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Citations to this article

Complex formation of platelet thrombospondin with fibrinogen.
L L Leung, R L Nachman
L L Leung, R L Nachman
Published September 1, 1982
Citation Information: J Clin Invest. 1982;70(3):542-549. https://doi.org/10.1172/JCI110646.
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Research Article

Complex formation of platelet thrombospondin with fibrinogen.

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Abstract

Using an enzyme-linked immunosorbent assay, we have demonstrated that purified human fibrinogen forms a complex with adsorbed platelet thrombospondin. The formation of the fibrinogen-thrombospondin complex was specific, saturable, and partially inhibited by mannosamine, glucosamine, and arginine. These same inhibitors have been previously shown to block thrombin-induced platelet lectin activity and platelet thrombospondin lectin activity. Adsorbed thrombospondin also formed a complex with fibronectin, although the extent of complex formation was significantly less than the extent of formation of the fibrinogen-thrombospondin complex. Platelet membrane glycoproteins IIb and IIIa, which have been previously shown to bind fibrinogen, did not inhibit the formation of the fibrinogen-thrombospondin complex. The present study supports the hypothesis that the interaction of fibrinogen with thrombospondin on the activated platelet surface may be an important step in the platelet aggregation process.

Authors

L L Leung, R L Nachman

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Total citations by year

Year: 2022 2018 2016 2014 2012 2010 2009 2008 2007 2006 2003 2001 2000 1999 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 1985 1984 1983 1969 Total
Citations: 1 1 1 2 2 3 1 1 1 2 1 2 3 1 4 3 1 2 8 5 5 7 8 9 14 20 15 21 5 1 150
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