell-derived factor 1 in autoantibody production and nephritis in murine lupus
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Journal of immunology (Baltimore, Md. : 1950) | 2003 |
O RIGINS AND F UNCTIONS OF B-1 C ELLS WITH N OTES ON THE R OLE OF CD5
R Berland, HH Wortis |
Annual Review of Immunology | 2002 |
ORIGINS ANDFUNCTIONS OFB-1 CELLS WITHNOTES ON THEROLE OFCD5
R Berland, HH Wortis |
Annual Review of Immunology | 2002 |
Pathways for self-tolerance and the treatment of autoimmune diseases
CC Goodnow |
The Lancet | 2001 |
Significant association between the skewed natural antibody repertoire ofXid mice and resistance toTrypanosoma cruzi infection
EC Santos-Lima, R Vasconcellos, B Reina-San-Martín, C Fesel, A Cordeiro-da-Silva, A Berneman, A Cosson, A Coutinho, P Minoprio |
European Journal of Immunology | 2001 |
xid mice reveal the interplay of homeostasis and Bruton's tyrosine kinase-mediated selection at multiple stages of B cell development
MP Cancro, AP Sah, SL Levy, DM Allman, MR Schmidt, RT Woodland |
International Immunology | 2001 |
A novel function of B lymphocytes from normal mice to suppress autoimmunity in (NZB x NZW)F1 mice
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Immunology | 2000 |
Molecular Mimicry, Microbes, and Autoimmunity
MW Cunningham, RS Fujinami |
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M Potter, JS Wax, CT Hansen, JJ Kenny |
International Immunology | 1999 |
Phenotypic and Functional Analysis of Activated B Cells of Autoimmune NZB x NZW F1 Mice
Ye, Suen, Chen, Chiang |
Scandinavian Journal of Immunology | 1998 |
Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways
AB Satterthwaite, CA Lowell, WN Khan, P Sideras, FW Alt, ON Witte |
Journal of Experimental Medicine | 1998 |
B-1 cell development: evidence for an uncommitted immunoglobulin (Ig)M+ B cell precursor in B-1 cell differentiation
SH Clarke, LW Arnold |
Journal of Experimental Medicine | 1998 |
B-1 Cell Development: Evidence for an Uncommitted Immunoglobulin (Ig)M+ B Cell Precursor in B-1 Cell Differentiation
SH Clarke, LW Arnold |
Journal of Experimental Medicine | 1998 |
Btk dosage determines sensitivity to B cell antigen receptor cross-linking
AB Satterthwaite, H Cheroutre, WN Khan, P Sideras, ON Witte |
Proceedings of the National Academy of Sciences | 1997 |
Interleukin-4 Protects against a Genetically Linked Lupus-like Autoimmune Syndrome
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Journal of Experimental Medicine | 1997 |
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CC Goodnow |
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Annals of the New York Academy of Sciences | 1995 |
Involvement of B-1 cells in mucosal immunity and autoimmunity
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Immunology Today | 1995 |
Role of Bruton's tyrosine kinase in immunodeficiency
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Current Opinion in Immunology | 1994 |
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The molecular pathogenesis of XLA involves a spectrum of mutations in Bruton's tyrosine kinase
DC Saffran, ON Witte |
Clinical Immunology Newsletter | 1994 |
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C Putterman, Y Naparstek |
Autoimmune Disease Models | 1994 |
Restricted immunoglobulin VH usage and VDJ combinations in the human response to Haemophilus influenzae type b capsular polysaccharide. Nucleotide sequences of monospecific anti-Haemophilus antibodies and polyspecific antibodies cross-reacting with self a
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Journal of Clinical Investigation | 1993 |
Immunoglobulin heavy chain constant region determines the pathogenicity and the antigen-binding activity of rheumatoid factor
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Annals of the rheumatic diseases | 1993 |
The Repertoire of Human Antibody to the Haemophilus influenzae Type b Capsular Polysaccharide
RA Insel, EE Adderson, WL Carroll |
International Reviews of Immunology | 1992 |
Development of autoimmune disease in SCID mice populated with long-term "in vitro" proliferating (NZB x NZW)F1 pre-B cells
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Journal of Experimental Medicine | 1992 |
Patterns of heavy and light chain utilization in the antibody response to single-stranded bacterial DNA in normal human subjects and patients with systemic lupus erythematosus
CR Robertson, GS Gilkeson, MM Ward, DS Pisetsky |
Clinical Immunology and Immunopathology | 1992 |
Induction of “wire-loop” lesions by murine monoclonal IgG3 cryoglobulins
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Kidney International | 1992 |
Antibodies elicited by pneumococcal antigens bear an anti-DNA--associated idiotype
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Journal of Clinical Investigation | 1991 |
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Postgraduate medical journal | 1991 |
The contribution of non-MHC genes to susceptibility to autoimmune diseases
HJ Garchon, JF Bach |
Human Immunology | 1991 |
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Immunologic Research | 1990 |
Pathogenic Anti-DNA Antibodies in SLE: Idiotypic Families and Genetic Origins
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International Reviews of Immunology | 1990 |
Cellular requirements for anti-DNA production induced in mice by immunization with bacterial DNA
GS Gilkeson, AJ Pritchard, DS Pisetsky |
European Journal of Immunology | 1990 |
Theiler's virus-induced demyelination in mice immunosuppressed with anti-IgM and in mice expressing the xid gene
M Rodriguez, JJ Kenny, RL Thiemann, GE Woloschak |
Microbial Pathogenesis | 1990 |
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Arthritis & Rheumatism | 1990 |
B cell hyperactivity in autoimmune continuous B cell lines
M Aldo-Benson, MS Brooks, L Scheiderer-Pratt |
Immunologic Research | 1989 |
Autoantibody repertoire analysis in normal and lupus-prone mice
M Starobinski, M Lacour, L Reininger, S Izui |
Journal of Autoimmunity | 1989 |
Expression of an endogenous retroviral transcript is associated with murine lupus
AM Krieg, AS Khan, AD Steinberg |
Arthritis & Rheumatism | 1989 |
Polyclonal activation and experimental nephropathies
M Goldman, D Baran, P Druet |
Kidney International | 1988 |
The role of splenic colony-forming units in autoimmune disease
CL Scribner, AD Steinberg |
Clinical Immunology and Immunopathology | 1988 |
Pathogenesis of Systemic Lupus Erythematosus
AD Steinberg, DM Klinman |
Rheumatic diseases clinics of North America | 1988 |
Effect of xid on autoimmune C3H-gld/gld mice
MF Seldin, JP Reeves, CL Scribner, JB Roths, WF Davidson, HC Morse, AD Steinberg |
Cellular Immunology | 1987 |
Inhibitory effect of TI-31 on autoimmune nephritis in NZB/NZW F1 mice through regulation of the immune response
K Komoriya, I Nagata, M Tsuchimoto, K Kunisawa, T Koyama, K Hosoda, T Takeshita, T Naruchi, I Yamamoto, C Abe, Y Shiokawa |
Immunopharmacology | 1987 |
Transfer of anti-DNA-producing B cells from NZB to unmanipulated xid recipients: Effects of age, sex, and environment
Y Ishigatsubo, DM Klinman, AD Steinberg |
Clinical Immunology and Immunopathology | 1987 |
Studies of the Effects of Y Chromosome Factors on the Expression of Autoimmune Disease
AD Steinberg, KH Triem, HR Smith, CA Laskin, YJ Rosenberg, DM Klinman, JF Mushinski, JD Mountz |
Annals of the New York Academy of Sciences | 1986 |
Immune Response Potential and Its Genetic Regulation in Autoimmune Diseases Alterations in Systemic Lupus Erythematosus and Thyroid Autoimmune Diseases
Z Bentwich, Y Shalev, R Segal, D Katz, E Mozes |
Annals of the New York Academy of Sciences | 1986 |
Treatment of Autoimmune Disease with Total Lymphoid Irradiation Cellular and Humoral Mechanisms
S Strober, B Kotzin, E Field, R Hoppe, B Myers, A Tanay |
Annals of the New York Academy of Sciences | 1986 |
Effect of anti-Ia treatment on the production of anti-DNA antibody by NZB mice
DM Klinman, MD Lefkowitz, ES Raveche, AD Steinberg |
European Journal of Immunology | 1986 |
Oncogene expression in autoimmune and normal peripheral blood mononuclear cells
DM Klinman, JF Mushinski, M Honda, Y Ishigatsubo, JD Mountz, ES Raveche, AD Steinberg |
Journal of Experimental Medicine | 1986 |
Prevention of lupus diseases in , NZBxNZW, and BXSB mice treated with a cyclophosphazene derived drug
M Dueymes, GJ Fournié, M Mignon-Conté, S In, JJ Conté |
Clinical Immunology and Immunopathology | 1986 |
Antinucleic Acid Antibodies, Gene Expression, and Autoimmune Mice
AD Steinberg, JD Mountz, BJ Steinberg, JF Mushinski, CC Hudgins, RT Steinberg |
Scandinavian Journal of Rheumatology | 1985 |
Expression of an X-linked gene family (XLR) in late-stage B cells and its alteration by the xid mutation
DI Cohen, AD Steinberg, WE Paul, MM Davis |
Nature | 1985 |
Successful treatment of autoimmunity in NZB/NZW F1 mice with monoclonal antibody to L3T4
D Wofsy, WE Seaman |
Journal of Experimental Medicine | 1985 |
Effect of the xid gene on graft-versus-host-induced autoantibody production in nonautoimmune mice
JP Reeves, AD Steinberg |
Clinical Immunology and Immunopathology | 1985 |
Effect of the BXSB Y chromosome accelerating gene on autoantibody production
RT Steinberg, ML Miller, AD Steinberg |
Clinical Immunology and Immunopathology | 1985 |
Polyclonal B-cell activation in SLE: Frequencies of autoantibody secreting cells
R Dziarski |
Clinical Immunology Newsletter | 1985 |
A Large Deletion Within the T-Cell Receptor Beta-Chain Gene Complex in New Zealand White Mice
BL Kotzin, VL Barr, E Palmer |
Science | 1985 |
Differential gene expression in autoimmune mice
J D Mountz, J F Mushinski, A D Steinberg |
Survey of immunologic research | 1985 |
B Cell-Tropic Interleukins in Murine Systemic Lupus Erythematosus (SLE) 1
GJ Prud-Homme, TM Fieser, FJ Dixon&, AN Theoflopoulos |
Immunological Reviews | 1984 |
Opposing effects of xid and nu mutations on proliferative and polyclonal antibody and autoantibody responses to peptidoglycan, LPS, protein A and PWM
R Dziarski |
Immunology | 1984 |
Abrogation of murine lupus by the xid gene is associated with reduced responsiveness of B cells to T-cell-helper signals
TM Fieser, ME Gershwin, AD Steinberg, FJ Dixon, AN Theofilopoulos |
Cellular Immunology | 1984 |
Cloning of B cells from autoimmune MRL-lpr/lpr and MRL.xid mice
DS Pisetsky, SA Caster, M Piper, DW Scott, AD Steinberg |
Cellular Immunology | 1984 |
Studies of immune defective mice
JD Mountz, ES Raveche, PD Noguchi, AD Steinberg |
Clinical Immunology and Immunopathology | 1984 |
Recent advances in SLE
JD Mountz, AD Steinberg |
Clinical Immunology Newsletter | 1984 |
Induction of murine autoimmune disease by chronic polyclonal B cell activation
L Hang, JH Slack, C Amundson, S Izui, AN Theofilopoulos, FJ Dixon |
Journal of Experimental Medicine | 1983 |
B-cell hyperactivity in murine lupus II. Defects in response to and production of accessory signals in lupus-prone mice
AN Theofilopoulos, GJ Prud'homme, TM Fieser, FJ Dixon |
Immunology Today | 1983 |
Effect of xid on anti-DNA B-cell precursors
DS Pisetsky, SA Caster, AD Steinberg |
Cellular Immunology | 1983 |